On page 7 showing 121 ~ 140 out of 226 results
TBI Model Type: Fluid percussion injury model
Organism Species: mouse
Organism Strain: C57BL/6J
Assessments: modified Neurological Severity Score (mNSS), qRT-PCR, Western blot, Brain water content, Oxidative Stress Evaluation
Citation: Chen Y, Lu Y, Xu S, Liu M, Chen W, Zhang Y, Wei L, Zhong C. HDAC1 expression is positively correlated with NADPH oxidase 4-mediated oxidative stress in a mouse model of traumatic brain injuryJ Neurophysiol. 2022 May 1;127(5):1438-1444. doi: 10.1152\/jn.00049.2022. Epub 2022 Apr 20.
TBI Model Type: Other
Organism Species: mouse
Organism Strain: C57BL/6J
Assessments: cued fear conditioning, social recognition test, tail suspension test, sucrose/water preference test
Citation: Klemenhagen KC, O'Brien SP, Brody DL. Repetitive concussive traumatic brain injury interacts with post-injury foot shock stress to worsen social and depression-like behavior in micePLoS One. 2013 Sep 18;8(9):e74510. doi: 10.1371\/journal.pone.0074510. eCollection 2013. PMC3776826
TBI Model Type: Other
Organism Species: mouse
Organism Strain: C57BL/6
Assessments: Brain water content, Enzyme-linked immunosorbent assay (ELISA), Evans blue permeability assay, Immunofluorescence, TUNEL staining, Western blot, modified Neurological Severity Score (mNSS)
Citation: Mannix R, Berkner J, Mei Z, Alcon S, Hashim J, Robinson S, Jantzie L, Meehan WP 3rd, Qiu J. Adolescent Mice Demonstrate a Distinct Pattern of Injury after Repetitive Mild Traumatic Brain InjuryJ Neurotrauma. 2017 Jan 15;34(2):495-504. doi: 10.1089\/neu.2016.4457. Epub 2016 Jul 27. PMC5220578
TBI Model Type: Weight-drop model
Organism Species: mouse
Organism Strain: Swiss
Assessments: Neurological Score test, Neurological deficit assessment, qRT-PCR, Western Blot, Brain water content
Citation: Lopez-Rodriguez AB, Acaz-Fonseca E, Viveros MP, Garcia-Segura LM. Changes in cannabinoid receptors, aquaporin 4 and vimentin expression after traumatic brain injury in adolescent male mice. Association with edema and neurological deficitPLoS One. 2015 Jun 3;10(6):e0128782. doi: 10.1371\/journal.pone.0128782. eCollection 2015. PMC4454518
TBI Model Type: Weight-drop model
Organism Species: mouse
Organism Strain: ICR
Assessments: Nissl staining, Enzyme-linked immunosorbent assay (ELISA), Grip test, Immunohistochemistry (IHC), Neurological Severity Score (NSS), Western blot, Grip test
Citation: Song Q, Xie D, Pan S, Xu W. Rapamycin protects neurons from brain contusion‑induced inflammatory reaction via modulation of microglial activationMol Med Rep. 2015 Nov;12(5):7203-10. doi: 10.3892\/mmr.2015.4407. Epub 2015 Oct 1. PMC4626160
TBI Model Type: Weight-drop model
Organism Species: mouse
Organism Strain: ICR
Assessments: Bioluminescent Somatic Cell Assay, Bradford method, Immunohistochemical staining, Mitochondrial membrane potential (MMP) measurement, Western blot, spectrophotometer
Citation: Li X, Wang H, Gao Y, Li L, Tang C, Wen G, Zhou Y, Zhou M, Mao L, Fan Y. Protective Effects of Quercetin on Mitochondrial Biogenesis in Experimental Traumatic Brain Injury via the Nrf2 Signaling PathwayPLoS One. 2016 Oct 25;11(10):e0164237. doi: 10.1371\/journal.pone.0164237. eCollection 2016. PMC5079551
TBI Model Type: Weight-drop model
Organism Species: mouse
Organism Strain: C57BL/6
Assessments: Histology, Microscopy, qRT-PCR, Neurological Severity Score (NSS), hematoma size
Citation: Förstner P, Rehman R, Anastasiadou S, Haffner-Luntzer M, Sinske D, Ignatius A, Roselli F, Knöll B. Neuroinflammation after Traumatic Brain Injury Is Enhanced in Activating Transcription Factor 3 Mutant MiceJ Neurotrauma. 2018 Oct 1;35(19):2317-2329. doi: 10.1089\/neu.2017.5593. Epub 2018 Jun 5.
