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On page 2 showing 21 ~ 40 out of 95 results
Snippet Table

TBI Model Type: Controlled cortical impact model
Organism Species: rat
Organism Strain: Long-Evans
Assessments: Immunohistochemistry (IHC), Cresyl violet staining
Citation: Meaney DF, Ross DT, Winkelstein BA, Brasko J, Goldstein D, Bilston LB, Thibault LE, Gennarelli TA. Modification of the cortical impact model to produce axonal injury in the rat cerebral cortexJ Neurotrauma. 1994 Oct;11(5):599-612. doi: 10.1089\/neu.1994.11.599.

TBI Model Type: Weight-drop model
Organism Species: rat
Organism Strain: Wistar
Assessments: Accelerometer measurement, Immunohistochemistry (IHC)
Citation: Viano DC, Hamberger A, Bolouri H, Säljö A. Evaluation of three animal models for concussion and serious brain injuryAnn Biomed Eng. 2012 Jan;40(1):213-26. doi: 10.1007\/s10439-011-0386-2. Epub 2011 Oct 20.

TBI Model Type: Weight-drop model
Organism Species: mouse
Organism Strain: C57BL/6J
Assessments: Fluoro-Jade C staining (FJC), Immunohistochemistry (IHC)
Citation: Hetzer SM, Shalosky EM, Torrens JN, Evanson NK. Chronic Histological Outcomes of Indirect Traumatic Optic Neuropathy in Adolescent Mice: Persistent Degeneration and Temporally Regulated Glial ResponsesCells. 2021 Nov 28;10(12):3343. doi: 10.3390\/cells10123343. PMC8699438

TBI Model Type: Blast model
Organism Species: mouse
Organism Strain: C57BL/6J
Assessments: Polyunsaturated Fatty Acids analysis, Sphingolipids analysis, Immunohistochemistry (IHC), Pavlovian fear conditioning, RT-PCR, Sphingomyelinase Assay, electroretinogram recording, open-field behavior assessment, optokinetic reflex measurement, tail suspension test
Citation: Mondal K, Takahashi H, Cole J 2nd, Del Mar NA, Li C, Stephenson DJ, Allegood J, Cowart LA, Chalfant CE, Reiner A, Mandal N. Systemic Elevation of n-3 Polyunsaturated Fatty Acids (n-3-PUFA) Is Associated with Protection against Visual, Motor, and Emotional Deficits in Mice following Closed-Head Mild Traumatic Brain InjuryMol Neurobiol. 2021 Nov;58(11):5564-5580. doi: 10.1007\/s12035-021-02501-y. Epub 2021 Aug 8. PMC8655834

TBI Model Type: Controlled cortical impact model
Organism Species: mouse
Organism Strain: C57BL/6J
Assessments: Cytokine Assay, Enzyme-linked immunosorbent assay (ELISA), Immunohistochemistry (IHC), astrocytic, hippocampal neurogenesis, microglia responses, radial arm water maze, Rotarod
Citation: Song S, Kong X, Acosta S, Sava V, Borlongan C, Sanchez-Ramos J. Granulocyte colony-stimulating factor promotes behavioral recovery in a mouse model of traumatic brain injuryJ Neurosci Res. 2016 May;94(5):409-23. doi: 10.1002\/jnr.23714. Epub 2016 Jan 29. PMC4805459

TBI Model Type: Blast model
Organism Species: rat
Organism Strain: Sprague-Dawley
Assessments: Enzyme-linked immunosorbent assay (ELISA), RT-PCR, Immunohistochemistry (IHC), Western blot, Brain water content, cortical oxidative stress
Citation: Yang Z, Simovic MO, Edsall PR, Liu B, Cancio TS, Batchinsky AI, Cancio LC, Li Y. HMGB1 Inhibition to Ameliorate Organ Failure and Increase Survival in TraumaBiomolecules. 2022 Jan 8;12(1):101. doi: 10.3390\/biom12010101. PMC8773879

TBI Model Type: Other
Organism Species: rat
Organism Strain: Sprague-Dawley
Assessments: Fluoro-Jade B staining (FJB), Histology, Locomotor behavior, Immunohistochemistry (IHC)
Citation: Turner RC, Naser ZJ, Lucke-Wold BP, Logsdon AF, Vangilder RL, Matsumoto RR, Huber JD, Rosen CL. Single low-dose lipopolysaccharide preconditioning: neuroprotective against axonal injury and modulates glial cellsNeuroimmunol Neuroinflamm. 2017 Jan;4:6-15. doi: 10.20517\/2347-8659.2016.40. Epub 2017 Jan 20. PMC5289820

TBI Model Type: Weight-drop model
Organism Species: rat
Organism Strain: Sprague-Dawley
Assessments: PET/CT imaging, Immunohistochemistry (IHC), optical density, CT, PET
Citation: Kamal SR, Potukutchi S, Gelovani DJ, Bonomi RE, Kallakuri S, Cavanaugh JM, Mangner T, Conti A, Liu RS, Pasqualini R, Arap W, Sidman RL, Perrine SA, Gelovani JG. Spatial and temporal dynamics of HDACs class IIa following mild traumatic brain injury in adult ratsMol Psychiatry. 2022 Mar;27(3):1683-1693. doi: 10.1038\/s41380-021-01369-7. Epub 2022 Jan 14.

