On page 2 showing 21 ~ 40 out of 47 results
TBI Model Type: Weight-drop model
Organism Species: mouse
Organism Strain: ICR
Assessments: open field test, CORT level, Novel object recognition test, foot fault test, Immunofluorescence, NeuN staining, Cresyl violet staining
Citation: Baratz R, Tweedie D, Wang JY, Rubovitch V, Luo W, Hoffer BJ, Greig NH, Pick CG. Transiently lowering tumor necrosis factor-α synthesis ameliorates neuronal cell loss and cognitive impairments induced by minimal traumatic brain injury in miceJ Neuroinflammation. 2015 Mar 7;12:45. doi: 10.1186\/s12974-015-0237-4. PMC4352276
TBI Model Type: Weight-drop model
Organism Species: mouse
Organism Strain: ICR
Assessments: open field test, CORT level, Novel object recognition test, foot fault test, Immunofluorescence, NeuN staining, Cresyl violet staining
Citation: Baratz-Goldstein R, Toussia-Cohen S, Elpaz A, Rubovitch V, Pick CG. Immediate and delayed hyperbaric oxygen therapy as a neuroprotective treatment for traumatic brain injury in miceMol Cell Neurosci. 2017 Sep;83:74-82. doi: 10.1016\/j.mcn.2017.06.004. Epub 2017 Jul 8.
TBI Model Type: Weight-drop model
Organism Species: mouse
Organism Strain: C57BL/6
Assessments: Enzyme-linked immunosorbent assay (ELISA), Evans blue dye extravasation, Functional Magnetic resonance imaging (MRI), Immunofluorescence, Western blot, Brain water content, Neurological Severity Score (NSS), wire grip test, motion test
Citation: Yang Q, Zhang S, Xu Z, Liu L, Fan S, Wu S, Ma C. The Effectiveness of Trigeminal Nerve Stimulation on Traumatic Brain InjuryNeuromodulation. 2022 Jan 20:S1094-7159(21)06389-3. doi: 10.1016\/j.neurom.2021.10.014. Online ahead of print.
TBI Model Type: Weight-drop model
Organism Species: rat
Organism Strain: Lewis
Assessments: Lowry’s method, Lung Wet/Dry Ratios, Hematoxylin and Eosin, Immunofluorescence, qRT-PCR, semiquantitative scoring system
Citation: Liu Y, Lu J, Wang X, Chen L, Liu S, Zhang Z, Yao W. Erythropoietin-Derived Peptide Protects Against Acute Lung Injury After Rat Traumatic Brain InjuryCell Physiol Biochem. 2017;41(5):2037-2044. doi: 10.1159\/000475434. Epub 2017 Apr 14.
TBI Model Type: Other
Organism Species: mouse
Organism Strain: C57BL/6
Assessments: Brain water content, Enzyme-linked immunosorbent assay (ELISA), Evans blue permeability assay, Immunofluorescence, TUNEL staining, Western blot, modified Neurological Severity Score (mNSS)
Citation: Mannix R, Berkner J, Mei Z, Alcon S, Hashim J, Robinson S, Jantzie L, Meehan WP 3rd, Qiu J. Adolescent Mice Demonstrate a Distinct Pattern of Injury after Repetitive Mild Traumatic Brain InjuryJ Neurotrauma. 2017 Jan 15;34(2):495-504. doi: 10.1089\/neu.2016.4457. Epub 2016 Jul 27. PMC5220578
TBI Model Type: Weight-drop model
Organism Species: rat
Organism Strain: Sprague-Dawley
Assessments: Immunofluorescence, Immunohistochemistry (IHC), Lesion Volume, Morris Water Maze (MWM), Neurobehavioral Evaluation, Nissl staining, beam walk
Citation: Li D, Ma S, Guo D, Cheng T, Li H, Tian Y, Li J, Guan F, Yang B, Wang J. Environmental Circadian Disruption Worsens Neurologic Impairment and Inhibits Hippocampal Neurogenesis in Adult Rats After Traumatic Brain InjuryCell Mol Neurobiol. 2016 Oct;36(7):1045-55. doi: 10.1007\/s10571-015-0295-2. Epub 2016 Feb 17. PMC4967018
TBI Model Type: Weight-drop model
Organism Species: mouse
Organism Strain: ICR
Assessments: Brain water content, Immunofluorescence, Nissl Staining, qRT-PCR, TUNEL staining, Western blot, Neurological Severity Score (NSS)
Citation: Liu Z, Wang H, Shi X, Li L, Zhou M, Ding H, Yang Y, Li X, Ding K. DL-3-n-Butylphthalide (NBP) Provides Neuroprotection in the Mice Models After Traumatic Brain Injury via Nrf2-ARE Signaling PathwayNeurochem Res. 2017 May;42(5):1375-1386. doi: 10.1007\/s11064-017-2186-z. Epub 2017 Feb 18.
