On page 14 showing 261 ~ 280 out of 420 results
TBI Model Type: Weight-drop model
Organism Species: mouse
Organism Strain: C57BL/6N
Assessments: IntelliCage Test, object recognition test, Organ Weight to Body Weight Ratio, Immunofluorescence, Neurological Severity Score (NSS)
Citation: Stetter C, Lopez-Caperuchipi S, Hopp-Krämer S, Bieber M, Kleinschnitz C, Sirén AL, Albert-Weißenberger C. Amelioration of Cognitive and Behavioral Deficits after Traumatic Brain Injury in Coagulation Factor XII Deficient MiceInt J Mol Sci. 2021 May 3;22(9):4855. doi: 10.3390\/ijms22094855. PMC8124758
TBI Model Type: Weight-drop model
Organism Species: mouse
Organism Strain: C57BL/6
Assessments: Lesion Volume, Cresyl Violet Staining, Enzyme-Linked Immunosorbent Assay (Enzyme-linked immunosorbent assay), Grip Strength Test, Immunofluorescence, Novel object recognition test, Rotarod Test, Western blot, Y-Maze Test
Citation: Ahmed ME, Selvakumar GP, Kempuraj D, Raikwar SP, Thangavel R, Bazley K, Wu K, Khan O, Khan A, Zaheer S, Iyer S, Burton C, James D, Zaheer A. Glia Maturation Factor (GMF) Regulates Microglial Expression Phenotypes and the Associated Neurological Deficits in a Mouse Model of Traumatic Brain InjuryMol Neurobiol. 2020 Nov;57(11):4438-4450. doi: 10.1007\/s12035-020-02040-y. Epub 2020 Jul 31.
TBI Model Type: Weight-drop model
Organism Species: mouse
Organism Strain: C57BL
Assessments: Neurological Severity Score (NSS), Prussian blue staining, Nuclear Fast Red Staining, gas liquid chromatography
Citation: Lecques JD, Kerr BJK, Hillyer LM, Kang JX, Robinson LE, Ma DWL. N-3 Polyunsaturated Fatty Acids Ameliorate Neurobehavioral Outcomes Post-Mild Traumatic Brain Injury in the Fat-1 Mouse ModelNutrients. 2021 Nov 15;13(11):4092. doi: 10.3390\/nu13114092. PMC8620437
TBI Model Type: Weight-drop model
Organism Species: mouse
Organism Strain: C57BL/6J
Assessments: Fluoro-Jade B staining (FJB), Immunofluorescence, Locomotion, Optomotor/Optokinetic Response, Visual Acuity Testing, Western blot, mean fluorescence intensity
Citation: Hetzer SM, Guilhaume-Correa F, Day D, Bedolla A, Evanson NK. Traumatic Optic Neuropathy Is Associated with Visual Impairment, Neurodegeneration, and Endoplasmic Reticulum Stress in Adolescent MiceCells. 2021 Apr 23;10(5):996. doi: 10.3390\/cells10050996. PMC8146890
TBI Model Type: Weight-drop model
Organism Species: mouse
Organism Strain: CD-1
Assessments: Brain water content, Enzyme-linked immunosorbent assay (ELISA), Evans blue extravasation, Neurological Severity Score (NSS), Novel object recognition test, Rotarod test, TUNEL staining, Western blot, lactate dehydrogenase release
Citation: Kempuraj D, Ahmed ME, Selvakumar GP, Thangavel R, Raikwar SP, Zaheer SA, Iyer SS, Govindarajan R, Nattanmai Chandrasekaran P, Burton C, James D, Zaheer A. Acute Traumatic Brain Injury-Induced Neuroinflammatory Response and Neurovascular Disorders in the BrainNeurotox Res. 2021 Apr;39(2):359-368. doi: 10.1007\/s12640-020-00288-9. Epub 2020 Sep 21. PMC7502806
TBI Model Type: Weight-drop model
Organism Species: rat
Organism Strain: Sprague-Dawley
Assessments: Magnetic resonance imaging (MRI), Cystometric measurements, measure external urethral sphincter electromyography
Citation: Praveen Rajneesh C, Liou JC, Hsieh TH, Chin HY, Peng CW. Efficacy of Deep Brain Stimulation on the Improvement of the Bladder Functions in Traumatic Brain Injured RatsBrain Sci. 2020 Nov 12;10(11):850. doi: 10.3390\/brainsci10110850. PMC7698168
TBI Model Type: Weight-drop model
Organism Species: rat
