On page 1 showing 1 ~ 20 out of 46 results
TBI Model Type: Controlled cortical impact model
Organism Species: mouse
Organism Strain: C57BL/6J (transgenic)
Assessments: Enzyme-linked immunosorbent assay (ELISA), qRT-PCR
Citation: Febinger HY, Thomasy HE, Pavlova MN, Ringgold KM, Barf PR, George AM, Grillo JN, Bachstetter AD, Garcia JA, Cardona AE, Opp MR, Gemma C. Time-dependent effects of CX3CR1 in a mouse model of mild traumatic brain injuryJ Neuroinflammation. 2015 Sep 2;12:154. doi: 10.1186\/s12974-015-0386-5. PMC4557842
TBI Model Type: Weight-drop model
Organism Species: rat
Organism Strain: Sprague-Dawley
Assessments: Enzyme-linked immunosorbent assay (ELISA), Modified limb-placing, Western Blot, modified Voetsch neuroscore
Citation: Chang CZ, Wu SC, Kwan AL, Lin CL. Magnesium Lithospermate B Implicates 3'-5'-Cyclic Adenosine Monophosphate\/Protein Kinase A Pathway and N-Methyl-d-Aspartate Receptors in an Experimental Traumatic Brain InjuryWorld Neurosurg. 2015 Oct;84(4):954-63. doi: 10.1016\/j.wneu.2015.05.075. Epub 2015 Jun 18.
TBI Model Type: Weight-drop model
Organism Species: rat
Organism Strain: Sprague-Dawley
Assessments: Enzyme-linked immunosorbent assay (ELISA), level of homocysteine, qRT-PCR
Citation: Tommy T, Islam AA, Hatta M, Bukhari A, Nasrullah, Adhimarta W, Aminuddin, Zainuddin AA. Effect of folinic acid on serum homocysteine, TNFα, IL-10, and HMGB1 gene expression in head injury modelAnn Med Surg (Lond). 2021 Apr 6;65:102273. doi: 10.1016\/j.amsu.2021.102273. eCollection 2021 May. PMC8100092
TBI Model Type: Weight-drop model
Organism Species: rat
Organism Strain: Sprague-Dawley
Assessments: Enzyme-linked immunosorbent assay (ELISA), Elevated plus maze, Immunofluorescence, open field test, TUNEL staining, Western blot
Citation: Xie LL, Li SS, Fan YJ, Qi MM, Li ZZ. Melatonin alleviates traumatic brain injury-induced anxiety-like behaviors in rats: Roles of the protein kinase A\/cAMP-response element binding signaling pathwayExp Ther Med. 2022 Apr;23(4):248. doi: 10.3892\/etm.2022.11173. Epub 2022 Jan 31. PMC8855513
TBI Model Type: Weight-drop model
Organism Species: rat
Organism Strain: Wister
Assessments: Enzyme-linked immunosorbent assay (ELISA), Hematoxylin and Eosin, RT-PCR, Western blot, permeability assay
Citation: Lang Y, Fu F, Sun D, Xi C, Chen F. Labetalol Prevents Intestinal Dysfunction Induced by Traumatic Brain InjuryPLoS One. 2015 Jul 17;10(7):e0133215. doi: 10.1371\/journal.pone.0133215. eCollection 2015. PMC4505891
TBI Model Type: Weight-drop model
Organism Species: mouse
Organism Strain: C57BL/6J
Assessments: Brain water content, Enzyme-linked immunosorbent assay (ELISA), Evans blue extravasation, Neurological Severity Score (NSS), Novel object recognition test, Rotarod test, TUNEL staining, Western blot, lactate dehydrogenase release
Citation: Evanson NK, Guilhaume-Correa F, Herman JP, Goodman MD. Optic tract injury after closed head traumatic brain injury in mice: A model of indirect traumatic optic neuropathyPLoS One. 2018 May 10;13(5):e0197346. doi: 10.1371\/journal.pone.0197346. eCollection 2018. PMC5944994
TBI Model Type: Blast model
Organism Species: mouse
Organism Strain: C57BL/6
Assessments: L/D emergence task, Enzyme-linked immunosorbent assay (ELISA), Barnes Maze test test, Contextual fear memory testing, Elevated zero maze, Fear conditioning, Immunohistochemistry (IHC), Light dark escape, Locomotor activity, Novel object localization test, Novel object recognition test, Oligomeric Aβ42 dot blot analysis, Social interaction, Sound-attenuated isolation, Behavioral Testing, Thioflavin S staining, social preference test
Citation: Perez Garcia G, De Gasperi R, Tschiffely AE, Gama Sosa MA, Abutarboush R, Kawoos U, Statz JK, Ciarlone S, Reed E, Jeyarajah T, Perez GM, Otero-Pagan A, Pryor D, Hof PR, Cook DG, Gandy S, Elder GA, Ahlers ST. Repetitive Low-Level Blast Exposure Improves Behavioral Deficits and Chronically Lowers Aβ42 in an Alzheimer Disease Transgenic Mouse ModelJ Neurotrauma. 2021 Nov 15;38(22):3146-3173. doi: 10.1089\/neu.2021.0184. Epub 2021 Sep 15. PMC8820291
