On page 15 showing 281 ~ 300 out of 498 results
TBI Model Type: Controlled cortical impact model
Organism Species: mouse
Organism Strain: C57BL/6
Assessments: Hematoxylin and Eosin, Morris Water Maze (MWM), Brain water content, Immunohistochemistry (IHC), seizure activity, wire-grip test
Citation: Dapul HR, Park J, Zhang J, Lee C, DanEshmand A, Lok J, Ayata C, Gray T, Scalzo A, Qiu J, Lo EH, Whalen MJ. Concussive injury before or after controlled cortical impact exacerbates histopathology and functional outcome in a mixed traumatic brain injury model in miceJ Neurotrauma. 2013 Mar 1;30(5):382-91. doi: 10.1089\/neu.2012.2536. Epub 2013 Feb 20. PMC3593692
TBI Model Type: Weight-drop model
Organism Species: mouse
Organism Strain: C57BL/6
Assessments: Barnes Maze test, Basal ROS production, Enzyme-linked immunosorbent assay (ELISA), Fluoro-Jade C staining (FJC), GSH/GSSG activity assay, Hypoxyprobe staining, Neurological Severity Score, NADPH oxidase activity, Novel object recognition test, Western blot, cell viability analysis, Immunocytochemistry, memory recall test
Citation: Ho MH, Yen CH, Hsieh TH, Kao TJ, Chiu JY, Chiang YH, Hoffer BJ, Chang WC, Chou SY. CCL5 via GPX1 activation protects hippocampal memory function after mild traumatic brain injuryRedox Biol. 2021 Oct;46:102067. doi: 10.1016\/j.redox.2021.102067. Epub 2021 Jul 17. PMC8327355
TBI Model Type: Fluid percussion injury model
Organism Species: mouse
Organism Strain: C57BL/6J
Assessments: modified Neurological Severity Score (mNSS), qRT-PCR, Western blot, Brain water content, Oxidative Stress Evaluation
Citation: Chen Y, Lu Y, Xu S, Liu M, Chen W, Zhang Y, Wei L, Zhong C. HDAC1 expression is positively correlated with NADPH oxidase 4-mediated oxidative stress in a mouse model of traumatic brain injuryJ Neurophysiol. 2022 May 1;127(5):1438-1444. doi: 10.1152\/jn.00049.2022. Epub 2022 Apr 20.
TBI Model Type: Controlled cortical impact model
Organism Species: monkey
Organism Strain: Rhesus macaque
Assessments: Magnetic resonance imaging (MRI)
Citation: King C, Robinson T, Dixon CE, Rao GR, Larnard D, Nemoto CE. Brain temperature profiles during epidural cooling with the ChillerPad in a monkey model of traumatic brain injuryJ Neurotrauma. 2010 Oct;27(10):1895-903. doi: 10.1089\/neu.2009.1178. Epub 2010 Sep 16.
TBI Model Type: Controlled cortical impact model
Organism Species: ferret
Organism Strain: No strain reported
Assessments: Histology
Citation: Lighthall JW. Controlled cortical impact: a new experimental brain injury modelJ Neurotrauma. 1988;5(1):1-15. doi: 10.1089\/neu.1988.5.1.
TBI Model Type: Controlled cortical impact model
Organism Species: ferret
Organism Strain: No strain reported
Assessments: Histology
Citation: Lighthall JW, Goshgarian HG, Pinderski CR. Characterization of axonal injury produced by controlled cortical impactJ Neurotrauma. 1990 Summer;7(2):65-76. doi: 10.1089\/neu.1990.7.65.
