On page 6 showing 101 ~ 120 out of 125 results
TBI Model Type: Weight-drop model
Organism Species: rat
Organism Strain: Sprague-Dawley
Assessments: Immunofluorescence, open field test, TUNEL staining, Western blot
Citation: Li SS, Xie LL, Li ZZ, Fan YJ, Qi MM, Xi YG. Androgen is responsible for enhanced susceptibility of melatonin against traumatic brain injury in femalesNeurosci Lett. 2021 May 1;752:135842. doi: 10.1016\/j.neulet.2021.135842. Epub 2021 Mar 22.
TBI Model Type: Weight-drop model
Organism Species: rat
Organism Strain: Sprague-Dawley
Assessments: Immunohistochemistry (IHC), Fluoro-Jade C staining (FJC), Neurological function score, TUNEL staining, Brain water content, Western blot
Citation: Zhu J, Lin X, Chen C, Tan H, Gao Y, Li D, Chen G. WNK3 Promotes Neuronal Survival after Traumatic Brain Injury in RatsNeuroscience. 2021 Nov 21;477:76-88. doi: 10.1016\/j.neuroscience.2021.09.021. Epub 2021 Oct 6.
TBI Model Type: Weight-drop model
Organism Species: mouse
Organism Strain: C57BL/6J
Assessments: Dichlorofluorescein Diacetate Dye, Immunofluorescence, Neurological Severity Score )NSS), Nissl staining, TUNEL staining, Western Blot, Optical density, qRT-PCR
Citation: Yang XJ, Ling S, Zhou ML, Deng HJ, Qi M, Liu XL, Zhen C, Chen YX, Fan XR, Wu ZY, Ma FC, Rong J, Di GF, Jiang XC. Inhibition of TRPA1 Attenuates Oxidative Stress-induced Damage After Traumatic Brain Injury via the ERK\/AKT Signaling PathwayNeuroscience. 2022 Feb 11;494:51-68. doi: 10.1016\/j.neuroscience.2022.02.003. Online ahead of print.
TBI Model Type: Weight-drop model
Organism Species: mouse
Organism Strain: C57BL/6
Assessments: Brain water content, M29, 79-dichlorodihydrofluorescein diacetate (DCFH-DA) staining, Morris Water Maze, Neurological Severity Scores, Nissl staining, TdT-mediated dUTP Nick-End Labeling, We performed modified Neurological Severity Scores (mNSS), rotarod test, and Morris Water Maze (MWM) test, respectively (n = 8 for each group), enzyme linked immunosorbent assay, immunofluorescence, immunohistochemistry, quantitative real time polymerase chain reaction, rotarod test, western blot
Citation: Wang H, Zhou XM, Wu LY, Liu GJ, Xu WD, Zhang XS, Gao YY, Tao T, Zhou Y, Lu Y, Wang J, Deng CL, Zhuang Z, Hang CH, Li W.Aucubin alleviates oxidative stress and inflammation via Nrf2-mediated signaling activity in experimental traumatic brain injuryJ Neuroinflammation. 2020 Jun 15;17(1):188. doi: 10.1186/s12974-020-01863-9.PMC729463110.1186/s12974-020-01863-9
TBI Model Type: Weight-drop model
Organism Species: rat
Organism Strain: Sprague-Dawley
Assessments: Bederson test, Evans blue fluorescence, MRI, Perls staining, TUNEL, Western blot, behavioral, brain water content, enzyme-linked immunosorbent assay, immunohistochemistry, magnetic resonance imaging, myelin basic protein (MBP) expression, quantitative real-time PCR
Citation: Wei L, Zhang J, Zhang B, Geng J, Tan Q, Wang L, Chen Z, Feng H, Zhu G.Complement C3 participates in the function and mechanism of traumatic brain injury at simulated high altitudeBrain Res. 2020 Jan 1;1726:146423. doi: 10.1016/j.brainres.2019.146423. Epub 2019 Oct 22.10.1016/j.brainres.2019.146423
TBI Model Type: Weight-drop model
Organism Species: mouse
Organism Strain: C57BL/6
Assessments: Brain Water, H & E stain, Immunofluorescence, Immunohistochemistry, Western Blot
Citation: Yi HJ, Lee JE, Lee DH, Kim YI, Cho CB, Kim IS, Sung JH, Yang SH.The role of NLRP3 in traumatic brain injury and its regulation by pioglitazoneJ Neurosurg. 2019 Sep 27;133(4):1083-1091. doi: 10.3171/2019.6.JNS1954. Print 2020 Oct 1.10.3171/2019.6.JNS1954
TBI Model Type: Controlled cortical impact model
Organism Species: rat
Organism Strain: Sprague-Dawley
Assessments: 16S ribosomal RNA gene sequencing, Blood–brain barrier permeability, Enzyme-linked immunosorbent assay (ELISA), Histology, RT-PCR, Western blot, Brain water content, limulus amebocyte lysate assay, Neurological Severity Score (NSS), Rotarod test
Citation: Mirzayan MJ, Klinge PM, Ude S, Hotop A, Samii M, Brinker T, Korkmaz Z, Meyer GJ, Knapp WH, Samii A. Modified calcium accumulation after controlled cortical impact under cyclosporin A treatment: a 45Ca autoradiographic studyNeurol Res. 2008 Jun;30(5):476-9. doi: 10.1179\/174313208X276916.
