On page 2 showing 21 ~ 40 out of 59 results
TBI Model Type: Weight-drop model
Organism Species: mouse
Organism Strain: C57BL/6
Assessments: ELISA, Neurological Severity Score, TUNEL histochemistry, immunohistochemistry, real-time RT-PCR
Citation: Leinhase I, Rozanski M, Harhausen D, Thurman JM, Schmidt OI, Hossini AM, Taha ME, Rittirsch D, Ward PA, Holers VM, Ertel W, Stahel PF.Inhibition of the alternative complement activation pathway in traumatic brain injury by a monoclonal anti-factor B antibody: a randomized placebo-controlled study in miceJ Neuroinflammation. 2007 May 2;4:13. doi: 10.1186/1742-2094-4-13.PMC186780810.1186/1742-2094-4-13
TBI Model Type: Weight-drop model
Organism Species: mouse
Organism Strain: C57BL/6
Assessments: Flow Cytometry, Immunohistochemistry, hematoxylin and eosin
Citation: Lee J, Costantini TW, D'Mello R, Eliceiri BP, Coimbra R, Bansal V.Altering leukocyte recruitment following traumatic brain injury with ghrelin therapy.J Trauma Acute Care Surg. 2014 Nov;77(5):709-715. doi: 10.1097/TA.0000000000000445.
TBI Model Type: Weight-drop model
Organism Species: mouse
Organism Strain: C57BL/6
Assessments: Western blotting, immunofluorescence, length of neurites
Citation: Surgucheva I, He S, Rich MC, Sharma R, Ninkina NN, Stahel PF, Surguchov A.Role of synucleins in traumatic brain injury — an experimental in vitro and in vivo study in mice.Mol Cell Neurosci. 2014 Nov;63:114-23. doi: 10.1016/j.mcn.2014.10.005.
TBI Model Type: Weight-drop model
Organism Species: mouse
Organism Strain: C57BL/6
Assessments: Evans Blue dye, Immunocytochemistry, Lesion volumes, flow cytometry, neurological severity score, real-time PCR, terminal deoxynucleotidyl transferase dUTP nick-end labeling, wet weight-dry weight
Citation: Mencl S, Hennig N, Hopp S, Schuhmann MK, Albert-Weissenberger C, Sirén AL, Kleinschnitz C.FTY720 does not protect from traumatic brain injury in mice despite reducing posttraumatic inflammation.J Neuroimmunol. 2014 Sep 15;274(1-2):125-31. doi: 10.1016/j.jneuroim.2014.07.010. Epub 2014 Jul 22.
TBI Model Type: Weight-drop model
Organism Species: mouse
Organism Strain: C57BL/6
Assessments: Flow Cytometry, Luminex Assays
Citation: Schwulst SJ, Trahanas DM, Saber R, Perlman H.Traumatic brain injury-induced alterations in peripheral immunityJ Trauma Acute Care Surg. 2013 Nov;75(5):780-8. doi: 10.1097/TA.0b013e318299616a.PMC380906010.1097/TA.0b013e318299616a
TBI Model Type: Weight-drop model
Organism Species: mouse
Organism Strain: C57BL/6
Assessments: Motor evaluation, Enzyme-linked immunosorbent assay (ELISA)
Citation: Yang SH, Gangidine M, Pritts TA, Goodman MD, Lentsch AB.Interleukin 6 mediates neuroinflammation and motor coordination deficits after mild traumatic brain injury and brief hypoxia in mice.Shock. 2013 Dec;40(6):471-5. doi: 10.1097/SHK.0000000000000037.
TBI Model Type: Weight-drop model
Organism Species: mouse
Organism Strain: C57BL/6
Assessments: Microdialysis in vivo, open field test, Resident-Intruder, Rotarod test, Tactile Allodynia, Tail Suspension Test, Three Chambers Sociability
Citation: Belardo C, Iannotta M, Boccella S, Rubino RC, Ricciardi F, Infantino R, Pieretti G, Stella L, Paino S, Marabese I, Maisto R, Luongo L, Maione S, Guida F. Oral Cannabidiol Prevents Allodynia and Neurological Dysfunctions in a Mouse Model of Mild Traumatic Brain InjuryFront Pharmacol. 2019 Apr 16;10:352. doi: 10.3389\/fphar.2019.00352. eCollection 2019. PMC6476923
TBI Model Type: Weight-drop model
Organism Species: mouse
Organism Strain: C57BL/6
Assessments: Caspase Enzyme Activity, Feeding Latency, Histopathology, rt-PCR, TUNEL staining, Western blot
Citation: Mikrogianakis A, Shaye RE, Griffin P, Kawesa S, Lockwood J, Gendron NH, Gaboury I, Merali Z, Mackenzie AE, Hutchison JS.J Neurotrauma. 2007 Feb;24(2):338-53. doi: 10.1089/neu.2006.003615.
