On page 1 showing 1 ~ 20 out of 68 results
TBI Model Type: Weight-drop model
Organism Species: mouse
Organism Strain: ICR
Assessments: Grip Test, Brain water content, Immunofluorescence, Immunohistochemistry (IHC), Mitochondrial MDA, SOD Content, Prussian Blue Staining, Reactive Oxygen Species Content, TUNEL staining, Western blot, dihydroethidium staining
Citation: Zhu Y, Wang H, Fang J, Dai W, Zhou J, Wang X, Zhou M. SS-31 Provides Neuroprotection by Reversing Mitochondrial Dysfunction after Traumatic Brain InjuryOxid Med Cell Longev. 2018 Aug 27;2018:4783602. doi: 10.1155\/2018\/4783602. eCollection 2018. PMC6129854
TBI Model Type: Weight-drop model
Organism Species: rat
Organism Strain: Sprague-Dawley
Assessments: Immunohistochemistry (IHC), Morris Water Maze (MWM), Neurological Severity Score (NSS), Western blot, Brain water content
Citation: Cui CM, Gao JL, Cui Y, Sun LQ, Wang YC, Wang KJ, Li R, Tian YX, Cui JZ. Chloroquine exerts neuroprotection following traumatic brain injury via suppression of inflammation and neuronal autophagic deathMol Med Rep. 2015 Aug;12(2):2323-8. doi: 10.3892\/mmr.2015.3611. Epub 2015 Apr 15.
TBI Model Type: Weight-drop model
Organism Species: mouse
Organism Strain: C57BL/6J
Assessments: Brain water content, Enzyme-linked immunosorbent assay (ELISA), Evans blue extravasation, Neurological Severity Score (NSS), Novel object recognition test, Rotarod test, TUNEL staining, Western blot, lactate dehydrogenase release
Citation: Evanson NK, Guilhaume-Correa F, Herman JP, Goodman MD. Optic tract injury after closed head traumatic brain injury in mice: A model of indirect traumatic optic neuropathyPLoS One. 2018 May 10;13(5):e0197346. doi: 10.1371\/journal.pone.0197346. eCollection 2018. PMC5944994
TBI Model Type: Weight-drop model
Organism Species: mouse
Organism Strain: C57Bl/6
Assessments: Brain water content, Enzyme-Linked Immunosorbent Assay (Enzyme-linked immunosorbent assay), Evans Blue Extravasation, Magnetic resonance imaging (MRI), Western Blot, Y-maze, open-field, rotarod
Citation: Shultz SR, Sun M, Wright DK, Brady RD, Liu S, Beynon S, Schmidt SF, Kaye AH, Hamilton JA, O'Brien TJ, Grills BL, McDonald SJ. Tibial fracture exacerbates traumatic brain injury outcomes and neuroinflammation in a novel mouse model of multitraumaJ Cereb Blood Flow Metab. 2015 Aug;35(8):1339-47. doi: 10.1038\/jcbfm.2015.56. Epub 2015 Apr 8. PMC4528010
TBI Model Type: Weight-drop model
Organism Species: rat
Organism Strain: Sprague-Dawley
Assessments: Biochemical Assay, Brain water content, Hematoxylin and Eosin, Immunohistochemistry (IHC), modified Neurological Severity Score (mNSS), qRT-PCR, TUNEL staining, Western blot
Citation: Tang Y, Dong X, Chen G, Ye W, Kang J, Tang Y, Feng Z. Vagus Nerve Stimulation Attenuates Early Traumatic Brain Injury by Regulating the NF-κB\/NLRP3 Signaling PathwayNeurorehabil Neural Repair. 2020 Sep;34(9):831-843. doi: 10.1177\/1545968320948065. Epub 2020 Aug 10.
TBI Model Type: Weight-drop model
Organism Species: rat
Organism Strain: Wistar
Assessments: Object Recognition Memory Test, Open-Field Test, Western blot, Brain Water Content, qRT-PCR
Citation: Furtado ABV, Gonçalves DF, Hartmann DD, Courtes AA, Cassol G, Nunez-Figueredo Y, Argolo DS, do Nascimento RP, Costa SL, da Silva VDA, Royes LFF, Soares FAA. JM-20 Treatment After Mild Traumatic Brain Injury Reduces Glial Cell Pro-inflammatory Signaling and Behavioral and Cognitive Deficits by Increasing Neurotrophin ExpressionMol Neurobiol. 2021 Sep;58(9):4615-4627. doi: 10.1007\/s12035-021-02436-4. Epub 2021 Jun 19.
