On page 2 showing 21 ~ 40 out of 47 results
TBI Model Type: Weight-drop model
Organism Species: mouse
Organism Strain: ICR
Assessments: open field test, CORT level, Novel object recognition test, foot fault test, Immunofluorescence, NeuN staining, Cresyl violet staining
Citation: Baratz R, Tweedie D, Wang JY, Rubovitch V, Luo W, Hoffer BJ, Greig NH, Pick CG. Transiently lowering tumor necrosis factor-α synthesis ameliorates neuronal cell loss and cognitive impairments induced by minimal traumatic brain injury in miceJ Neuroinflammation. 2015 Mar 7;12:45. doi: 10.1186\/s12974-015-0237-4. PMC4352276
TBI Model Type: Weight-drop model
Organism Species: mouse
Organism Strain: ICR
Assessments: open field test, CORT level, Novel object recognition test, foot fault test, Immunofluorescence, NeuN staining, Cresyl violet staining
Citation: Baratz-Goldstein R, Toussia-Cohen S, Elpaz A, Rubovitch V, Pick CG. Immediate and delayed hyperbaric oxygen therapy as a neuroprotective treatment for traumatic brain injury in miceMol Cell Neurosci. 2017 Sep;83:74-82. doi: 10.1016\/j.mcn.2017.06.004. Epub 2017 Jul 8.
TBI Model Type: Weight-drop model
Organism Species: mouse
Organism Strain: ICR
Assessments: Brain water content, Immunohistochemistry (IHC), Nissl Staining, Western blot, Grip test, spectrophotometer
Citation: Zhai X, Ding Y, Wang Q, Zhang H, Li F. Rutin Acid Ameliorates Neural Apoptosis Induced by Traumatic Brain Injury via Mitochondrial Pathways in MiceNeuroimmunomodulation. 2016;23(3):179-187. doi: 10.1159\/000448716. Epub 2016 Sep 20.
TBI Model Type: Weight-drop model
Organism Species: mouse
Organism Strain: ICR
Assessments: Nissl staining, Enzyme-linked immunosorbent assay (ELISA), Grip test, Immunohistochemistry (IHC), Neurological Severity Score (NSS), Western blot, Grip test
Citation: Song Q, Xie D, Pan S, Xu W. Rapamycin protects neurons from brain contusion‑induced inflammatory reaction via modulation of microglial activationMol Med Rep. 2015 Nov;12(5):7203-10. doi: 10.3892\/mmr.2015.4407. Epub 2015 Oct 1. PMC4626160
TBI Model Type: Weight-drop model
Organism Species: mouse
Organism Strain: ICR
Assessments: Bioluminescent Somatic Cell Assay, Bradford method, Immunohistochemical staining, Mitochondrial membrane potential (MMP) measurement, Western blot, spectrophotometer
Citation: Li X, Wang H, Gao Y, Li L, Tang C, Wen G, Zhou Y, Zhou M, Mao L, Fan Y. Protective Effects of Quercetin on Mitochondrial Biogenesis in Experimental Traumatic Brain Injury via the Nrf2 Signaling PathwayPLoS One. 2016 Oct 25;11(10):e0164237. doi: 10.1371\/journal.pone.0164237. eCollection 2016. PMC5079551
TBI Model Type: Weight-drop model
Organism Species: mouse
Organism Strain: ICR
Assessments: Brain water content, Immunofluorescence, Nissl Staining, qRT-PCR, TUNEL staining, Western blot, Neurological Severity Score (NSS)
Citation: Liu Z, Wang H, Shi X, Li L, Zhou M, Ding H, Yang Y, Li X, Ding K. DL-3-n-Butylphthalide (NBP) Provides Neuroprotection in the Mice Models After Traumatic Brain Injury via Nrf2-ARE Signaling PathwayNeurochem Res. 2017 May;42(5):1375-1386. doi: 10.1007\/s11064-017-2186-z. Epub 2017 Feb 18.
