On page 8 showing 141 ~ 160 out of 226 results
TBI Model Type: Weight-drop model
Organism Species: mouse
Organism Strain: CD-1
Assessments: Brain water content, Enzyme-linked immunosorbent assay (ELISA), Evans blue extravasation, Neurological Severity Score (NSS), Novel object recognition test, Rotarod test, TUNEL staining, Western blot, lactate dehydrogenase release
Citation: Kempuraj D, Ahmed ME, Selvakumar GP, Thangavel R, Raikwar SP, Zaheer SA, Iyer SS, Govindarajan R, Nattanmai Chandrasekaran P, Burton C, James D, Zaheer A. Acute Traumatic Brain Injury-Induced Neuroinflammatory Response and Neurovascular Disorders in the BrainNeurotox Res. 2021 Apr;39(2):359-368. doi: 10.1007\/s12640-020-00288-9. Epub 2020 Sep 21. PMC7502806
TBI Model Type: Weight-drop model
Organism Species: mouse
Organism Strain: ICR
Assessments: Brain water content, Enzyme-linked immunosorbent assay (ELISA), Evans blue permeability assay, Immunofluorescence, TUNEL staining, Western blot, modified Neurological Severity Score (mNSS)
Citation: Cheng H, Di G, Gao CC, He G, Wang X, Han YL, Sun LA, Zhou ML, Jiang X. FTY720 Reduces Endothelial Cell Apoptosis and Remodels Neurovascular Unit after Experimental Traumatic Brain InjuryInt J Med Sci. 2021 Jan 1;18(2):304-313. doi: 10.7150\/ijms.49066. eCollection 2021. PMC7757143
TBI Model Type: Weight-drop model
Organism Species: mouse
Organism Strain: ICR
Assessments: Aggleton index, Immunohistochemistry (IHC), Novel object recognition test, Y-maze, Enzyme-linked immunosorbent assay (ELISA)
Citation: Benady A, Freidin D, Pick CG, Rubovitch V. GM1 ganglioside prevents axonal regeneration inhibition and cognitive deficits in a mouse model of traumatic brain injurySci Rep. 2018 Sep 6;8(1):13340. doi: 10.1038\/s41598-018-31623-y. PMC6127193
TBI Model Type: Weight-drop model
Organism Species: mouse
Organism Strain: ICR
Assessments: Histology, Immunohistochemitry, Western blot, error ladder walking test, Novel object recognition test
Citation: Li Y, Bader M, Tamargo I, Rubovitch V, Tweedie D, Pick CG, Greig NH. Liraglutide is neurotrophic and neuroprotective in neuronal cultures and mitigates mild traumatic brain injury in miceJ Neurochem. 2015 Dec;135(6):1203-1217. doi: 10.1111\/jnc.13169. Epub 2015 Jun 18. PMC4644713
TBI Model Type: Controlled cortical impact model
Organism Species: mouse
Organism Strain: C57BL/6
Assessments: Histology, Morris Water Maze (MWM), Beam balance test, Beam walk test, memory retention, rotarod
Citation: Hill JL, Kobori N, Zhao J, Rozas NS, Hylin MJ, Moore AN, Dash PK. Traumatic brain injury decreases AMP-activated protein kinase activity and pharmacological enhancement of its activity improves cognitive outcomeJ Neurochem. 2016 Oct;139(1):106-19. doi: 10.1111\/jnc.13726. Epub 2016 Aug 1. PMC5037010
TBI Model Type: Weight-drop model
Organism Species: mouse
Organism Strain: C57BL/6
Assessments: Rotational thromboelastometry
Citation: Midura EF, Jernigan PL, Kuethe JW, Friend LA, Veile R, Makley AT, Caldwell CC, Goodman MD. Microparticles impact coagulation after traumatic brain injuryJ Surg Res. 2015 Jul;197(1):25-31. doi: 10.1016\/j.jss.2015.02.064. Epub 2015 Mar 5. PMC5857955
TBI Model Type: Weight-drop model
Organism Species: mouse
Organism Strain: Swiss Albino
Assessments: Neurological score
Citation: Lopez-Rodriguez AB, Acaz-Fonseca E, Giatti S, Caruso D, Viveros MP, Melcangi RC, Garcia-Segura LM. Correlation of brain levels of progesterone and dehydroepiandrosterone with neurological recovery after traumatic brain injury in female micePsychoneuroendocrinology. 2015 Jun;56:1-11. doi: 10.1016\/j.psyneuen.2015.02.018. Epub 2015 Mar 3.
