On page 17 showing 321 ~ 340 out of 498 results
TBI Model Type: Weight-drop model
Organism Species: rat
Organism Strain: Sprague-Dawley
Assessments: Electrophysiological, Magnetic resonance imaging (MRI), Immunofluorescence
Citation: Goddeyne C, Nichols J, Wu C, Anderson T. Repetitive mild traumatic brain injury induces ventriculomegaly and cortical thinning in juvenile ratsJ Neurophysiol. 2015 May 1;113(9):3268-80. doi: 10.1152\/jn.00970.2014. Epub 2015 Feb 18. PMC4440238
TBI Model Type: Weight-drop model
Organism Species: zebrafish
Organism Strain: No strain reported
Assessments: Sonic Hedgehog Modulation, Evans Blue Assay, Fluid Content Measurement, Hoshi protocol, Image Acquisition, Immediate and Delayed Recall, Immunohistochemistry (IHC), Learning, Locomotion velocity, qRT-PCR, Sensorimotor Assay, Shuttle Box Assay Testing Apparatus, Startle Response Habituation, TUNEL staining, Vascular Injury, optical density, tonic-clonic seizure metrics
Citation: Hentig J, Cloghessy K, Lahne M, Jung YJ, Petersen RA, Morris AC, Hyde DR. Zebrafish Blunt-Force TBI Induces Heterogenous Injury Pathologies That Mimic Human TBI and Responds with Sonic Hedgehog-Dependent Cell Proliferation across the NeuroaxisBiomedicines. 2021 Jul 22;9(8):861. doi: 10.3390\/biomedicines9080861. PMC8389629
TBI Model Type: Weight-drop model
Organism Species: mouse
Organism Strain: ICR
Assessments: Brain water content, Enzyme-linked immunosorbent assay (ELISA), Evans blue permeability assay, Immunofluorescence, TUNEL staining, Western blot, modified Neurological Severity Score (mNSS)
Citation: Cheng H, Di G, Gao CC, He G, Wang X, Han YL, Sun LA, Zhou ML, Jiang X. FTY720 Reduces Endothelial Cell Apoptosis and Remodels Neurovascular Unit after Experimental Traumatic Brain InjuryInt J Med Sci. 2021 Jan 1;18(2):304-313. doi: 10.7150\/ijms.49066. eCollection 2021. PMC7757143
TBI Model Type: Blast model
Organism Species: rat
Organism Strain: Sprague-Dawley
Assessments: Fractional anisotropy, Heart rate, core temperature, functional Magnetic resonance imaging (MRI), regional heterogeneity, respiration
Citation: Chen H, Chan YL, Nguyen LT, Mao Y, de Rosa A, Beh IT, Chee C, Oliver B, Herok G, Saad S, Gorrie C. Moderate traumatic brain injury is linked to acute behaviour deficits and long term mitochondrial alterationsClin Exp Pharmacol Physiol. 2016 Nov;43(11):1107-1114. doi: 10.1111\/1440-1681.12650.
