On page 2 showing 21 ~ 40 out of 226 results
TBI Model Type: Controlled cortical impact model
Organism Species: mouse
Organism Strain: C57BL
Assessments: Histology, Morris Water Maze (MWM)
Citation: Smith DH, Soares HD, Pierce JS, Perlman KG, Saatman KE, Meaney DF, Dixon CE, McIntosh TK. A model of parasagittal controlled cortical impact in the mouse: cognitive and histopathologic effectsJ Neurotrauma. 1995 Apr;12(2):169-78. doi: 10.1089\/neu.1995.12.169.
TBI Model Type: Controlled cortical impact model
Organism Species: mouse
Organism Strain: C57BL/6
Assessments: RT-PCR
Citation: Sandhir R, Berman NE. Age-dependent response of CCAAT\/enhancer binding proteins following traumatic brain injury in miceNeurochem Int. 2010 Jan;56(1):188-93. doi: 10.1016\/j.neuint.2009.10.002. Epub 2009 Oct 13. PMC2815015
TBI Model Type: Controlled cortical impact model
Organism Species: mouse
Organism Strain: C57BL/6
Assessments: flow cytometry, ATP detection, Bradford method, Hematoxylin and eosin, Immunofluorescence, L-lactate assay kit, Morris Water Maze (MWM)
Citation: Dong T, Zhang Q, Hamblin MR, Wu MX. Low-level light in combination with metabolic modulators for effective therapy of injured brainJ Cereb Blood Flow Metab. 2015 Sep;35(9):1435-44. doi: 10.1038\/jcbfm.2015.87. Epub 2015 May 13. PMC4640344
TBI Model Type: Blast model
Organism Species: mouse
Organism Strain: C57BL/6
Assessments: L/D emergence task, Enzyme-linked immunosorbent assay (ELISA), Barnes Maze test test, Contextual fear memory testing, Elevated zero maze, Fear conditioning, Immunohistochemistry (IHC), Light dark escape, Locomotor activity, Novel object localization test, Novel object recognition test, Oligomeric Aβ42 dot blot analysis, Social interaction, Sound-attenuated isolation, Behavioral Testing, Thioflavin S staining, social preference test
Citation: Perez Garcia G, De Gasperi R, Tschiffely AE, Gama Sosa MA, Abutarboush R, Kawoos U, Statz JK, Ciarlone S, Reed E, Jeyarajah T, Perez GM, Otero-Pagan A, Pryor D, Hof PR, Cook DG, Gandy S, Elder GA, Ahlers ST. Repetitive Low-Level Blast Exposure Improves Behavioral Deficits and Chronically Lowers Aβ42 in an Alzheimer Disease Transgenic Mouse ModelJ Neurotrauma. 2021 Nov 15;38(22):3146-3173. doi: 10.1089\/neu.2021.0184. Epub 2021 Sep 15. PMC8820291
TBI Model Type: Controlled cortical impact model
Organism Species: mouse
Organism Strain: C57BL/6J
Assessments: Elevated plus maze, Forced swim test, Horizontal ladder beam, Immunohistochemistry (IHC), Morris Water Maze (MWM), Rotarod, Tail suspension test, Western Blots, optical fractionator probe
Citation: Gold EM, Vasilevko V, Hasselmann J, Tiefenthaler C, Hoa D, Ranawaka K, Cribbs DH, Cummings BJ. Repeated Mild Closed Head Injuries Induce Long-Term White Matter Pathology and Neuronal Loss That Are Correlated With Behavioral DeficitsASN Neuro. 2018 Jan-Dec;10:1759091418781921. doi: 10.1177\/1759091418781921. PMC6050992
TBI Model Type: Controlled cortical impact model
Organism Species: mouse
Organism Strain: C57BL/6-SJLF1
Assessments: Conditioned fear testing, Morris Water Maze (MWM), Rotorod test, Histology, shock sensitivity testing
Citation: Brody DL, Mac Donald C, Kessens CC, Yuede C, Parsadanian M, Spinner M, Kim E, Schwetye KE, Holtzman DM, Bayly PV. Electromagnetic controlled cortical impact device for precise, graded experimental traumatic brain injuryJ Neurotrauma. 2007 Apr;24(4):657-73. doi: 10.1089\/neu.2006.0011. PMC2435168
TBI Model Type: Controlled cortical impact model
Organism Species: mouse
Organism Strain: C57BL/6J
Assessments: Amyloid precursor protein, Cortical contusion volume, Immunoglobulin, Immunohistochemistry (IHC), Morris Water Maze (MWM), Neurological Severity Score (NSS), Neuroscore, Regional hippocampal neurodegeneration