TBI Model Type: Weight-drop model
Organism Species: mouse
Organism Strain: C57BL/6J
Assessments: Image acquisition, Immunohistochemistry (IHC), Microscopy, reflex, Neurological Severity Score (NSS), Prussian blue
Citation: Kahriman A, Bouley J, Smith TW, Bosco DA, Woerman AL, Henninger N. Mouse closed head traumatic brain injury replicates the histological tau pathology pattern of human disease: characterization of a novel model and systematic review of the literatureActa Neuropathol Commun. 2021 Jun 29;9(1):118. doi: 10.1186\/s40478-021-01220-8. PMC8243463
TBI Model Type: Weight-drop model
Organism Species: mouse
Organism Strain: ICR
Assessments: Gene expression, Ingenuity Pathway Analysis tool, Gene Set Enrichment analysis
Citation: Tweedie D, Rachmany L, Kim DS, Rubovitch V, Lehrmann E, Zhang Y, Becker KG, Perez E, Pick CG, Greig NH. Mild traumatic brain injury-induced hippocampal gene expressions: The identification of target cellular processes for drug developmentJ Neurosci Methods. 2016 Oct 15;272:4-18. doi: 10.1016\/j.jneumeth.2016.02.003. Epub 2016 Feb 8. PMC4977213
TBI Model Type: Blast model
Organism Species: mouse
Organism Strain: C57BL/6J
Assessments: Calcium imaging, Off chip micro-bead assay, Western blot, flow cytometry, righting time
Citation: Ko J, Hemphill MA, Gabrieli D, Wu L, Yelleswarapu V, Lawrence G, Pennycooke W, Singh A, Meaney DF, Issadore D. Smartphone-enabled optofluidic exosome diagnostic for concussion recoverySci Rep. 2016 Aug 8;6:31215. doi: 10.1038\/srep31215. PMC4976377
TBI Model Type: Weight-drop model
Organism Species: mouse
Organism Strain: C57BL/6
Assessments: Evans blue dye, Fluoro-jade C staining (FJC), Histology, Immunofluorescence, Neurological Severity Score (NSS), Western blot, Brain water content
Citation: Li H, Sun J, Wang F, Ding G, Chen W, Fang R, Yao Y, Pang M, Lu ZQ, Liu J. Sodium butyrate exerts neuroprotective effects by restoring the blood-brain barrier in traumatic brain injury miceBrain Res. 2016 Jul 1;1642:70-78. doi: 10.1016\/j.brainres.2016.03.031. Epub 2016 Mar 24.
TBI Model Type: Weight-drop model
Organism Species: mouse
Organism Strain: Swiss Albino
Assessments: Enzyme-linked immunosorbent assay (ELISA), Neurological deficit assessment, qRT-PCR, neurological test, RT-PCR
Citation: Lopez-Rodriguez AB, Mela V, Acaz-Fonseca E, Garcia-Segura LM, Viveros MP. CB2 cannabinoid receptor is involved in the anti-inflammatory effects of leptin in a model of traumatic brain injuryExp Neurol. 2016 May;279:274-282. doi: 10.1016\/j.expneurol.2016.03.018. Epub 2016 Mar 19.
TBI Model Type: Weight-drop model
Organism Species: mouse
Organism Strain: C57BL/6-SJL
Assessments: Beam walk test, Blood ethanol level, Confocal imaging, Neurological Severity Score (NSS), open field test, qRT-PCR, Western blot, histology
Citation: Chandrasekar A, Aksan B, Heuvel FO, Förstner P, Sinske D, Rehman R, Palmer A, Ludolph A, Huber-Lang M, Böckers T, Mauceri D, Knöll B, Roselli F. Neuroprotective effect of acute ethanol intoxication in TBI is associated to the hierarchical modulation of early transcriptional responsesExp Neurol. 2018 Apr;302:34-45. doi: 10.1016\/j.expneurol.2017.12.017. Epub 2018 Jan 4.
TBI Model Type: Weight-drop model
Organism Species: mouse
Organism Strain: C57BL/6N
Assessments: Elevated plus maze, Histology, Immunohistochemistry (IHC), open field test, Paw preference test, handedness, Neurological Severity Score (NSS)
Citation: Lopez-Caperuchipi S, Kürzinger L, Hopp-Krämer S, Albert-Weißenberger C, Paul MM, Sirén AL, Stetter C. Posttraumatic learning deficits correlate with initial trauma severity and chronic cellular reactions after closed head injury in male miceExp Neurol. 2021 Jul;341:113721. doi: 10.1016\/j.expneurol.2021.113721. Epub 2021 Apr 11.
