On page 2 showing 21 ~ 40 out of 68 results
TBI Model Type: Weight-drop model
Organism Species: mouse
Organism Strain: C57BL/6
Assessments: 16S ribosomal RNA gene sequencing, Blood–brain barrier permeability, Enzyme-linked immunosorbent assay (ELISA), Histology, RT-PCR, Western blot, Brain water content, limulus amebocyte lysate assay, Neurological Severity Score (NSS), Rotarod test
Citation: Ma Y, Liu T, Fu J, Fu S, Hu C, Sun B, Fan X, Zhu J. Lactobacillus acidophilus Exerts Neuroprotective Effects in Mice with Traumatic Brain InjuryJ Nutr. 2019 Sep 1;149(9):1543-1552. doi: 10.1093\/jn\/nxz105.
TBI Model Type: Weight-drop model
Organism Species: rat
Organism Strain: Sprague-Dawley
Assessments: ELISA, Brain water content, EMSA, rt-PCR, Immunohistochemistry (IHC), Western blot
Citation: Lv Q, Fan X, Xu G, Liu Q, Tian L, Cai X, Sun W, Wang X, Cai Q, Bao Y, Zhou L, Zhang Y, Ge L, Guo R, Liu X.Brain Res. 2013 Feb 1;1493:80-9. doi: 10.1016/j.brainres.2012.11.028. Epub 2012 Nov 23.
TBI Model Type: Weight-drop model
Organism Species: rat
Organism Strain: Sprague-Dawley
Assessments: ELISA, Immunofluorescence, Lesion volume, Nissl staining, Beam balance test, Brain water content, Prehensile traction test
Citation: Zhao GW, Wang Y, Li YC, Jiang ZL, Sun L, Xi X, He P, Wang GH, Xu SH, Ma DM, Ke KF.J Ethnopharmacol. 2014;151(1):694-703. doi: 10.1016/j.jep.2013.11.041. Epub 2013 Dec 1.
TBI Model Type: Weight-drop model
Organism Species: mouse
Organism Strain: ICR
Assessments: TTC staining method, Current responses, Enzyme-linked immunosorbent assay, Nissl staining, brain water content, immunofluorescent staining, neurological severity score, wet and dry weight method
Citation: Zhai PP, Xu LH, Yang JJ, Jiang ZL, Zhao GW, Sun L, Wang GH, Li X.Reduction of inflammatory responses by L-serine treatment leads to neuroprotection in mice after traumatic brain injury.Neuropharmacology. 2015 Aug;95:1-11. doi: 10.1016/j.neuropharm.2015.02.026. Epub 2015 Mar 5.
TBI Model Type: Weight-drop model
Organism Species: rat
Organism Strain: Sprague-Dawley
Assessments: Haematoxylin-eosin staining, NO content, Real-time polymerase chain reaction, Western blotting, brain water content, neurological severity score
Citation: Wei L, Zhang Y, Yang C, Wang Q, Zhuang Z, Sun Z.Neuroprotective effects of ebselen in traumatic brain injury model: involvement of nitric oxide and p38 mitogen-activated protein kinase signalling pathwayClin Exp Pharmacol Physiol. 2014 Feb;41(2):134-8. doi: 10.1111/1440-1681.12186.10.1111/1440-1681.12186
TBI Model Type: Weight-drop model
Organism Species: mouse
Organism Strain: ICR
Assessments: Brain water content, Enzyme-linked immunosorbent assay (ELISA), Western blot
Citation: Lu XY, Wang HD, Xu JG, Ding K, Li T.Pretreatment with tert-butylhydroquinone attenuates cerebral oxidative stress in mice after traumatic brain injury.J Surg Res. 2014 May 1;188(1):206-12. doi: 10.1016/j.jss.2013.11.1106. Epub 2013 Dec 1.
TBI Model Type: Weight-drop model
Organism Species: rat
Organism Strain: Albino
Assessments: Evans blue dye, Intracranial pressure assessment, Veterinary Coma Scale, blood - brain –barrier permeability, Brain water content
Citation: Khaksari M, Mahmmodi R, Shahrokhi N, Shabani M, Joukar S, Aqapour M.The Effects of Shilajit on Brain Edema, Intracranial Pressure and Neurologic Outcomes following the Traumatic Brain Injury in Rat.Iran J Basic Med Sci. 2013 Jul;16(7):858-64.