TBI Model Type: Weight-drop model
Organism Species: mouse
Organism Strain: C57BL/6N
Assessments: IntelliCage Test, object recognition test, Organ Weight to Body Weight Ratio, Immunofluorescence, Neurological Severity Score (NSS)
Citation: Stetter C, Lopez-Caperuchipi S, Hopp-Krämer S, Bieber M, Kleinschnitz C, Sirén AL, Albert-Weißenberger C. Amelioration of Cognitive and Behavioral Deficits after Traumatic Brain Injury in Coagulation Factor XII Deficient MiceInt J Mol Sci. 2021 May 3;22(9):4855. doi: 10.3390\/ijms22094855. PMC8124758
TBI Model Type: Weight-drop model
Organism Species: mouse
Organism Strain: C57BL/6
Assessments: Lesion Volume, Cresyl Violet Staining, Enzyme-Linked Immunosorbent Assay (Enzyme-linked immunosorbent assay), Grip Strength Test, Immunofluorescence, Novel object recognition test, Rotarod Test, Western blot, Y-Maze Test
Citation: Ahmed ME, Selvakumar GP, Kempuraj D, Raikwar SP, Thangavel R, Bazley K, Wu K, Khan O, Khan A, Zaheer S, Iyer S, Burton C, James D, Zaheer A. Glia Maturation Factor (GMF) Regulates Microglial Expression Phenotypes and the Associated Neurological Deficits in a Mouse Model of Traumatic Brain InjuryMol Neurobiol. 2020 Nov;57(11):4438-4450. doi: 10.1007\/s12035-020-02040-y. Epub 2020 Jul 31.
TBI Model Type: Weight-drop model
Organism Species: mouse
Organism Strain: C57BL/6J
Assessments: Fluoro-Jade B staining (FJB), Immunofluorescence, Locomotion, Optomotor/Optokinetic Response, Visual Acuity Testing, Western blot, mean fluorescence intensity
Citation: Hetzer SM, Guilhaume-Correa F, Day D, Bedolla A, Evanson NK. Traumatic Optic Neuropathy Is Associated with Visual Impairment, Neurodegeneration, and Endoplasmic Reticulum Stress in Adolescent MiceCells. 2021 Apr 23;10(5):996. doi: 10.3390\/cells10050996. PMC8146890
TBI Model Type: Weight-drop model
Organism Species: rat
Organism Strain: Sprague-Dawley
Assessments: Electrophysiological, Magnetic resonance imaging (MRI), Immunofluorescence
Citation: Goddeyne C, Nichols J, Wu C, Anderson T. Repetitive mild traumatic brain injury induces ventriculomegaly and cortical thinning in juvenile ratsJ Neurophysiol. 2015 May 1;113(9):3268-80. doi: 10.1152\/jn.00970.2014. Epub 2015 Feb 18. PMC4440238
TBI Model Type: Weight-drop model
Organism Species: mouse
Organism Strain: ICR
Assessments: Brain water content, Enzyme-linked immunosorbent assay (ELISA), Evans blue permeability assay, Immunofluorescence, TUNEL staining, Western blot, modified Neurological Severity Score (mNSS)
Citation: Cheng H, Di G, Gao CC, He G, Wang X, Han YL, Sun LA, Zhou ML, Jiang X. FTY720 Reduces Endothelial Cell Apoptosis and Remodels Neurovascular Unit after Experimental Traumatic Brain InjuryInt J Med Sci. 2021 Jan 1;18(2):304-313. doi: 10.7150\/ijms.49066. eCollection 2021. PMC7757143
TBI Model Type: Weight-drop model
Organism Species: mouse
Organism Strain: C57BL/6
Assessments: Evans blue dye, Fluoro-jade C staining (FJC), Histology, Immunofluorescence, Neurological Severity Score (NSS), Western blot, Brain water content
Citation: Li H, Sun J, Wang F, Ding G, Chen W, Fang R, Yao Y, Pang M, Lu ZQ, Liu J. Sodium butyrate exerts neuroprotective effects by restoring the blood-brain barrier in traumatic brain injury miceBrain Res. 2016 Jul 1;1642:70-78. doi: 10.1016\/j.brainres.2016.03.031. Epub 2016 Mar 24.