TBI Model Type: Weight-drop model
Organism Species: rat
Organism Strain: Sprague-Dawley
Assessments: Brain water content, Morris Water Maze (MWM), Neurologic Deficit Scoring, Western Blot, Novel object recognition test, RT-PCR
Citation: Cheng T, Yang B, Li D, Ma S, Tian Y, Qu R, Zhang W, Zhang Y, Hu K, Guan F, Wang J. Wharton's Jelly Transplantation Improves Neurologic Function in a Rat Model of Traumatic Brain InjuryCell Mol Neurobiol. 2015 Jul;35(5):641-9. doi: 10.1007\/s10571-015-0159-9. Epub 2015 Feb 1. PMC4481175
TBI Model Type: Blast model
Organism Species: rat
Organism Strain: Sprague-Dawley
Assessments: Enzyme-linked immunosorbent assay (ELISA), RT-PCR, Immunohistochemistry (IHC), Western blot, Brain water content, cortical oxidative stress
Citation: Yang Z, Simovic MO, Edsall PR, Liu B, Cancio TS, Batchinsky AI, Cancio LC, Li Y. HMGB1 Inhibition to Ameliorate Organ Failure and Increase Survival in TraumaBiomolecules. 2022 Jan 8;12(1):101. doi: 10.3390\/biom12010101. PMC8773879
TBI Model Type: Weight-drop model
Organism Species: rat
Organism Strain: Wistar
Assessments: Brain water content, Western blot
Citation: Lu KT, Huang TC, Tsai YH, Yang YL. Transient receptor potential vanilloid type 4 channels mediate Na-K-Cl-co-transporter-induced brain edema after traumatic brain injuryJ Neurochem. 2017 Mar;140(5):718-727. doi: 10.1111\/jnc.13920.
TBI Model Type: Weight-drop model
Organism Species: mouse
Organism Strain: C57BL/6
Assessments: Brain water content, Enzyme-linked immunosorbent assay (ELISA), Evans blue permeability assay, Immunofluorescence staining, TUNEL staining, Western blot, Immunofluorescence, modified Neurological Severity Score (mNSS)
Citation: Li H, Sun J, Du J, Wang F, Fang R, Yu C, Xiong J, Chen W, Lu Z, Liu J. Clostridium butyricum exerts a neuroprotective effect in a mouse model of traumatic brain injury via the gut-brain axisNeurogastroenterol Motil. 2018 May;30(5):e13260. doi: 10.1111\/nmo.13260. Epub 2017 Nov 27.
TBI Model Type: Weight-drop model
Organism Species: rat
Organism Strain: Sprague-Dawley
Assessments: Evans blue dye, Immunohistochemistry (IHC), SOD activity, GSH-PX activity, MDA activity, qRT-PCR, Western blot, Brain water content
Citation: Zhang B, Wang B, Cao S, Wang Y. Epigallocatechin-3-Gallate (EGCG) Attenuates Traumatic Brain Injury by Inhibition of Edema Formation and Oxidative StressKorean J Physiol Pharmacol. 2015 Nov;19(6):491-7. doi: 10.4196\/kjpp.2015.19.6.491. Epub 2015 Oct 16. PMC4637351
TBI Model Type: Weight-drop model
Organism Species: rat
Organism Strain: Wistar
Assessments: Brain water content, Hematoxylin and Eosin, qRT-PCR, Western blot, Neurological Severity Score (NSS), TUNEL staining
Citation: Li Z, Wang Y, Zeng G, Zheng X, Wang W, Ling Y, Tang H, Zhang J. Increased miR-155 and heme oxygenase-1 expression is involved in the protective effects of formononetin in traumatic brain injury in ratsAm J Transl Res. 2017 Dec 15;9(12):5653-5661. eCollection 2017. PMC5752915
TBI Model Type: Weight-drop model
Organism Species: rat
Organism Strain: Sprague-Dawley
Assessments: ATP Assay, Behavioral Testing, Activity score, Brain water content, Fluoro-jade C staining (FJC), Immunofluorescence, Neurological score, RT-PCR, TUNEL staining, Western blot
Citation: Chen C, Lu L, Zhu J, Gu X, Liu B, Li D, Chen G. Miro1 provides neuroprotection via the mitochondrial trafficking pathway in a rat model of traumatic brain injuryBrain Res. 2021 Dec 15;1773:147685. doi: 10.1016\/j.brainres.2021.147685. Epub 2021 Oct 9.