TBI Model Type: Weight-drop model
Organism Species: mouse
Organism Strain: ICR
Assessments: Brain water content, Enzyme-linked immunosorbent assay (ELISA), Evans blue permeability assay, Immunofluorescence, TUNEL staining, Western blot, modified Neurological Severity Score (mNSS)
Citation: Cheng H, Di G, Gao CC, He G, Wang X, Han YL, Sun LA, Zhou ML, Jiang X. FTY720 Reduces Endothelial Cell Apoptosis and Remodels Neurovascular Unit after Experimental Traumatic Brain InjuryInt J Med Sci. 2021 Jan 1;18(2):304-313. doi: 10.7150\/ijms.49066. eCollection 2021. PMC7757143
TBI Model Type: Weight-drop model
Organism Species: mouse
Organism Strain: ICR
Assessments: Aggleton index, Immunohistochemistry (IHC), Novel object recognition test, Y-maze, Enzyme-linked immunosorbent assay (ELISA)
Citation: Benady A, Freidin D, Pick CG, Rubovitch V. GM1 ganglioside prevents axonal regeneration inhibition and cognitive deficits in a mouse model of traumatic brain injurySci Rep. 2018 Sep 6;8(1):13340. doi: 10.1038\/s41598-018-31623-y. PMC6127193
TBI Model Type: Weight-drop model
Organism Species: mouse
Organism Strain: ICR
Assessments: Histology, Immunohistochemitry, Western blot, error ladder walking test, Novel object recognition test
Citation: Li Y, Bader M, Tamargo I, Rubovitch V, Tweedie D, Pick CG, Greig NH. Liraglutide is neurotrophic and neuroprotective in neuronal cultures and mitigates mild traumatic brain injury in miceJ Neurochem. 2015 Dec;135(6):1203-1217. doi: 10.1111\/jnc.13169. Epub 2015 Jun 18. PMC4644713
TBI Model Type: Weight-drop model
Organism Species: mouse
Organism Strain: ICR
Assessments: Gene expression, Ingenuity Pathway Analysis tool, Gene Set Enrichment analysis
Citation: Tweedie D, Rachmany L, Kim DS, Rubovitch V, Lehrmann E, Zhang Y, Becker KG, Perez E, Pick CG, Greig NH. Mild traumatic brain injury-induced hippocampal gene expressions: The identification of target cellular processes for drug developmentJ Neurosci Methods. 2016 Oct 15;272:4-18. doi: 10.1016\/j.jneumeth.2016.02.003. Epub 2016 Feb 8. PMC4977213
TBI Model Type: Weight-drop model
Organism Species: mouse
Organism Strain: ICR
Assessments: Brain water content, Immunofluorescence, Malondialdehyde level, Neurological Severity Score (NSS), qRT-PCR, TUNEL staining, Western blot, glutathione peroxidase, superoxide dismutase
Citation: Fang J, Wang H, Zhou J, Dai W, Zhu Y, Zhou Y, Wang X, Zhou M. Baicalin provides neuroprotection in traumatic brain injury mice model through Akt\/Nrf2 pathwayDrug Des Devel Ther. 2018 Aug 10;12:2497-2508. doi: 10.2147\/DDDT.S163951. eCollection 2018. PMC6089097
TBI Model Type: Weight-drop model
Organism Species: mouse
Organism Strain: ICR
Assessments: Brain water content, Immunofluorescence, TUNEL staining, Western blot, grip test, qRT-PCR, spectrophotometer
Citation: Yang Y, Wang H, Li L, Li X, Wang Q, Ding H, Wang X, Ye Z, Wu L, Zhang X, Zhou M, Pan H. Sinomenine Provides Neuroprotection in Model of Traumatic Brain Injury via the Nrf2-ARE PathwayFront Neurosci. 2016 Dec 23;10:580. doi: 10.3389\/fnins.2016.00580. eCollection 2016. PMC5179594
TBI Model Type: Weight-drop model
Organism Species: mouse
Organism Strain: ICR
Assessments: Brain water content, Enzyme-linked immunosorbent assay (ELISA), Immunofluorescence, Neurological evaluation, Nissl Staining, Western blot, modified Garcia method
Citation: He GY, Zhao CH, Wu DG, Cheng H, Sun LA, Zhang DL, Yang XJ, Fan XR, Di GF, Jiang XC. S100A8 Promotes Inflammation via Toll-Like Receptor 4 After Experimental Traumatic Brain InjuryFront Neurosci. 2021 Feb 3;14:616559. doi: 10.3389\/fnins.2020.616559. eCollection 2020. PMC7887321
TBI Model Type: Weight-drop model
Organism Species: mouse
Organism Strain: ICR