TBI Model Type: Controlled cortical impact model
Organism Species: mouse
Organism Strain: C57BL/6J
Assessments: Cytokine Assay, Enzyme-linked immunosorbent assay (ELISA), Immunohistochemistry (IHC), astrocytic, hippocampal neurogenesis, microglia responses, radial arm water maze, Rotarod
Citation: Song S, Kong X, Acosta S, Sava V, Borlongan C, Sanchez-Ramos J. Granulocyte colony-stimulating factor promotes behavioral recovery in a mouse model of traumatic brain injuryJ Neurosci Res. 2016 May;94(5):409-23. doi: 10.1002\/jnr.23714. Epub 2016 Jan 29. PMC4805459
TBI Model Type: Blast model
Organism Species: rat
Organism Strain: Sprague-Dawley
Assessments: Enzyme-linked immunosorbent assay (ELISA), RT-PCR, Immunohistochemistry (IHC), Western blot, Brain water content, cortical oxidative stress
Citation: Yang Z, Simovic MO, Edsall PR, Liu B, Cancio TS, Batchinsky AI, Cancio LC, Li Y. HMGB1 Inhibition to Ameliorate Organ Failure and Increase Survival in TraumaBiomolecules. 2022 Jan 8;12(1):101. doi: 10.3390\/biom12010101. PMC8773879
TBI Model Type: Other
Organism Species: mouse
Organism Strain: C57Bl/6
Assessments: Barnes Maze test, Enzyme-Linked Immunosorbent Assay (ELISA), Histology, LRR, Neurological Severity Score (NSS), open field test, Silver staining, Western blot, Rotarod test, passive avoidance task, thigmotaxis index
Citation: Namjoshi DR, Cheng WH, McInnes KA, Martens KM, Carr M, Wilkinson A, Fan J, Robert J, Hayat A, Cripton PA, Wellington CL. Merging pathology with biomechanics using CHIMERA (Closed-Head Impact Model of Engineered Rotational Acceleration): a novel, surgery-free model of traumatic brain injuryMol Neurodegener. 2014 Dec 1;9:55. doi: 10.1186\/1750-1326-9-55. PMC4269957
TBI Model Type: Weight-drop model
Organism Species: mouse
Organism Strain: C57BL/6
Assessments: Brain water content, Enzyme-linked immunosorbent assay (ELISA), Evans blue permeability assay, Immunofluorescence staining, TUNEL staining, Western blot, Immunofluorescence, modified Neurological Severity Score (mNSS)
Citation: Li H, Sun J, Du J, Wang F, Fang R, Yu C, Xiong J, Chen W, Lu Z, Liu J. Clostridium butyricum exerts a neuroprotective effect in a mouse model of traumatic brain injury via the gut-brain axisNeurogastroenterol Motil. 2018 May;30(5):e13260. doi: 10.1111\/nmo.13260. Epub 2017 Nov 27.
TBI Model Type: Weight-drop model
Organism Species: rat
Organism Strain: Sprague-Dawley
Assessments: CM-DiI dye, DiR dye, Enzyme-Linked Immunosorbent Assay (ELISA), Immunohistochemistry (IHC), TUNEL staining, Western blot, qRT-PCR
Citation: Chen Y, Li J, Ma B, Li N, Wang S, Sun Z, Xue C, Han Q, Wei J, Zhao RC. MSC-derived exosomes promote recovery from traumatic brain injury via microglia\/macrophages in ratAging (Albany NY). 2020 Sep 23;12(18):18274-18296. doi: 10.18632\/aging.103692. Online ahead of print. PMC7585083
TBI Model Type: Weight-drop model
Organism Species: rat
Organism Strain: Sprague-Dawley
Assessments: wet weight-dry weight, Enzyme-linked immunosorbent assay (ELISA), Immunohistochemistry (IHC)
Citation: Weiss E, Dhir T, Collett A, Reola M, Kaplan M, Minimo C, Omert L, Leung P. Effect of complement C1-esterase inhibitor on brain edema and inflammation after mild traumatic brain injury in an animal modelClin Exp Emerg Med. 2020 Jun;7(2):87-94. doi: 10.15441\/ceem.19.050. Epub 2020 Jun 30. PMC7348678
TBI Model Type: Weight-drop model
Organism Species: rat
Organism Strain: Sprague-Dawley
Assessments: DTI data processing, Histology, Magnetic resonance imaging (MRI), Microscope analysis, Enzyme-linked immunosorbent assay (ELISA)
Citation: Singh K, Trivedi R, Devi MM, Tripathi RP, Khushu S. Longitudinal changes in the DTI measures, anti-GFAP expression and levels of serum inflammatory cytokines following mild traumatic brain injuryExp Neurol. 2016 Jan;275 Pt 3:427-435. doi: 10.1016\/j.expneurol.2015.07.016. Epub 2015 Jul 26.
