On page 3 showing 41 ~ 59 out of 59 results
TBI Model Type: Weight-drop model
Organism Species: mouse
Organism Strain: C57BL/6
Assessments: Evans blue dye, Fluoro-jade C staining (FJC), Histology, Immunofluorescence, Neurological Severity Score (NSS), Western blot, Brain water content
Citation: Li H, Sun J, Wang F, Ding G, Chen W, Fang R, Yao Y, Pang M, Lu ZQ, Liu J. Sodium butyrate exerts neuroprotective effects by restoring the blood-brain barrier in traumatic brain injury miceBrain Res. 2016 Jul 1;1642:70-78. doi: 10.1016\/j.brainres.2016.03.031. Epub 2016 Mar 24.
TBI Model Type: Weight-drop model
Organism Species: mouse
Organism Strain: C57BL/6
Assessments: Brain water content, Fluoro-Jade C staining (FJC), Immunofluorescence, TUNEL staining, Western blot, qPCR, spectrophotometer
Citation: Dong W, Yang B, Wang L, Li B, Guo X, Zhang M, Jiang Z, Fu J, Pi J, Guan D, Zhao R. Curcumin plays neuroprotective roles against traumatic brain injury partly via Nrf2 signalingToxicol Appl Pharmacol. 2018 May 1;346:28-36. doi: 10.1016\/j.taap.2018.03.020. Epub 2018 Mar 21.
TBI Model Type: Controlled cortical impact model
Organism Species: mouse
Organism Strain: C57BL/6
Assessments: Magnetic resonance imaging (MRI), Rotarod test, Spin-echo multislice images, T2-weighted image, cylinder forelimb test, spontaneous forelimb test, Gridwalk test, Histology, laterality score
Citation: Onyszchuk G, Al-Hafez B, He YY, Bilgen M, Berman NE, Brooks WM. A mouse model of sensorimotor controlled cortical impact: characterization using longitudinal magnetic resonance imaging, behavioral assessments and histologyJ Neurosci Methods. 2007 Mar 15;160(2):187-96. doi: 10.1016\/j.jneumeth.2006.09.007. Epub 2006 Oct 16. PMC1941707
TBI Model Type: Weight-drop model
Organism Species: mouse
Organism Strain: C57BL/6
Assessments: Enzyme-linked immunosorbent assay (ELISA), Immunofluorescence, Novel object recognition test, Toluidine Blue stain, crystal violet staining
Citation: Kempuraj D, Ahmed ME, Selvakumar GP, Thangavel R, Raikwar SP, Zaheer SA, Iyer SS, Burton C, James D, Zaheer A. Mast Cell Activation, Neuroinflammation, and Tight Junction Protein Derangement in Acute Traumatic Brain InjuryMediators Inflamm. 2020 Jun 24;2020:4243953. doi: 10.1155\/2020\/4243953. eCollection 2020. PMC7333064
TBI Model Type: Weight-drop model
Organism Species: mouse
Organism Strain: C57BL/6
Assessments: Brain water content, M29, 79-dichlorodihydrofluorescein diacetate (DCFH-DA) staining, Morris Water Maze, Neurological Severity Scores, Nissl staining, TdT-mediated dUTP Nick-End Labeling, We performed modified Neurological Severity Scores (mNSS), rotarod test, and Morris Water Maze (MWM) test, respectively (n = 8 for each group), enzyme linked immunosorbent assay, immunofluorescence, immunohistochemistry, quantitative real time polymerase chain reaction, rotarod test, western blot