TBI Model Type: Weight-drop model
Organism Species: mouse
Organism Strain: C57BL/6J
Assessments: Elevated plus maze, Forced swim test, Horizontal ladder beam, Immunohistochemistry (IHC), Morris Water Maze (MWM), Rotarod, Tail suspension test, Western Blots, optical fractionator probe
Citation: Gold EM, Vasilevko V, Hasselmann J, Tiefenthaler C, Hoa D, Ranawaka K, Cribbs DH, Cummings BJ. Repeated Mild Closed Head Injuries Induce Long-Term White Matter Pathology and Neuronal Loss That Are Correlated With Behavioral DeficitsASN Neuro. 2018 Jan-Dec;10:1759091418781921. doi: 10.1177\/1759091418781921. PMC6050992

TBI Model Type: Weight-drop model
Organism Species: rat
Organism Strain: Sprague-Dawley
Assessments: Evans blue dye, Immunohistochemistry (IHC), SOD activity, GSH-PX activity, MDA activity, qRT-PCR, Western blot, Brain water content
Citation: Zhang B, Wang B, Cao S, Wang Y. Epigallocatechin-3-Gallate (EGCG) Attenuates Traumatic Brain Injury by Inhibition of Edema Formation and Oxidative StressKorean J Physiol Pharmacol. 2015 Nov;19(6):491-7. doi: 10.4196\/kjpp.2015.19.6.491. Epub 2015 Oct 16. PMC4637351

TBI Model Type: Weight-drop model
Organism Species: rat
Organism Strain: Sprague-Dawley
Assessments: CM-DiI dye, DiR dye, Enzyme-Linked Immunosorbent Assay (ELISA), Immunohistochemistry (IHC), TUNEL staining, Western blot, qRT-PCR
Citation: Chen Y, Li J, Ma B, Li N, Wang S, Sun Z, Xue C, Han Q, Wei J, Zhao RC. MSC-derived exosomes promote recovery from traumatic brain injury via microglia\/macrophages in ratAging (Albany NY). 2020 Sep 23;12(18):18274-18296. doi: 10.18632\/aging.103692. Online ahead of print. PMC7585083

TBI Model Type: Weight-drop model
Organism Species: rat
Organism Strain: Sprague-Dawley
Assessments: wet weight-dry weight, Enzyme-linked immunosorbent assay (ELISA), Immunohistochemistry (IHC)
Citation: Weiss E, Dhir T, Collett A, Reola M, Kaplan M, Minimo C, Omert L, Leung P. Effect of complement C1-esterase inhibitor on brain edema and inflammation after mild traumatic brain injury in an animal modelClin Exp Emerg Med. 2020 Jun;7(2):87-94. doi: 10.15441\/ceem.19.050. Epub 2020 Jun 30. PMC7348678

TBI Model Type: Weight-drop model
Organism Species: rat
Organism Strain: Sprague-Dawley
Assessments: Cytokine Assay, Enzyme-linked immunosorbent assay(ELISA), Immunohistochemistry (IHC), hippocampal neurogenesis, microglia response, radial arm water maze, Rotarod
Citation: Chen MM, Zhao GW, He P, Jiang ZL, Xi X, Xu SH, Ma DM, Wang Y, Li YC, Wang GH. Improvement in the neural stem cell proliferation in rats treated with modified \Shengyu\ decoction may contribute to the neurorestorationJ Ethnopharmacol. 2015 May 13;165:9-19. doi: 10.1016\/j.jep.2015.02.037. Epub 2015 Feb 20.

