On page 10 showing 181 ~ 200 out of 226 results
TBI Model Type: Weight-drop model
Organism Species: mouse
Organism Strain: C57BL/6
Assessments: Immunofluorescence, Processing brain tissue for histology
At 1, 3, 7 and 14 dpi, mice were deeply anesthetized (100 mg/kg sodium pentobarbital) and transcardially perfused with cold phosphate-buffered saline (PBS) followed by 4% paraformaldehyde (PFA) at 4°C, Western blotting, histology
Citation: Dong W, Sun Y, Cheng H, Yang B, Wang L, Jiang Z, Li B, Wen S, Guo X, Guan D, Zhao R.Dynamic cell type-specific expression of Nrf2 after traumatic brain injury in miceEur J Neurosci. 2019 Jul;50(2):1981-1993. doi: 10.1111/ejn.14399. Epub 2019 Apr 23.10.1111/ejn.14399
TBI Model Type: Weight-drop model
Organism Species: mouse
Organism Strain: C57BL/6
Assessments: Automated Capillary Western Blots, Behavioral, Cerebral Edema, Quantitative Real-Time PCR
Citation: Sun M, Brady RD, van der Poel C, Apted D, Semple BD, Church JE, O'Brien TJ, McDonald SJ, Shultz SR.A Concomitant Muscle Injury Does Not Worsen Traumatic Brain Injury Outcomes in MiceFront Neurol. 2018 Dec 11;9:1089. doi: 10.3389/fneur.2018.01089. eCollection 2018.PMC629786710.3389/fneur.2018.01089
TBI Model Type: Weight-drop model
Organism Species: mouse
Organism Strain: C57BL/6
Assessments: EMSA, Immunohistochemistry (IHC), qrt-PCR, Western blot
Citation: Ling HP, Li W, Zhou ML, Tang Y, Chen ZR, Hang CH.J Surg Res. 2013 Jan;179(1):e227-34. doi: 10.1016/j.jss.2012.03.030. Epub 2012 Apr 5.
TBI Model Type: Controlled cortical impact model
Organism Species: mouse
Organism Strain: C57/BL6J
Assessments: Elevated plus maze, Forced swim tests, Immunohistochemistry, Morris Water Maze, Open field test, Western blot analysis, rotarod testing, sucrose preference test
Citation: Wu L, Kalish BT, Finander B, Cao T, Jin G, Yahya T, Levy ES, Kukreja B, LaRovere ES, Chung JY, Lo EH, Brown-Whalen A, El Khoury J, Kaplan DL, Whalen MJ.J Neurosci. 2022 Mar 23;42(12):2418-2432. doi: 10.1523/JNEUROSCI.0682-21.2021. Epub 2022 Feb 1.10.1523/JNEUROSCI.0682-21.2021
TBI Model Type: Weight-drop model
Organism Species: mouse
Organism Strain: ICR
Assessments: Behavioral, FJC, Immunofluorescence staining, Neurological Severity Score, RT-qPCR, TUNEL, Western blot
Citation: Zhou Y, Wang HD, Zhou XM, Fang J, Zhu L, Ding K.N-acetylcysteine amide provides neuroprotection via Nrf2-ARE pathway in a mouse model of traumatic brain injuryDrug Des Devel Ther. 2018 Dec 4;12:4117-4127. doi: 10.2147/DDDT.S179227. eCollection 2018.PMC628453210.2147/DDDT.S179227
TBI Model Type: Weight-drop model
Organism Species: mouse
Organism Strain: C57BL/6
Assessments: Brain water content, Cresyl violet, Forced swim test, Forelimb placement test, Morris water maze test, Novel object recognition, Rotarod test, Sucrose preference test, Tail suspension test, Western blotting, Wire hanging test, enzyme-linked immunosorbent assay, histology, lesion volume, modified neurologic severity score, neuronal death
Citation: Wang J, Jiang C, Zhang K, Lan X, Chen X, Zang W, Wang Z, Guan F, Zhu C, Yang X, Lu H, Wang J.Melatonin receptor activation provides cerebral protection after traumatic brain injury by mitigating oxidative stress and inflammation via the Nrf2 signaling pathwayFree Radic Biol Med. 2019 Feb 1;131:345-355. doi: 10.1016/j.freeradbiomed.2018.12.014. Epub 2018 Dec 13.10.1016/j.freeradbiomed.2018.12.014
TBI Model Type: Weight-drop model
Organism Species: mouse
Organism Strain: ICR
Assessments: open field test, CatWalk, Erasmus ladder, Grip strength, Immunohistochemistry (IHC), Rotarod test, Treadmill, Running wheel
Citation: Namdar I, Feldman R, Glazer S, Meningher I, Shlobin NA, Rubovitch V, Bikovski L, Been E, Pick CG. Motor Effects of Minimal Traumatic Brain Injury in MiceJ Mol Neurosci. 2020 Mar;70(3):365-377. doi: 10.1007\/s12031-019-01422-9. Epub 2019 Dec 9.