Citation: Wang H, Zhou XM, Wu LY, Liu GJ, Xu WD, Zhang XS, Gao YY, Tao T, Zhou Y, Lu Y, Wang J, Deng CL, Zhuang Z, Hang CH, Li W.Aucubin alleviates oxidative stress and inflammation via Nrf2-mediated signaling activity in experimental traumatic brain injuryJ Neuroinflammation. 2020 Jun 15;17(1):188. doi: 10.1186/s12974-020-01863-9.PMC729463110.1186/s12974-020-01863-9
TBI Model Type: Weight-drop model
Organism Species: mouse
Organism Strain: C57BL/6
Assessments: EEG
Citation: Shandra O, Robel S.Inducing Post-Traumatic Epilepsy in a Mouse Model of Repetitive Diffuse Traumatic Brain InjuryJ Vis Exp. 2020 Feb 10;(156):10.3791/60360. doi: 10.3791/60360.PMC967733110.3791/60360
TBI Model Type: Weight-drop model
Organism Species: mouse
Organism Strain: C57BL/6
Assessments: Brain Water, H & E stain, Immunofluorescence, Immunohistochemistry, Western Blot
Citation: Yi HJ, Lee JE, Lee DH, Kim YI, Cho CB, Kim IS, Sung JH, Yang SH.The role of NLRP3 in traumatic brain injury and its regulation by pioglitazoneJ Neurosurg. 2019 Sep 27;133(4):1083-1091. doi: 10.3171/2019.6.JNS1954. Print 2020 Oct 1.10.3171/2019.6.JNS1954
TBI Model Type: Weight-drop model
Organism Species: mouse
Organism Strain: C57BL/6
Assessments: Cognitive function—novel location recognition test, Immunohistochemistry, Open field test, Rotarod, Western blotting
Citation: Sekar S, Zhang Y, Miranzadeh Mahabadi H, Parvizi A, Taghibiglou C.Low-Field Magnetic Stimulation Restores Cognitive and Motor Functions in the Mouse Model of Repeated Traumatic Brain Injury: Role of Cellular Prion ProteinJ Neurotrauma. 2019 Nov 15;36(22):3103-3114. doi: 10.1089/neu.2018.5918. Epub 2019 Jun 6.10.1089/neu.2018.5918
TBI Model Type: Weight-drop model
Organism Species: mouse
Organism Strain: C57BL/6
Assessments: Immunofluorescence, Processing brain tissue for histology
At 1, 3, 7 and 14 dpi, mice were deeply anesthetized (100 mg/kg sodium pentobarbital) and transcardially perfused with cold phosphate-buffered saline (PBS) followed by 4% paraformaldehyde (PFA) at 4°C, Western blotting, histology
Citation: Dong W, Sun Y, Cheng H, Yang B, Wang L, Jiang Z, Li B, Wen S, Guo X, Guan D, Zhao R.Dynamic cell type-specific expression of Nrf2 after traumatic brain injury in miceEur J Neurosci. 2019 Jul;50(2):1981-1993. doi: 10.1111/ejn.14399. Epub 2019 Apr 23.10.1111/ejn.14399
TBI Model Type: Weight-drop model
Organism Species: mouse
Organism Strain: C57BL/6
Assessments: Automated Capillary Western Blots, Behavioral, Cerebral Edema, Quantitative Real-Time PCR
Citation: Sun M, Brady RD, van der Poel C, Apted D, Semple BD, Church JE, O'Brien TJ, McDonald SJ, Shultz SR.A Concomitant Muscle Injury Does Not Worsen Traumatic Brain Injury Outcomes in MiceFront Neurol. 2018 Dec 11;9:1089. doi: 10.3389/fneur.2018.01089. eCollection 2018.PMC629786710.3389/fneur.2018.01089
TBI Model Type: Weight-drop model
Organism Species: mouse
Organism Strain: C57BL/6
Assessments: EMSA, Immunohistochemistry (IHC), qrt-PCR, Western blot
Citation: Ling HP, Li W, Zhou ML, Tang Y, Chen ZR, Hang CH.J Surg Res. 2013 Jan;179(1):e227-34. doi: 10.1016/j.jss.2012.03.030. Epub 2012 Apr 5.
