On page 3 showing 41 ~ 55 out of 55 results
TBI Model Type: Other
Organism Species: pig
Organism Strain: No strain reported
Assessments: Histology, Immunohistochemistry (IHC), microdialysis
Citation: Kilbaugh TJ, Bhandare S, Lorom DH, Saraswati M, Robertson CL, Margulies SS. Cyclosporin A preserves mitochondrial function after traumatic brain injury in the immature rat and pigletJ Neurotrauma. 2011 May;28(5):763-74. doi: 10.1089\/neu.2010.1635. Epub 2011 Apr 12. PMC3125546
TBI Model Type: Weight-drop model
Organism Species: mouse
Organism Strain: C57BL/6
Assessments: Evans blue dye, Fluoro-jade C staining (FJC), Histology, Immunofluorescence, Neurological Severity Score (NSS), Western blot, Brain water content
Citation: Li H, Sun J, Wang F, Ding G, Chen W, Fang R, Yao Y, Pang M, Lu ZQ, Liu J. Sodium butyrate exerts neuroprotective effects by restoring the blood-brain barrier in traumatic brain injury miceBrain Res. 2016 Jul 1;1642:70-78. doi: 10.1016\/j.brainres.2016.03.031. Epub 2016 Mar 24.
TBI Model Type: Weight-drop model
Organism Species: mouse
Organism Strain: C57BL/6-SJL
Assessments: Beam walk test, Blood ethanol level, Confocal imaging, Neurological Severity Score (NSS), open field test, qRT-PCR, Western blot, histology
Citation: Chandrasekar A, Aksan B, Heuvel FO, Förstner P, Sinske D, Rehman R, Palmer A, Ludolph A, Huber-Lang M, Böckers T, Mauceri D, Knöll B, Roselli F. Neuroprotective effect of acute ethanol intoxication in TBI is associated to the hierarchical modulation of early transcriptional responsesExp Neurol. 2018 Apr;302:34-45. doi: 10.1016\/j.expneurol.2017.12.017. Epub 2018 Jan 4.
TBI Model Type: Weight-drop model
Organism Species: mouse
Organism Strain: C57BL/6N
Assessments: Elevated plus maze, Histology, Immunohistochemistry (IHC), open field test, Paw preference test, handedness, Neurological Severity Score (NSS)
Citation: Lopez-Caperuchipi S, Kürzinger L, Hopp-Krämer S, Albert-Weißenberger C, Paul MM, Sirén AL, Stetter C. Posttraumatic learning deficits correlate with initial trauma severity and chronic cellular reactions after closed head injury in male miceExp Neurol. 2021 Jul;341:113721. doi: 10.1016\/j.expneurol.2021.113721. Epub 2021 Apr 11.
TBI Model Type: Controlled cortical impact model
Organism Species: mouse
Organism Strain: C57BL/6
Assessments: Magnetic resonance imaging (MRI), Rotarod test, Spin-echo multislice images, T2-weighted image, cylinder forelimb test, spontaneous forelimb test, Gridwalk test, Histology, laterality score
Citation: Onyszchuk G, Al-Hafez B, He YY, Bilgen M, Berman NE, Brooks WM. A mouse model of sensorimotor controlled cortical impact: characterization using longitudinal magnetic resonance imaging, behavioral assessments and histologyJ Neurosci Methods. 2007 Mar 15;160(2):187-96. doi: 10.1016\/j.jneumeth.2006.09.007. Epub 2006 Oct 16. PMC1941707
TBI Model Type: Blast model
Organism Species: rat
Organism Strain: Sprague-Dawley
Assessments: Elevated Plus Maze, Immunohistochemistry (IHC), Histology, Three-Chamber Sociability Test
Citation: Dickerson MR, Murphy SF, Urban MJ, White Z, VandeVord PJ. Chronic Anxiety- and Depression-Like Behaviors Are Associated With Glial-Driven Pathology Following Repeated Blast Induced NeurotraumaFront Behav Neurosci. 2021 Dec 10;15:787475. doi: 10.3389\/fnbeh.2021.787475. eCollection 2021. PMC8703020
TBI Model Type: Blast model
Organism Species: mouse
Organism Strain: C57BL/6-C3F1/J transgenic
Assessments: Amyloid burden, Astrocytic end feet contacts estimation, Capillary density estimation, Immunohistochemistry (IHC), Pericyte estimation, Histology
Citation: Clark AT, Abrahamson EE, Harper MM, Ikonomovic MD. Chronic effects of blast injury on the microvasculature in a transgenic mouse model of Alzheimer's disease related Aβ amyloidosisFluids Barriers CNS. 2022 Jan 10;19(1):5. doi: 10.1186\/s12987-021-00301-z. PMC8751260
TBI Model Type: Fluid percussion injury model
Organism Species: rat
Organism Strain: Long-Evans
Assessments: Caspase activity assays, Cavalieri probe method, Conditioned freezing response test, Counting APC-positive cells, Counting NeuN-positive cells, Histology, Immunohistochemistry, Object recognition test, Quantification of TrkA phosphorylation, Western blot analysis, cell counts, immunocytochemistry, kainate sensitivity test, microglia activation, myelin loss, paw placement test
Citation: Delbary-Gossart S, Lee S, Baroni M, Lamarche I, Arnone M, Canolle B, Lin A, Sacramento J, Salegio EA, Castel MN, Delesque-Touchard N, Alam A, Laboudie P, Ferzaz B, Savi P, Herbert JM, Manley GT, Ferguson AR, Bresnahan JC, Bono F, Beattie MS.Brain. 2016 Jun;139(Pt 6):1762-82. doi: 10.1093/brain/aww074. Epub 2016 Apr 15.10.1093/brain/aww074
TBI Model Type: Controlled cortical impact model
Organism Species: rat
Organism Strain: Sprague-Dawley
Assessments: 16S ribosomal RNA gene sequencing, Blood–brain barrier permeability, Enzyme-linked immunosorbent assay (ELISA), Histology, RT-PCR, Western blot, Brain water content, limulus amebocyte lysate assay, Neurological Severity Score (NSS), Rotarod test
Citation: Mirzayan MJ, Klinge PM, Ude S, Hotop A, Samii M, Brinker T, Korkmaz Z, Meyer GJ, Knapp WH, Samii A. Modified calcium accumulation after controlled cortical impact under cyclosporin A treatment: a 45Ca autoradiographic studyNeurol Res. 2008 Jun;30(5):476-9. doi: 10.1179\/174313208X276916.