TBI Model Type: Weight-drop model
Organism Species: mouse
Organism Strain: C57BL/6
Assessments: Enzyme-linked immunosorbent assay (ELISA), Evans blue dye extravasation, Functional Magnetic resonance imaging (MRI), Immunofluorescence, Western blot, Brain water content, Neurological Severity Score (NSS), wire grip test, motion test
Citation: Yang Q, Zhang S, Xu Z, Liu L, Fan S, Wu S, Ma C. The Effectiveness of Trigeminal Nerve Stimulation on Traumatic Brain InjuryNeuromodulation. 2022 Jan 20:S1094-7159(21)06389-3. doi: 10.1016\/j.neurom.2021.10.014. Online ahead of print.
TBI Model Type: Weight-drop model
Organism Species: mouse
Organism Strain: C57BL/6
Assessments: Hippocampal histology, neuron-specific enolase
Citation: Wallen TE, Singer KE, Baucom MR, England LG, Schuster RM, Pritts TA, Goodman MD. Effects of antifibrinolytics on systemic and cerebral inflammation after traumatic brain injuryJ Trauma Acute Care Surg. 2022 Mar 22. doi: 10.1097\/TA.0000000000003607. Online ahead of print.
TBI Model Type: Weight-drop model
Organism Species: mouse
Organism Strain: C57BL/6
Assessments: Brain water content, Enzyme-linked immunosorbent assay (ELISA), Evans blue extravasation, Neurological Severity Score (NSS), Novel object recognition, Rotarod test, TUNEL staining, Western blot, lactate dehydrogenase release
Citation: Wang P, Pan B, Tian J, Yang L, Chen Z, Yang L, Fan Z. Ac-FLTD-CMK inhibits pyroptosis and exerts neuroprotective effect in a mice model of traumatic brain injuryNeuroreport. 2021 Feb 3;32(3):188-197. doi: 10.1097\/WNR.0000000000001580.
TBI Model Type: Controlled cortical impact model
Organism Species: mouse
Organism Strain: C57BL/6
Assessments: Hematoxylin and Eosin, Morris Water Maze (MWM), Brain water content, Immunohistochemistry (IHC), seizure activity, wire-grip test
Citation: Dapul HR, Park J, Zhang J, Lee C, DanEshmand A, Lok J, Ayata C, Gray T, Scalzo A, Qiu J, Lo EH, Whalen MJ. Concussive injury before or after controlled cortical impact exacerbates histopathology and functional outcome in a mixed traumatic brain injury model in miceJ Neurotrauma. 2013 Mar 1;30(5):382-91. doi: 10.1089\/neu.2012.2536. Epub 2013 Feb 20. PMC3593692
TBI Model Type: Weight-drop model
Organism Species: mouse
Organism Strain: C57BL/6
Assessments: Barnes Maze test, Basal ROS production, Enzyme-linked immunosorbent assay (ELISA), Fluoro-Jade C staining (FJC), GSH/GSSG activity assay, Hypoxyprobe staining, Neurological Severity Score, NADPH oxidase activity, Novel object recognition test, Western blot, cell viability analysis, Immunocytochemistry, memory recall test
Citation: Ho MH, Yen CH, Hsieh TH, Kao TJ, Chiu JY, Chiang YH, Hoffer BJ, Chang WC, Chou SY. CCL5 via GPX1 activation protects hippocampal memory function after mild traumatic brain injuryRedox Biol. 2021 Oct;46:102067. doi: 10.1016\/j.redox.2021.102067. Epub 2021 Jul 17. PMC8327355
TBI Model Type: Other
Organism Species: mouse
Organism Strain: C57BL/6
Assessments: Brain water content, Enzyme-linked immunosorbent assay (ELISA), Evans blue permeability assay, Immunofluorescence, TUNEL staining, Western blot, modified Neurological Severity Score (mNSS)
Citation: Mannix R, Berkner J, Mei Z, Alcon S, Hashim J, Robinson S, Jantzie L, Meehan WP 3rd, Qiu J. Adolescent Mice Demonstrate a Distinct Pattern of Injury after Repetitive Mild Traumatic Brain InjuryJ Neurotrauma. 2017 Jan 15;34(2):495-504. doi: 10.1089\/neu.2016.4457. Epub 2016 Jul 27. PMC5220578
TBI Model Type: Weight-drop model
Organism Species: mouse
Organism Strain: C57BL/6
Assessments: Histology, Microscopy, qRT-PCR, Neurological Severity Score (NSS), hematoma size
Citation: Förstner P, Rehman R, Anastasiadou S, Haffner-Luntzer M, Sinske D, Ignatius A, Roselli F, Knöll B. Neuroinflammation after Traumatic Brain Injury Is Enhanced in Activating Transcription Factor 3 Mutant MiceJ Neurotrauma. 2018 Oct 1;35(19):2317-2329. doi: 10.1089\/neu.2017.5593. Epub 2018 Jun 5.