Citation: Pleasant JM, Carlson SW, Mao H, Scheff SW, Yang KH, Saatman KE. Rate of neurodegeneration in the mouse controlled cortical impact model is influenced by impactor tip shape: implications for mechanistic and therapeutic studiesJ Neurotrauma. 2011 Nov;28(11):2245-62. doi: 10.1089\/neu.2010.1499. Epub 2011 Apr 21. PMC3218388
TBI Model Type: Controlled cortical impact model
Organism Species: mouse
Organism Strain: C57BL/6J
Assessments: Acoustic startle response, Body curl test, Elevated-plus maze, Forced swim test, Lesion volume, Morris Water Maze (MWM), open field test, prepulse inhibition
Citation: Washington PM, Forcelli PA, Wilkins T, Zapple DN, Parsadanian M, Burns MP. The effect of injury severity on behavior: a phenotypic study of cognitive and emotional deficits after mild, moderate, and severe controlled cortical impact injury in miceJ Neurotrauma. 2012 Sep;29(13):2283-96. doi: 10.1089\/neu.2012.2456. Epub 2012 Aug 3. PMC3430487
TBI Model Type: Controlled cortical impact model
Organism Species: mouse
Organism Strain: C57BL/6J
Assessments: mean arterial blood pressure (MAP), Fluoro-Jade C staining (FJC), Hematoxylin and Eosin
Citation: Dennis AM, Haselkorn ML, Vagni VA, Garman RH, Janesko-Feldman K, Bayir H, Clark RS, Jenkins LW, Dixon CE, Kochanek PM. Hemorrhagic shock after experimental traumatic brain injury in mice: effect on neuronal deathJ Neurotrauma. 2009 Jun;26(6):889-99. doi: 10.1089\/neu.2008.0512. PMC2694227
TBI Model Type: Weight-drop model
Organism Species: mouse
Organism Strain: Swiss Albino
Assessments: Immunofluorescence, modified Neurological Severity Score (mNSS)
Citation: Karakaya D, Cakir-Aktas C, Uzun S, Soylemezoglu F, Mut M. Tailored Therapeutic Doses of Dexmedetomidine in Evolving Neuroinflammation after Traumatic Brain InjuryNeurocrit Care. 2022 Jun;36(3):802-814. doi: 10.1007\/s12028-021-01381-3. Epub 2021 Nov 16.
TBI Model Type: Weight-drop model
Organism Species: mouse
Organism Strain: ICR
Assessments: Immunohistochemistry, Novel object recognition test, Y-Maze, elevated plus maze test, staircase test
Citation: Qubty D, Rubovitch V, Benromano T, Ovadia M, Pick CG. Orally Administered Cinnamon Extract Attenuates Cognitive and Neuronal Deficits Following Traumatic Brain InjuryJ Mol Neurosci. 2021 Jan;71(1):178-186. doi: 10.1007\/s12031-020-01688-4. Epub 2020 Sep 8.
TBI Model Type: Weight-drop model
Organism Species: mouse
Organism Strain: C57BL/6J
Assessments: Fluoro-Jade C staining (FJC), Immunohistochemistry (IHC)
Citation: Hetzer SM, Shalosky EM, Torrens JN, Evanson NK. Chronic Histological Outcomes of Indirect Traumatic Optic Neuropathy in Adolescent Mice: Persistent Degeneration and Temporally Regulated Glial ResponsesCells. 2021 Nov 28;10(12):3343. doi: 10.3390\/cells10123343. PMC8699438
TBI Model Type: Blast model
Organism Species: mouse
Organism Strain: C57BL/6J
Assessments: Polyunsaturated Fatty Acids analysis, Sphingolipids analysis, Immunohistochemistry (IHC), Pavlovian fear conditioning, RT-PCR, Sphingomyelinase Assay, electroretinogram recording, open-field behavior assessment, optokinetic reflex measurement, tail suspension test
Citation: Mondal K, Takahashi H, Cole J 2nd, Del Mar NA, Li C, Stephenson DJ, Allegood J, Cowart LA, Chalfant CE, Reiner A, Mandal N. Systemic Elevation of n-3 Polyunsaturated Fatty Acids (n-3-PUFA) Is Associated with Protection against Visual, Motor, and Emotional Deficits in Mice following Closed-Head Mild Traumatic Brain InjuryMol Neurobiol. 2021 Nov;58(11):5564-5580. doi: 10.1007\/s12035-021-02501-y. Epub 2021 Aug 8. PMC8655834
TBI Model Type: Blast model
Organism Species: mouse
Organism Strain: C57BL/6J
Assessments: Image Acquisition, Western blot