TBI Model Type: Weight-drop model
Organism Species: rat
Organism Strain: Sprague-Dawley
Assessments: Brain water content, Dual-luciferase reporter gene assay, Histology, qRT-PCR, TUNEL staining, Western blot, Enzyme-linked immunosorbent assay (ELISA), Neurological Severity Score (NSS)
Citation: Cui C, Zhang D, Sun K, Li H, Xu L, Lin G, Guo Y, Hu J, Chen J, Nong L, Cai Y, Yu D, Yang W, Wang P, Sun Y. Propofol maintains Th17\/Treg cell balance and reduces inflammation in rats with traumatic brain injury via the miR‑145‑3p\/NFATc2\/NF‑κB axisInt J Mol Med. 2021 Jul;48(1):135. doi: 10.3892\/ijmm.2021.4968. Epub 2021 May 26. PMC8148094
TBI Model Type: Weight-drop model
Organism Species: rat
Organism Strain: Sprague-Dawley
Assessments: Immunohistochemistry (IHC), Western blot, Brain water content, Neurological Severity Score (NSS)
Citation: Wang YC, Cui Y, Cui JZ, Sun LQ, Cui CM, Zhang HA, Zhu HX, Li R, Tian YX, Gao JL. Neuroprotective effects of brilliant blue G on the brain following traumatic brain injury in ratsMol Med Rep. 2015 Aug;12(2):2149-54. doi: 10.3892\/mmr.2015.3607. Epub 2015 Apr 14.
TBI Model Type: Other
Organism Species: mouse
Organism Strain: C57BL/6J
Assessments: cued fear conditioning, social recognition test, tail suspension test, sucrose/water preference test
Citation: Klemenhagen KC, O'Brien SP, Brody DL. Repetitive concussive traumatic brain injury interacts with post-injury foot shock stress to worsen social and depression-like behavior in micePLoS One. 2013 Sep 18;8(9):e74510. doi: 10.1371\/journal.pone.0074510. eCollection 2013. PMC3776826
TBI Model Type: Other
Organism Species: mouse
Organism Strain: C57BL/6
Assessments: Brain water content, Enzyme-linked immunosorbent assay (ELISA), Evans blue permeability assay, Immunofluorescence, TUNEL staining, Western blot, modified Neurological Severity Score (mNSS)
Citation: Mannix R, Berkner J, Mei Z, Alcon S, Hashim J, Robinson S, Jantzie L, Meehan WP 3rd, Qiu J. Adolescent Mice Demonstrate a Distinct Pattern of Injury after Repetitive Mild Traumatic Brain InjuryJ Neurotrauma. 2017 Jan 15;34(2):495-504. doi: 10.1089\/neu.2016.4457. Epub 2016 Jul 27. PMC5220578
TBI Model Type: Weight-drop model
Organism Species: mouse
Organism Strain: Swiss
Assessments: Neurological Score test, Neurological deficit assessment, qRT-PCR, Western Blot, Brain water content
Citation: Lopez-Rodriguez AB, Acaz-Fonseca E, Viveros MP, Garcia-Segura LM. Changes in cannabinoid receptors, aquaporin 4 and vimentin expression after traumatic brain injury in adolescent male mice. Association with edema and neurological deficitPLoS One. 2015 Jun 3;10(6):e0128782. doi: 10.1371\/journal.pone.0128782. eCollection 2015. PMC4454518
TBI Model Type: Weight-drop model
Organism Species: mouse
Organism Strain: ICR
Assessments: Nissl staining, Enzyme-linked immunosorbent assay (ELISA), Grip test, Immunohistochemistry (IHC), Neurological Severity Score (NSS), Western blot, Grip test
Citation: Song Q, Xie D, Pan S, Xu W. Rapamycin protects neurons from brain contusion‑induced inflammatory reaction via modulation of microglial activationMol Med Rep. 2015 Nov;12(5):7203-10. doi: 10.3892\/mmr.2015.4407. Epub 2015 Oct 1. PMC4626160
TBI Model Type: Weight-drop model
Organism Species: rat
Organism Strain: Sprague-Dawley
Assessments: Duration of unconsciousness, Elevated Plus Maze, H-reflex, Morris Water Maze (MWM), T2-weighted Magnetic resonance imaging (MRI), Rotorod test
Citation: Hou J, Nelson R, Wilkie Z, Mustafa G, Tsuda S, Thompson FJ, Bose P. Mild and Mild-to-Moderate Traumatic Brain Injury-Induced Significant Progressive and Enduring Multiple ComorbiditiesJ Neurotrauma. 2017 Aug 15;34(16):2456-2466. doi: 10.1089\/neu.2016.4851. Epub 2017 Jun 9.
