On page 2 showing 21 ~ 40 out of 45 results
TBI Model Type: Weight-drop model
Organism Species: rat
Organism Strain: Sprague-Dawlay
Assessments: TUNEL staining, transmission electron microscope, Enzyme-linked immunosorbent assay (ELISA), Immunofluorescence, Neurological Severity Score (NSS), Morris Water Maze (MWM), Western blot, Brain water content
Citation: Shen M, Wang S, Wen X, Han XR, Wang YJ, Zhou XM, Zhang MH, Wu DM, Lu J, Zheng YL. Dexmedetomidine exerts neuroprotective effect via the activation of the PI3K\/Akt\/mTOR signaling pathway in rats with traumatic brain injuryBiomed Pharmacother. 2017 Nov;95:885-893. doi: 10.1016\/j.biopha.2017.08.125. Epub 2017 Sep 10.
TBI Model Type: Weight-drop model
Organism Species: mouse
Organism Strain: C57BL/6
Assessments: Brain water content, Enzyme-linked immunosorbent assay (ELISA), Evans blue extravasation, Neurological Severity Score (NSS), Novel object recognition, Rotarod test, TUNEL staining, Western blot, lactate dehydrogenase release
Citation: Wang P, Pan B, Tian J, Yang L, Chen Z, Yang L, Fan Z. Ac-FLTD-CMK inhibits pyroptosis and exerts neuroprotective effect in a mice model of traumatic brain injuryNeuroreport. 2021 Feb 3;32(3):188-197. doi: 10.1097\/WNR.0000000000001580.
TBI Model Type: Weight-drop model
Organism Species: rat
Organism Strain: Sprague-Dawley
Assessments: Brain water content, Dual-luciferase reporter gene assay, Histology, qRT-PCR, TUNEL staining, Western blot, Enzyme-linked immunosorbent assay (ELISA), Neurological Severity Score (NSS)
Citation: Cui C, Zhang D, Sun K, Li H, Xu L, Lin G, Guo Y, Hu J, Chen J, Nong L, Cai Y, Yu D, Yang W, Wang P, Sun Y. Propofol maintains Th17\/Treg cell balance and reduces inflammation in rats with traumatic brain injury via the miR‑145‑3p\/NFATc2\/NF‑κB axisInt J Mol Med. 2021 Jul;48(1):135. doi: 10.3892\/ijmm.2021.4968. Epub 2021 May 26. PMC8148094
TBI Model Type: Other
Organism Species: mouse
Organism Strain: C57BL/6
Assessments: Brain water content, Enzyme-linked immunosorbent assay (ELISA), Evans blue permeability assay, Immunofluorescence, TUNEL staining, Western blot, modified Neurological Severity Score (mNSS)
Citation: Mannix R, Berkner J, Mei Z, Alcon S, Hashim J, Robinson S, Jantzie L, Meehan WP 3rd, Qiu J. Adolescent Mice Demonstrate a Distinct Pattern of Injury after Repetitive Mild Traumatic Brain InjuryJ Neurotrauma. 2017 Jan 15;34(2):495-504. doi: 10.1089\/neu.2016.4457. Epub 2016 Jul 27. PMC5220578
TBI Model Type: Controlled cortical impact model
Organism Species: mouse
Organism Strain: C57BL/6J
Assessments: Neurological evaluation, Histology, Immunohistochemistry (IHC), Morris Water Maze (MWM), Beam walk test, forepaw contraflexion, Rotarod test, TUNEL staining
Citation: Fox GB, Fan L, Levasseur RA, Faden AI. Sustained sensory\/motor and cognitive deficits with neuronal apoptosis following controlled cortical impact brain injury in the mouseJ Neurotrauma. 1998 Aug;15(8):599-614. doi: 10.1089\/neu.1998.15.599.
TBI Model Type: Weight-drop model
Organism Species: mouse
Organism Strain: ICR
Assessments: Brain water content, Immunofluorescence, Nissl Staining, qRT-PCR, TUNEL staining, Western blot, Neurological Severity Score (NSS)
Citation: Liu Z, Wang H, Shi X, Li L, Zhou M, Ding H, Yang Y, Li X, Ding K. DL-3-n-Butylphthalide (NBP) Provides Neuroprotection in the Mice Models After Traumatic Brain Injury via Nrf2-ARE Signaling PathwayNeurochem Res. 2017 May;42(5):1375-1386. doi: 10.1007\/s11064-017-2186-z. Epub 2017 Feb 18.