TBI Model Type: Weight-drop model
Organism Species: mouse
Organism Strain: C57BL/6
Assessments: Hematoxylin and Eosin, Nissl staining, Serum S100β, Neurological Severity Score (NSS)
Citation: Guo D, Li D, Li J, Li Y, Hu X, Guan F, Yang B. Topical application of the hematostatic agent Surgiflo® could attenuate brain injury in experimental TBI miceNeurol Res. 2017 Sep;39(9):830-836. doi: 10.1080\/01616412.2017.1330815. Epub 2017 May 31.
TBI Model Type: Controlled cortical impact model
Organism Species: mouse
Organism Strain: C57BL/6J
Assessments: Electron Microscopy, Morris Water Maze (MWM), Immunohistochemistry (IHC)
Citation: Shitaka Y, Tran HT, Bennett RE, Sanchez L, Levy MA, Dikranian K, Brody DL. Repetitive closed-skull traumatic brain injury in mice causes persistent multifocal axonal injury and microglial reactivityJ Neuropathol Exp Neurol. 2011 Jul;70(7):551-67. doi: 10.1097\/NEN.0b013e31821f891f. PMC3118973
TBI Model Type: Controlled cortical impact model
Organism Species: mouse
Organism Strain: C57BL/6
Assessments: Intracranial pressure (ICP), Morris Water Maze (MWM), arterial blood gas, blood urea nitrogen, calcium, glucose, hematocrit, hemoglobin, lactate, lesion volme, hemispheric volume, magnesium, neuropathology, osmolarity, potassium, sodium
Citation: Hemerka JN, Wu X, Dixon CE, Garman RH, Exo JL, Shellington DK, Blasiole B, Vagni VA, Janesko-Feldman K, Xu M, Wisniewski SR, Bayır H, Jenkins LW, Clark RS, Tisherman SA, Kochanek PM. Severe brief pressure-controlled hemorrhagic shock after traumatic brain injury exacerbates functional deficits and long-term neuropathological damage in miceJ Neurotrauma. 2012 Aug 10;29(12):2192-208. doi: 10.1089\/neu.2011.2303. PMC3472682
TBI Model Type: Controlled cortical impact model
Organism Species: mouse
Organism Strain: C57BL/6J
Assessments: Neurological evaluation, Histology, Immunohistochemistry (IHC), Morris Water Maze (MWM), Beam walk test, forepaw contraflexion, Rotarod test, TUNEL staining
Citation: Fox GB, Fan L, Levasseur RA, Faden AI. Sustained sensory\/motor and cognitive deficits with neuronal apoptosis following controlled cortical impact brain injury in the mouseJ Neurotrauma. 1998 Aug;15(8):599-614. doi: 10.1089\/neu.1998.15.599.
TBI Model Type: Weight-drop model
Organism Species: mouse
Organism Strain: ICR
Assessments: Brain water content, Immunofluorescence, Nissl Staining, qRT-PCR, TUNEL staining, Western blot, Neurological Severity Score (NSS)
Citation: Liu Z, Wang H, Shi X, Li L, Zhou M, Ding H, Yang Y, Li X, Ding K. DL-3-n-Butylphthalide (NBP) Provides Neuroprotection in the Mice Models After Traumatic Brain Injury via Nrf2-ARE Signaling PathwayNeurochem Res. 2017 May;42(5):1375-1386. doi: 10.1007\/s11064-017-2186-z. Epub 2017 Feb 18.
TBI Model Type: Weight-drop model
Organism Species: mouse
Organism Strain: C57BL/6J
Assessments: Beam walk test, Immunofluorescent, Immunohistochemistry (IHC), Lesion Volume Assessment, Morris Water Maze (MWM)
Citation: Huang SX, Qiu G, Cheng FR, Pei Z, Yang Z, Deng XH, Zhu JH, Chen L, Chen CC, Lin WF, Liu Y, Liu Z, Zhu FQ. Berberine Protects Secondary Injury in Mice with Traumatic Brain Injury Through Anti-oxidative and Anti-inflammatory ModulationNeurochem Res. 2018 Sep;43(9):1814-1825. doi: 10.1007\/s11064-018-2597-5. Epub 2018 Jul 19.