TBI Model Type: Weight-drop model
Organism Species: mouse
Organism Strain: C57BL/6
Assessments: Brain water content, Cresyl violet, Forced swim test, Forelimb placement test, Morris water maze test, Novel object recognition, Rotarod test, Sucrose preference test, Tail suspension test, Western blotting, Wire hanging test, enzyme-linked immunosorbent assay, histology, lesion volume, modified neurologic severity score, neuronal death
Citation: Wang J, Jiang C, Zhang K, Lan X, Chen X, Zang W, Wang Z, Guan F, Zhu C, Yang X, Lu H, Wang J.Melatonin receptor activation provides cerebral protection after traumatic brain injury by mitigating oxidative stress and inflammation via the Nrf2 signaling pathwayFree Radic Biol Med. 2019 Feb 1;131:345-355. doi: 10.1016/j.freeradbiomed.2018.12.014. Epub 2018 Dec 13.10.1016/j.freeradbiomed.2018.12.014
TBI Model Type: Weight-drop model
Organism Species: mouse
Organism Strain: C57BL/6
Assessments: Evans Blue dye, Immunocytochemistry (IHC), Lesion volume, flow cytometry, Neurologic Severity Score (NSS), rt-PCR, TUNEL staining
Citation: Mencl S, Hennig N, Hopp S, Schuhmann MK, Albert-Weissenberger C, Sirén AL, Kleinschnitz C.J Neuroimmunol. 2014 Sep 15;274(1-2):125-31. doi: 10.1016/j.jneuroim.2014.07.010. Epub 2014 Jul 22.
TBI Model Type: Controlled cortical impact model
Organism Species: mouse
Organism Strain: C57BL/6
Citation: Romine J, Gao X, Chen J.Controlled cortical impact model for traumatic brain injury.J Vis Exp. 2014 Aug 5;(90):e51781. doi: 10.3791/51781.
TBI Model Type: Weight-drop model
Organism Species: mouse
Organism Strain: C57BL/6
Assessments: Torsion test, Nissl staining, Prussian blue, rt-PCR
Citation: Yu H, Wergedal JE, Rundle CH, Mohan S.J Rehabil Res Dev. 2014;51(9):1427-37. doi: 10.1682/JRRD.2014.04.0095.
TBI Model Type: Weight-drop model
Organism Species: mouse
Organism Strain: C57BL/6
Assessments: Cytotoxicity assay, Enzyme-linked immunosorbent assay (ELISA), Fluoro-Jade B, Immunofluorescence, TUNEL staining, Western blot analysis, modified Neurological Severity Score, wet/dry method
Citation: Zhu HT, Bian C, Yuan JC, Chu WH, Xiang X, Chen F, Wang CS, Feng H, Lin JK.Curcumin attenuates acute inflammatory injury by inhibiting the TLR4/MyD88/NF-κB signaling pathway in experimental traumatic brain injury.J Neuroinflammation. 2014 Mar 27;11:59. doi: 10.1186/1742-2094-11-59.
TBI Model Type: Weight-drop model
Organism Species: mouse
Organism Strain: C57Bl/6
Assessments: Immunohistochemistry, Neurobehavioral Evaluation, Real-Time PCR
Citation: Albert-Weissenberger C, Stetter C, Meuth SG, Göbel K, Bader M, Sirén AL, Kleinschnitz C.Blocking of bradykinin receptor B1 protects from focal closed head injury in mice by reducing axonal damage and astroglia activationJ Cereb Blood Flow Metab. 2012 Sep;32(9):1747-56. doi: 10.1038/jcbfm.2012.62. Epub 2012 May 9.PMC343462510.1038/jcbfm.2012.62
TBI Model Type: Weight-drop model
Organism Species: mouse
Organism Strain: C57BL/6
Assessments: Neurological severity score (NSS), Passive avoidance test
Citation: Khalin I, Alyautdin R, Wong TW, Gnanou J, Kocherga G, Kreuter J.Drug Deliv. 2016 Nov;23(9):3520-3528. doi: 10.1080/10717544.2016.1199609. Epub 2016 Jul 16.
TBI Model Type: Weight-drop model
Organism Species: mouse
Organism Strain: C57BL/6
Assessments: Neurological Severity Score, Terminal deoxynucleotidyl transferase dUTP nick end labeling, Western blotting, brain water content, oxidative stress
Citation: Liu C, He D, Zhao Q.Licoricidin improves neurological dysfunction after traumatic brain injury in mice via regulating FoxO3/Wnt/β-catenin pathwayJ Nat Med. 2020 Sep;74(4):767-776. doi: 10.1007/s11418-020-01434-5. Epub 2020 Jul 12.10.1007/s11418-020-01434-5