TBI Model Type: Weight-drop model
Organism Species: mouse
Organism Strain: C57BL/6
Assessments: Immunofluorescence, Processing brain tissue for histology
At 1, 3, 7 and 14 dpi, mice were deeply anesthetized (100 mg/kg sodium pentobarbital) and transcardially perfused with cold phosphate-buffered saline (PBS) followed by 4% paraformaldehyde (PFA) at 4°C, Western blotting, histology
Citation: Dong W, Sun Y, Cheng H, Yang B, Wang L, Jiang Z, Li B, Wen S, Guo X, Guan D, Zhao R.Dynamic cell type-specific expression of Nrf2 after traumatic brain injury in miceEur J Neurosci. 2019 Jul;50(2):1981-1993. doi: 10.1111/ejn.14399. Epub 2019 Apr 23.10.1111/ejn.14399
TBI Model Type: Weight-drop model
Organism Species: mouse
Organism Strain: C57BL/6
Assessments: Brain water content, Cresyl violet, Forced swim test, Forelimb placement test, Morris water maze test, Novel object recognition, Rotarod test, Sucrose preference test, Tail suspension test, Western blotting, Wire hanging test, enzyme-linked immunosorbent assay, histology, lesion volume, modified neurologic severity score, neuronal death
Citation: Wang J, Jiang C, Zhang K, Lan X, Chen X, Zang W, Wang Z, Guan F, Zhu C, Yang X, Lu H, Wang J.Melatonin receptor activation provides cerebral protection after traumatic brain injury by mitigating oxidative stress and inflammation via the Nrf2 signaling pathwayFree Radic Biol Med. 2019 Feb 1;131:345-355. doi: 10.1016/j.freeradbiomed.2018.12.014. Epub 2018 Dec 13.10.1016/j.freeradbiomed.2018.12.014
TBI Model Type: Weight-drop model
Organism Species: rat
Organism Strain: Wistar
Assessments: Histology, silver nitrate
Citation: Fleishman MY, Yakusheva NY, Malofey YB, Tolstenok IV, Innokentiev AA. Effect of MGHPPGP Peptide Administered during the Post-Traumatic Period on Morphometric Parameters of the Neocortex and Hippocampus, Hepatocytes, and Epithelium of the Tongue and Small Intestine in RatsBull Exp Biol Med. 2020 Feb;168(4):521-524. doi: 10.1007\/s10517-020-04745-5. Epub 2020 Mar 9.
TBI Model Type: Weight-drop model
Organism Species: mouse
Organism Strain: C57/BL6
Assessments: ELISA, Histology, Magnetic Resonance Imaging, Novel object recognition, righting reflex response, rotarod
Citation: Yang SH, Gustafson J, Gangidine M, Stepien D, Schuster R, Pritts TA, Goodman MD, Remick DG, Lentsch AB.A murine model of mild traumatic brain injury exhibiting cognitive and motor deficitsJ Surg Res. 2013 Oct;184(2):981-8. doi: 10.1016/j.jss.2013.03.075. Epub 2013 Apr 18.PMC407378610.1016/j.jss.2013.03.075
TBI Model Type: Weight-drop model
Organism Species: mouse
Organism Strain: B6C3F1
Assessments: Nissl staining, blood-brain barrier integrity, Novel object test, Histology, Latency to right, Mean arterial pressure, Morris water maze (MWM)
Citation: DeFord SM, Wilson MS, Rice AC, Clausen T, Rice LK, Barabnova A, Bullock R, Hamm RJ.J Neurotrauma. 2002 Apr;19(4):427-38. doi: 10.1089/08977150252932389.
TBI Model Type: Weight-drop model
Organism Species: mouse
Organism Strain: Swiss
Assessments: Elevated plus maze test, Forced swimming test, Histology, Neurological Severity Score, Open field test, Step-down inhibitory avoidance test, Tail suspension test
Citation: Schwarzbold ML, Rial D, De Bem T, Machado DG, Cunha MP, dos Santos AA, dos Santos DB, Figueiredo CP, Farina M, Goldfeder EM, Rodrigues AL, Prediger RD, Walz R.J Neurotrauma. 2010 Oct;27(10):1883-93. doi: 10.1089/neu.2010.1318.
