On page 3 showing 41 ~ 60 out of 65 results
TBI Model Type: Weight-drop model
Organism Species: mouse
Organism Strain: C57BL/6
Assessments: Histology, Microscopy, qRT-PCR, Neurological Severity Score (NSS), hematoma size
Citation: Förstner P, Rehman R, Anastasiadou S, Haffner-Luntzer M, Sinske D, Ignatius A, Roselli F, Knöll B. Neuroinflammation after Traumatic Brain Injury Is Enhanced in Activating Transcription Factor 3 Mutant MiceJ Neurotrauma. 2018 Oct 1;35(19):2317-2329. doi: 10.1089\/neu.2017.5593. Epub 2018 Jun 5.
TBI Model Type: Weight-drop model
Organism Species: mouse
Organism Strain: C57BL/6N
Assessments: IntelliCage Test, object recognition test, Organ Weight to Body Weight Ratio, Immunofluorescence, Neurological Severity Score (NSS)
Citation: Stetter C, Lopez-Caperuchipi S, Hopp-Krämer S, Bieber M, Kleinschnitz C, Sirén AL, Albert-Weißenberger C. Amelioration of Cognitive and Behavioral Deficits after Traumatic Brain Injury in Coagulation Factor XII Deficient MiceInt J Mol Sci. 2021 May 3;22(9):4855. doi: 10.3390\/ijms22094855. PMC8124758
TBI Model Type: Weight-drop model
Organism Species: mouse
Organism Strain: C57BL/6J
Assessments: Apoptosis Assay, Evans blue method, S100β Quantification, Viability Assay, Western blot, necrosis index
Citation: Rosas-Hernandez H, Cuevas E, Escudero-Lourdes C, Lantz SM, Gomez-Crisostomo NP, Sturdivant NM, Balachandran K, Imam SZ, Slikker W Jr, Paule MG, Ali SF. Characterization of Biaxial Stretch as an In Vitro Model of Traumatic Brain Injury to the Blood-Brain BarrierMol Neurobiol. 2018 Jan;55(1):258-266. doi: 10.1007\/s12035-017-0738-5.
TBI Model Type: Weight-drop model
Organism Species: mouse
Organism Strain: C57BL
Assessments: Neurological Severity Score (NSS), Prussian blue staining, Nuclear Fast Red Staining, gas liquid chromatography
Citation: Lecques JD, Kerr BJK, Hillyer LM, Kang JX, Robinson LE, Ma DWL. N-3 Polyunsaturated Fatty Acids Ameliorate Neurobehavioral Outcomes Post-Mild Traumatic Brain Injury in the Fat-1 Mouse ModelNutrients. 2021 Nov 15;13(11):4092. doi: 10.3390\/nu13114092. PMC8620437
TBI Model Type: Weight-drop model
Organism Species: zebrafish
Organism Strain: No strain reported
Assessments: Sonic Hedgehog Modulation, Evans Blue Assay, Fluid Content Measurement, Hoshi protocol, Image Acquisition, Immediate and Delayed Recall, Immunohistochemistry (IHC), Learning, Locomotion velocity, qRT-PCR, Sensorimotor Assay, Shuttle Box Assay Testing Apparatus, Startle Response Habituation, TUNEL staining, Vascular Injury, optical density, tonic-clonic seizure metrics
Citation: Hentig J, Cloghessy K, Lahne M, Jung YJ, Petersen RA, Morris AC, Hyde DR. Zebrafish Blunt-Force TBI Induces Heterogenous Injury Pathologies That Mimic Human TBI and Responds with Sonic Hedgehog-Dependent Cell Proliferation across the NeuroaxisBiomedicines. 2021 Jul 22;9(8):861. doi: 10.3390\/biomedicines9080861. PMC8389629
TBI Model Type: Other
Organism Species: pig
Organism Strain: No strain reported
Assessments: Histology, Immunohistochemistry (IHC), microdialysis
Citation: Kilbaugh TJ, Bhandare S, Lorom DH, Saraswati M, Robertson CL, Margulies SS. Cyclosporin A preserves mitochondrial function after traumatic brain injury in the immature rat and pigletJ Neurotrauma. 2011 May;28(5):763-74. doi: 10.1089\/neu.2010.1635. Epub 2011 Apr 12. PMC3125546
TBI Model Type: Weight-drop model
Organism Species: mouse
Organism Strain: Swiss Albino
Assessments: Neurological score
Citation: Lopez-Rodriguez AB, Acaz-Fonseca E, Giatti S, Caruso D, Viveros MP, Melcangi RC, Garcia-Segura LM. Correlation of brain levels of progesterone and dehydroepiandrosterone with neurological recovery after traumatic brain injury in female micePsychoneuroendocrinology. 2015 Jun;56:1-11. doi: 10.1016\/j.psyneuen.2015.02.018. Epub 2015 Mar 3.