Organism Strain: Sprague-Dawley
Assessments: Electrophysiological, Magnetic resonance imaging (MRI), Immunofluorescence
Citation: Goddeyne C, Nichols J, Wu C, Anderson T. Repetitive mild traumatic brain injury induces ventriculomegaly and cortical thinning in juvenile ratsJ Neurophysiol. 2015 May 1;113(9):3268-80. doi: 10.1152\/jn.00970.2014. Epub 2015 Feb 18. PMC4440238
TBI Model Type: Weight-drop model
Organism Species: zebrafish
Organism Strain: No strain reported
Assessments: Sonic Hedgehog Modulation, Evans Blue Assay, Fluid Content Measurement, Hoshi protocol, Image Acquisition, Immediate and Delayed Recall, Immunohistochemistry (IHC), Learning, Locomotion velocity, qRT-PCR, Sensorimotor Assay, Shuttle Box Assay Testing Apparatus, Startle Response Habituation, TUNEL staining, Vascular Injury, optical density, tonic-clonic seizure metrics
Citation: Hentig J, Cloghessy K, Lahne M, Jung YJ, Petersen RA, Morris AC, Hyde DR. Zebrafish Blunt-Force TBI Induces Heterogenous Injury Pathologies That Mimic Human TBI and Responds with Sonic Hedgehog-Dependent Cell Proliferation across the NeuroaxisBiomedicines. 2021 Jul 22;9(8):861. doi: 10.3390\/biomedicines9080861. PMC8389629
TBI Model Type: Blast model
Organism Species: rat
Organism Strain: Sprague-Dawley
Assessments: Fractional anisotropy, Heart rate, core temperature, functional Magnetic resonance imaging (MRI), regional heterogeneity, respiration
Citation: Chen H, Chan YL, Nguyen LT, Mao Y, de Rosa A, Beh IT, Chee C, Oliver B, Herok G, Saad S, Gorrie C. Moderate traumatic brain injury is linked to acute behaviour deficits and long term mitochondrial alterationsClin Exp Pharmacol Physiol. 2016 Nov;43(11):1107-1114. doi: 10.1111\/1440-1681.12650.
TBI Model Type: Weight-drop model
Organism Species: mouse
Organism Strain: ICR
Assessments: Aggleton index, Immunohistochemistry (IHC), Novel object recognition test, Y-maze, Enzyme-linked immunosorbent assay (ELISA)
Citation: Benady A, Freidin D, Pick CG, Rubovitch V. GM1 ganglioside prevents axonal regeneration inhibition and cognitive deficits in a mouse model of traumatic brain injurySci Rep. 2018 Sep 6;8(1):13340. doi: 10.1038\/s41598-018-31623-y. PMC6127193
TBI Model Type: Weight-drop model
Organism Species: mouse
Organism Strain: ICR
Assessments: Histology, Immunohistochemitry, Western blot, error ladder walking test, Novel object recognition test
Citation: Li Y, Bader M, Tamargo I, Rubovitch V, Tweedie D, Pick CG, Greig NH. Liraglutide is neurotrophic and neuroprotective in neuronal cultures and mitigates mild traumatic brain injury in miceJ Neurochem. 2015 Dec;135(6):1203-1217. doi: 10.1111\/jnc.13169. Epub 2015 Jun 18. PMC4644713
TBI Model Type: Controlled cortical impact model
Organism Species: rat
Organism Strain: Sprague-Dawley
Assessments: Immunohistochemistry (IHC)
Citation: Farajzadeh Khosroshahi S, Yin X, K Donat C, McGarry A, Yanez Lopez M, Baxan N, J Sharp D, Sastre M, Ghajari M. Multiscale modelling of cerebrovascular injury reveals the role of vascular anatomy and parenchymal shear stressesSci Rep. 2021 Jun 21;11(1):12927. doi: 10.1038\/s41598-021-92371-0. PMC8217506
TBI Model Type: Controlled cortical impact model
Organism Species: mouse
Organism Strain: C57BL/6
Assessments: Histology, Morris Water Maze (MWM), Beam balance test, Beam walk test, memory retention, rotarod
Citation: Hill JL, Kobori N, Zhao J, Rozas NS, Hylin MJ, Moore AN, Dash PK. Traumatic brain injury decreases AMP-activated protein kinase activity and pharmacological enhancement of its activity improves cognitive outcomeJ Neurochem. 2016 Oct;139(1):106-19. doi: 10.1111\/jnc.13726. Epub 2016 Aug 1. PMC5037010