TBI Model Type: Weight-drop model
Organism Species: rat
Organism Strain: Sprague-Dawley
Assessments: Nissl staining, Lipid peroxidation assay, GSH assay, SOD activity, Western blot, Beam balance test, Brain water content, MDA, TUNEL staining
Citation: He Y, Qu S, Wang J, He X, Lin W, Zhen H, Zhang X.Brain Res. 2012 Jan 18;1433:127-36. doi: 10.1016/j.brainres.2011.11.027. Epub 2011 Nov 18.
TBI Model Type: Weight-drop model
Organism Species: mouse
Organism Strain: C57BL/6
Assessments: EMSA, Immunohistochemistry (IHC), qrt-PCR, Western blot
Citation: Ling HP, Li W, Zhou ML, Tang Y, Chen ZR, Hang CH.J Surg Res. 2013 Jan;179(1):e227-34. doi: 10.1016/j.jss.2012.03.030. Epub 2012 Apr 5.
TBI Model Type: Weight-drop model
Organism Species: rat
Organism Strain: Sprague-Dawley
Assessments: Brain water content, ELISA, Morris water maze (MWM), qrt-PCR, Western blot, Immunofluorescence, hematoxylin and eosin, Inclined plane test, modified Neurologic Severity Score (mNSS)
Citation: Mao SS, Hua R, Zhao XP, Qin X, Sun ZQ, Zhang Y, Wu YQ, Jia MX, Cao JL, Zhang YM.J Neurotrauma. 2012 Jul 1;29(10):1941-59. doi: 10.1089/neu.2011.2244.
TBI Model Type: Weight-drop model
Organism Species: mouse
Organism Strain: ICR
Assessments: Behavioral, FJC, Immunofluorescence staining, Neurological Severity Score, RT-qPCR, TUNEL, Western blot
Citation: Zhou Y, Wang HD, Zhou XM, Fang J, Zhu L, Ding K.N-acetylcysteine amide provides neuroprotection via Nrf2-ARE pathway in a mouse model of traumatic brain injuryDrug Des Devel Ther. 2018 Dec 4;12:4117-4127. doi: 10.2147/DDDT.S179227. eCollection 2018.PMC628453210.2147/DDDT.S179227
TBI Model Type: Weight-drop model
Organism Species: rat
Organism Strain: Sprague-Dawley
Assessments: Brain water content, Enzyme-linked immunosorbent assay (ELISA), Foot fault test, Immunohistochemitry (IHC), Morris Water Maze (MWM), open field test, qRT-PCR, Western blot
Citation: Lan YL, Wang X, Zou YJ, Xing JS, Lou JC, Zou S, Ma BB, Ding Y, Zhang B. Bazedoxifene protects cerebral autoregulation after traumatic brain injury and attenuates impairments in blood-brain barrier damage: involvement of anti-inflammatory pathways by blocking MAPK signalingInflamm Res. 2019 Apr;68(4):311-323. doi: 10.1007\/s00011-019-01217-z. Epub 2019 Jan 31.