TBI Model Type: Weight-drop model
Organism Species: mouse
Organism Strain: ICR
Assessments: Behavioral, Elevated plus maze, Fluoro-Jade, Immunohistochemical staining, Novel object recognition, Y-maze, pharmacokinetic
Citation: Bader M, Li Y, Lecca D, Rubovitch V, Tweedie D, Glotfelty E, Rachmany L, Kim HK, Choi HI, Hoffer BJ, Pick CG, Greig NH, Kim DS.Pharmacokinetics and efficacy of PT302, a sustained-release Exenatide formulation, in a murine model of mild traumatic brain injuryNeurobiol Dis. 2019 Apr;124:439-453. doi: 10.1016/j.nbd.2018.11.023. Epub 2018 Nov 22.PMC671083110.1016/j.nbd.2018.11.023
TBI Model Type: Weight-drop model
Organism Species: mouse
Organism Strain: Balb/C
Assessments: Fluoro-Jade B staining, Beam walk test, hematoxylin and eosin
Citation: Lopez NE, Gaston L, Lopez KR, Hageny AM, Putnam J, Eliceiri B, Coimbra R, Bansal V.J Surg Res. 2014 Mar;187(1):230-236. doi: 10.1016/j.jss.2013.09.030. Epub 2013 Oct 7.
TBI Model Type: Weight-drop model
Organism Species: mouse
Organism Strain: ICR
Assessments: Immunohistochemical, electrophoretic
mobility shift assay, enzyme-linked immunosorbent assay
Citation: Jin W, Wang H, Yan W, Xu L, Wang X, Zhao X, Yang X, Chen G, Ji Y.Disruption of Nrf2 enhances upregulation of nuclear factor-kappaB activity, proinflammatory cytokines, and intercellular adhesion molecule-1 in the brain after traumatic brain injuryMediators Inflamm. 2008;2008:725174. doi: 10.1155/2008/725174. Epub 2009 Jan 25.PMC263040510.1155/2008/725174
TBI Model Type: Blast model
Organism Species: mouse
Organism Strain: C57BL/6J
Assessments: Barnes maze, Simple Neuroassessment of Asymmetric impairment (SNAP), TEM, histopathology, immunohistochemistry, light-dark box, myelin sheath defects, nesting behavior tests, open-field
Citation: Song H, Konan LM, Cui J, Johnson CE, Langenderfer M, Grant D, Ndam T, Simonyi A, White T, Demirci U, Mott DR, Schwer D, Hubler GK, Cernak I, DePalma RG, Gu Z.Ultrastructural brain abnormalities and associated behavioral changes in mice after low-intensity blast exposure.Behav Brain Res. 2018 Jul 16;347:148-157. doi: 10.1016/j.bbr.2018.03.007. Epub 2018 Mar 8.
TBI Model Type: Blast model
Organism Species: mouse
Organism Strain: C57BL/6J
Assessments: Global and phospho-proteomes, Liquid chromatography-mass spectrometry (LC-MS/MS), Simple Neuroassessment of Asymmetric imPairment (SNAP) test, silver staining, KEGG pathway analysis, STRING network
Citation: Chen M, Song H, Cui J, Johnson CE, Hubler GK, DePalma RG, Gu Z, Xia W.Proteomic Profiling of Mouse Brains Exposed to Blast-Induced Mild Traumatic Brain Injury Reveals Changes in Axonal Proteins and Phosphorylated Tau.J Alzheimers Dis. 2018;66(2):751-773. doi: 10.3233/JAD-180726.