TBI Model Type: Weight-drop model
Organism Species: mouse
Organism Strain: C57BL/6
Assessments: Rotational thromboelastometry
Citation: Midura EF, Jernigan PL, Kuethe JW, Friend LA, Veile R, Makley AT, Caldwell CC, Goodman MD. Microparticles impact coagulation after traumatic brain injuryJ Surg Res. 2015 Jul;197(1):25-31. doi: 10.1016\/j.jss.2015.02.064. Epub 2015 Mar 5. PMC5857955
TBI Model Type: Controlled cortical impact model
Organism Species: rat
Organism Strain: Sprague-Dawley
Assessments: Bicinchoninic acid (BCA) assay, Western blot
Citation: Osier ND, Pham L, Pugh BJ, Puccio A, Ren D, Conley YP, Alexander S, Dixon CE. Brain injury results in lower levels of melatonin receptors subtypes MT1 and MT2Neurosci Lett. 2017 May 22;650:18-24. doi: 10.1016\/j.neulet.2017.03.053. Epub 2017 Apr 2. PMC5886725
TBI Model Type: Controlled cortical impact model
Organism Species: ferret
Organism Strain: No strain reported
Assessments: Adhesive tape detection test, Gait, Immunohistochemistry (IHC), Magnetic resonance imaging (MRI), Novel object recognition test, Open field test
Citation: Schwerin SC, Hutchinson EB, Radomski KL, Ngalula KP, Pierpaoli CM, Juliano SL. Establishing the ferret as a gyrencephalic animal model of traumatic brain injury: Optimization of controlled cortical impact proceduresJ Neurosci Methods. 2017 Jun 15;285:82-96. doi: 10.1016\/j.jneumeth.2017.05.010. Epub 2017 May 10. PMC6320441
TBI Model Type: Weight-drop model
Organism Species: rat
Organism Strain: Sprague-Dawley
Assessments: Western blot
Citation: Arun P, Oguntayo S, Albert SV, Gist I, Wang Y, Nambiar MP, Long JB. Acute decrease in alkaline phosphatase after brain injury: A potential mechanism for tauopathyNeurosci Lett. 2015 Nov 16;609:152-8. doi: 10.1016\/j.neulet.2015.10.036. Epub 2015 Oct 19.
TBI Model Type: Controlled cortical impact model
Organism Species: rat
Organism Strain: Wistar
Assessments: Depth of injured tissue
Citation: Eslami M, Ghanbari E, Sayyah M, Etemadi F, Choopani S, Soleimani M, Amiri Z, Hadjighassem M. Traumatic brain injury accelerates kindling epileptogenesis in ratsNeurol Res. 2016 Mar;38(3):269-74. doi: 10.1179\/1743132815Y.0000000086. Epub 2016 Apr 19.
TBI Model Type: Weight-drop model
Organism Species: rat
Organism Strain: Wistar
Assessments: Actophotometer, Acetylcholinesterase Activity, Estimation of nitrite, Estimation of protein, Estimation of reduced glutathione, Estimation of superoxide dismutase, Morris Water Maze (MWM), Preference index, degree of lipid peroxidation, hidden platform task, object recognition task, probe trial, Rotarod
Citation: Kaur A, Jaiswal G, Brar J, Kumar P. Neuroprotective effect of nerolidol in traumatic brain injury associated behavioural comorbidities in ratsToxicol Res (Camb). 2021 Jan 5;10(1):40-50. doi: 10.1093\/toxres\/tfaa100. eCollection 2021 Jan. PMC7885190
TBI Model Type: Weight-drop model
Organism Species: mouse
Organism Strain: C57BL/6J
Assessments: Image acquisition, Immunohistochemistry (IHC), Microscopy, reflex, Neurological Severity Score (NSS), Prussian blue
Citation: Kahriman A, Bouley J, Smith TW, Bosco DA, Woerman AL, Henninger N. Mouse closed head traumatic brain injury replicates the histological tau pathology pattern of human disease: characterization of a novel model and systematic review of the literatureActa Neuropathol Commun. 2021 Jun 29;9(1):118. doi: 10.1186\/s40478-021-01220-8. PMC8243463
