On page 4 showing 61 ~ 80 out of 95 results
TBI Model Type: Other
Organism Species: mouse
Organism Strain: C57BL/6N
Assessments: Autoradiography, Immunohistochemistry (IHC), Neurological Severity Score (NSS), hematoxylin and eosin, μPET
Citation: Israel I, Ohsiek A, Al-Momani E, Albert-Weissenberger C, Stetter C, Mencl S, Buck AK, Kleinschnitz C, Samnick S, Sirén AL. Combined [(18)F]DPA-714 micro-positron emission tomography and autoradiography imaging of microglia activation after closed head injury in miceJ Neuroinflammation. 2016 Jun 7;13(1):140. doi: 10.1186\/s12974-016-0604-9. PMC4897946
TBI Model Type: Weight-drop model
Organism Species: mouse
Organism Strain: ICR
Assessments: Brain water content, Immunohistochemistry (IHC), Nissl Staining, Western blot, Grip test, spectrophotometer
Citation: Zhai X, Ding Y, Wang Q, Zhang H, Li F. Rutin Acid Ameliorates Neural Apoptosis Induced by Traumatic Brain Injury via Mitochondrial Pathways in MiceNeuroimmunomodulation. 2016;23(3):179-187. doi: 10.1159\/000448716. Epub 2016 Sep 20.
TBI Model Type: Controlled cortical impact model
Organism Species: mouse
Organism Strain: C57BL/6
Assessments: Hematoxylin and Eosin, Morris Water Maze (MWM), Brain water content, Immunohistochemistry (IHC), seizure activity, wire-grip test
Citation: Dapul HR, Park J, Zhang J, Lee C, DanEshmand A, Lok J, Ayata C, Gray T, Scalzo A, Qiu J, Lo EH, Whalen MJ. Concussive injury before or after controlled cortical impact exacerbates histopathology and functional outcome in a mixed traumatic brain injury model in miceJ Neurotrauma. 2013 Mar 1;30(5):382-91. doi: 10.1089\/neu.2012.2536. Epub 2013 Feb 20. PMC3593692
TBI Model Type: Weight-drop model
Organism Species: rat
Organism Strain: Sprague-Dawley
Assessments: Immunohistochemistry (IHC), Western blot, Brain water content, Neurological Severity Score (NSS)
Citation: Wang YC, Cui Y, Cui JZ, Sun LQ, Cui CM, Zhang HA, Zhu HX, Li R, Tian YX, Gao JL. Neuroprotective effects of brilliant blue G on the brain following traumatic brain injury in ratsMol Med Rep. 2015 Aug;12(2):2149-54. doi: 10.3892\/mmr.2015.3607. Epub 2015 Apr 14.
TBI Model Type: Weight-drop model
Organism Species: mouse
Organism Strain: ICR
Assessments: Nissl staining, Enzyme-linked immunosorbent assay (ELISA), Grip test, Immunohistochemistry (IHC), Neurological Severity Score (NSS), Western blot, Grip test
Citation: Song Q, Xie D, Pan S, Xu W. Rapamycin protects neurons from brain contusion‑induced inflammatory reaction via modulation of microglial activationMol Med Rep. 2015 Nov;12(5):7203-10. doi: 10.3892\/mmr.2015.4407. Epub 2015 Oct 1. PMC4626160
TBI Model Type: Weight-drop model
Organism Species: rat
Organism Strain: Sprague-Dawley
Assessments: Immunohistochemistry (IHC), Morris Water Maze (MWM), Neurological Severity Score (NSS), Western blot, Brain water content
Citation: Zhang MH, Zhou XM, Cui JZ, Wang KJ, Feng Y, Zhang HA. Neuroprotective effects of dexmedetomidine on traumatic brain injury: Involvement of neuronal apoptosis and HSP70 expressionMol Med Rep. 2018 Jun;17(6):8079-8086. doi: 10.3892\/mmr.2018.8898. Epub 2018 Apr 19. PMC5983975
TBI Model Type: Controlled cortical impact model
Organism Species: rat
Organism Strain: Sprague-Dawley
Assessments: Diffusion tensor imaging, Luxol fast blue staining, Magnetic resonance imaging (MRI), T2 weighted imaging, Transmission electron microscopy, Immunohistochemistry (IHC), myelin thickness measurement
Citation: Donovan V, Kim C, Anugerah AK, Coats JS, Oyoyo U, Pardo AC, Obenaus A. Repeated mild traumatic brain injury results in long-term white-matter disruptionJ Cereb Blood Flow Metab. 2014 Apr;34(4):715-23. doi: 10.1038\/jcbfm.2014.6. Epub 2014 Jan 29. PMC3982100