TBI Model Type: Weight-drop model
Organism Species: rat
Organism Strain: Wistar
Assessments: Actophotometer, Acetylcholinesterase Activity, Estimation of nitrite, Estimation of protein, Estimation of reduced glutathione, Estimation of superoxide dismutase, Morris Water Maze (MWM), Preference index, degree of lipid peroxidation, hidden platform task, object recognition task, probe trial, Rotarod
Citation: Kaur A, Jaiswal G, Brar J, Kumar P. Neuroprotective effect of nerolidol in traumatic brain injury associated behavioural comorbidities in ratsToxicol Res (Camb). 2021 Jan 5;10(1):40-50. doi: 10.1093\/toxres\/tfaa100. eCollection 2021 Jan. PMC7885190
TBI Model Type: Other
Organism Species: rat
Organism Strain: in-house bred
Assessments: Beam walk test, Elevated plus maze, Forced swim test, Novel context mismatch test, open field test, qRT-PCR
Citation: Mychasiuk R, Hehar H, Candy S, Ma I, Esser MJ. The direction of the acceleration and rotational forces associated with mild traumatic brain injury in rodents effect behavioural and molecular outcomesJ Neurosci Methods. 2016 Jan 15;257:168-78. doi: 10.1016\/j.jneumeth.2015.10.002. Epub 2015 Oct 17.
TBI Model Type: Blast model
Organism Species: mouse
Organism Strain: C57BL/6J
Assessments: Calcium imaging, Off chip micro-bead assay, Western blot, flow cytometry, righting time
Citation: Ko J, Hemphill MA, Gabrieli D, Wu L, Yelleswarapu V, Lawrence G, Pennycooke W, Singh A, Meaney DF, Issadore D. Smartphone-enabled optofluidic exosome diagnostic for concussion recoverySci Rep. 2016 Aug 8;6:31215. doi: 10.1038\/srep31215. PMC4976377
TBI Model Type: Weight-drop model
Organism Species: mouse
Organism Strain: C57
Assessments: Fluorescence Imaging, LDH assay, Neurological Severity Score (NSS), UV-visible spectra, beam balance, transmission electron microscopy, zeta potential
Citation: Shi J, Li X, Cavagnaro MJ, Cai J, Zhang C, Li N. A Versatile Pep-CPDs Nanoprobe for Rapid Detection of mTBI Biomarker in Clinical Instances and Safe Fluorescence Imaging In Vivo for Improved Weight-Drop Mouse ModelFront Bioeng Biotechnol. 2022 Mar 7;10:807486. doi: 10.3389\/fbioe.2022.807486. eCollection 2022. PMC8942774
TBI Model Type: Weight-drop model
Organism Species: rat
Organism Strain: Sprague-Dawley
Assessments: Five serial choice reaction time task, Immunohistochemistry (IHC), Western blot
Citation: Kaukas L, Holmes JL, Rahimi F, Collins-Praino L, Corrigan F. Injury during adolescence leads to sex-specific executive function deficits in adulthood in a pre-clinical model of mild traumatic brain injuryBehav Brain Res. 2021 Mar 26;402:113067. doi: 10.1016\/j.bbr.2020.113067. Epub 2020 Dec 14.
TBI Model Type: Weight-drop model
Organism Species: rat
Organism Strain: Sprague-Dawley
Assessments: Immunofluorescence, open field test, TUNEL staining, Western blot
Citation: Li SS, Xie LL, Li ZZ, Fan YJ, Qi MM, Xi YG. Androgen is responsible for enhanced susceptibility of melatonin against traumatic brain injury in femalesNeurosci Lett. 2021 May 1;752:135842. doi: 10.1016\/j.neulet.2021.135842. Epub 2021 Mar 22.