TBI Model Type: Weight-drop model
Organism Species: rat
Organism Strain: Sprague-Dawley
Assessments: Brain water content, Neurological severity score (NSS)
Citation: Ohayon S, Boyko M, Saad A, Douvdevani A, Gruenbaum BF, Melamed I, Shapira Y, Teichberg VI, Zlotnik A.J Neurotrauma. 2012 Jan 20;29(2):261-7. doi: 10.1089/neu.2011.1938. Epub 2011 Dec 7.
TBI Model Type: Weight-drop model
Organism Species: rat
Organism Strain: Sprague-Dawlay
Assessments: TUNEL staining, transmission electron microscope, Enzyme-linked immunosorbent assay (ELISA), Immunofluorescence, Neurological Severity Score (NSS), Morris Water Maze (MWM), Western blot, Brain water content
Citation: Shen M, Wang S, Wen X, Han XR, Wang YJ, Zhou XM, Zhang MH, Wu DM, Lu J, Zheng YL. Dexmedetomidine exerts neuroprotective effect via the activation of the PI3K\/Akt\/mTOR signaling pathway in rats with traumatic brain injuryBiomed Pharmacother. 2017 Nov;95:885-893. doi: 10.1016\/j.biopha.2017.08.125. Epub 2017 Sep 10.
TBI Model Type: Weight-drop model
Organism Species: mouse
Organism Strain: C57BL/6
Assessments: Enzyme-linked immunosorbent assay (ELISA), Evans blue dye extravasation, Functional Magnetic resonance imaging (MRI), Immunofluorescence, Western blot, Brain water content, Neurological Severity Score (NSS), wire grip test, motion test
Citation: Yang Q, Zhang S, Xu Z, Liu L, Fan S, Wu S, Ma C. The Effectiveness of Trigeminal Nerve Stimulation on Traumatic Brain InjuryNeuromodulation. 2022 Jan 20:S1094-7159(21)06389-3. doi: 10.1016\/j.neurom.2021.10.014. Online ahead of print.
TBI Model Type: Weight-drop model
Organism Species: mouse
Organism Strain: ICR
Assessments: Brain water content, Immunohistochemistry (IHC), Nissl Staining, Western blot, Grip test, spectrophotometer
Citation: Zhai X, Ding Y, Wang Q, Zhang H, Li F. Rutin Acid Ameliorates Neural Apoptosis Induced by Traumatic Brain Injury via Mitochondrial Pathways in MiceNeuroimmunomodulation. 2016;23(3):179-187. doi: 10.1159\/000448716. Epub 2016 Sep 20.
TBI Model Type: Weight-drop model
Organism Species: mouse
Organism Strain: C57BL/6
Assessments: Brain water content, Enzyme-linked immunosorbent assay (ELISA), Evans blue extravasation, Neurological Severity Score (NSS), Novel object recognition, Rotarod test, TUNEL staining, Western blot, lactate dehydrogenase release
Citation: Wang P, Pan B, Tian J, Yang L, Chen Z, Yang L, Fan Z. Ac-FLTD-CMK inhibits pyroptosis and exerts neuroprotective effect in a mice model of traumatic brain injuryNeuroreport. 2021 Feb 3;32(3):188-197. doi: 10.1097\/WNR.0000000000001580.
TBI Model Type: Controlled cortical impact model
Organism Species: mouse
Organism Strain: C57BL/6
Assessments: Hematoxylin and Eosin, Morris Water Maze (MWM), Brain water content, Immunohistochemistry (IHC), seizure activity, wire-grip test
Citation: Dapul HR, Park J, Zhang J, Lee C, DanEshmand A, Lok J, Ayata C, Gray T, Scalzo A, Qiu J, Lo EH, Whalen MJ. Concussive injury before or after controlled cortical impact exacerbates histopathology and functional outcome in a mixed traumatic brain injury model in miceJ Neurotrauma. 2013 Mar 1;30(5):382-91. doi: 10.1089\/neu.2012.2536. Epub 2013 Feb 20. PMC3593692
TBI Model Type: Fluid percussion injury model
Organism Species: mouse
Organism Strain: C57BL/6J
Assessments: modified Neurological Severity Score (mNSS), qRT-PCR, Western blot, Brain water content, Oxidative Stress Evaluation
Citation: Chen Y, Lu Y, Xu S, Liu M, Chen W, Zhang Y, Wei L, Zhong C. HDAC1 expression is positively correlated with NADPH oxidase 4-mediated oxidative stress in a mouse model of traumatic brain injuryJ Neurophysiol. 2022 May 1;127(5):1438-1444. doi: 10.1152\/jn.00049.2022. Epub 2022 Apr 20.