TBI Model Type: Weight-drop model
Organism Species: rat
Organism Strain: Wistar
Assessments: Immunofluorescence Double Labeling, NKCC1 Messenger RNA Assay, Neuron Damage, Water Content Measurement, Western Blot
Citation: Lu KT, Cheng NC, Wu CY, Yang YL.NKCC1-mediated traumatic brain injury-induced brain edema and neuron death via Raf/MEK/MAPK cascadeCrit Care Med. 2008 Mar;36(3):917-22. doi: 10.1097/CCM.0B013E31816590C4.10.1097/CCM.0B013E31816590C4
TBI Model Type: Weight-drop model
Organism Species: mouse
Organism Strain: ICR
Assessments: Grip Test, Brain Water Content, Immunofluorescence, Immunohistochemical Staining, Mitochondrial MDA and SOD Content, Prussian Blue Staining, Reactive Oxygen Species (ROS) Content, Terminal Deoxynucleotidyl Transferase-Mediated dUTP Nick End Labeling (TUNEL) Analysis, Western Blot, dihydroethidium (DHE) staining
Citation: Xu J, Wang H, Ding K, Zhang L, Wang C, Li T, Wei W, Lu X.Luteolin provides neuroprotection in models of traumatic brain injury via the Nrf2-ARE pathway.Free Radic Biol Med. 2014 Jun;71:186-195. doi: 10.1016/j.freeradbiomed.2014.03.009. Epub 2014 Mar 15.
TBI Model Type: Weight-drop model
Organism Species: rat
Organism Strain: Sprague-Dawley
Assessments: Neurological Severity Score (NSS), RT-PCR, Western blot, Immunohistochemistry analysis
Citation: Fu XM, Liu SJ, Dan QQ, Wang YP, Lin N, Lv LY, Zou Y, Liu S, Zhou X, Wang TH.Combined Bone Mesenchymal Stem Cell and Olfactory Ensheathing Cell Transplantation Promotes Neural Repair Associated With CNTF Expression in Traumatic Brain-Injured Rats.Cell Transplant. 2015;24(8):1533-44. doi: 10.3727/096368914X679345. Epub 2014 Mar 7.
TBI Model Type: Weight-drop model
Organism Species: rat
Organism Strain: Sprague-Dawley
Assessments: Western blot, ELISA
Citation: Carballosa-Gonzalez MM, Vitores A, Hentall ID.Hindbrain raphe stimulation boosts cyclic adenosine monophosphate and signaling proteins in the injured spinal cord.Brain Res. 2014 Jan 16;1543:165-72. doi: 10.1016/j.brainres.2013.11.013. Epub 2013 Nov 16.
TBI Model Type: Weight-drop model
Organism Species: rat
Organism Strain: Sprague-Dawley
Assessments: Immunofluorescence staining, Transmission electron microscopy, Western blot
Citation: Sun L, Gao J, Zhao M, Jing X, Cui Y, Xu X, Wang K, Zhang W, Cui J.The effects of BMSCs transplantation on autophagy by CX43 in the hippocampus following traumatic brain injury in rats.Neurol Sci. 2014 May;35(5):677-82. doi: 10.1007/s10072-013-1575-6. Epub 2013 Nov 13.
TBI Model Type: Weight-drop model
Organism Species: mouse
Organism Strain: No strain reported
Assessments: Immunohistochemistry (IHC), Ladder walk, Neurological Severity Score (NSS), open field test, qRT-PCR, Western blot
Citation: Förstner P, Knöll B. Interference of neuronal activity-mediated gene expression through serum response factor deletion enhances mortality and hyperactivity after traumatic brain injuryFASEB J. 2020 Mar;34(3):3855-3873. doi: 10.1096\/fj.201902257RR. Epub 2020 Jan 12.
TBI Model Type: Controlled cortical impact model
Organism Species: rat
Organism Strain: Sprague-Dawley
Assessments: Brain water content, Enzyme-linked immunosorbent assay (ELISA), Foot fault test, Immunohistochemitry (IHC), Morris Water Maze (MWM), open field test, qRT-PCR, Western blot
Citation: Lan YL, Wang X, Zou YJ, Xing JS, Lou JC, Zou S, Ma BB, Ding Y, Zhang B. Bazedoxifene protects cerebral autoregulation after traumatic brain injury and attenuates impairments in blood-brain barrier damage: involvement of anti-inflammatory pathways by blocking MAPK signalingInflamm Res. 2019 Apr;68(4):311-323. doi: 10.1007\/s00011-019-01217-z. Epub 2019 Jan 31.
TBI Model Type: Weight-drop model
Organism Species: mouse
Organism Strain: ICR
Assessments: Brain Water Content, Immunohistochemistry (IHC), Nissl Staining, Western blot, grip test, Spectrophotometer
Citation: Xu J, Shi J, Zhang J, Zhang Y.Folia Neuropathol. 2018;56(3):179-186. doi: 10.5114/fn.2018.78697.
