On page 4 showing 61 ~ 80 out of 125 results
TBI Model Type: Weight-drop model
Organism Species: mouse
Organism Strain: C57BL/6
Assessments: Caspase Enzyme Activity, Feeding Latency, Histopathology, rt-PCR, TUNEL staining, Western blot
Citation: Mikrogianakis A, Shaye RE, Griffin P, Kawesa S, Lockwood J, Gendron NH, Gaboury I, Merali Z, Mackenzie AE, Hutchison JS.J Neurotrauma. 2007 Feb;24(2):338-53. doi: 10.1089/neu.2006.003615.
TBI Model Type: Weight-drop model
Organism Species: rat
Organism Strain: Sprague-Dawley
Assessments: Immunofluorescence, Western blot
Citation: Kreipke CW, Morgan R, Roberts G, Bagchi M, Rafols JA.Neurol Res. 2007 Jun;29(4):369-74. doi: 10.1179/016164107X204684.
TBI Model Type: Weight-drop model
Organism Species: rat
Organism Strain: Sprague-Dawley
Assessments: Immunohistochemistry (IHC), Western blot, in-situ hybridization
Citation: Hüttemann M, Lee I, Kreipke CW, Petrov T.Neuroscience. 2008 Jan 2;151(1):148-54. doi: 10.1016/j.neuroscience.2007.09.029. Epub 2007 Sep 20.
TBI Model Type: Weight-drop model
Organism Species: rat
Organism Strain: Sprague-Dawlay
Assessments: TUNEL staining, transmission electron microscope, Enzyme-linked immunosorbent assay (ELISA), Immunofluorescence, Neurological Severity Score (NSS), Morris Water Maze (MWM), Western blot, Brain water content
Citation: Shen M, Wang S, Wen X, Han XR, Wang YJ, Zhou XM, Zhang MH, Wu DM, Lu J, Zheng YL. Dexmedetomidine exerts neuroprotective effect via the activation of the PI3K\/Akt\/mTOR signaling pathway in rats with traumatic brain injuryBiomed Pharmacother. 2017 Nov;95:885-893. doi: 10.1016\/j.biopha.2017.08.125. Epub 2017 Sep 10.
TBI Model Type: Weight-drop model
Organism Species: mouse
Organism Strain: C57BL/6
Assessments: Enzyme-linked immunosorbent assay (ELISA), Evans blue dye extravasation, Functional Magnetic resonance imaging (MRI), Immunofluorescence, Western blot, Brain water content, Neurological Severity Score (NSS), wire grip test, motion test
Citation: Yang Q, Zhang S, Xu Z, Liu L, Fan S, Wu S, Ma C. The Effectiveness of Trigeminal Nerve Stimulation on Traumatic Brain InjuryNeuromodulation. 2022 Jan 20:S1094-7159(21)06389-3. doi: 10.1016\/j.neurom.2021.10.014. Online ahead of print.
TBI Model Type: Weight-drop model
Organism Species: rat
Organism Strain: Wistar
Assessments: ATP Assay, MeDIP-sequencing and analysis, qRT-PCR, STM-SOL method, Western blot, Immunoprecipitation assay
Citation: Balasubramanian N, Jadhav G, Sakharkar AJ. Repeated mild traumatic brain injuries perturb the mitochondrial biogenesis via DNA methylation in the hippocampus of ratMitochondrion. 2021 Nov;61:11-24. doi: 10.1016\/j.mito.2021.09.001. Epub 2021 Sep 9.
TBI Model Type: Weight-drop model
Organism Species: mouse
Organism Strain: ICR
Assessments: Brain water content, Immunohistochemistry (IHC), Nissl Staining, Western blot, Grip test, spectrophotometer
Citation: Zhai X, Ding Y, Wang Q, Zhang H, Li F. Rutin Acid Ameliorates Neural Apoptosis Induced by Traumatic Brain Injury via Mitochondrial Pathways in MiceNeuroimmunomodulation. 2016;23(3):179-187. doi: 10.1159\/000448716. Epub 2016 Sep 20.