TBI Model Type: Weight-drop model
Organism Species: rat
Organism Strain: Sprague-Dawley
Assessments: Brain water content, Dual-luciferase reporter gene assay, Histology, qRT-PCR, TUNEL staining, Western blot, Enzyme-linked immunosorbent assay (ELISA), Neurological Severity Score (NSS)
Citation: Cui C, Zhang D, Sun K, Li H, Xu L, Lin G, Guo Y, Hu J, Chen J, Nong L, Cai Y, Yu D, Yang W, Wang P, Sun Y. Propofol maintains Th17\/Treg cell balance and reduces inflammation in rats with traumatic brain injury via the miR‑145‑3p\/NFATc2\/NF‑κB axisInt J Mol Med. 2021 Jul;48(1):135. doi: 10.3892\/ijmm.2021.4968. Epub 2021 May 26. PMC8148094
TBI Model Type: Weight-drop model
Organism Species: rat
Organism Strain: Sprague-Dawley
Assessments: Immunohistochemistry (IHC), Western blot, Brain water content, Neurological Severity Score (NSS)
Citation: Wang YC, Cui Y, Cui JZ, Sun LQ, Cui CM, Zhang HA, Zhu HX, Li R, Tian YX, Gao JL. Neuroprotective effects of brilliant blue G on the brain following traumatic brain injury in ratsMol Med Rep. 2015 Aug;12(2):2149-54. doi: 10.3892\/mmr.2015.3607. Epub 2015 Apr 14.
TBI Model Type: Other
Organism Species: mouse
Organism Strain: C57BL/6
Assessments: Brain water content, Enzyme-linked immunosorbent assay (ELISA), Evans blue permeability assay, Immunofluorescence, TUNEL staining, Western blot, modified Neurological Severity Score (mNSS)
Citation: Mannix R, Berkner J, Mei Z, Alcon S, Hashim J, Robinson S, Jantzie L, Meehan WP 3rd, Qiu J. Adolescent Mice Demonstrate a Distinct Pattern of Injury after Repetitive Mild Traumatic Brain InjuryJ Neurotrauma. 2017 Jan 15;34(2):495-504. doi: 10.1089\/neu.2016.4457. Epub 2016 Jul 27. PMC5220578
TBI Model Type: Weight-drop model
Organism Species: mouse
Organism Strain: Swiss
Assessments: Neurological Score test, Neurological deficit assessment, qRT-PCR, Western Blot, Brain water content
Citation: Lopez-Rodriguez AB, Acaz-Fonseca E, Viveros MP, Garcia-Segura LM. Changes in cannabinoid receptors, aquaporin 4 and vimentin expression after traumatic brain injury in adolescent male mice. Association with edema and neurological deficitPLoS One. 2015 Jun 3;10(6):e0128782. doi: 10.1371\/journal.pone.0128782. eCollection 2015. PMC4454518
TBI Model Type: Weight-drop model
Organism Species: rat
Organism Strain: Sprague-Dawley
Assessments: Immunohistochemistry (IHC), Morris Water Maze (MWM), Neurological Severity Score (NSS), Western blot, Brain water content
Citation: Zhang MH, Zhou XM, Cui JZ, Wang KJ, Feng Y, Zhang HA. Neuroprotective effects of dexmedetomidine on traumatic brain injury: Involvement of neuronal apoptosis and HSP70 expressionMol Med Rep. 2018 Jun;17(6):8079-8086. doi: 10.3892\/mmr.2018.8898. Epub 2018 Apr 19. PMC5983975
TBI Model Type: Weight-drop model
Organism Species: mouse
Organism Strain: ICR
Assessments: Brain water content, Immunofluorescence, Nissl Staining, qRT-PCR, TUNEL staining, Western blot, Neurological Severity Score (NSS)
Citation: Liu Z, Wang H, Shi X, Li L, Zhou M, Ding H, Yang Y, Li X, Ding K. DL-3-n-Butylphthalide (NBP) Provides Neuroprotection in the Mice Models After Traumatic Brain Injury via Nrf2-ARE Signaling PathwayNeurochem Res. 2017 May;42(5):1375-1386. doi: 10.1007\/s11064-017-2186-z. Epub 2017 Feb 18.