TBI Model Type: Weight-drop model
Organism Species: mouse
Organism Strain: C57BL/6
Assessments: Hematoxylin and Eosin, Nissl staining, Serum S100β, Neurological Severity Score (NSS)
Citation: Guo D, Li D, Li J, Li Y, Hu X, Guan F, Yang B. Topical application of the hematostatic agent Surgiflo® could attenuate brain injury in experimental TBI miceNeurol Res. 2017 Sep;39(9):830-836. doi: 10.1080\/01616412.2017.1330815. Epub 2017 May 31.
TBI Model Type: Controlled cortical impact model
Organism Species: mouse
Organism Strain: C57BL/6
Assessments: Intracranial pressure (ICP), Morris Water Maze (MWM), arterial blood gas, blood urea nitrogen, calcium, glucose, hematocrit, hemoglobin, lactate, lesion volme, hemispheric volume, magnesium, neuropathology, osmolarity, potassium, sodium
Citation: Hemerka JN, Wu X, Dixon CE, Garman RH, Exo JL, Shellington DK, Blasiole B, Vagni VA, Janesko-Feldman K, Xu M, Wisniewski SR, Bayır H, Jenkins LW, Clark RS, Tisherman SA, Kochanek PM. Severe brief pressure-controlled hemorrhagic shock after traumatic brain injury exacerbates functional deficits and long-term neuropathological damage in miceJ Neurotrauma. 2012 Aug 10;29(12):2192-208. doi: 10.1089\/neu.2011.2303. PMC3472682
TBI Model Type: Weight-drop model
Organism Species: mouse
Organism Strain: C57BL/6
Assessments: Lesion Volume, Cresyl Violet Staining, Enzyme-Linked Immunosorbent Assay (Enzyme-linked immunosorbent assay), Grip Strength Test, Immunofluorescence, Novel object recognition test, Rotarod Test, Western blot, Y-Maze Test
Citation: Ahmed ME, Selvakumar GP, Kempuraj D, Raikwar SP, Thangavel R, Bazley K, Wu K, Khan O, Khan A, Zaheer S, Iyer S, Burton C, James D, Zaheer A. Glia Maturation Factor (GMF) Regulates Microglial Expression Phenotypes and the Associated Neurological Deficits in a Mouse Model of Traumatic Brain InjuryMol Neurobiol. 2020 Nov;57(11):4438-4450. doi: 10.1007\/s12035-020-02040-y. Epub 2020 Jul 31.
TBI Model Type: Controlled cortical impact model
Organism Species: mouse
Organism Strain: C57BL/6
Assessments: Histology, Morris Water Maze (MWM), Beam balance test, Beam walk test, memory retention, rotarod
Citation: Hill JL, Kobori N, Zhao J, Rozas NS, Hylin MJ, Moore AN, Dash PK. Traumatic brain injury decreases AMP-activated protein kinase activity and pharmacological enhancement of its activity improves cognitive outcomeJ Neurochem. 2016 Oct;139(1):106-19. doi: 10.1111\/jnc.13726. Epub 2016 Aug 1. PMC5037010
TBI Model Type: Weight-drop model
Organism Species: mouse
Organism Strain: C57BL/6
Assessments: Rotational thromboelastometry
Citation: Midura EF, Jernigan PL, Kuethe JW, Friend LA, Veile R, Makley AT, Caldwell CC, Goodman MD. Microparticles impact coagulation after traumatic brain injuryJ Surg Res. 2015 Jul;197(1):25-31. doi: 10.1016\/j.jss.2015.02.064. Epub 2015 Mar 5. PMC5857955