TBI Model Type: Weight-drop model
Organism Species: mouse
Organism Strain: C57BL/6
Assessments: Brain water content, Enzyme-linked immunosorbent assay (ELISA), Evans blue extravasation, Neurological Severity Score (NSS), Novel object recognition, Rotarod test, TUNEL staining, Western blot, lactate dehydrogenase release
Citation: Wang P, Pan B, Tian J, Yang L, Chen Z, Yang L, Fan Z. Ac-FLTD-CMK inhibits pyroptosis and exerts neuroprotective effect in a mice model of traumatic brain injuryNeuroreport. 2021 Feb 3;32(3):188-197. doi: 10.1097\/WNR.0000000000001580.
TBI Model Type: Controlled cortical impact model
Organism Species: mouse
Organism Strain: CF-1
Assessments: Western blot
Citation: Thompson SN, Gibson TR, Thompson BM, Deng Y, Hall ED. Relationship of calpain-mediated proteolysis to the expression of axonal and synaptic plasticity markers following traumatic brain injury in miceExp Neurol. 2006 Sep;201(1):253-65. doi: 10.1016\/j.expneurol.2006.04.013. Epub 2006 Jun 30.
TBI Model Type: Weight-drop model
Organism Species: mouse
Organism Strain: C57BL/6
Assessments: Barnes Maze test, Basal ROS production, Enzyme-linked immunosorbent assay (ELISA), Fluoro-Jade C staining (FJC), GSH/GSSG activity assay, Hypoxyprobe staining, Neurological Severity Score, NADPH oxidase activity, Novel object recognition test, Western blot, cell viability analysis, Immunocytochemistry, memory recall test
Citation: Ho MH, Yen CH, Hsieh TH, Kao TJ, Chiu JY, Chiang YH, Hoffer BJ, Chang WC, Chou SY. CCL5 via GPX1 activation protects hippocampal memory function after mild traumatic brain injuryRedox Biol. 2021 Oct;46:102067. doi: 10.1016\/j.redox.2021.102067. Epub 2021 Jul 17. PMC8327355
TBI Model Type: Fluid percussion injury model
Organism Species: mouse
Organism Strain: C57BL/6J
Assessments: modified Neurological Severity Score (mNSS), qRT-PCR, Western blot, Brain water content, Oxidative Stress Evaluation
Citation: Chen Y, Lu Y, Xu S, Liu M, Chen W, Zhang Y, Wei L, Zhong C. HDAC1 expression is positively correlated with NADPH oxidase 4-mediated oxidative stress in a mouse model of traumatic brain injuryJ Neurophysiol. 2022 May 1;127(5):1438-1444. doi: 10.1152\/jn.00049.2022. Epub 2022 Apr 20.
TBI Model Type: Weight-drop model
Organism Species: rat
Organism Strain: Sprague-Dawley
Assessments: Brain water content, Dual-luciferase reporter gene assay, Histology, qRT-PCR, TUNEL staining, Western blot, Enzyme-linked immunosorbent assay (ELISA), Neurological Severity Score (NSS)
Citation: Cui C, Zhang D, Sun K, Li H, Xu L, Lin G, Guo Y, Hu J, Chen J, Nong L, Cai Y, Yu D, Yang W, Wang P, Sun Y. Propofol maintains Th17\/Treg cell balance and reduces inflammation in rats with traumatic brain injury via the miR‑145‑3p\/NFATc2\/NF‑κB axisInt J Mol Med. 2021 Jul;48(1):135. doi: 10.3892\/ijmm.2021.4968. Epub 2021 May 26. PMC8148094
TBI Model Type: Weight-drop model
Organism Species: rat
Organism Strain: Sprague-Dawley
Assessments: Immunohistochemistry (IHC), Western blot, Brain water content, Neurological Severity Score (NSS)
Citation: Wang YC, Cui Y, Cui JZ, Sun LQ, Cui CM, Zhang HA, Zhu HX, Li R, Tian YX, Gao JL. Neuroprotective effects of brilliant blue G on the brain following traumatic brain injury in ratsMol Med Rep. 2015 Aug;12(2):2149-54. doi: 10.3892\/mmr.2015.3607. Epub 2015 Apr 14.
