On page 4 showing 61 ~ 80 out of 498 results
TBI Model Type: Controlled cortical impact model
Organism Species: mouse
Organism Strain: C57BL/6J
Assessments: Acoustic startle response, Body curl test, Elevated-plus maze, Forced swim test, Lesion volume, Morris Water Maze (MWM), open field test, prepulse inhibition
Citation: Washington PM, Forcelli PA, Wilkins T, Zapple DN, Parsadanian M, Burns MP. The effect of injury severity on behavior: a phenotypic study of cognitive and emotional deficits after mild, moderate, and severe controlled cortical impact injury in miceJ Neurotrauma. 2012 Sep;29(13):2283-96. doi: 10.1089\/neu.2012.2456. Epub 2012 Aug 3. PMC3430487
TBI Model Type: Controlled cortical impact model
Organism Species: rat
Organism Strain: Long-Evans
Assessments: Immunohistochemistry (IHC), Cresyl violet staining
Citation: Meaney DF, Ross DT, Winkelstein BA, Brasko J, Goldstein D, Bilston LB, Thibault LE, Gennarelli TA. Modification of the cortical impact model to produce axonal injury in the rat cerebral cortexJ Neurotrauma. 1994 Oct;11(5):599-612. doi: 10.1089\/neu.1994.11.599.
TBI Model Type: Weight-drop model
Organism Species: rat
Organism Strain: Wistar
Assessments: Accelerometer measurement, Immunohistochemistry (IHC)
Citation: Viano DC, Hamberger A, Bolouri H, Säljö A. Evaluation of three animal models for concussion and serious brain injuryAnn Biomed Eng. 2012 Jan;40(1):213-26. doi: 10.1007\/s10439-011-0386-2. Epub 2011 Oct 20.
TBI Model Type: Weight-drop model
Organism Species: rat
Organism Strain: Wistar
Assessments: modified Neurological Severity Score (mNSS), Neurological examination, Sensorimotor examination, Nissl staining, light/dark anxiety transition test, conditioned passive avoidance response, elevated plus-maze, histology, Hematoxylin and Eosin
Citation: Plekhova NG, Radkov IV, Zinoviev SV, Dyuizen IV, Baryshev AN, Shumatov VB. Effect of Mild Traumatic Brain Injury on Behavioral Reactions and Neocortical Morphology in RatsBull Exp Biol Med. 2021 Mar;170(5):672-676. doi: 10.1007\/s10517-021-05130-6. Epub 2021 Mar 31.
TBI Model Type: Controlled cortical impact model
Organism Species: pig
Organism Strain: Yorkshire
Assessments: Intracranial Pressure (ICP), Nissl staining, Fluoro-Jade B staining (FJB), NeuN staining, cerebral perfusion pressure, heart rate, mean arterial blood pressure (MAP)
Citation: Manley GT, Rosenthal G, Lam M, Morabito D, Yan D, Derugin N, Bollen A, Knudson MM, Panter SS. Controlled cortical impact in swine: pathophysiology and biomechanicsJ Neurotrauma. 2006 Feb;23(2):128-39. doi: 10.1089\/neu.2006.23.128.
TBI Model Type: Controlled cortical impact model
Organism Species: mouse
Organism Strain: C57BL/6J
Assessments: mean arterial blood pressure (MAP), Fluoro-Jade C staining (FJC), Hematoxylin and Eosin
Citation: Dennis AM, Haselkorn ML, Vagni VA, Garman RH, Janesko-Feldman K, Bayir H, Clark RS, Jenkins LW, Dixon CE, Kochanek PM. Hemorrhagic shock after experimental traumatic brain injury in mice: effect on neuronal deathJ Neurotrauma. 2009 Jun;26(6):889-99. doi: 10.1089\/neu.2008.0512. PMC2694227
TBI Model Type: Blast model
Organism Species: rat
Organism Strain: Sprague-Dawley
Assessments: Electrophysiological recording, Propidium iodideluorescence
Citation: Effgen GB, Vogel EW 3rd, Lynch KA, Lobel A, Hue CD, Meaney DF, Bass CR, Morrison B 3rd. Isolated primary blast alters neuronal function with minimal cell death in organotypic hippocampal slice culturesJ Neurotrauma. 2014 Jul 1;31(13):1202-10. doi: 10.1089\/neu.2013.3227. Epub 2014 May 8.