TBI Model Type: Weight-drop model
Organism Species: mouse
Organism Strain: ICR
Assessments: Immunohistochemistry (IHC), Nissl staining, Western blot, Brain water content, grip test, spectrophotometer, Neurological Severity Score (NSS)
Citation: Liang J, Wu S, Xie W, He H. Ketamine ameliorates oxidative stress-induced apoptosis in experimental traumatic brain injury via the Nrf2 pathwayDrug Des Devel Ther. 2018 Apr 16;12:845-853. doi: 10.2147\/DDDT.S160046. eCollection 2018. PMC5907785
TBI Model Type: Weight-drop model
Organism Species: mouse
Organism Strain: ICR
Assessments: Brain water content, Immunohistochemistry (IHC), Nissl staining, Western blot, grip test, spectrophotometer
Citation: Fu C, Wang Q, Zhai X, Gao J. Sinomenine reduces neuronal cell apoptosis in mice after traumatic brain injury via its effect on mitochondrial pathwayDrug Des Devel Ther. 2018 Jan 5;12:77-84. doi: 10.2147\/DDDT.S154391. eCollection 2018. PMC5759853
TBI Model Type: Weight-drop model
Organism Species: rat
Organism Strain: Sprague-Dawley
Assessments: TUNEL staining, Brain water content, Fluoro-Jade B staining (FJB), Immunofluorescence, RT- PCR, Western blot, modified Garcia score
Citation: Rui Q, Ni H, Gao F, Dang B, Li D, Gao R, Chen G. LRRK2 Contributes to Secondary Brain Injury Through a p38\/Drosha Signaling Pathway After Traumatic Brain Injury in RatsFront Cell Neurosci. 2018 Mar 1;12:51. doi: 10.3389\/fncel.2018.00051. eCollection 2018. PMC5837969
TBI Model Type: Weight-drop model
Organism Species: mouse
Organism Strain: ICR
Assessments: Brain water content, Immunofluorescence, TUNEL staining, Western blot, spectrophotometer
Citation: Dai W, Wang H, Fang J, Zhu Y, Zhou J, Wang X, Zhou Y, Zhou M. Curcumin provides neuroprotection in model of traumatic brain injury via the Nrf2-ARE signaling pathwayBrain Res Bull. 2018 Jun;140:65-71. doi: 10.1016\/j.brainresbull.2018.03.020. Epub 2018 Apr 4.
TBI Model Type: Weight-drop model
Organism Species: rat
Organism Strain: Sprague‐Dawley
Assessments: Brain water content, Enzyme‐linked immunosorbent assay, Immunohistochemical, Real‐time quantitative polymerase chain reaction, TUNEL, Terminal deoxynucleotidyl transferase‐mediated dUTP nick‐end labeling, Western blot, neurological severity score
Citation: Li F, Wang X, Zhang Z, Zhang X, Gao P.Dexmedetomidine Attenuates Neuroinflammatory-Induced Apoptosis after Traumatic Brain Injury via Nrf2 signaling pathwayAnn Clin Transl Neurol. 2019 Sep;6(9):1825-1835. doi: 10.1002/acn3.50878. Epub 2019 Sep 3.PMC676450110.1002/acn3.50878
TBI Model Type: Weight-drop model
Organism Species: rat
Organism Strain: Sprague-Dawley
Assessments: Brain water content, Evans blue, FABP7, Neurological score, brain edema, immunofluorescence staining, real-time PCR, western blotting
Citation: Rui Q, Ni H, Lin X, Zhu X, Li D, Liu H, Chen G.Astrocyte-derived fatty acid-binding protein 7 protects blood-brain barrier integrity through a caveolin-1/MMP signaling pathway following traumatic brain injuryExp Neurol. 2019 Dec;322:113044. doi: 10.1016/j.expneurol.2019.113044. Epub 2019 Aug 24.10.1016/j.expneurol.2019.113044
TBI Model Type: Weight-drop model
Organism Species: rat
Organism Strain: Sprague-Dawley
Assessments: Glycerol Assay, Western blot, Brain water content
Citation: Ali A, Konakondla S, Zwagerman NT, Peng C, Schafer S, Ding JY, Dornbos D 3rd, Sikharam C, Geng X, Guthikonda M, Kreipke CW, Rafols JA, Ding Y.Neurol Res. 2012 Jun;34(5):462-8. doi: 10.1179/1743132812Y.0000000014. Epub 2012 Mar 20.