TBI Model Type: Weight-drop model
Organism Species: rat
Organism Strain: Sprague-Dawley
Assessments: Immunohistochemistry (IHC), Morris Water Maze (MWM), Neurological Severity Score (NSS), Western blot, Brain water content
Citation: Zhang MH, Zhou XM, Cui JZ, Wang KJ, Feng Y, Zhang HA. Neuroprotective effects of dexmedetomidine on traumatic brain injury: Involvement of neuronal apoptosis and HSP70 expressionMol Med Rep. 2018 Jun;17(6):8079-8086. doi: 10.3892\/mmr.2018.8898. Epub 2018 Apr 19. PMC5983975
TBI Model Type: Weight-drop model
Organism Species: mouse
Organism Strain: ICR
Assessments: Bioluminescent Somatic Cell Assay, Bradford method, Immunohistochemical staining, Mitochondrial membrane potential (MMP) measurement, Western blot, spectrophotometer
Citation: Li X, Wang H, Gao Y, Li L, Tang C, Wen G, Zhou Y, Zhou M, Mao L, Fan Y. Protective Effects of Quercetin on Mitochondrial Biogenesis in Experimental Traumatic Brain Injury via the Nrf2 Signaling PathwayPLoS One. 2016 Oct 25;11(10):e0164237. doi: 10.1371\/journal.pone.0164237. eCollection 2016. PMC5079551
TBI Model Type: Weight-drop model
Organism Species: rat
Organism Strain: Sprague-Dawley
Assessments: Hematoxylin and Eosin, Nissl staining
Citation: Zhào H, Liu Y, Zeng J, Li D, Huang Y. Troxerutin cerebroprotein hydrolysate injection ameliorates neurovascular injury induced by traumatic brain injury - via endothelial nitric oxide synthase pathway regulationInt J Neurosci. 2018 Dec;128(12):1118-1127. doi: 10.1080\/00207454.2018.1486828. Epub 2018 Nov 4.
TBI Model Type: Weight-drop model
Organism Species: mouse
Organism Strain: C57BL/6
Assessments: Histology, Microscopy, qRT-PCR, Neurological Severity Score (NSS), hematoma size
Citation: Förstner P, Rehman R, Anastasiadou S, Haffner-Luntzer M, Sinske D, Ignatius A, Roselli F, Knöll B. Neuroinflammation after Traumatic Brain Injury Is Enhanced in Activating Transcription Factor 3 Mutant MiceJ Neurotrauma. 2018 Oct 1;35(19):2317-2329. doi: 10.1089\/neu.2017.5593. Epub 2018 Jun 5.
TBI Model Type: Controlled cortical impact model
Organism Species: rat
Organism Strain: Sprague-Dawley
Assessments: Diffusion tensor imaging, Luxol fast blue staining, Magnetic resonance imaging (MRI), T2 weighted imaging, Transmission electron microscopy, Immunohistochemistry (IHC), myelin thickness measurement
Citation: Donovan V, Kim C, Anugerah AK, Coats JS, Oyoyo U, Pardo AC, Obenaus A. Repeated mild traumatic brain injury results in long-term white-matter disruptionJ Cereb Blood Flow Metab. 2014 Apr;34(4):715-23. doi: 10.1038\/jcbfm.2014.6. Epub 2014 Jan 29. PMC3982100
TBI Model Type: Weight-drop model
Organism Species: mouse
Organism Strain: C57BL/6
Assessments: Hematoxylin and Eosin, Nissl staining, Serum S100β, Neurological Severity Score (NSS)
Citation: Guo D, Li D, Li J, Li Y, Hu X, Guan F, Yang B. Topical application of the hematostatic agent Surgiflo® could attenuate brain injury in experimental TBI miceNeurol Res. 2017 Sep;39(9):830-836. doi: 10.1080\/01616412.2017.1330815. Epub 2017 May 31.
TBI Model Type: Controlled cortical impact model
Organism Species: mouse
Organism Strain: C57BL/6J
Assessments: Electron Microscopy, Morris Water Maze (MWM), Immunohistochemistry (IHC)
Citation: Shitaka Y, Tran HT, Bennett RE, Sanchez L, Levy MA, Dikranian K, Brody DL. Repetitive closed-skull traumatic brain injury in mice causes persistent multifocal axonal injury and microglial reactivityJ Neuropathol Exp Neurol. 2011 Jul;70(7):551-67. doi: 10.1097\/NEN.0b013e31821f891f. PMC3118973