TBI Model Type: Weight-drop model
Organism Species: mouse
Organism Strain: Swiss Albino
Assessments: Immunofluorescence, modified Neurological Severity Score (mNSS)
Citation: Karakaya D, Cakir-Aktas C, Uzun S, Soylemezoglu F, Mut M. Tailored Therapeutic Doses of Dexmedetomidine in Evolving Neuroinflammation after Traumatic Brain InjuryNeurocrit Care. 2022 Jun;36(3):802-814. doi: 10.1007\/s12028-021-01381-3. Epub 2021 Nov 16.
TBI Model Type: Fluid percussion injury model
Organism Species: pig
Organism Strain: Yorkshire
Assessments: Cardiac output, Cerebral blood flow, renal blood flow, Doppler imaging, Pulsed wave Doppler measurements, Transesophageal echocardiography, blood gas, central venous pressure, intracranial pressure monitor
Citation: Adedipe A, John AS, Krishnamoorthy V, Wang X, Steck DT, Ferreira R, White N, Stern S. Left Ventricular Function in the Initial Period After Severe Traumatic Brain Injury in SwineNeurocrit Care. 2022 Mar 21. doi: 10.1007\/s12028-022-01468-5. Online ahead of print.
TBI Model Type: Weight-drop model
Organism Species: mouse
Organism Strain: ICR
Assessments: Immunohistochemistry, Novel object recognition test, Y-Maze, elevated plus maze test, staircase test
Citation: Qubty D, Rubovitch V, Benromano T, Ovadia M, Pick CG. Orally Administered Cinnamon Extract Attenuates Cognitive and Neuronal Deficits Following Traumatic Brain InjuryJ Mol Neurosci. 2021 Jan;71(1):178-186. doi: 10.1007\/s12031-020-01688-4. Epub 2020 Sep 8.
TBI Model Type: Weight-drop model
Organism Species: rat
Organism Strain: Wistar
Assessments: Object Recognition Memory Test, Open-Field Test, Western blot, Brain Water Content, qRT-PCR
Citation: Furtado ABV, Gonçalves DF, Hartmann DD, Courtes AA, Cassol G, Nunez-Figueredo Y, Argolo DS, do Nascimento RP, Costa SL, da Silva VDA, Royes LFF, Soares FAA. JM-20 Treatment After Mild Traumatic Brain Injury Reduces Glial Cell Pro-inflammatory Signaling and Behavioral and Cognitive Deficits by Increasing Neurotrophin ExpressionMol Neurobiol. 2021 Sep;58(9):4615-4627. doi: 10.1007\/s12035-021-02436-4. Epub 2021 Jun 19.
TBI Model Type: Weight-drop model
Organism Species: mouse
Organism Strain: C57BL/6J
Assessments: Fluoro-Jade C staining (FJC), Immunohistochemistry (IHC)
Citation: Hetzer SM, Shalosky EM, Torrens JN, Evanson NK. Chronic Histological Outcomes of Indirect Traumatic Optic Neuropathy in Adolescent Mice: Persistent Degeneration and Temporally Regulated Glial ResponsesCells. 2021 Nov 28;10(12):3343. doi: 10.3390\/cells10123343. PMC8699438
TBI Model Type: Blast model
Organism Species: mouse
Organism Strain: C57BL/6J
Assessments: Polyunsaturated Fatty Acids analysis, Sphingolipids analysis, Immunohistochemistry (IHC), Pavlovian fear conditioning, RT-PCR, Sphingomyelinase Assay, electroretinogram recording, open-field behavior assessment, optokinetic reflex measurement, tail suspension test
Citation: Mondal K, Takahashi H, Cole J 2nd, Del Mar NA, Li C, Stephenson DJ, Allegood J, Cowart LA, Chalfant CE, Reiner A, Mandal N. Systemic Elevation of n-3 Polyunsaturated Fatty Acids (n-3-PUFA) Is Associated with Protection against Visual, Motor, and Emotional Deficits in Mice following Closed-Head Mild Traumatic Brain InjuryMol Neurobiol. 2021 Nov;58(11):5564-5580. doi: 10.1007\/s12035-021-02501-y. Epub 2021 Aug 8. PMC8655834
TBI Model Type: Blast model
Organism Species: mouse
Organism Strain: C57BL/6J
Assessments: Image Acquisition, Western blot
