On page 19 showing 361 ~ 380 out of 498 results
TBI Model Type: Weight-drop model
Organism Species: rat
Organism Strain: Sprague-Dawley
Assessments: Five serial choice reaction time task, Immunohistochemistry (IHC), Western blot
Citation: Kaukas L, Holmes JL, Rahimi F, Collins-Praino L, Corrigan F. Injury during adolescence leads to sex-specific executive function deficits in adulthood in a pre-clinical model of mild traumatic brain injuryBehav Brain Res. 2021 Mar 26;402:113067. doi: 10.1016\/j.bbr.2020.113067. Epub 2020 Dec 14.
TBI Model Type: Weight-drop model
Organism Species: rat
Organism Strain: Sprague-Dawley
Assessments: Brain water content, Immunohistochemistry (IHC), Neurological evaluation, Nissl staining, TUNEL staining, Western blot, spectrophotometer
Citation: Wei W, Wang H, Wu Y, Ding K, Li T, Cong Z, Xu J, Zhou M, Huang L, Ding H, Wu H. Alpha lipoic acid inhibits neural apoptosis via a mitochondrial pathway in rats following traumatic brain injuryNeurochem Int. 2015 Aug;87:85-91. doi: 10.1016\/j.neuint.2015.06.003. Epub 2015 Jun 6.
TBI Model Type: Weight-drop model
Organism Species: rat
Organism Strain: Wistar Albino
Assessments: Biuret method, Malondialdehyde content, CAT activity, Enzyme-linked immunosorbent assay (ELISA), GSH estimation, Hyper-emotionality test, SOD activity, Sucrose preference test, colorimetric assay, open field test
Citation: Jindal A, Mahesh R, Bhatt S, Pandey D. Molecular modifications by regulating cAMP signaling and oxidant-antioxidant defence mechanisms, produce antidepressant-like effect: A possible mechanism of etazolate aftermaths of impact accelerated traumatic brain injury in rat modelNeurochem Int. 2017 Dec;111:3-11. doi: 10.1016\/j.neuint.2016.12.004. Epub 2016 Dec 14.
TBI Model Type: Weight-drop model
Organism Species: mouse
Organism Strain: ICR
Assessments: Brain water content, Immunofluorescence, TUNEL staining, Western blot, grip test, qRT-PCR, spectrophotometer
Citation: Yang Y, Wang H, Li L, Li X, Wang Q, Ding H, Wang X, Ye Z, Wu L, Zhang X, Zhou M, Pan H. Sinomenine Provides Neuroprotection in Model of Traumatic Brain Injury via the Nrf2-ARE PathwayFront Neurosci. 2016 Dec 23;10:580. doi: 10.3389\/fnins.2016.00580. eCollection 2016. PMC5179594
TBI Model Type: Weight-drop model
Organism Species: mouse
Organism Strain: ICR
Assessments: Brain water content, Enzyme-linked immunosorbent assay (ELISA), Immunofluorescence, Neurological evaluation, Nissl Staining, Western blot, modified Garcia method
Citation: He GY, Zhao CH, Wu DG, Cheng H, Sun LA, Zhang DL, Yang XJ, Fan XR, Di GF, Jiang XC. S100A8 Promotes Inflammation via Toll-Like Receptor 4 After Experimental Traumatic Brain InjuryFront Neurosci. 2021 Feb 3;14:616559. doi: 10.3389\/fnins.2020.616559. eCollection 2020. PMC7887321
TBI Model Type: Weight-drop model
Organism Species: rat
Organism Strain: Sprague-Dawley
Assessments: Immunofluorescence, open field test, TUNEL staining, Western blot
Citation: Li SS, Xie LL, Li ZZ, Fan YJ, Qi MM, Xi YG. Androgen is responsible for enhanced susceptibility of melatonin against traumatic brain injury in femalesNeurosci Lett. 2021 May 1;752:135842. doi: 10.1016\/j.neulet.2021.135842. Epub 2021 Mar 22.
TBI Model Type: Blast model
Organism Species: mouse
Organism Strain: C57BL/6J
Assessments: AP firing patterns, AP threshold, Electrophysiological recordings, Input resistance, Resting membrane potential, Spontaneous neuronal activity, action potential generation, fast after-hyperpolarizations, hyperpolarization-activated cation current recordings, infrared-differential interference contrast microscopy
Citation: Simmons S, Langlois LD, Oyola MG, Gouty S, Wu TJ, Nugent FS. Blast-Induced Mild Traumatic Brain Injury Alterations of Corticotropin-Releasing Factor Neuronal Activity in the Mouse Hypothalamic Paraventricular NucleusFront Synaptic Neurosci. 2022 Jan 27;13:804898. doi: 10.3389\/fnsyn.2021.804898. eCollection 2021. PMC8828487
TBI Model Type: Weight-drop model
Organism Species: rat
Organism Strain: Sprague-Dawley
Assessments: Immunohistochemistry (IHC), Fluoro-Jade C staining (FJC), Neurological function score, TUNEL staining, Brain water content, Western blot
Citation: Zhu J, Lin X, Chen C, Tan H, Gao Y, Li D, Chen G. WNK3 Promotes Neuronal Survival after Traumatic Brain Injury in RatsNeuroscience. 2021 Nov 21;477:76-88. doi: 10.1016\/j.neuroscience.2021.09.021. Epub 2021 Oct 6.