TBI Model Type: Weight-drop model
Organism Species: mouse
Organism Strain: ICR
Assessments: Aggleton index, Immunohistochemistry (IHC), Novel object recognition test, Y-maze, Enzyme-linked immunosorbent assay (ELISA)
Citation: Benady A, Freidin D, Pick CG, Rubovitch V. GM1 ganglioside prevents axonal regeneration inhibition and cognitive deficits in a mouse model of traumatic brain injurySci Rep. 2018 Sep 6;8(1):13340. doi: 10.1038\/s41598-018-31623-y. PMC6127193
TBI Model Type: Weight-drop model
Organism Species: mouse
Organism Strain: ICR
Assessments: Histology, Immunohistochemitry, Western blot, error ladder walking test, Novel object recognition test
Citation: Li Y, Bader M, Tamargo I, Rubovitch V, Tweedie D, Pick CG, Greig NH. Liraglutide is neurotrophic and neuroprotective in neuronal cultures and mitigates mild traumatic brain injury in miceJ Neurochem. 2015 Dec;135(6):1203-1217. doi: 10.1111\/jnc.13169. Epub 2015 Jun 18. PMC4644713
TBI Model Type: Controlled cortical impact model
Organism Species: rat
Organism Strain: Sprague-Dawley
Assessments: Immunohistochemistry (IHC)
Citation: Farajzadeh Khosroshahi S, Yin X, K Donat C, McGarry A, Yanez Lopez M, Baxan N, J Sharp D, Sastre M, Ghajari M. Multiscale modelling of cerebrovascular injury reveals the role of vascular anatomy and parenchymal shear stressesSci Rep. 2021 Jun 21;11(1):12927. doi: 10.1038\/s41598-021-92371-0. PMC8217506
TBI Model Type: Controlled cortical impact model
Organism Species: mouse
Organism Strain: C57BL/6
Assessments: Histology, Morris Water Maze (MWM), Beam balance test, Beam walk test, memory retention, rotarod
Citation: Hill JL, Kobori N, Zhao J, Rozas NS, Hylin MJ, Moore AN, Dash PK. Traumatic brain injury decreases AMP-activated protein kinase activity and pharmacological enhancement of its activity improves cognitive outcomeJ Neurochem. 2016 Oct;139(1):106-19. doi: 10.1111\/jnc.13726. Epub 2016 Aug 1. PMC5037010
TBI Model Type: Weight-drop model
Organism Species: mouse
Organism Strain: C57BL/6
Assessments: Rotational thromboelastometry
Citation: Midura EF, Jernigan PL, Kuethe JW, Friend LA, Veile R, Makley AT, Caldwell CC, Goodman MD. Microparticles impact coagulation after traumatic brain injuryJ Surg Res. 2015 Jul;197(1):25-31. doi: 10.1016\/j.jss.2015.02.064. Epub 2015 Mar 5. PMC5857955
TBI Model Type: Controlled cortical impact model
Organism Species: rat
Organism Strain: Sprague-Dawley
Assessments: Bicinchoninic acid (BCA) assay, Western blot
Citation: Osier ND, Pham L, Pugh BJ, Puccio A, Ren D, Conley YP, Alexander S, Dixon CE. Brain injury results in lower levels of melatonin receptors subtypes MT1 and MT2Neurosci Lett. 2017 May 22;650:18-24. doi: 10.1016\/j.neulet.2017.03.053. Epub 2017 Apr 2. PMC5886725
TBI Model Type: Controlled cortical impact model
Organism Species: ferret
Organism Strain: No strain reported
Assessments: Adhesive tape detection test, Gait, Immunohistochemistry (IHC), Magnetic resonance imaging (MRI), Novel object recognition test, Open field test
Citation: Schwerin SC, Hutchinson EB, Radomski KL, Ngalula KP, Pierpaoli CM, Juliano SL. Establishing the ferret as a gyrencephalic animal model of traumatic brain injury: Optimization of controlled cortical impact proceduresJ Neurosci Methods. 2017 Jun 15;285:82-96. doi: 10.1016\/j.jneumeth.2017.05.010. Epub 2017 May 10. PMC6320441
TBI Model Type: Weight-drop model
Organism Species: rat
Organism Strain: Sprague-Dawley
Assessments: Western blot
Citation: Arun P, Oguntayo S, Albert SV, Gist I, Wang Y, Nambiar MP, Long JB. Acute decrease in alkaline phosphatase after brain injury: A potential mechanism for tauopathyNeurosci Lett. 2015 Nov 16;609:152-8. doi: 10.1016\/j.neulet.2015.10.036. Epub 2015 Oct 19.
TBI Model Type: Other
Organism Species: pig
Organism Strain: No strain reported
Assessments: Histology, Immunohistochemistry (IHC), microdialysis
Citation: Kilbaugh TJ, Bhandare S, Lorom DH, Saraswati M, Robertson CL, Margulies SS. Cyclosporin A preserves mitochondrial function after traumatic brain injury in the immature rat and pigletJ Neurotrauma. 2011 May;28(5):763-74. doi: 10.1089\/neu.2010.1635. Epub 2011 Apr 12. PMC3125546
TBI Model Type: Weight-drop model
Organism Species: mouse
Organism Strain: Swiss Albino
Assessments: Neurological score
Citation: Lopez-Rodriguez AB, Acaz-Fonseca E, Giatti S, Caruso D, Viveros MP, Melcangi RC, Garcia-Segura LM. Correlation of brain levels of progesterone and dehydroepiandrosterone with neurological recovery after traumatic brain injury in female micePsychoneuroendocrinology. 2015 Jun;56:1-11. doi: 10.1016\/j.psyneuen.2015.02.018. Epub 2015 Mar 3.