TBI Model Type: Weight-drop model
Organism Species: mouse
Organism Strain: ICR
Assessments: Brain water content, Immunofluorescence, Malondialdehyde level, Neurological Severity Score (NSS), qRT-PCR, TUNEL staining, Western blot, glutathione peroxidase, superoxide dismutase
Citation: Fang J, Wang H, Zhou J, Dai W, Zhu Y, Zhou Y, Wang X, Zhou M. Baicalin provides neuroprotection in traumatic brain injury mice model through Akt\/Nrf2 pathwayDrug Des Devel Ther. 2018 Aug 10;12:2497-2508. doi: 10.2147\/DDDT.S163951. eCollection 2018. PMC6089097
TBI Model Type: Weight-drop model
Organism Species: mouse
Organism Strain: C57BL/6
Assessments: Brain water content, Fluoro-Jade C staining (FJC), Immunofluorescence, TUNEL staining, Western blot, qPCR, spectrophotometer
Citation: Dong W, Yang B, Wang L, Li B, Guo X, Zhang M, Jiang Z, Fu J, Pi J, Guan D, Zhao R. Curcumin plays neuroprotective roles against traumatic brain injury partly via Nrf2 signalingToxicol Appl Pharmacol. 2018 May 1;346:28-36. doi: 10.1016\/j.taap.2018.03.020. Epub 2018 Mar 21.
TBI Model Type: Weight-drop model
Organism Species: mouse
Organism Strain: ICR
Assessments: Brain water content, Immunofluorescence, TUNEL staining, Western blot, grip test, qRT-PCR, spectrophotometer
Citation: Yang Y, Wang H, Li L, Li X, Wang Q, Ding H, Wang X, Ye Z, Wu L, Zhang X, Zhou M, Pan H. Sinomenine Provides Neuroprotection in Model of Traumatic Brain Injury via the Nrf2-ARE PathwayFront Neurosci. 2016 Dec 23;10:580. doi: 10.3389\/fnins.2016.00580. eCollection 2016. PMC5179594
TBI Model Type: Weight-drop model
Organism Species: mouse
Organism Strain: ICR
Assessments: Brain water content, Enzyme-linked immunosorbent assay (ELISA), Immunofluorescence, Neurological evaluation, Nissl Staining, Western blot, modified Garcia method
Citation: He GY, Zhao CH, Wu DG, Cheng H, Sun LA, Zhang DL, Yang XJ, Fan XR, Di GF, Jiang XC. S100A8 Promotes Inflammation via Toll-Like Receptor 4 After Experimental Traumatic Brain InjuryFront Neurosci. 2021 Feb 3;14:616559. doi: 10.3389\/fnins.2020.616559. eCollection 2020. PMC7887321
TBI Model Type: Weight-drop model
Organism Species: rat
Organism Strain: Sprague-Dawley
Assessments: Immunofluorescence, open field test, TUNEL staining, Western blot
Citation: Li SS, Xie LL, Li ZZ, Fan YJ, Qi MM, Xi YG. Androgen is responsible for enhanced susceptibility of melatonin against traumatic brain injury in femalesNeurosci Lett. 2021 May 1;752:135842. doi: 10.1016\/j.neulet.2021.135842. Epub 2021 Mar 22.
TBI Model Type: Weight-drop model
Organism Species: mouse
Organism Strain: C57BL/6J
Assessments: Dichlorofluorescein Diacetate Dye, Immunofluorescence, Neurological Severity Score )NSS), Nissl staining, TUNEL staining, Western Blot, Optical density, qRT-PCR
Citation: Yang XJ, Ling S, Zhou ML, Deng HJ, Qi M, Liu XL, Zhen C, Chen YX, Fan XR, Wu ZY, Ma FC, Rong J, Di GF, Jiang XC. Inhibition of TRPA1 Attenuates Oxidative Stress-induced Damage After Traumatic Brain Injury via the ERK\/AKT Signaling PathwayNeuroscience. 2022 Feb 11;494:51-68. doi: 10.1016\/j.neuroscience.2022.02.003. Online ahead of print.
TBI Model Type: Weight-drop model
Organism Species: mouse
Organism Strain: C57BL/6
Assessments: Enzyme-linked immunosorbent assay (ELISA), Immunofluorescence, Novel object recognition test, Toluidine Blue stain, crystal violet staining
Citation: Kempuraj D, Ahmed ME, Selvakumar GP, Thangavel R, Raikwar SP, Zaheer SA, Iyer SS, Burton C, James D, Zaheer A. Mast Cell Activation, Neuroinflammation, and Tight Junction Protein Derangement in Acute Traumatic Brain InjuryMediators Inflamm. 2020 Jun 24;2020:4243953. doi: 10.1155\/2020\/4243953. eCollection 2020. PMC7333064