TBI Model Type: Weight-drop model
Organism Species: rat
Organism Strain: Wistar Han
Assessments: Barnes Maze test, GC/MS methods, Rotarod test, Enzyme-linked immunosorbent assay (ELISA), ultrasensitive single-molecule array
Citation: Scrimgeour AG, Condlin ML, Loban A, DeMar JC. Omega-3 Fatty Acids and Vitamin D Decrease Plasma T-Tau, GFAP, and UCH-L1 in Experimental Traumatic Brain InjuryFront Nutr. 2021 Jun 4;8:685220. doi: 10.3389\/fnut.2021.685220. eCollection 2021. PMC8211733
TBI Model Type: Weight-drop model
Organism Species: mouse
Organism Strain: C57BL/6J
Assessments: Dichlorofluorescein Diacetate Dye, Immunofluorescence, Neurological Severity Score )NSS), Nissl staining, TUNEL staining, Western Blot, Optical density, qRT-PCR
Citation: Yang XJ, Ling S, Zhou ML, Deng HJ, Qi M, Liu XL, Zhen C, Chen YX, Fan XR, Wu ZY, Ma FC, Rong J, Di GF, Jiang XC. Inhibition of TRPA1 Attenuates Oxidative Stress-induced Damage After Traumatic Brain Injury via the ERK\/AKT Signaling PathwayNeuroscience. 2022 Feb 11;494:51-68. doi: 10.1016\/j.neuroscience.2022.02.003. Online ahead of print.
TBI Model Type: Weight-drop model
Organism Species: mouse
Organism Strain: CD-1
Assessments: RayBiotech cytokine array, SOMA scan assay
Citation: Tweedie D, Karnati HK, Mullins R, Pick CG, Hoffer BJ, Goetzl EJ, Kapogiannis D, Greig NH. Time-dependent cytokine and chemokine changes in mouse cerebral cortex following a mild traumatic brain injuryElife. 2020 Aug 17;9:e55827. doi: 10.7554\/eLife.55827. PMC7473773
TBI Model Type: Weight-drop model
Organism Species: mouse
Organism Strain: C57BL/6
Assessments: Enzyme-linked immunosorbent assay (ELISA), Immunofluorescence, Novel object recognition test, Toluidine Blue stain, crystal violet staining
Citation: Kempuraj D, Ahmed ME, Selvakumar GP, Thangavel R, Raikwar SP, Zaheer SA, Iyer SS, Burton C, James D, Zaheer A. Mast Cell Activation, Neuroinflammation, and Tight Junction Protein Derangement in Acute Traumatic Brain InjuryMediators Inflamm. 2020 Jun 24;2020:4243953. doi: 10.1155\/2020\/4243953. eCollection 2020. PMC7333064
TBI Model Type: Blast model
Organism Species: mouse
Organism Strain: C57BL/6-C3F1/J transgenic
Assessments: Amyloid burden, Astrocytic end feet contacts estimation, Capillary density estimation, Immunohistochemistry (IHC), Pericyte estimation, Histology
Citation: Clark AT, Abrahamson EE, Harper MM, Ikonomovic MD. Chronic effects of blast injury on the microvasculature in a transgenic mouse model of Alzheimer's disease related Aβ amyloidosisFluids Barriers CNS. 2022 Jan 10;19(1):5. doi: 10.1186\/s12987-021-00301-z. PMC8751260
TBI Model Type: Weight-drop model
Organism Species: mouse
Organism Strain: C57BL/6
Assessments: Brain water content, M29, 79-dichlorodihydrofluorescein diacetate (DCFH-DA) staining, Morris Water Maze, Neurological Severity Scores, Nissl staining, TdT-mediated dUTP Nick-End Labeling, We performed modified Neurological Severity Scores (mNSS), rotarod test, and Morris Water Maze (MWM) test, respectively (n = 8 for each group), enzyme linked immunosorbent assay, immunofluorescence, immunohistochemistry, quantitative real time polymerase chain reaction, rotarod test, western blot
Citation: Wang H, Zhou XM, Wu LY, Liu GJ, Xu WD, Zhang XS, Gao YY, Tao T, Zhou Y, Lu Y, Wang J, Deng CL, Zhuang Z, Hang CH, Li W.Aucubin alleviates oxidative stress and inflammation via Nrf2-mediated signaling activity in experimental traumatic brain injuryJ Neuroinflammation. 2020 Jun 15;17(1):188. doi: 10.1186/s12974-020-01863-9.PMC729463110.1186/s12974-020-01863-9
