On page 3 showing 41 ~ 60 out of 68 results
TBI Model Type: Weight-drop model
Organism Species: mouse
Organism Strain: CD-1
Assessments: Brain water content, Enzyme-linked immunosorbent assay (ELISA), Evans blue extravasation, Neurological Severity Score (NSS), Novel object recognition test, Rotarod test, TUNEL staining, Western blot, lactate dehydrogenase release
Citation: Kempuraj D, Ahmed ME, Selvakumar GP, Thangavel R, Raikwar SP, Zaheer SA, Iyer SS, Govindarajan R, Nattanmai Chandrasekaran P, Burton C, James D, Zaheer A. Acute Traumatic Brain Injury-Induced Neuroinflammatory Response and Neurovascular Disorders in the BrainNeurotox Res. 2021 Apr;39(2):359-368. doi: 10.1007\/s12640-020-00288-9. Epub 2020 Sep 21. PMC7502806
TBI Model Type: Weight-drop model
Organism Species: mouse
Organism Strain: ICR
Assessments: Brain water content, Enzyme-linked immunosorbent assay (ELISA), Evans blue permeability assay, Immunofluorescence, TUNEL staining, Western blot, modified Neurological Severity Score (mNSS)
Citation: Cheng H, Di G, Gao CC, He G, Wang X, Han YL, Sun LA, Zhou ML, Jiang X. FTY720 Reduces Endothelial Cell Apoptosis and Remodels Neurovascular Unit after Experimental Traumatic Brain InjuryInt J Med Sci. 2021 Jan 1;18(2):304-313. doi: 10.7150\/ijms.49066. eCollection 2021. PMC7757143
TBI Model Type: Weight-drop model
Organism Species: mouse
Organism Strain: C57BL/6
Assessments: Evans blue dye, Fluoro-jade C staining (FJC), Histology, Immunofluorescence, Neurological Severity Score (NSS), Western blot, Brain water content
Citation: Li H, Sun J, Wang F, Ding G, Chen W, Fang R, Yao Y, Pang M, Lu ZQ, Liu J. Sodium butyrate exerts neuroprotective effects by restoring the blood-brain barrier in traumatic brain injury miceBrain Res. 2016 Jul 1;1642:70-78. doi: 10.1016\/j.brainres.2016.03.031. Epub 2016 Mar 24.
TBI Model Type: Weight-drop model
Organism Species: rat
Organism Strain: Sprague-Dawley
Assessments: Brain water content, Fluoro-Jade B staining (FJB), Garcia test score system, Immunofluorescence staining, RT-PCR, TUNEL staining, Western blot
Citation: Ni H, Rui Q, Xu Y, Zhu J, Gao F, Dang B, Li D, Gao R, Chen G. RACK1 upregulation induces neuroprotection by activating the IRE1-XBP1 signaling pathway following traumatic brain injury in ratsExp Neurol. 2018 Jun;304:102-113. doi: 10.1016\/j.expneurol.2018.03.003. Epub 2018 Mar 6.
TBI Model Type: Weight-drop model
Organism Species: mouse
Organism Strain: ICR
Assessments: Brain water content, Immunofluorescence, Malondialdehyde level, Neurological Severity Score (NSS), qRT-PCR, TUNEL staining, Western blot, glutathione peroxidase, superoxide dismutase
Citation: Fang J, Wang H, Zhou J, Dai W, Zhu Y, Zhou Y, Wang X, Zhou M. Baicalin provides neuroprotection in traumatic brain injury mice model through Akt\/Nrf2 pathwayDrug Des Devel Ther. 2018 Aug 10;12:2497-2508. doi: 10.2147\/DDDT.S163951. eCollection 2018. PMC6089097
TBI Model Type: Weight-drop model
Organism Species: mouse
Organism Strain: C57BL/6
Assessments: Brain water content, Fluoro-Jade C staining (FJC), Immunofluorescence, TUNEL staining, Western blot, qPCR, spectrophotometer
Citation: Dong W, Yang B, Wang L, Li B, Guo X, Zhang M, Jiang Z, Fu J, Pi J, Guan D, Zhao R. Curcumin plays neuroprotective roles against traumatic brain injury partly via Nrf2 signalingToxicol Appl Pharmacol. 2018 May 1;346:28-36. doi: 10.1016\/j.taap.2018.03.020. Epub 2018 Mar 21.
TBI Model Type: Weight-drop model
Organism Species: rat
Organism Strain: Sprague-Dawley
Assessments: Brain water content, Immunohistochemistry (IHC), Neurological evaluation, Nissl staining, TUNEL staining, Western blot, spectrophotometer
Citation: Wei W, Wang H, Wu Y, Ding K, Li T, Cong Z, Xu J, Zhou M, Huang L, Ding H, Wu H. Alpha lipoic acid inhibits neural apoptosis via a mitochondrial pathway in rats following traumatic brain injuryNeurochem Int. 2015 Aug;87:85-91. doi: 10.1016\/j.neuint.2015.06.003. Epub 2015 Jun 6.
