On page 2 showing 21 ~ 39 out of 39 results
TBI Model Type: Weight-drop model
Organism Species: rat
Organism Strain: Sprague-Dawlay
Assessments: TUNEL staining, transmission electron microscope, Enzyme-linked immunosorbent assay (ELISA), Immunofluorescence, Neurological Severity Score (NSS), Morris Water Maze (MWM), Western blot, Brain water content
Citation: Shen M, Wang S, Wen X, Han XR, Wang YJ, Zhou XM, Zhang MH, Wu DM, Lu J, Zheng YL. Dexmedetomidine exerts neuroprotective effect via the activation of the PI3K\/Akt\/mTOR signaling pathway in rats with traumatic brain injuryBiomed Pharmacother. 2017 Nov;95:885-893. doi: 10.1016\/j.biopha.2017.08.125. Epub 2017 Sep 10.
TBI Model Type: Controlled cortical impact model
Organism Species: rat
Organism Strain: Sprague-Dawley
Assessments: Beam walk test, Morris Water Maze (MWM), Beam balance test
Citation: Statler KD, Alexander H, Vagni V, Holubkov R, Dixon CE, Clark RS, Jenkins L, Kochanek PM. Isoflurane exerts neuroprotective actions at or near the time of severe traumatic brain injuryBrain Res. 2006 Mar 3;1076(1):216-24. doi: 10.1016\/j.brainres.2005.12.106. Epub 2006 Feb 13.
TBI Model Type: Controlled cortical impact model
Organism Species: mouse
Organism Strain: C57BL/6
Assessments: Hematoxylin and Eosin, Morris Water Maze (MWM), Brain water content, Immunohistochemistry (IHC), seizure activity, wire-grip test
Citation: Dapul HR, Park J, Zhang J, Lee C, DanEshmand A, Lok J, Ayata C, Gray T, Scalzo A, Qiu J, Lo EH, Whalen MJ. Concussive injury before or after controlled cortical impact exacerbates histopathology and functional outcome in a mixed traumatic brain injury model in miceJ Neurotrauma. 2013 Mar 1;30(5):382-91. doi: 10.1089\/neu.2012.2536. Epub 2013 Feb 20. PMC3593692
TBI Model Type: Weight-drop model
Organism Species: rat
Organism Strain: Sprague-Dawley
Assessments: Duration of unconsciousness, Elevated Plus Maze, H-reflex, Morris Water Maze (MWM), T2-weighted Magnetic resonance imaging (MRI), Rotorod test
Citation: Hou J, Nelson R, Wilkie Z, Mustafa G, Tsuda S, Thompson FJ, Bose P. Mild and Mild-to-Moderate Traumatic Brain Injury-Induced Significant Progressive and Enduring Multiple ComorbiditiesJ Neurotrauma. 2017 Aug 15;34(16):2456-2466. doi: 10.1089\/neu.2016.4851. Epub 2017 Jun 9.
TBI Model Type: Weight-drop model
Organism Species: rat
Organism Strain: Sprague-Dawley
Assessments: Immunohistochemistry (IHC), Morris Water Maze (MWM), Neurological Severity Score (NSS), Western blot, Brain water content
Citation: Zhang MH, Zhou XM, Cui JZ, Wang KJ, Feng Y, Zhang HA. Neuroprotective effects of dexmedetomidine on traumatic brain injury: Involvement of neuronal apoptosis and HSP70 expressionMol Med Rep. 2018 Jun;17(6):8079-8086. doi: 10.3892\/mmr.2018.8898. Epub 2018 Apr 19. PMC5983975
TBI Model Type: Controlled cortical impact model
Organism Species: mouse
Organism Strain: C57BL/6J
Assessments: Electron Microscopy, Morris Water Maze (MWM), Immunohistochemistry (IHC)
Citation: Shitaka Y, Tran HT, Bennett RE, Sanchez L, Levy MA, Dikranian K, Brody DL. Repetitive closed-skull traumatic brain injury in mice causes persistent multifocal axonal injury and microglial reactivityJ Neuropathol Exp Neurol. 2011 Jul;70(7):551-67. doi: 10.1097\/NEN.0b013e31821f891f. PMC3118973
TBI Model Type: Controlled cortical impact model
Organism Species: mouse
Organism Strain: C57BL/6
Assessments: Intracranial pressure (ICP), Morris Water Maze (MWM), arterial blood gas, blood urea nitrogen, calcium, glucose, hematocrit, hemoglobin, lactate, lesion volme, hemispheric volume, magnesium, neuropathology, osmolarity, potassium, sodium
Citation: Hemerka JN, Wu X, Dixon CE, Garman RH, Exo JL, Shellington DK, Blasiole B, Vagni VA, Janesko-Feldman K, Xu M, Wisniewski SR, Bayır H, Jenkins LW, Clark RS, Tisherman SA, Kochanek PM. Severe brief pressure-controlled hemorrhagic shock after traumatic brain injury exacerbates functional deficits and long-term neuropathological damage in miceJ Neurotrauma. 2012 Aug 10;29(12):2192-208. doi: 10.1089\/neu.2011.2303. PMC3472682