TBI Model Type: Blast model
Organism Species: mouse
Organism Strain: C57BL/6J
Assessments: mEPSCs, home-cage monitoring (HCM), CognitionWall, label-free quantitative proteomics, STRING Protein interaction
Citation: Chen S, Siedhoff HR, Zhang H, Liu P, Balderrama A, Li R, Johnson C, Greenlief CM, Koopmans B, Hoffman T, DePalma RG, Li DP, Cui J, Gu Z.Low-intensity blast induces acute glutamatergic hyperexcitability in mouse hippocampus leading to long-term learning deficits and altered expression of proteins involved in synaptic plasticity and serine protease inhibitors.Neurobiol Dis. 2022 Apr;165:105634. doi: 10.1016/j.nbd.2022.105634. Epub 2022 Jan 22.
TBI Model Type: Weight-drop model
Organism Species: mouse
Organism Strain: ICR
Assessments: Brain water content, Immunohistochemical Staining, SOD Activity and Malondialdehyde (MDA) Level, Western Blot analysis, assay kits, neurological severity score, wet/dry weight ratio method
Citation: Lu XY, Wang HD, Xu JG, Ding K, Li T.Deletion of Nrf2 Exacerbates Oxidative Stress After Traumatic Brain Injury in Mice.Cell Mol Neurobiol. 2015 Jul;35(5):713-21. doi: 10.1007/s10571-015-0167-9. Epub 2015 Mar 3.
TBI Model Type: Weight-drop model
Organism Species: mouse
Organism Strain: C57BL/6
Assessments: Evans Blue dye, Immunocytochemistry (IHC), Lesion volume, flow cytometry, Neurologic Severity Score (NSS), rt-PCR, TUNEL staining
Citation: Mencl S, Hennig N, Hopp S, Schuhmann MK, Albert-Weissenberger C, Sirén AL, Kleinschnitz C.J Neuroimmunol. 2014 Sep 15;274(1-2):125-31. doi: 10.1016/j.jneuroim.2014.07.010. Epub 2014 Jul 22.
TBI Model Type: Controlled cortical impact model
Organism Species: mouse
Organism Strain: C57BL/6
Citation: Romine J, Gao X, Chen J.Controlled cortical impact model for traumatic brain injury.J Vis Exp. 2014 Aug 5;(90):e51781. doi: 10.3791/51781.
TBI Model Type: Weight-drop model
Organism Species: mouse
Organism Strain: ICR
Assessments: Brain water content, Enzyme-Linked Immunosorbent Assay, Immunofluorescence staining, Nissl staining, Terminal deoxynucleotidyl transferase-mediated dUTP nick 3′-end labeling (TUNEL), Western blot analysis, neurological severity score
Citation: Ding K, Wang H, Xu J, Lu X, Zhang L, Zhu L.Melatonin reduced microglial activation and alleviated neuroinflammation induced neuron degeneration in experimental traumatic brain injury: Possible involvement of mTOR pathway.Neurochem Int. 2014 Oct;76:23-31. doi: 10.1016/j.neuint.2014.06.015. Epub 2014 Jul 1.
TBI Model Type: Weight-drop model
Organism Species: mouse
Organism Strain: C57BL/6
Assessments: Torsion test, Nissl staining, Prussian blue, rt-PCR
Citation: Yu H, Wergedal JE, Rundle CH, Mohan S.J Rehabil Res Dev. 2014;51(9):1427-37. doi: 10.1682/JRRD.2014.04.0095.
TBI Model Type: Weight-drop model
Organism Species: mouse
Organism Strain: Swiss Webster
Assessments: GFAP and CD45 staining, Histological analysis, Object recognition task assessment, rotor rod test, water content
Citation: Liu P, Li YS, Quartermain D, Boutajangout A, Ji Y.Inhaled nitric oxide improves short term memory and reduces the inflammatory reaction in a mouse model of mild traumatic brain injuryBrain Res. 2013 Jul 19;1522:67-75. doi: 10.1016/j.brainres.2013.05.032. Epub 2013 Jun 4.10.1016/j.brainres.2013.05.032
TBI Model Type: Weight-drop model
Organism Species: mouse
Organism Strain: C57/BL6
Assessments: ELISA, Histology, Magnetic Resonance Imaging, Novel object recognition, righting reflex response, rotarod
Citation: Yang SH, Gustafson J, Gangidine M, Stepien D, Schuster R, Pritts TA, Goodman MD, Remick DG, Lentsch AB.A murine model of mild traumatic brain injury exhibiting cognitive and motor deficitsJ Surg Res. 2013 Oct;184(2):981-8. doi: 10.1016/j.jss.2013.03.075. Epub 2013 Apr 18.PMC407378610.1016/j.jss.2013.03.075