TBI Model Type: Weight-drop model
Organism Species: mouse
Organism Strain: ICR
Assessments: Brain water content, Immunofluorescence, TUNEL staining, Western blot, grip test, qRT-PCR, spectrophotometer
Citation: Yang Y, Wang H, Li L, Li X, Wang Q, Ding H, Wang X, Ye Z, Wu L, Zhang X, Zhou M, Pan H. Sinomenine Provides Neuroprotection in Model of Traumatic Brain Injury via the Nrf2-ARE PathwayFront Neurosci. 2016 Dec 23;10:580. doi: 10.3389\/fnins.2016.00580. eCollection 2016. PMC5179594
TBI Model Type: Weight-drop model
Organism Species: mouse
Organism Strain: ICR
Assessments: Brain water content, Enzyme-linked immunosorbent assay (ELISA), Immunofluorescence, Neurological evaluation, Nissl Staining, Western blot, modified Garcia method
Citation: He GY, Zhao CH, Wu DG, Cheng H, Sun LA, Zhang DL, Yang XJ, Fan XR, Di GF, Jiang XC. S100A8 Promotes Inflammation via Toll-Like Receptor 4 After Experimental Traumatic Brain InjuryFront Neurosci. 2021 Feb 3;14:616559. doi: 10.3389\/fnins.2020.616559. eCollection 2020. PMC7887321
TBI Model Type: Weight-drop model
Organism Species: rat
Organism Strain: Sprague-Dawley
Assessments: Immunohistochemistry (IHC), Fluoro-Jade C staining (FJC), Neurological function score, TUNEL staining, Brain water content, Western blot
Citation: Zhu J, Lin X, Chen C, Tan H, Gao Y, Li D, Chen G. WNK3 Promotes Neuronal Survival after Traumatic Brain Injury in RatsNeuroscience. 2021 Nov 21;477:76-88. doi: 10.1016\/j.neuroscience.2021.09.021. Epub 2021 Oct 6.
TBI Model Type: Weight-drop model
Organism Species: mouse
Organism Strain: C57BL/6
Assessments: Brain water content, M29, 79-dichlorodihydrofluorescein diacetate (DCFH-DA) staining, Morris Water Maze, Neurological Severity Scores, Nissl staining, TdT-mediated dUTP Nick-End Labeling, We performed modified Neurological Severity Scores (mNSS), rotarod test, and Morris Water Maze (MWM) test, respectively (n = 8 for each group), enzyme linked immunosorbent assay, immunofluorescence, immunohistochemistry, quantitative real time polymerase chain reaction, rotarod test, western blot
Citation: Wang H, Zhou XM, Wu LY, Liu GJ, Xu WD, Zhang XS, Gao YY, Tao T, Zhou Y, Lu Y, Wang J, Deng CL, Zhuang Z, Hang CH, Li W.Aucubin alleviates oxidative stress and inflammation via Nrf2-mediated signaling activity in experimental traumatic brain injuryJ Neuroinflammation. 2020 Jun 15;17(1):188. doi: 10.1186/s12974-020-01863-9.PMC729463110.1186/s12974-020-01863-9
TBI Model Type: Weight-drop model
Organism Species: rat
Organism Strain: Sprague-Dawley
Assessments: Bederson test, Evans blue fluorescence, MRI, Perls staining, TUNEL, Western blot, behavioral, brain water content, enzyme-linked immunosorbent assay, immunohistochemistry, magnetic resonance imaging, myelin basic protein (MBP) expression, quantitative real-time PCR
Citation: Wei L, Zhang J, Zhang B, Geng J, Tan Q, Wang L, Chen Z, Feng H, Zhu G.Complement C3 participates in the function and mechanism of traumatic brain injury at simulated high altitudeBrain Res. 2020 Jan 1;1726:146423. doi: 10.1016/j.brainres.2019.146423. Epub 2019 Oct 22.10.1016/j.brainres.2019.146423
TBI Model Type: Controlled cortical impact model
Organism Species: rat
Organism Strain: Sprague-Dawley
Assessments: 16S ribosomal RNA gene sequencing, Blood–brain barrier permeability, Enzyme-linked immunosorbent assay (ELISA), Histology, RT-PCR, Western blot, Brain water content, limulus amebocyte lysate assay, Neurological Severity Score (NSS), Rotarod test
Citation: Mirzayan MJ, Klinge PM, Ude S, Hotop A, Samii M, Brinker T, Korkmaz Z, Meyer GJ, Knapp WH, Samii A. Modified calcium accumulation after controlled cortical impact under cyclosporin A treatment: a 45Ca autoradiographic studyNeurol Res. 2008 Jun;30(5):476-9. doi: 10.1179\/174313208X276916.