TBI Model Type: Weight-drop model
Organism Species: mouse
Organism Strain: ICR
Assessments: Immunohistochemistry (IHC), Western blot, spectrophotometer
Citation: Li X, Wang H, Gao Y, Li L, Tang C, Wen G, Yang Y, Zhuang Z, Zhou M, Mao L, Fan Y. Quercetin induces mitochondrial biogenesis in experimental traumatic brain injury via the PGC-1α signaling pathwayAm J Transl Res. 2016 Aug 15;8(8):3558-66. eCollection 2016. PMC5009408

TBI Model Type: Weight-drop model
Organism Species: mouse
Organism Strain: Swiss Albino
Assessments: Evans blue staining, Immunohistochemistry (IHC), Neurological Severity Score (NSS), open field test, R(−)-apomorphine challenge, Rotarod test, Western blot
Citation: de Oliveira PA, Ben J, Matheus FC, Schwarzbold ML, Moreira ELG, Rial D, Walz R, Prediger RD. Moderate traumatic brain injury increases the vulnerability to neurotoxicity induced by systemic administration of 6-hydroxydopamine in miceBrain Res. 2017 May 15;1663:78-86. doi: 10.1016\/j.brainres.2017.03.002. Epub 2017 Mar 11.

TBI Model Type: Fluid percussion injury model
Organism Species: mouse
Organism Strain: C57BL/6
Assessments: Agilent 2200 TapeStation assay, DEX, Immunohistochemistry (IHC), LTP assessment, NanoString nCounter analysis, open field test, Paired-pulse ratio, Trace fear conditioning, Y-maze task, electrophysiological assessment
Citation: Tapp ZM, Cornelius S, Oberster A, Kumar JE, Atluri R, Witcher KG, Oliver B, Bray C, Velasquez J, Zhao F, Peng J, Sheridan J, Askwith C, Godbout JP, Kokiko-Cochran ON. Sleep fragmentation engages stress-responsive circuitry, enhances inflammation and compromises hippocampal function following traumatic brain injuryExp Neurol. 2022 Jul;353:114058. doi: 10.1016\/j.expneurol.2022.114058. Epub 2022 Mar 28. PMC9068267

TBI Model Type: Weight-drop model
Organism Species: rat
Organism Strain: Sprague-Dawley
Assessments: Immunohistochemistry (IHC), LC-MS/MS analysis, RT-PCR, Western blot
Citation: Wang H, Chen J, Gao C, Chen W, Chen G, Zhang M, Luo C, Wang T, Chen X, Tao L. TMT-based proteomics analysis to screen potential biomarkers of acute-phase TBI in ratsLife Sci. 2021 Jan 1;264:118631. doi: 10.1016\/j.lfs.2020.118631. Epub 2020 Oct 22.

TBI Model Type: Weight-drop model
Organism Species: mouse
Organism Strain: C57BL6
Assessments: L/D emergence task, Enzyme-linked immunosorbent assay (ELISA), Barnes Maze test test, Contextual fear memory testing, Elevated zero maze, Fear conditioning, Immunohistochemistry (IHC), Light dark escape, Locomotor activity, Novel object localization test, Novel object recognition test, Oligomeric Aβ42 dot blot analysis, Social interaction, Sound-attenuated isolation, Behavioral Testing, Thioflavin S staining, social preference test
Citation: Lesniak A, Pick CG, Misicka A, Lipkowski AW, Sacharczuk M. Biphalin protects against cognitive deficits in a mouse model of mild traumatic brain injury (mTBI)Neuropharmacology. 2016 Feb;101:506-18. doi: 10.1016\/j.neuropharm.2015.10.014. Epub 2015 Oct 22.

TBI Model Type: Weight-drop model
Organism Species: mouse
Organism Strain: ICR
Assessments: Immunohistochemistry (IHC), Nissl staining, Western blot, Brain water content, grip test, spectrophotometer, Neurological Severity Score (NSS)
Citation: Liang J, Wu S, Xie W, He H. Ketamine ameliorates oxidative stress-induced apoptosis in experimental traumatic brain injury via the Nrf2 pathwayDrug Des Devel Ther. 2018 Apr 16;12:845-853. doi: 10.2147\/DDDT.S160046. eCollection 2018. PMC5907785

TBI Model Type: Weight-drop model
Organism Species: mouse
Organism Strain: ICR
Assessments: Brain water content, Immunohistochemistry (IHC), Nissl staining, Western blot, grip test, spectrophotometer
Citation: Fu C, Wang Q, Zhai X, Gao J. Sinomenine reduces neuronal cell apoptosis in mice after traumatic brain injury via its effect on mitochondrial pathwayDrug Des Devel Ther. 2018 Jan 5;12:77-84. doi: 10.2147\/DDDT.S154391. eCollection 2018. PMC5759853

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The PRECISE-TBI toolbox are a collection tools and resources to increase rigor and reproducibility with Traumatic Brain Injury within the PRE Clinical Interagency reSearch resourcE - Traumatic Brain Injury (PRECISE-TBI). Please learn more about PRECISE-TBI at https://www.precise-tbi.org

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