TBI Model Type: Weight-drop model
Organism Species: rat
Organism Strain: Wistar Han
Assessments: RT-PCR, elevated plus maze, Barnes Maze test, Microarray, Rotarod test, Enzyme-linked immunosorbent assay (ELISA), rotating pole
Citation: Chakraborty N, Hammamieh R, Gautam A, Miller SA, Condlin ML, Jett M, Scrimgeour AG. TBI weight-drop model with variable impact heights differentially perturbs hippocampus-cerebellum specific transcriptomic profileExp Neurol. 2021 Jan;335:113516. doi: 10.1016\/j.expneurol.2020.113516. Epub 2020 Oct 22.
TBI Model Type: Weight-drop model
Organism Species: mouse
Organism Strain: C57BL/6
Assessments: Enzyme-linked immunosorbent assay (ELISA), Rotational thromboelastometry, Splenic cytology
Citation: Boudreau RM, Johnson M, Veile R, Friend LA, Goetzman H, Pritts TA, Caldwell CC, Makley AT, Goodman MD. Impact of tranexamic acid on coagulation and inflammation in murine models of traumatic brain injury and hemorrhageJ Surg Res. 2017 Jul;215:47-54. doi: 10.1016\/j.jss.2017.03.031. Epub 2017 Apr 1.
TBI Model Type: Weight-drop model
Organism Species: mouse
Organism Strain: C57BL6
Assessments: L/D emergence task, Enzyme-linked immunosorbent assay (ELISA), Barnes Maze test test, Contextual fear memory testing, Elevated zero maze, Fear conditioning, Immunohistochemistry (IHC), Light dark escape, Locomotor activity, Novel object localization test, Novel object recognition test, Oligomeric Aβ42 dot blot analysis, Social interaction, Sound-attenuated isolation, Behavioral Testing, Thioflavin S staining, social preference test
Citation: Lesniak A, Pick CG, Misicka A, Lipkowski AW, Sacharczuk M. Biphalin protects against cognitive deficits in a mouse model of mild traumatic brain injury (mTBI)Neuropharmacology. 2016 Feb;101:506-18. doi: 10.1016\/j.neuropharm.2015.10.014. Epub 2015 Oct 22.
TBI Model Type: Weight-drop model
Organism Species: mouse
Organism Strain: C57BL/6J
Assessments: Enzyme-linked immunosorbent assay (ELISA), GC-MS analysis, Metabolomic Analysis, Y-maze, discrimination index, Novel object recognition test, open field test
Citation: Alqahtani F, Assiri MA, Mohany M, Imran I, Javaid S, Rasool MF, Shakeel W, Sivandzade F, Alanazi AZ, Al-Rejaie SS, Alshammari MA, Alasmari F, Alanazi MM, Alamri FF. Coadministration of Ketamine and Perampanel Improves Behavioral Function and Reduces Inflammation in Acute Traumatic Brain Injury Mouse ModelBiomed Res Int. 2020 Dec 10;2020:3193725. doi: 10.1155\/2020\/3193725. eCollection 2020. PMC7749776
TBI Model Type: Weight-drop model
Organism Species: mouse
Organism Strain: C57BL/6
Assessments: 16S ribosomal RNA gene sequencing, Blood–brain barrier permeability, Enzyme-linked immunosorbent assay (ELISA), Histology, RT-PCR, Western blot, Brain water content, limulus amebocyte lysate assay, Neurological Severity Score (NSS), Rotarod test
Citation: Ma Y, Liu T, Fu J, Fu S, Hu C, Sun B, Fan X, Zhu J. Lactobacillus acidophilus Exerts Neuroprotective Effects in Mice with Traumatic Brain InjuryJ Nutr. 2019 Sep 1;149(9):1543-1552. doi: 10.1093\/jn\/nxz105.
TBI Model Type: Weight-drop model
Organism Species: rat
Organism Strain: Sprague-Dawley
Assessments: Histology, Enzyme-linked immunosorbent assay (ELISA), Morris Water Maze (MWM)
Citation: Luo ML, Pan L, Wang L, Wang HY, Li S, Long ZY, Zeng L, Liu Y. Transplantation of NSCs Promotes the Recovery of Cognitive Functions by Regulating Neurotransmitters in Rats with Traumatic Brain InjuryNeurochem Res. 2019 Dec;44(12):2765-2775. doi: 10.1007\/s11064-019-02897-z. Epub 2019 Nov 7.