TBI Model Type: Weight-drop model
Organism Species: rat
Organism Strain: Sprague-Dawley
Assessments: Nissl staining, Lipid peroxidation assay, GSH assay, SOD activity, Western blot, Beam balance test, Brain water content, MDA, TUNEL staining
Citation: He Y, Qu S, Wang J, He X, Lin W, Zhen H, Zhang X.Brain Res. 2012 Jan 18;1433:127-36. doi: 10.1016/j.brainres.2011.11.027. Epub 2011 Nov 18.
TBI Model Type: Weight-drop model
Organism Species: rat
Organism Strain: Sprague-Dawley
Assessments: Brain water content, ELISA, Morris water maze (MWM), qrt-PCR, Western blot, Immunofluorescence, hematoxylin and eosin, Inclined plane test, modified Neurologic Severity Score (mNSS)
Citation: Mao SS, Hua R, Zhao XP, Qin X, Sun ZQ, Zhang Y, Wu YQ, Jia MX, Cao JL, Zhang YM.J Neurotrauma. 2012 Jul 1;29(10):1941-59. doi: 10.1089/neu.2011.2244.
TBI Model Type: Weight-drop model
Organism Species: mouse
Organism Strain: C57BL/6
Assessments: Brain water content, Cresyl violet, Forced swim test, Forelimb placement test, Morris water maze test, Novel object recognition, Rotarod test, Sucrose preference test, Tail suspension test, Western blotting, Wire hanging test, enzyme-linked immunosorbent assay, histology, lesion volume, modified neurologic severity score, neuronal death
Citation: Wang J, Jiang C, Zhang K, Lan X, Chen X, Zang W, Wang Z, Guan F, Zhu C, Yang X, Lu H, Wang J.Melatonin receptor activation provides cerebral protection after traumatic brain injury by mitigating oxidative stress and inflammation via the Nrf2 signaling pathwayFree Radic Biol Med. 2019 Feb 1;131:345-355. doi: 10.1016/j.freeradbiomed.2018.12.014. Epub 2018 Dec 13.10.1016/j.freeradbiomed.2018.12.014
TBI Model Type: Weight-drop model
Organism Species: rat
Organism Strain: Sprague-Dawley
Assessments: Brain water content, Enzyme-linked immunosorbent assay (ELISA), Foot fault test, Immunohistochemitry (IHC), Morris Water Maze (MWM), open field test, qRT-PCR, Western blot
Citation: Lan YL, Wang X, Zou YJ, Xing JS, Lou JC, Zou S, Ma BB, Ding Y, Zhang B. Bazedoxifene protects cerebral autoregulation after traumatic brain injury and attenuates impairments in blood-brain barrier damage: involvement of anti-inflammatory pathways by blocking MAPK signalingInflamm Res. 2019 Apr;68(4):311-323. doi: 10.1007\/s00011-019-01217-z. Epub 2019 Jan 31.
TBI Model Type: Weight-drop model
Organism Species: mouse
Organism Strain: ICR
Assessments: Brain water content, Immunohistochemical Staining, SOD Activity and Malondialdehyde (MDA) Level, Western Blot analysis, assay kits, neurological severity score, wet/dry weight ratio method
Citation: Lu XY, Wang HD, Xu JG, Ding K, Li T.Deletion of Nrf2 Exacerbates Oxidative Stress After Traumatic Brain Injury in Mice.Cell Mol Neurobiol. 2015 Jul;35(5):713-21. doi: 10.1007/s10571-015-0167-9. Epub 2015 Mar 3.
TBI Model Type: Weight-drop model
Organism Species: mouse
Organism Strain: ICR
Assessments: Brain water content, Enzyme-Linked Immunosorbent Assay, Immunofluorescence staining, Nissl staining, Terminal deoxynucleotidyl transferase-mediated dUTP nick 3′-end labeling (TUNEL), Western blot analysis, neurological severity score
Citation: Ding K, Wang H, Xu J, Lu X, Zhang L, Zhu L.Melatonin reduced microglial activation and alleviated neuroinflammation induced neuron degeneration in experimental traumatic brain injury: Possible involvement of mTOR pathway.Neurochem Int. 2014 Oct;76:23-31. doi: 10.1016/j.neuint.2014.06.015. Epub 2014 Jul 1.
TBI Model Type: Weight-drop model
Organism Species: mouse
Organism Strain: ICR
Assessments: Grip Test, Brain Water Content, Immunofluorescence, Immunohistochemical Staining, Mitochondrial MDA and SOD Content, Prussian Blue Staining, Reactive Oxygen Species (ROS) Content, Terminal Deoxynucleotidyl Transferase-Mediated dUTP Nick End Labeling (TUNEL) Analysis, Western Blot, dihydroethidium (DHE) staining
Citation: Xu J, Wang H, Ding K, Zhang L, Wang C, Li T, Wei W, Lu X.Luteolin provides neuroprotection in models of traumatic brain injury via the Nrf2-ARE pathway.Free Radic Biol Med. 2014 Jun;71:186-195. doi: 10.1016/j.freeradbiomed.2014.03.009. Epub 2014 Mar 15.