TBI Model Type: Other
Organism Species: mouse
Organism Strain: C57BL/6
Assessments: Brain water content, Enzyme-linked immunosorbent assay (ELISA), Evans blue permeability assay, Immunofluorescence, TUNEL staining, Western blot, modified Neurological Severity Score (mNSS)
Citation: Mannix R, Berkner J, Mei Z, Alcon S, Hashim J, Robinson S, Jantzie L, Meehan WP 3rd, Qiu J. Adolescent Mice Demonstrate a Distinct Pattern of Injury after Repetitive Mild Traumatic Brain InjuryJ Neurotrauma. 2017 Jan 15;34(2):495-504. doi: 10.1089\/neu.2016.4457. Epub 2016 Jul 27. PMC5220578
TBI Model Type: Weight-drop model
Organism Species: mouse
Organism Strain: Swiss
Assessments: Neurological Score test, Neurological deficit assessment, qRT-PCR, Western Blot, Brain water content
Citation: Lopez-Rodriguez AB, Acaz-Fonseca E, Viveros MP, Garcia-Segura LM. Changes in cannabinoid receptors, aquaporin 4 and vimentin expression after traumatic brain injury in adolescent male mice. Association with edema and neurological deficitPLoS One. 2015 Jun 3;10(6):e0128782. doi: 10.1371\/journal.pone.0128782. eCollection 2015. PMC4454518
TBI Model Type: Weight-drop model
Organism Species: mouse
Organism Strain: ICR
Assessments: Nissl staining, Enzyme-linked immunosorbent assay (ELISA), Grip test, Immunohistochemistry (IHC), Neurological Severity Score (NSS), Western blot, Grip test
Citation: Song Q, Xie D, Pan S, Xu W. Rapamycin protects neurons from brain contusion‑induced inflammatory reaction via modulation of microglial activationMol Med Rep. 2015 Nov;12(5):7203-10. doi: 10.3892\/mmr.2015.4407. Epub 2015 Oct 1. PMC4626160
TBI Model Type: Weight-drop model
Organism Species: rat
Organism Strain: Sprague-Dawley
Assessments: Immunohistochemistry (IHC), Morris Water Maze (MWM), Neurological Severity Score (NSS), Western blot, Brain water content
Citation: Zhang MH, Zhou XM, Cui JZ, Wang KJ, Feng Y, Zhang HA. Neuroprotective effects of dexmedetomidine on traumatic brain injury: Involvement of neuronal apoptosis and HSP70 expressionMol Med Rep. 2018 Jun;17(6):8079-8086. doi: 10.3892\/mmr.2018.8898. Epub 2018 Apr 19. PMC5983975
TBI Model Type: Weight-drop model
Organism Species: mouse
Organism Strain: ICR
Assessments: Bioluminescent Somatic Cell Assay, Bradford method, Immunohistochemical staining, Mitochondrial membrane potential (MMP) measurement, Western blot, spectrophotometer
Citation: Li X, Wang H, Gao Y, Li L, Tang C, Wen G, Zhou Y, Zhou M, Mao L, Fan Y. Protective Effects of Quercetin on Mitochondrial Biogenesis in Experimental Traumatic Brain Injury via the Nrf2 Signaling PathwayPLoS One. 2016 Oct 25;11(10):e0164237. doi: 10.1371\/journal.pone.0164237. eCollection 2016. PMC5079551
TBI Model Type: Controlled cortical impact model
Organism Species: rat
Organism Strain: Sprague-Dawley
Assessments: Tyrosine Hydroxylase activity, Western blot, microdialysis
Citation: Shin SS, Bray ER, Dixon CE. Effects of nicotine administration on striatal dopamine signaling after traumatic brain injury in ratsJ Neurotrauma. 2012 Mar 20;29(5):843-50. doi: 10.1089\/neu.2011.1966. Epub 2011 Oct 24. PMC3303095
TBI Model Type: Controlled cortical impact model
Organism Species: rat
Organism Strain: Sprague-Dawley
Assessments: RT-PCR, Western blot
Citation: Shin SS, Bales JW, Yan HQ, Kline AE, Wagner AK, Lyons-Weiler J, Dixon CE. The effect of environmental enrichment on substantia nigra gene expression after traumatic brain injury in ratsJ Neurotrauma. 2013 Feb 15;30(4):259-70. doi: 10.1089\/neu.2012.2462. Epub 2013 Feb 5. PMC3579325