TBI Model Type: Weight-drop model
Organism Species: mouse
Organism Strain: CD-1
Assessments: Brain water content, Enzyme-linked immunosorbent assay (ELISA), Evans blue extravasation, Neurological Severity Score (NSS), Novel object recognition test, Rotarod test, TUNEL staining, Western blot, lactate dehydrogenase release
Citation: Kempuraj D, Ahmed ME, Selvakumar GP, Thangavel R, Raikwar SP, Zaheer SA, Iyer SS, Govindarajan R, Nattanmai Chandrasekaran P, Burton C, James D, Zaheer A. Acute Traumatic Brain Injury-Induced Neuroinflammatory Response and Neurovascular Disorders in the BrainNeurotox Res. 2021 Apr;39(2):359-368. doi: 10.1007\/s12640-020-00288-9. Epub 2020 Sep 21. PMC7502806
TBI Model Type: Weight-drop model
Organism Species: zebrafish
Organism Strain: No strain reported
Assessments: Sonic Hedgehog Modulation, Evans Blue Assay, Fluid Content Measurement, Hoshi protocol, Image Acquisition, Immediate and Delayed Recall, Immunohistochemistry (IHC), Learning, Locomotion velocity, qRT-PCR, Sensorimotor Assay, Shuttle Box Assay Testing Apparatus, Startle Response Habituation, TUNEL staining, Vascular Injury, optical density, tonic-clonic seizure metrics
Citation: Hentig J, Cloghessy K, Lahne M, Jung YJ, Petersen RA, Morris AC, Hyde DR. Zebrafish Blunt-Force TBI Induces Heterogenous Injury Pathologies That Mimic Human TBI and Responds with Sonic Hedgehog-Dependent Cell Proliferation across the NeuroaxisBiomedicines. 2021 Jul 22;9(8):861. doi: 10.3390\/biomedicines9080861. PMC8389629
TBI Model Type: Weight-drop model
Organism Species: mouse
Organism Strain: ICR
Assessments: Brain water content, Enzyme-linked immunosorbent assay (ELISA), Evans blue permeability assay, Immunofluorescence, TUNEL staining, Western blot, modified Neurological Severity Score (mNSS)
Citation: Cheng H, Di G, Gao CC, He G, Wang X, Han YL, Sun LA, Zhou ML, Jiang X. FTY720 Reduces Endothelial Cell Apoptosis and Remodels Neurovascular Unit after Experimental Traumatic Brain InjuryInt J Med Sci. 2021 Jan 1;18(2):304-313. doi: 10.7150\/ijms.49066. eCollection 2021. PMC7757143
TBI Model Type: Weight-drop model
Organism Species: rat
Organism Strain: Sprague-Dawley
Assessments: Brain water content, Fluoro-Jade B staining (FJB), Garcia test score system, Immunofluorescence staining, RT-PCR, TUNEL staining, Western blot
Citation: Ni H, Rui Q, Xu Y, Zhu J, Gao F, Dang B, Li D, Gao R, Chen G. RACK1 upregulation induces neuroprotection by activating the IRE1-XBP1 signaling pathway following traumatic brain injury in ratsExp Neurol. 2018 Jun;304:102-113. doi: 10.1016\/j.expneurol.2018.03.003. Epub 2018 Mar 6.
TBI Model Type: Weight-drop model
Organism Species: mouse
Organism Strain: ICR
Assessments: Brain water content, Immunofluorescence, Malondialdehyde level, Neurological Severity Score (NSS), qRT-PCR, TUNEL staining, Western blot, glutathione peroxidase, superoxide dismutase
Citation: Fang J, Wang H, Zhou J, Dai W, Zhu Y, Zhou Y, Wang X, Zhou M. Baicalin provides neuroprotection in traumatic brain injury mice model through Akt\/Nrf2 pathwayDrug Des Devel Ther. 2018 Aug 10;12:2497-2508. doi: 10.2147\/DDDT.S163951. eCollection 2018. PMC6089097
TBI Model Type: Weight-drop model
Organism Species: mouse
Organism Strain: C57BL/6
Assessments: Brain water content, Fluoro-Jade C staining (FJC), Immunofluorescence, TUNEL staining, Western blot, qPCR, spectrophotometer
Citation: Dong W, Yang B, Wang L, Li B, Guo X, Zhang M, Jiang Z, Fu J, Pi J, Guan D, Zhao R. Curcumin plays neuroprotective roles against traumatic brain injury partly via Nrf2 signalingToxicol Appl Pharmacol. 2018 May 1;346:28-36. doi: 10.1016\/j.taap.2018.03.020. Epub 2018 Mar 21.