TBI Model Type: Controlled cortical impact model
Organism Species: mouse
Organism Strain: C57BL/6J
Assessments: Electron Microscopy, Morris Water Maze (MWM), Immunohistochemistry (IHC)
Citation: Shitaka Y, Tran HT, Bennett RE, Sanchez L, Levy MA, Dikranian K, Brody DL. Repetitive closed-skull traumatic brain injury in mice causes persistent multifocal axonal injury and microglial reactivityJ Neuropathol Exp Neurol. 2011 Jul;70(7):551-67. doi: 10.1097\/NEN.0b013e31821f891f. PMC3118973
TBI Model Type: Controlled cortical impact model
Organism Species: mouse
Organism Strain: C57BL/6J
Assessments: Neurological evaluation, Histology, Immunohistochemistry (IHC), Morris Water Maze (MWM), Beam walk test, forepaw contraflexion, Rotarod test, TUNEL staining
Citation: Fox GB, Fan L, Levasseur RA, Faden AI. Sustained sensory\/motor and cognitive deficits with neuronal apoptosis following controlled cortical impact brain injury in the mouseJ Neurotrauma. 1998 Aug;15(8):599-614. doi: 10.1089\/neu.1998.15.599.
TBI Model Type: Weight-drop model
Organism Species: rat
Organism Strain: Sprague-Dawley
Assessments: Immunofluorescence, Immunohistochemistry (IHC), Lesion Volume, Morris Water Maze (MWM), Neurobehavioral Evaluation, Nissl staining, beam walk
Citation: Li D, Ma S, Guo D, Cheng T, Li H, Tian Y, Li J, Guan F, Yang B, Wang J. Environmental Circadian Disruption Worsens Neurologic Impairment and Inhibits Hippocampal Neurogenesis in Adult Rats After Traumatic Brain InjuryCell Mol Neurobiol. 2016 Oct;36(7):1045-55. doi: 10.1007\/s10571-015-0295-2. Epub 2016 Feb 17. PMC4967018
TBI Model Type: Weight-drop model
Organism Species: mouse
Organism Strain: C57BL/6J
Assessments: Beam walk test, Immunofluorescent, Immunohistochemistry (IHC), Lesion Volume Assessment, Morris Water Maze (MWM)
Citation: Huang SX, Qiu G, Cheng FR, Pei Z, Yang Z, Deng XH, Zhu JH, Chen L, Chen CC, Lin WF, Liu Y, Liu Z, Zhu FQ. Berberine Protects Secondary Injury in Mice with Traumatic Brain Injury Through Anti-oxidative and Anti-inflammatory ModulationNeurochem Res. 2018 Sep;43(9):1814-1825. doi: 10.1007\/s11064-018-2597-5. Epub 2018 Jul 19.
TBI Model Type: Weight-drop model
Organism Species: zebrafish
Organism Strain: No strain reported
Assessments: Sonic Hedgehog Modulation, Evans Blue Assay, Fluid Content Measurement, Hoshi protocol, Image Acquisition, Immediate and Delayed Recall, Immunohistochemistry (IHC), Learning, Locomotion velocity, qRT-PCR, Sensorimotor Assay, Shuttle Box Assay Testing Apparatus, Startle Response Habituation, TUNEL staining, Vascular Injury, optical density, tonic-clonic seizure metrics
Citation: Hentig J, Cloghessy K, Lahne M, Jung YJ, Petersen RA, Morris AC, Hyde DR. Zebrafish Blunt-Force TBI Induces Heterogenous Injury Pathologies That Mimic Human TBI and Responds with Sonic Hedgehog-Dependent Cell Proliferation across the NeuroaxisBiomedicines. 2021 Jul 22;9(8):861. doi: 10.3390\/biomedicines9080861. PMC8389629
TBI Model Type: Weight-drop model
Organism Species: mouse
Organism Strain: ICR
Assessments: Aggleton index, Immunohistochemistry (IHC), Novel object recognition test, Y-maze, Enzyme-linked immunosorbent assay (ELISA)
Citation: Benady A, Freidin D, Pick CG, Rubovitch V. GM1 ganglioside prevents axonal regeneration inhibition and cognitive deficits in a mouse model of traumatic brain injurySci Rep. 2018 Sep 6;8(1):13340. doi: 10.1038\/s41598-018-31623-y. PMC6127193
TBI Model Type: Controlled cortical impact model
Organism Species: rat
Organism Strain: Sprague-Dawley
Assessments: Immunohistochemistry (IHC)
