Curator Dashboard

The Animal Resources Centre (ARC) is a self-funding Statutory Authority of the Government of Western Australia for biomedical research to produce and supply genetically-defined, specific pathogen free (SPF) research rats and mice. Provides contribution of mouse resource information to the IMSR database.

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• SciCrunch
• 8 years ago - submitted by Mason Pairish

GMP compliant Organic Synthesis Core Facility (OSCF) mission is to provide chemical synthesis work.

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• SciCrunch
• 14 years ago - by Anonymous

THIS RESOURCE IS NO LONGER IN SERVCE, documented September 6, 2016. HealthGrid is a wiki dedicated to grids for health. It is maintained as a dynamic knowledge resource for the healthgrid community. The HealthGrid community (a world-wide initiative) gathers individuals from the public and private domain world-wide who are actively exploring the beneficial impact of healthgrid technology on healthcare provision and research.

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• SciCrunch
• 16 years ago - by Anonymous

The genome of the domesticated dog, a close evolutionary relation to human, is a powerful new tool for understanding the human genome. Comparison of the dog with human and other mammals reveals key information about the structure and evolution of genes and genomes. The unique breeding history of dogs, with their extraordinary behavioral and physical diversity, offers the opportunity to find important genes underlying diseases shared between dogs and humans, such as cancer, diabetes, and epilepsy. The Canine Genome Sequencing Project produced a high-quality draft sequence of a female boxer named Tasha. By comparing Tasha with many other breeds, the project also compiled a comprehensive set of SNPs (single nucleotide polymorphisms) useful in all dog breeds. These closely spaced genomic landmarks are critical for disease mapping. By comparing the dog, rodent, and human lineages, researchers at the Broad Institute uncovered exciting new information about human genes, their evolution, and the regulatory mechanisms governing their expression. Using SNPs, researchers describe the strikingly different haplotype structure in dog breeds compared with the entire dog population. In addition, they show that by understanding the patterns of variation in dog breeds, scientists can design powerful gene mapping experiments for complex diseases that are difficult to map in human populations. Contribute Although the astounding generosity of Eli and Edythe L. Broad and several other venture philanthropists empowers our scientists to tackle many of the most important problems at the cutting edge of genomic medicine, there are many other critical challenges that they cannot yet pursue because of limited resources. We need additional visionary partners to join the Broads and the Broad Institute in transforming medicine with the power of genomics.

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• SciCrunch
• 17 years ago - by Anonymous

Provides instruments and expertise needed to visualize molecules in preparations ranging from single cells to entire animals. All facility users receive individualized instrument training as well as project specific advice for optimal data acquisition. Consultation on sample preparation, image rendering, and data analysis are also available as our knowledge base permits.

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• SciCrunch
• 14 years ago - by Anonymous

Supplemental instrument that is a measure of immediate recall in which the participant is presented with a list of 15 unrelated words via audio recording and is asked to recall as many as he/she can. This process is repeated twice more, and the score is equal to the total number of words recalled across all three trials. This instrument is recommended for ages 8-85 as a supplement to the Picture Sequence Memory Test or as a potential alternative in cases where a participant's visual limitations would preclude administering the Picture Sequence Memory Test. The test takes approximately 3 minutes to administer. (The NIH Toolbox version of this test differs from some other available versions in that there are three rather than five learning trials and there is neither a delayed recall trial nor an interference trial.)

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• SciCrunch
• 13 years ago - by Anonymous

Software tool as an open source knowledge mapping software that increases the visibility of research findings for science and society. Visual interface to the world's scientific knowledge.

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• SciCrunch
• 8 years ago - submitted by Anita Bandrowski

Core offers services in areas of peptide synthesis, peptide modification, purification and quality analysis, N-terminal protein sequencing by Edman degradation, and biomolecular interaction analysis and equilibrium and kinetic measurements.

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• SciCrunch
• 14 years ago - by Anonymous

Assessment test that directly measures participants' visual acuity, or distance vision. The participant is seated 12.5 feet away from a computer monitor at eye level, and letters (called optotypes) are displayed one at a time on the screen for the participant to identify, using both eyes at the same time. As the participant successfully identifies optotypes of a given size, smaller ones appear on the screen, until the computer program ascertains the smallest-size optotype the participant can successfully see. Conversely, the program displays larger optotypes if the participant cannot see the letter size that is first displayed, until a size that he/she can accurately see is found. For participants ages 3-7, only the letters H, O, T, and V are used, and children may point to a laminated card showing the letters if they cannot verbalize or cannot recall the letter names. For participants ages 8 and above, the entire set of optotypes is used, following a common protocol used in professional vision testing. This test takes approximately three minutes to administer and is recommended for ages 3-85.

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• SciCrunch
• 13 years ago - by Anonymous

Software application as an open source Pyton library to search and predict miRNA targets.

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• RRID-Legacy
• 8 years ago - by Anonymous

Core microscopy facility managed by Cancer Research Laboratory. Provides campus community with training and access to state-of-the-art light microscopy equipment. Now in two locations: Life Sciences Addition Building (LSA) and the new Li Ka-Shing Center for Biomedical and Health Sciences (LKS). The MIC specializes in live cell imaging, confocal, multi-photon, fluorescent lifetime imaging (FLIM), and equipment for optogenetic research.