TBI Model Type: Controlled cortical impact model
Organism Species: mouse
Organism Strain: C57BL/6J
Assessments: Neurological evaluation, Histology, Immunohistochemistry (IHC), Morris Water Maze (MWM), Beam walk test, forepaw contraflexion, Rotarod test, TUNEL staining
Citation: Fox GB, Fan L, Levasseur RA, Faden AI. Sustained sensory\/motor and cognitive deficits with neuronal apoptosis following controlled cortical impact brain injury in the mouseJ Neurotrauma. 1998 Aug;15(8):599-614. doi: 10.1089\/neu.1998.15.599.
TBI Model Type: Weight-drop model
Organism Species: rat
Organism Strain: Sprague-Dawley
Assessments: Immunofluorescence, Immunohistochemistry (IHC), Lesion Volume, Morris Water Maze (MWM), Neurobehavioral Evaluation, Nissl staining, beam walk
Citation: Li D, Ma S, Guo D, Cheng T, Li H, Tian Y, Li J, Guan F, Yang B, Wang J. Environmental Circadian Disruption Worsens Neurologic Impairment and Inhibits Hippocampal Neurogenesis in Adult Rats After Traumatic Brain InjuryCell Mol Neurobiol. 2016 Oct;36(7):1045-55. doi: 10.1007\/s10571-015-0295-2. Epub 2016 Feb 17. PMC4967018
TBI Model Type: Weight-drop model
Organism Species: mouse
Organism Strain: C57BL/6J
Assessments: Beam walk test, Immunofluorescent, Immunohistochemistry (IHC), Lesion Volume Assessment, Morris Water Maze (MWM)
Citation: Huang SX, Qiu G, Cheng FR, Pei Z, Yang Z, Deng XH, Zhu JH, Chen L, Chen CC, Lin WF, Liu Y, Liu Z, Zhu FQ. Berberine Protects Secondary Injury in Mice with Traumatic Brain Injury Through Anti-oxidative and Anti-inflammatory ModulationNeurochem Res. 2018 Sep;43(9):1814-1825. doi: 10.1007\/s11064-018-2597-5. Epub 2018 Jul 19.
TBI Model Type: Controlled cortical impact model
Organism Species: mouse
Organism Strain: C57BL/6J
Assessments: Electroencephalography, Morris Water Maze (MWM), Neurological Severity Score (NSS), Porsolt forced swim test, electromyography, elevated plus maze, tail suspension test, wire grip test
Citation: Petraglia AL, Plog BA, Dayawansa S, Chen M, Dashnaw ML, Czerniecka K, Walker CT, Viterise T, Hyrien O, Iliff JJ, Deane R, Nedergaard M, Huang JH. The spectrum of neurobehavioral sequelae after repetitive mild traumatic brain injury: a novel mouse model of chronic traumatic encephalopathyJ Neurotrauma. 2014 Jul 1;31(13):1211-24. doi: 10.1089\/neu.2013.3255. Epub 2014 Jun 12. PMC4082360
TBI Model Type: Controlled cortical impact model
Organism Species: mouse
Organism Strain: C57BL/6
Assessments: Histology, Morris Water Maze (MWM), Beam balance test, Beam walk test, memory retention, rotarod
Citation: Hill JL, Kobori N, Zhao J, Rozas NS, Hylin MJ, Moore AN, Dash PK. Traumatic brain injury decreases AMP-activated protein kinase activity and pharmacological enhancement of its activity improves cognitive outcomeJ Neurochem. 2016 Oct;139(1):106-19. doi: 10.1111\/jnc.13726. Epub 2016 Aug 1. PMC5037010
TBI Model Type: Weight-drop model
Organism Species: rat
Organism Strain: Wistar
Assessments: Actophotometer, Acetylcholinesterase Activity, Estimation of nitrite, Estimation of protein, Estimation of reduced glutathione, Estimation of superoxide dismutase, Morris Water Maze (MWM), Preference index, degree of lipid peroxidation, hidden platform task, object recognition task, probe trial, Rotarod
Citation: Kaur A, Jaiswal G, Brar J, Kumar P. Neuroprotective effect of nerolidol in traumatic brain injury associated behavioural comorbidities in ratsToxicol Res (Camb). 2021 Jan 5;10(1):40-50. doi: 10.1093\/toxres\/tfaa100. eCollection 2021 Jan. PMC7885190
TBI Model Type: Weight-drop model
Organism Species: rat
Organism Strain: Sprague-Dawley
Assessments: Brain water content, ELISA, Morris water maze (MWM), qrt-PCR, Western blot, Immunofluorescence, hematoxylin and eosin, Inclined plane test, modified Neurologic Severity Score (mNSS)
Citation: Mao SS, Hua R, Zhao XP, Qin X, Sun ZQ, Zhang Y, Wu YQ, Jia MX, Cao JL, Zhang YM.J Neurotrauma. 2012 Jul 1;29(10):1941-59. doi: 10.1089/neu.2011.2244.