Citation: Farajzadeh Khosroshahi S, Yin X, K Donat C, McGarry A, Yanez Lopez M, Baxan N, J Sharp D, Sastre M, Ghajari M. Multiscale modelling of cerebrovascular injury reveals the role of vascular anatomy and parenchymal shear stressesSci Rep. 2021 Jun 21;11(1):12927. doi: 10.1038\/s41598-021-92371-0. PMC8217506
TBI Model Type: Controlled cortical impact model
Organism Species: ferret
Organism Strain: No strain reported
Assessments: Adhesive tape detection test, Gait, Immunohistochemistry (IHC), Magnetic resonance imaging (MRI), Novel object recognition test, Open field test
Citation: Schwerin SC, Hutchinson EB, Radomski KL, Ngalula KP, Pierpaoli CM, Juliano SL. Establishing the ferret as a gyrencephalic animal model of traumatic brain injury: Optimization of controlled cortical impact proceduresJ Neurosci Methods. 2017 Jun 15;285:82-96. doi: 10.1016\/j.jneumeth.2017.05.010. Epub 2017 May 10. PMC6320441
TBI Model Type: Other
Organism Species: pig
Organism Strain: No strain reported
Assessments: Histology, Immunohistochemistry (IHC), microdialysis
Citation: Kilbaugh TJ, Bhandare S, Lorom DH, Saraswati M, Robertson CL, Margulies SS. Cyclosporin A preserves mitochondrial function after traumatic brain injury in the immature rat and pigletJ Neurotrauma. 2011 May;28(5):763-74. doi: 10.1089\/neu.2010.1635. Epub 2011 Apr 12. PMC3125546
TBI Model Type: Weight-drop model
Organism Species: mouse
Organism Strain: C57BL/6J
Assessments: Image acquisition, Immunohistochemistry (IHC), Microscopy, reflex, Neurological Severity Score (NSS), Prussian blue
Citation: Kahriman A, Bouley J, Smith TW, Bosco DA, Woerman AL, Henninger N. Mouse closed head traumatic brain injury replicates the histological tau pathology pattern of human disease: characterization of a novel model and systematic review of the literatureActa Neuropathol Commun. 2021 Jun 29;9(1):118. doi: 10.1186\/s40478-021-01220-8. PMC8243463
TBI Model Type: Weight-drop model
Organism Species: mouse
Organism Strain: C57BL/6N
Assessments: Elevated plus maze, Histology, Immunohistochemistry (IHC), open field test, Paw preference test, handedness, Neurological Severity Score (NSS)
Citation: Lopez-Caperuchipi S, Kürzinger L, Hopp-Krämer S, Albert-Weißenberger C, Paul MM, Sirén AL, Stetter C. Posttraumatic learning deficits correlate with initial trauma severity and chronic cellular reactions after closed head injury in male miceExp Neurol. 2021 Jul;341:113721. doi: 10.1016\/j.expneurol.2021.113721. Epub 2021 Apr 11.
TBI Model Type: Weight-drop model
Organism Species: rat
Organism Strain: Sprague-Dawley
Assessments: GPx, CAT, MDA level, Immunohistochemistry (IHC), RT-PCR, Western blot, modified Neurological Severity Score (mNSS)
Citation: Yuan J, Wang D, Liu Y, Chen X, Zhang H, Shen F, Liu X, Fu J. Hydrogen-rich water attenuates oxidative stress in rats with traumatic brain injury via Nrf2 pathwayJ Surg Res. 2018 Aug;228:238-246. doi: 10.1016\/j.jss.2018.03.024. Epub 2018 Apr 11.
TBI Model Type: Blast model
Organism Species: rat
Organism Strain: Long-Evans outbred
Assessments: Electroretinography, Optomotor response, Spectral domain optical coherence tomography, TUNEL staining, Y-maze, Immunohistochemistry (IHC), spectral-domain optical coherence tomography
Citation: Allen RS, Motz CT, Singh A, Feola A, Hutson L, Douglass A, Ramachandra Rao S, Skelton LA, Cardelle L, Bales KL, Chesler K, Gudapati K, Ethier CR, Harper MM, Fliesler SJ, Pardue MT. Dependence of visual and cognitive outcomes on animal holder configuration in a rodent model of blast overpressure exposureVision Res. 2021 Nov;188:162-173. doi: 10.1016\/j.visres.2021.07.008. Epub 2021 Jul 30. PMC8440444