TBI Model Type: Blast model
Organism Species: mouse
Organism Strain: C57BL/6J
Assessments: Sucrose Preference Test, forced swim test, step down inhibitory avoidance, sucrose preference test, Forced Swim Test, Gait analysis, Passive avoidance, Prepulse Inhibition, righting reflex suppression
Citation: Browne CA, Wulf HA, Jacobson ML, Oyola MG, Wu TJ, Lucki I. Long-term increase in sensitivity to ketamine's behavioral effects in mice exposed to mild blast induced traumatic brain injuryExp Neurol. 2022 Apr;350:113963. doi: 10.1016\/j.expneurol.2021.113963. Epub 2021 Dec 28. PMC8858880
TBI Model Type: Weight-drop model
Organism Species: mouse
Organism Strain: ICR
Assessments: Brain water content, Immunofluorescence, Malondialdehyde level, Neurological Severity Score (NSS), qRT-PCR, TUNEL staining, Western blot, glutathione peroxidase, superoxide dismutase
Citation: Fang J, Wang H, Zhou J, Dai W, Zhu Y, Zhou Y, Wang X, Zhou M. Baicalin provides neuroprotection in traumatic brain injury mice model through Akt\/Nrf2 pathwayDrug Des Devel Ther. 2018 Aug 10;12:2497-2508. doi: 10.2147\/DDDT.S163951. eCollection 2018. PMC6089097
TBI Model Type: Weight-drop model
Organism Species: mouse
Organism Strain: C57BL/6
Assessments: Brain water content, Fluoro-Jade C staining (FJC), Immunofluorescence, TUNEL staining, Western blot, qPCR, spectrophotometer
Citation: Dong W, Yang B, Wang L, Li B, Guo X, Zhang M, Jiang Z, Fu J, Pi J, Guan D, Zhao R. Curcumin plays neuroprotective roles against traumatic brain injury partly via Nrf2 signalingToxicol Appl Pharmacol. 2018 May 1;346:28-36. doi: 10.1016\/j.taap.2018.03.020. Epub 2018 Mar 21.
TBI Model Type: Controlled cortical impact model
Organism Species: mouse
Organism Strain: C57BL/6
Assessments: Magnetic resonance imaging (MRI), Rotarod test, Spin-echo multislice images, T2-weighted image, cylinder forelimb test, spontaneous forelimb test, Gridwalk test, Histology, laterality score
Citation: Onyszchuk G, Al-Hafez B, He YY, Bilgen M, Berman NE, Brooks WM. A mouse model of sensorimotor controlled cortical impact: characterization using longitudinal magnetic resonance imaging, behavioral assessments and histologyJ Neurosci Methods. 2007 Mar 15;160(2):187-96. doi: 10.1016\/j.jneumeth.2006.09.007. Epub 2006 Oct 16. PMC1941707
TBI Model Type: Weight-drop model
Organism Species: mouse
Organism Strain: C57
Assessments: Fluorescence Imaging, LDH assay, Neurological Severity Score (NSS), UV-visible spectra, beam balance, transmission electron microscopy, zeta potential
Citation: Shi J, Li X, Cavagnaro MJ, Cai J, Zhang C, Li N. A Versatile Pep-CPDs Nanoprobe for Rapid Detection of mTBI Biomarker in Clinical Instances and Safe Fluorescence Imaging In Vivo for Improved Weight-Drop Mouse ModelFront Bioeng Biotechnol. 2022 Mar 7;10:807486. doi: 10.3389\/fbioe.2022.807486. eCollection 2022. PMC8942774
TBI Model Type: Weight-drop model
Organism Species: mouse
Organism Strain: ICR
Assessments: Brain water content, Immunofluorescence, TUNEL staining, Western blot, grip test, qRT-PCR, spectrophotometer
Citation: Yang Y, Wang H, Li L, Li X, Wang Q, Ding H, Wang X, Ye Z, Wu L, Zhang X, Zhou M, Pan H. Sinomenine Provides Neuroprotection in Model of Traumatic Brain Injury via the Nrf2-ARE PathwayFront Neurosci. 2016 Dec 23;10:580. doi: 10.3389\/fnins.2016.00580. eCollection 2016. PMC5179594