TBI Model Type: Other
Organism Species: rat
Organism Strain: Sprague-Dawley
Assessments: light microscope, Immunocytochemistry, electron microscope
Citation: Foda MA, Marmarou A. A new model of diffuse brain injury in rats. Part II: Morphological characterizationJ Neurosurg. 1994 Feb;80(2):301-13. doi: 10.3171\/jns.1994.80.2.0301.
TBI Model Type: Controlled cortical impact model
Organism Species: rat
Organism Strain: Wistar
Assessments: Depth of injured tissue
Citation: Eslami M, Ghanbari E, Sayyah M, Etemadi F, Choopani S, Soleimani M, Amiri Z, Hadjighassem M. Traumatic brain injury accelerates kindling epileptogenesis in ratsNeurol Res. 2016 Mar;38(3):269-74. doi: 10.1179\/1743132815Y.0000000086. Epub 2016 Apr 19.
TBI Model Type: Weight-drop model
Organism Species: rat
Organism Strain: Wistar
Assessments: Actophotometer, Acetylcholinesterase Activity, Estimation of nitrite, Estimation of protein, Estimation of reduced glutathione, Estimation of superoxide dismutase, Morris Water Maze (MWM), Preference index, degree of lipid peroxidation, hidden platform task, object recognition task, probe trial, Rotarod
Citation: Kaur A, Jaiswal G, Brar J, Kumar P. Neuroprotective effect of nerolidol in traumatic brain injury associated behavioural comorbidities in ratsToxicol Res (Camb). 2021 Jan 5;10(1):40-50. doi: 10.1093\/toxres\/tfaa100. eCollection 2021 Jan. PMC7885190
TBI Model Type: Weight-drop model
Organism Species: mouse
Organism Strain: C57BL/6J
Assessments: Image acquisition, Immunohistochemistry (IHC), Microscopy, reflex, Neurological Severity Score (NSS), Prussian blue
Citation: Kahriman A, Bouley J, Smith TW, Bosco DA, Woerman AL, Henninger N. Mouse closed head traumatic brain injury replicates the histological tau pathology pattern of human disease: characterization of a novel model and systematic review of the literatureActa Neuropathol Commun. 2021 Jun 29;9(1):118. doi: 10.1186\/s40478-021-01220-8. PMC8243463
TBI Model Type: Other
Organism Species: rat
Organism Strain: in-house bred
Assessments: Beam walk test, Elevated plus maze, Forced swim test, Novel context mismatch test, open field test, qRT-PCR
Citation: Mychasiuk R, Hehar H, Candy S, Ma I, Esser MJ. The direction of the acceleration and rotational forces associated with mild traumatic brain injury in rodents effect behavioural and molecular outcomesJ Neurosci Methods. 2016 Jan 15;257:168-78. doi: 10.1016\/j.jneumeth.2015.10.002. Epub 2015 Oct 17.
TBI Model Type: Weight-drop model
Organism Species: mouse
Organism Strain: ICR
Assessments: Gene expression, Ingenuity Pathway Analysis tool, Gene Set Enrichment analysis
Citation: Tweedie D, Rachmany L, Kim DS, Rubovitch V, Lehrmann E, Zhang Y, Becker KG, Perez E, Pick CG, Greig NH. Mild traumatic brain injury-induced hippocampal gene expressions: The identification of target cellular processes for drug developmentJ Neurosci Methods. 2016 Oct 15;272:4-18. doi: 10.1016\/j.jneumeth.2016.02.003. Epub 2016 Feb 8. PMC4977213