TBI Model Type: Blast model
Organism Species: mouse
Organism Strain: C57BL/6-C3F1/J transgenic
Assessments: Amyloid burden, Astrocytic end feet contacts estimation, Capillary density estimation, Immunohistochemistry (IHC), Pericyte estimation, Histology
Citation: Clark AT, Abrahamson EE, Harper MM, Ikonomovic MD. Chronic effects of blast injury on the microvasculature in a transgenic mouse model of Alzheimer's disease related Aβ amyloidosisFluids Barriers CNS. 2022 Jan 10;19(1):5. doi: 10.1186\/s12987-021-00301-z. PMC8751260
TBI Model Type: Weight-drop model
Organism Species: mouse
Organism Strain: C57BL/6
Assessments: Brain water content, M29, 79-dichlorodihydrofluorescein diacetate (DCFH-DA) staining, Morris Water Maze, Neurological Severity Scores, Nissl staining, TdT-mediated dUTP Nick-End Labeling, We performed modified Neurological Severity Scores (mNSS), rotarod test, and Morris Water Maze (MWM) test, respectively (n = 8 for each group), enzyme linked immunosorbent assay, immunofluorescence, immunohistochemistry, quantitative real time polymerase chain reaction, rotarod test, western blot
Citation: Wang H, Zhou XM, Wu LY, Liu GJ, Xu WD, Zhang XS, Gao YY, Tao T, Zhou Y, Lu Y, Wang J, Deng CL, Zhuang Z, Hang CH, Li W.Aucubin alleviates oxidative stress and inflammation via Nrf2-mediated signaling activity in experimental traumatic brain injuryJ Neuroinflammation. 2020 Jun 15;17(1):188. doi: 10.1186/s12974-020-01863-9.PMC729463110.1186/s12974-020-01863-9
TBI Model Type: Weight-drop model
Organism Species: rat
Organism Strain: Sprague-Dawley
Assessments: Behavioral, Western blotting, beam walk, elevated plus maze, forced swim, multi-plex enzyme-linked immunosorbent assay, novel context mismatch, quantitative polymerase chain reaction
Citation: Fraunberger EA, DeJesus P, Zanier ER, Shutt TE, Esser MJ.Acute and Persistent Alterations of Cerebellar Inflammatory Networks and Glial Activation in a Rat Model of Pediatric Mild Traumatic Brain InjuryJ Neurotrauma. 2020 Jun 1;37(11):1315-1330. doi: 10.1089/neu.2019.6714. Epub 2020 Feb 25.10.1089/neu.2019.6714
TBI Model Type: Weight-drop model
Organism Species: rat
Organism Strain: Sprague-Dawley
Assessments: Brain water content, Enzyme-linked immunosorbent assay (ELISA), Foot fault test, Immunohistochemitry (IHC), Morris Water Maze (MWM), open field test, qRT-PCR, Western blot
Citation: Lan YL, Wang X, Zou YJ, Xing JS, Lou JC, Zou S, Ma BB, Ding Y, Zhang B. Bazedoxifene protects cerebral autoregulation after traumatic brain injury and attenuates impairments in blood-brain barrier damage: involvement of anti-inflammatory pathways by blocking MAPK signalingInflamm Res. 2019 Apr;68(4):311-323. doi: 10.1007\/s00011-019-01217-z. Epub 2019 Jan 31.
TBI Model Type: Weight-drop model
Organism Species: mouse
Organism Strain: C57BL/6
Assessments: Torsion test, Nissl staining, Prussian blue, rt-PCR
Citation: Yu H, Wergedal JE, Rundle CH, Mohan S.J Rehabil Res Dev. 2014;51(9):1427-37. doi: 10.1682/JRRD.2014.04.0095.
TBI Model Type: Weight-drop model
Organism Species: rat
Organism Strain: Sprague-Dawley
Assessments: Neurological Severity Score (NSS), RT-PCR, Western blot, Immunohistochemistry analysis
Citation: Fu XM, Liu SJ, Dan QQ, Wang YP, Lin N, Lv LY, Zou Y, Liu S, Zhou X, Wang TH.Combined Bone Mesenchymal Stem Cell and Olfactory Ensheathing Cell Transplantation Promotes Neural Repair Associated With CNTF Expression in Traumatic Brain-Injured Rats.Cell Transplant. 2015;24(8):1533-44. doi: 10.3727/096368914X679345. Epub 2014 Mar 7.
TBI Model Type: Weight-drop model
Organism Species: mouse
Organism Strain: C57BL/6J
Assessments: micro-CT analysis, RT-PCR, three-point bending
Citation: Yu H, Watt H, Mohan S.The negative impact of traumatic brain injury (TBI) on bone in a mouse model.Brain Inj. 2014;28(2):244-51. doi: 10.3109/02699052.2013.859735. Epub 2013 Dec 2.