TBI Model Type: Blast model
Organism Species: rat
Organism Strain: Long-Evans outbred
Assessments: Electroretinography, Optomotor response, Spectral domain optical coherence tomography, TUNEL staining, Y-maze, Immunohistochemistry (IHC), spectral-domain optical coherence tomography
Citation: Allen RS, Motz CT, Singh A, Feola A, Hutson L, Douglass A, Ramachandra Rao S, Skelton LA, Cardelle L, Bales KL, Chesler K, Gudapati K, Ethier CR, Harper MM, Fliesler SJ, Pardue MT. Dependence of visual and cognitive outcomes on animal holder configuration in a rodent model of blast overpressure exposureVision Res. 2021 Nov;188:162-173. doi: 10.1016\/j.visres.2021.07.008. Epub 2021 Jul 30. PMC8440444
TBI Model Type: Weight-drop model
Organism Species: rat
Organism Strain: Sprague-Dawley
Assessments: Brain water content, Immunohistochemistry (IHC), Neurological evaluation, Nissl staining, TUNEL staining, Western blot, spectrophotometer
Citation: Wei W, Wang H, Wu Y, Ding K, Li T, Cong Z, Xu J, Zhou M, Huang L, Ding H, Wu H. Alpha lipoic acid inhibits neural apoptosis via a mitochondrial pathway in rats following traumatic brain injuryNeurochem Int. 2015 Aug;87:85-91. doi: 10.1016\/j.neuint.2015.06.003. Epub 2015 Jun 6.
TBI Model Type: Weight-drop model
Organism Species: mouse
Organism Strain: ICR
Assessments: Brain water content, Immunofluorescence, TUNEL staining, Western blot, grip test, qRT-PCR, spectrophotometer
Citation: Yang Y, Wang H, Li L, Li X, Wang Q, Ding H, Wang X, Ye Z, Wu L, Zhang X, Zhou M, Pan H. Sinomenine Provides Neuroprotection in Model of Traumatic Brain Injury via the Nrf2-ARE PathwayFront Neurosci. 2016 Dec 23;10:580. doi: 10.3389\/fnins.2016.00580. eCollection 2016. PMC5179594
TBI Model Type: Weight-drop model
Organism Species: rat
Organism Strain: Sprague-Dawley
Assessments: Immunofluorescence, open field test, TUNEL staining, Western blot
Citation: Li SS, Xie LL, Li ZZ, Fan YJ, Qi MM, Xi YG. Androgen is responsible for enhanced susceptibility of melatonin against traumatic brain injury in femalesNeurosci Lett. 2021 May 1;752:135842. doi: 10.1016\/j.neulet.2021.135842. Epub 2021 Mar 22.
TBI Model Type: Weight-drop model
Organism Species: rat
Organism Strain: Sprague-Dawley
Assessments: Immunohistochemistry (IHC), Fluoro-Jade C staining (FJC), Neurological function score, TUNEL staining, Brain water content, Western blot
Citation: Zhu J, Lin X, Chen C, Tan H, Gao Y, Li D, Chen G. WNK3 Promotes Neuronal Survival after Traumatic Brain Injury in RatsNeuroscience. 2021 Nov 21;477:76-88. doi: 10.1016\/j.neuroscience.2021.09.021. Epub 2021 Oct 6.
TBI Model Type: Weight-drop model
Organism Species: mouse
Organism Strain: C57BL/6J
Assessments: Dichlorofluorescein Diacetate Dye, Immunofluorescence, Neurological Severity Score )NSS), Nissl staining, TUNEL staining, Western Blot, Optical density, qRT-PCR
Citation: Yang XJ, Ling S, Zhou ML, Deng HJ, Qi M, Liu XL, Zhen C, Chen YX, Fan XR, Wu ZY, Ma FC, Rong J, Di GF, Jiang XC. Inhibition of TRPA1 Attenuates Oxidative Stress-induced Damage After Traumatic Brain Injury via the ERK\/AKT Signaling PathwayNeuroscience. 2022 Feb 11;494:51-68. doi: 10.1016\/j.neuroscience.2022.02.003. Online ahead of print.
TBI Model Type: Weight-drop model
Organism Species: rat
Organism Strain: Sprague-Dawley
Assessments: Nissl staining, Lipid peroxidation assay, GSH assay, SOD activity, Western blot, Beam balance test, Brain water content, MDA, TUNEL staining
Citation: He Y, Qu S, Wang J, He X, Lin W, Zhen H, Zhang X.Brain Res. 2012 Jan 18;1433:127-36. doi: 10.1016/j.brainres.2011.11.027. Epub 2011 Nov 18.
TBI Model Type: Weight-drop model
Organism Species: mouse
Organism Strain: C57BL/6
Assessments: Evans Blue dye, Immunocytochemistry (IHC), Lesion volume, flow cytometry, Neurologic Severity Score (NSS), rt-PCR, TUNEL staining
Citation: Mencl S, Hennig N, Hopp S, Schuhmann MK, Albert-Weissenberger C, Sirén AL, Kleinschnitz C.J Neuroimmunol. 2014 Sep 15;274(1-2):125-31. doi: 10.1016/j.jneuroim.2014.07.010. Epub 2014 Jul 22.