Assessments: Behavioral, Elevated Plus Maze Paradigm, Fluoro Jade B, Immunohistochemistry, Novel Object Recognition Paradigm, Western Blotting, Y-Maze Paradigm, glial fibrillary acidic protein, neuronal nuclear antigen
Citation: Bader M, Li Y, Tweedie D, Shlobin NA, Bernstein A, Rubovitch V, Tovar-Y-Romo LB, DiMarchi RD, Hoffer BJ, Greig NH, Pick CG.Neuroprotective Effects and Treatment Potential of Incretin Mimetics in a Murine Model of Mild Traumatic Brain InjuryFront Cell Dev Biol. 2020 Jan 10;7:356. doi: 10.3389/fcell.2019.00356. eCollection 2019.PMC696503110.3389/fcell.2019.00356
TBI Model Type: Weight-drop model
Organism Species: mouse
Organism Strain: ICR
Assessments: Behavioral, FJC, Immunofluorescence staining, Neurological Severity Score, RT-qPCR, TUNEL, Western blot
Citation: Zhou Y, Wang HD, Zhou XM, Fang J, Zhu L, Ding K.N-acetylcysteine amide provides neuroprotection via Nrf2-ARE pathway in a mouse model of traumatic brain injuryDrug Des Devel Ther. 2018 Dec 4;12:4117-4127. doi: 10.2147/DDDT.S179227. eCollection 2018.PMC628453210.2147/DDDT.S179227
TBI Model Type: Weight-drop model
Organism Species: mouse
Organism Strain: ICR
Assessments: open field test, CatWalk, Erasmus ladder, Grip strength, Immunohistochemistry (IHC), Rotarod test, Treadmill, Running wheel
Citation: Namdar I, Feldman R, Glazer S, Meningher I, Shlobin NA, Rubovitch V, Bikovski L, Been E, Pick CG. Motor Effects of Minimal Traumatic Brain Injury in MiceJ Mol Neurosci. 2020 Mar;70(3):365-377. doi: 10.1007\/s12031-019-01422-9. Epub 2019 Dec 9.
TBI Model Type: Weight-drop model
Organism Species: mouse
Organism Strain: ICR
Assessments: Behavioral, Elevated plus maze, Fluoro-Jade, Immunohistochemical staining, Novel object recognition, Y-maze, pharmacokinetic
Citation: Bader M, Li Y, Lecca D, Rubovitch V, Tweedie D, Glotfelty E, Rachmany L, Kim HK, Choi HI, Hoffer BJ, Pick CG, Greig NH, Kim DS.Pharmacokinetics and efficacy of PT302, a sustained-release Exenatide formulation, in a murine model of mild traumatic brain injuryNeurobiol Dis. 2019 Apr;124:439-453. doi: 10.1016/j.nbd.2018.11.023. Epub 2018 Nov 22.PMC671083110.1016/j.nbd.2018.11.023
TBI Model Type: Weight-drop model
Organism Species: mouse
Organism Strain: ICR
Assessments: Immunohistochemical, electrophoretic
mobility shift assay, enzyme-linked immunosorbent assay
Citation: Jin W, Wang H, Yan W, Xu L, Wang X, Zhao X, Yang X, Chen G, Ji Y.Disruption of Nrf2 enhances upregulation of nuclear factor-kappaB activity, proinflammatory cytokines, and intercellular adhesion molecule-1 in the brain after traumatic brain injuryMediators Inflamm. 2008;2008:725174. doi: 10.1155/2008/725174. Epub 2009 Jan 25.PMC263040510.1155/2008/725174
TBI Model Type: Weight-drop model
Organism Species: mouse
Organism Strain: ICR
Assessments: Brain water content, Immunohistochemical Staining, SOD Activity and Malondialdehyde (MDA) Level, Western Blot analysis, assay kits, neurological severity score, wet/dry weight ratio method
Citation: Lu XY, Wang HD, Xu JG, Ding K, Li T.Deletion of Nrf2 Exacerbates Oxidative Stress After Traumatic Brain Injury in Mice.Cell Mol Neurobiol. 2015 Jul;35(5):713-21. doi: 10.1007/s10571-015-0167-9. Epub 2015 Mar 3.
TBI Model Type: Weight-drop model
Organism Species: mouse
Organism Strain: ICR
Assessments: Brain water content, Enzyme-Linked Immunosorbent Assay, Immunofluorescence staining, Nissl staining, Terminal deoxynucleotidyl transferase-mediated dUTP nick 3′-end labeling (TUNEL), Western blot analysis, neurological severity score
Citation: Ding K, Wang H, Xu J, Lu X, Zhang L, Zhu L.Melatonin reduced microglial activation and alleviated neuroinflammation induced neuron degeneration in experimental traumatic brain injury: Possible involvement of mTOR pathway.Neurochem Int. 2014 Oct;76:23-31. doi: 10.1016/j.neuint.2014.06.015. Epub 2014 Jul 1.