Citation: Wang C, Shao C, Zhang L, Siedlak SL, Meabon JS, Peskind ER, Lu Y, Wang W, Perry G, Cook DG, Zhu X. Oxidative Stress Signaling in Blast TBI-Induced Tau PhosphorylationAntioxidants (Basel). 2021 Jun 15;10(6):955. doi: 10.3390\/antiox10060955. PMC8232162
TBI Model Type: Weight-drop model
Organism Species: rat
Organism Strain: Sprague-Dawley
Assessments: Brain water content, Morris Water Maze (MWM), Neurologic Deficit Scoring, Western Blot, Novel object recognition test, RT-PCR
Citation: Cheng T, Yang B, Li D, Ma S, Tian Y, Qu R, Zhang W, Zhang Y, Hu K, Guan F, Wang J. Wharton's Jelly Transplantation Improves Neurologic Function in a Rat Model of Traumatic Brain InjuryCell Mol Neurobiol. 2015 Jul;35(5):641-9. doi: 10.1007\/s10571-015-0159-9. Epub 2015 Feb 1. PMC4481175
TBI Model Type: Controlled cortical impact model
Organism Species: mouse
Organism Strain: C57BL/6J
Assessments: Cytokine Assay, Enzyme-linked immunosorbent assay (ELISA), Immunohistochemistry (IHC), astrocytic, hippocampal neurogenesis, microglia responses, radial arm water maze, Rotarod
Citation: Song S, Kong X, Acosta S, Sava V, Borlongan C, Sanchez-Ramos J. Granulocyte colony-stimulating factor promotes behavioral recovery in a mouse model of traumatic brain injuryJ Neurosci Res. 2016 May;94(5):409-23. doi: 10.1002\/jnr.23714. Epub 2016 Jan 29. PMC4805459
TBI Model Type: Blast model
Organism Species: rat
Organism Strain: Sprague-Dawley
Assessments: Enzyme-linked immunosorbent assay (ELISA), RT-PCR, Immunohistochemistry (IHC), Western blot, Brain water content, cortical oxidative stress
Citation: Yang Z, Simovic MO, Edsall PR, Liu B, Cancio TS, Batchinsky AI, Cancio LC, Li Y. HMGB1 Inhibition to Ameliorate Organ Failure and Increase Survival in TraumaBiomolecules. 2022 Jan 8;12(1):101. doi: 10.3390\/biom12010101. PMC8773879
TBI Model Type: Other
Organism Species: mouse
Organism Strain: C57Bl/6
Assessments: Barnes Maze test, Enzyme-Linked Immunosorbent Assay (ELISA), Histology, LRR, Neurological Severity Score (NSS), open field test, Silver staining, Western blot, Rotarod test, passive avoidance task, thigmotaxis index
Citation: Namjoshi DR, Cheng WH, McInnes KA, Martens KM, Carr M, Wilkinson A, Fan J, Robert J, Hayat A, Cripton PA, Wellington CL. Merging pathology with biomechanics using CHIMERA (Closed-Head Impact Model of Engineered Rotational Acceleration): a novel, surgery-free model of traumatic brain injuryMol Neurodegener. 2014 Dec 1;9:55. doi: 10.1186\/1750-1326-9-55. PMC4269957
TBI Model Type: Weight-drop model
Organism Species: zebrafish
Organism Strain: No strain reported
Assessments: Learning, Glutamate Excitotoxicity, Immunoblot, Memory, qRT-PCR, ataxia, bending, circling, corkscrew swimming, clonic-seizure metrics, modified Puppala, Fluid Content Measurement
Citation: Hentig J, Campbell LJ, Cloghessy K, Lee M, Boggess W, Hyde DR. Prophylactic Activation of Shh Signaling Attenuates TBI-Induced Seizures in Zebrafish by Modulating Glutamate Excitotoxicity through Eaat2aBiomedicines. 2021 Dec 24;10(1):32. doi: 10.3390\/biomedicines10010032. PMC8773121
TBI Model Type: Other
Organism Species: rat
Organism Strain: Sprague-Dawley
Assessments: Fluoro-Jade B staining (FJB), Histology, Locomotor behavior, Immunohistochemistry (IHC)
Citation: Turner RC, Naser ZJ, Lucke-Wold BP, Logsdon AF, Vangilder RL, Matsumoto RR, Huber JD, Rosen CL. Single low-dose lipopolysaccharide preconditioning: neuroprotective against axonal injury and modulates glial cellsNeuroimmunol Neuroinflamm. 2017 Jan;4:6-15. doi: 10.20517\/2347-8659.2016.40. Epub 2017 Jan 20. PMC5289820