Citation: Wang C, Shao C, Zhang L, Siedlak SL, Meabon JS, Peskind ER, Lu Y, Wang W, Perry G, Cook DG, Zhu X. Oxidative Stress Signaling in Blast TBI-Induced Tau PhosphorylationAntioxidants (Basel). 2021 Jun 15;10(6):955. doi: 10.3390\/antiox10060955. PMC8232162
TBI Model Type: Controlled cortical impact model
Organism Species: mouse
Organism Strain: C57BL/6J
Assessments: Cytokine Assay, Enzyme-linked immunosorbent assay (ELISA), Immunohistochemistry (IHC), astrocytic, hippocampal neurogenesis, microglia responses, radial arm water maze, Rotarod
Citation: Song S, Kong X, Acosta S, Sava V, Borlongan C, Sanchez-Ramos J. Granulocyte colony-stimulating factor promotes behavioral recovery in a mouse model of traumatic brain injuryJ Neurosci Res. 2016 May;94(5):409-23. doi: 10.1002\/jnr.23714. Epub 2016 Jan 29. PMC4805459
TBI Model Type: Other
Organism Species: mouse
Organism Strain: C57Bl/6
Assessments: Barnes Maze test, Enzyme-Linked Immunosorbent Assay (ELISA), Histology, LRR, Neurological Severity Score (NSS), open field test, Silver staining, Western blot, Rotarod test, passive avoidance task, thigmotaxis index
Citation: Namjoshi DR, Cheng WH, McInnes KA, Martens KM, Carr M, Wilkinson A, Fan J, Robert J, Hayat A, Cripton PA, Wellington CL. Merging pathology with biomechanics using CHIMERA (Closed-Head Impact Model of Engineered Rotational Acceleration): a novel, surgery-free model of traumatic brain injuryMol Neurodegener. 2014 Dec 1;9:55. doi: 10.1186\/1750-1326-9-55. PMC4269957
TBI Model Type: Weight-drop model
Organism Species: mouse
Organism Strain: C57BL/6
Assessments: Brain water content, Enzyme-linked immunosorbent assay (ELISA), Evans blue permeability assay, Immunofluorescence staining, TUNEL staining, Western blot, Immunofluorescence, modified Neurological Severity Score (mNSS)
Citation: Li H, Sun J, Du J, Wang F, Fang R, Yu C, Xiong J, Chen W, Lu Z, Liu J. Clostridium butyricum exerts a neuroprotective effect in a mouse model of traumatic brain injury via the gut-brain axisNeurogastroenterol Motil. 2018 May;30(5):e13260. doi: 10.1111\/nmo.13260. Epub 2017 Nov 27.
TBI Model Type: Controlled cortical impact model
Organism Species: mouse
Organism Strain: CD-1
Assessments: Elevated plus maze test, Histology, Novel object recognition test, Open field test, T-Maze, Western blot, infarct volume
Citation: Farr SA, Cuzzocrea S, Esposito E, Campolo M, Niehoff ML, Doyle TM, Salvemini D. Adenosine A(3) receptor as a novel therapeutic target to reduce secondary events and improve neurocognitive functions following traumatic brain injuryJ Neuroinflammation. 2020 Nov 12;17(1):339. doi: 10.1186\/s12974-020-02009-7. PMC7659122
TBI Model Type: Weight-drop model
Organism Species: mouse
Organism Strain: C57BL/6J
Assessments: Elevated plus maze, Forced swim test, Horizontal ladder beam, Immunohistochemistry (IHC), Morris Water Maze (MWM), Rotarod, Tail suspension test, Western Blots, optical fractionator probe
Citation: Gold EM, Vasilevko V, Hasselmann J, Tiefenthaler C, Hoa D, Ranawaka K, Cribbs DH, Cummings BJ. Repeated Mild Closed Head Injuries Induce Long-Term White Matter Pathology and Neuronal Loss That Are Correlated With Behavioral DeficitsASN Neuro. 2018 Jan-Dec;10:1759091418781921. doi: 10.1177\/1759091418781921. PMC6050992
TBI Model Type: Weight-drop model
Organism Species: mouse
Organism Strain: C57BL
Assessments: Apnea, Histology, self-righting reflex
Citation: Brady RD, Grills BL, Church JE, Walsh NC, McDonald AC, Agoston DV, Sun M, O'Brien TJ, Shultz SR, McDonald SJ. Closed head experimental traumatic brain injury increases size and bone volume of callus in mice with concomitant tibial fractureSci Rep. 2016 Sep 29;6:34491. doi: 10.1038\/srep34491. PMC5041102