TBI Model Type: Weight-drop model
Organism Species: rat
Organism Strain: Sprague-Dawley
Assessments: Brain water content, Enzyme-linked immunosorbent assay (ELISA), Foot fault test, Immunohistochemitry (IHC), Morris Water Maze (MWM), open field test, qRT-PCR, Western blot
Citation: Lan YL, Wang X, Zou YJ, Xing JS, Lou JC, Zou S, Ma BB, Ding Y, Zhang B. Bazedoxifene protects cerebral autoregulation after traumatic brain injury and attenuates impairments in blood-brain barrier damage: involvement of anti-inflammatory pathways by blocking MAPK signalingInflamm Res. 2019 Apr;68(4):311-323. doi: 10.1007\/s00011-019-01217-z. Epub 2019 Jan 31.
TBI Model Type: Fluid percussion injury model
Organism Species: mouse
Organism Strain: ICR
Assessments: Morris water maze (MWM), Hidden Platform, Probe Trial, Visible Platform, Novel object recognition test, Y-Maze Test
Citation: Eakin K, Baratz-Goldstein R, Pick CG, Zindel O, Balaban CD, Hoffer ME, Lockwood M, Miller J, Hoffer BJ.Efficacy of N-acetyl cysteine in traumatic brain injury.PLoS One. 2014 Apr 16;9(4):e90617. doi: 10.1371/journal.pone.0090617. eCollection 2014.
TBI Model Type: Controlled cortical impact model
Organism Species: rat
Organism Strain: Sprague-Dawley
Assessments: Brain water content, Enzyme-linked immunosorbent assay (ELISA), Foot fault test, Immunohistochemitry (IHC), Morris Water Maze (MWM), open field test, qRT-PCR, Western blot
Citation: Lan YL, Wang X, Zou YJ, Xing JS, Lou JC, Zou S, Ma BB, Ding Y, Zhang B. Bazedoxifene protects cerebral autoregulation after traumatic brain injury and attenuates impairments in blood-brain barrier damage: involvement of anti-inflammatory pathways by blocking MAPK signalingInflamm Res. 2019 Apr;68(4):311-323. doi: 10.1007\/s00011-019-01217-z. Epub 2019 Jan 31.
TBI Model Type: Weight-drop model
Organism Species: mouse
Organism Strain: B6C3F1
Assessments: Nissl staining, blood-brain barrier integrity, Novel object test, Histology, Latency to right, Mean arterial pressure, Morris water maze (MWM)
Citation: DeFord SM, Wilson MS, Rice AC, Clausen T, Rice LK, Barabnova A, Bullock R, Hamm RJ.J Neurotrauma. 2002 Apr;19(4):427-38. doi: 10.1089/08977150252932389.
TBI Model Type: Weight-drop model
Organism Species: mouse
Organism Strain: ICR
Assessments: Morris water maze (MWM), Free swim test
Citation: Zohar O, Getslev V, Miller AL, Schreiber S, Pick CG.Neurosci Lett. 2006 Feb 20;394(3):239-42. doi: 10.1016/j.neulet.2005.10.099. Epub 2005 Dec 13.