TBI Model Type: Weight-drop model
Organism Species: rat
Organism Strain: Wistar
Assessments: ELISA antibody kits, Estimation of GABA and glutamate, Estimation of lipid peroxidation, Estimation of nitrite, High-performance liquid chromatography, Morris water maze, exploration behavior test, forelimb grip strength, method of Ellman, method of Lowry, novel object, open field apparatus
Citation: Rana A, Singh S, Deshmukh R, Kumar A.Pharmacological potential of tocopherol and doxycycline against traumatic brain injury-induced cognitive/motor impairment in ratsBrain Inj. 2020 Jul 2;34(8):1039-1050. doi: 10.1080/02699052.2020.1772508. Epub 2020 Jun 4.10.1080/02699052.2020.1772508
TBI Model Type: Weight-drop model
Organism Species: mouse
Organism Strain: C57BL6/J
Assessments: Neuropsychiatric, Rotarod, forced swim test, immunohistochemistry
Citation: Niziolek GM, Boudreau RM, Baker J, Friend LA, Makley AT, Edwards MJ, Gulbins E, Goodman MD.Acid Sphingomyelinase Inhibition Mitigates Histopathological and Behavioral Changes in a Murine Model of Traumatic Brain InjuryJ Neurotrauma. 2020 Sep 1;37(17):1902-1909. doi: 10.1089/neu.2019.6436. Epub 2020 May 4.PMC748489510.1089/neu.2019.6436
TBI Model Type: Weight-drop model
Organism Species: mouse
Organism Strain: C57BL/6
Assessments: EEG
Citation: Shandra O, Robel S.Inducing Post-Traumatic Epilepsy in a Mouse Model of Repetitive Diffuse Traumatic Brain InjuryJ Vis Exp. 2020 Feb 10;(156):10.3791/60360. doi: 10.3791/60360.PMC967733110.3791/60360
TBI Model Type: Weight-drop model
Organism Species: mouse
Organism Strain: ICR
Assessments: Behavioral, Elevated Plus Maze Paradigm, Fluoro Jade B, Immunohistochemistry, Novel Object Recognition Paradigm, Western Blotting, Y-Maze Paradigm, glial fibrillary acidic protein, neuronal nuclear antigen
Citation: Bader M, Li Y, Tweedie D, Shlobin NA, Bernstein A, Rubovitch V, Tovar-Y-Romo LB, DiMarchi RD, Hoffer BJ, Greig NH, Pick CG.Neuroprotective Effects and Treatment Potential of Incretin Mimetics in a Murine Model of Mild Traumatic Brain InjuryFront Cell Dev Biol. 2020 Jan 10;7:356. doi: 10.3389/fcell.2019.00356. eCollection 2019.PMC696503110.3389/fcell.2019.00356
TBI Model Type: Weight-drop model
Organism Species: rat
Organism Strain: Sprague-Dawley
Assessments: Behavioral, Western blotting, beam walk, elevated plus maze, forced swim, multi-plex enzyme-linked immunosorbent assay, novel context mismatch, quantitative polymerase chain reaction
Citation: Fraunberger EA, DeJesus P, Zanier ER, Shutt TE, Esser MJ.Acute and Persistent Alterations of Cerebellar Inflammatory Networks and Glial Activation in a Rat Model of Pediatric Mild Traumatic Brain InjuryJ Neurotrauma. 2020 Jun 1;37(11):1315-1330. doi: 10.1089/neu.2019.6714. Epub 2020 Feb 25.10.1089/neu.2019.6714
TBI Model Type: Weight-drop model
Organism Species: rat
Organism Strain: Sprague-Dawley
Assessments: Bederson test, Evans blue fluorescence, MRI, Perls staining, TUNEL, Western blot, behavioral, brain water content, enzyme-linked immunosorbent assay, immunohistochemistry, magnetic resonance imaging, myelin basic protein (MBP) expression, quantitative real-time PCR
Citation: Wei L, Zhang J, Zhang B, Geng J, Tan Q, Wang L, Chen Z, Feng H, Zhu G.Complement C3 participates in the function and mechanism of traumatic brain injury at simulated high altitudeBrain Res. 2020 Jan 1;1726:146423. doi: 10.1016/j.brainres.2019.146423. Epub 2019 Oct 22.10.1016/j.brainres.2019.146423