TBI Model Type: Controlled cortical impact model
Organism Species: mouse
Organism Strain: C57BL/6J
Assessments: Electroencephalography, Morris Water Maze (MWM), Neurological Severity Score (NSS), Porsolt forced swim test, electromyography, elevated plus maze, tail suspension test, wire grip test
Citation: Petraglia AL, Plog BA, Dayawansa S, Chen M, Dashnaw ML, Czerniecka K, Walker CT, Viterise T, Hyrien O, Iliff JJ, Deane R, Nedergaard M, Huang JH. The spectrum of neurobehavioral sequelae after repetitive mild traumatic brain injury: a novel mouse model of chronic traumatic encephalopathyJ Neurotrauma. 2014 Jul 1;31(13):1211-24. doi: 10.1089\/neu.2013.3255. Epub 2014 Jun 12. PMC4082360
TBI Model Type: Controlled cortical impact model
Organism Species: mouse
Organism Strain: C57BL/6J
Assessments: Enzyme-linked immunosorbent assay (ELISA)
Citation: Shein SL, Shellington DK, Exo JL, Jackson TC, Wisniewski SR, Jackson EK, Vagni VA, Bayır H, Clark RS, Dixon CE, Janesko-Feldman KL, Kochanek PM. Hemorrhagic shock shifts the serum cytokine profile from pro- to anti-inflammatory after experimental traumatic brain injury in miceJ Neurotrauma. 2014 Aug 15;31(16):1386-95. doi: 10.1089\/neu.2013.2985. PMC4186809
TBI Model Type: Weight-drop model
Organism Species: mouse
Organism Strain: C57BL/6N
Assessments: IntelliCage Test, object recognition test, Organ Weight to Body Weight Ratio, Immunofluorescence, Neurological Severity Score (NSS)
Citation: Stetter C, Lopez-Caperuchipi S, Hopp-Krämer S, Bieber M, Kleinschnitz C, Sirén AL, Albert-Weißenberger C. Amelioration of Cognitive and Behavioral Deficits after Traumatic Brain Injury in Coagulation Factor XII Deficient MiceInt J Mol Sci. 2021 May 3;22(9):4855. doi: 10.3390\/ijms22094855. PMC8124758
TBI Model Type: Weight-drop model
Organism Species: mouse
Organism Strain: C57BL/6J
Assessments: Apoptosis Assay, Evans blue method, S100β Quantification, Viability Assay, Western blot, necrosis index
Citation: Rosas-Hernandez H, Cuevas E, Escudero-Lourdes C, Lantz SM, Gomez-Crisostomo NP, Sturdivant NM, Balachandran K, Imam SZ, Slikker W Jr, Paule MG, Ali SF. Characterization of Biaxial Stretch as an In Vitro Model of Traumatic Brain Injury to the Blood-Brain BarrierMol Neurobiol. 2018 Jan;55(1):258-266. doi: 10.1007\/s12035-017-0738-5.
TBI Model Type: Weight-drop model
Organism Species: mouse
Organism Strain: C57BL/6
Assessments: Lesion Volume, Cresyl Violet Staining, Enzyme-Linked Immunosorbent Assay (Enzyme-linked immunosorbent assay), Grip Strength Test, Immunofluorescence, Novel object recognition test, Rotarod Test, Western blot, Y-Maze Test
Citation: Ahmed ME, Selvakumar GP, Kempuraj D, Raikwar SP, Thangavel R, Bazley K, Wu K, Khan O, Khan A, Zaheer S, Iyer S, Burton C, James D, Zaheer A. Glia Maturation Factor (GMF) Regulates Microglial Expression Phenotypes and the Associated Neurological Deficits in a Mouse Model of Traumatic Brain InjuryMol Neurobiol. 2020 Nov;57(11):4438-4450. doi: 10.1007\/s12035-020-02040-y. Epub 2020 Jul 31.
TBI Model Type: Weight-drop model
Organism Species: mouse
Organism Strain: C57BL
Assessments: Neurological Severity Score (NSS), Prussian blue staining, Nuclear Fast Red Staining, gas liquid chromatography
Citation: Lecques JD, Kerr BJK, Hillyer LM, Kang JX, Robinson LE, Ma DWL. N-3 Polyunsaturated Fatty Acids Ameliorate Neurobehavioral Outcomes Post-Mild Traumatic Brain Injury in the Fat-1 Mouse ModelNutrients. 2021 Nov 15;13(11):4092. doi: 10.3390\/nu13114092. PMC8620437
TBI Model Type: Weight-drop model
Organism Species: mouse
Organism Strain: C57BL/6J
Assessments: Fluoro-Jade B staining (FJB), Immunofluorescence, Locomotion, Optomotor/Optokinetic Response, Visual Acuity Testing, Western blot, mean fluorescence intensity
Citation: Hetzer SM, Guilhaume-Correa F, Day D, Bedolla A, Evanson NK. Traumatic Optic Neuropathy Is Associated with Visual Impairment, Neurodegeneration, and Endoplasmic Reticulum Stress in Adolescent MiceCells. 2021 Apr 23;10(5):996. doi: 10.3390\/cells10050996. PMC8146890