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• SciCrunch
• 14 years ago - by Anonymous

A collaboration to test an adaptive clinical trial model that would assess the efficacy of a candidate therapeutic earlier than traditional clinical trials, potentially enabling drugs to be developed and approved using fewer patients, less time and fewer resources. This trial focuses on women with newly diagnosed locally advanced breast cancer to test whether adding investigational drugs to standard chemotherapy is better than standard chemotherapy alone. It uses genetic and biological markers from individual patients' tumors to screen several promising new treatments simultaneously and allows doctors to quickly measure the effectiveness of the treatment prior to removing the tumor. The experimental adaptive trial design uses patient outcomes to immediately inform treatment options for subsequent trial participants. The trial has 5 components that differentiate it from conventional clinical trial models. # I-SPY2 uses tissue and imaging biomarkers from individual cancer patients' tumors to determine eligibility, guide/screen promising new treatments and identify which treatments are most effective in specific tumor subtypes. # The trial's adaptive design allows the Team to learn as they go, enabling researchers to use data from patients early in the trial to guide decisions about which treatments might be more useful for patients who enter the trial earlier. I-SPY2 provides a scientific basis for researchers to eliminate ineffective treatments and graduate effective treatments more quickly. # The neoadjuvant treatment approach - in which chemotherapy is given to patients prior to surgery - allow the team to evaluate tumor response with MRI before removal. This approach is safe as treating after surgery, allowing tumors to shrink, and more importantly, it enables critical learning early on about how well treatments work. # The ability for the team to screen multiple drug candidates developed by multiple companies. New agents will be selected and added as those used initially and either graduate to Phase III, or are dropped, based on their efficacy in targeted patients. # The trials informatics system allows data to be collected, verified, and shared in real-time. This allows data to be assessed early and in an integrated fashion - with an aim to enhance and encourage collaboration

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• Consortia-pedia, a FasterCures Project
• 13 years ago - by Anonymous

Software tool written in Java that reads DICOM-files from Dynamic Susceptibility Contrast (DSC) Magnetic Resonance Imaging (MRI) and calculates standardized Time-to-Peak (stdTTP) parameter. Maps from this calculation are provided as RGB- and Monochrom2-Dicom files and may be sent to a PACS automatically. Works on windows® platforms on PC’s (Intel® CPUs from Pentium I up to the I7-octo cores) together with the Philips 1.5T ACS-NT up to the Ingenia Systems (n> 20.000), with the Philips 3.0T Systems (n ~ 1.000), the Siemens 1.5T Avanto (SQ-machine) (n> 10.000) and the Siemens 3.0T TimTrio (n ~ 200) so far. Works with uncompressed DICOM-standard files.

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• RRID-Legacy
• 8 years ago - by Anonymous

Core provides both short and long read sequencing capabilities for analysis of gene function and expression.Facility specializes in functional genomics and single cell biology. Services include consultation, sample preparation (especially for spatial and single cell applications), quality control, sequencing analysis, bioinformatics support, and assistance with grant and publication writing related to the services. Applications include:gene function analysis - pooled CRISPR screening, multiplexed barcode screens; whole genome sequencing - both short- and long-read sequencing; bulk gene expression profiling; single cell biology (single cells and single nuclei); spatial profiling; pathogen detection and profiling.

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• SciCrunch
• 2 years ago - submitted by Edyta Vieth

Consortium that has aggregated resting state fMRI (R-fMRI) and diffusion imaging data from laboratories around the world, creating an open science resource for the imaging community, that facilitates the assessment of test-retest reliability and reproducibility for functional and structural connectomics. Given that this was a retrospective data collection, they have focused on basic phenotypic measures that are relatively standard in the neuroimaging field, as well as fundamental for analyses and sample characterization. Their phenotypic key is organized to reflect three classifications of variables: 1) core (i.e., minimal variables required to characterize any dataset), 2) preferred (i.e., variables that were strongly suggested for inclusion due to their relative import and/or likelihood of being collected by most sites), and 3) optional (variables that are data-set specific or only shared by a few sites). CoRR includes 33 datasets consisting of: * 1629 Subjects * 3357 Anatomical Scans * 5093 Resting Functional Scans * 1302 Diffusion Scans * 300 CBF and ASL Scans

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• SciCrunch
• 13 years ago - by Anonymous

System for sharing sleep data. Organization portal that aggregates, harmonizes, and organizes sleep and clinical data from individuals studied as part of cohort studies or clinical trials and provides suite of tools to facilitate data exploration and data visualization. National Heart, Lung, and Blood Institute resource designed to provide big data resources to sleep research community.

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• SciCrunch
• 8 years ago - submitted by Edyta Vieth

Software platform to annotate cell types.

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• RRID
• 2 years ago - submitted by Anita Bandrowski

Data repository where researchers can publicly store and share unthresholded statistical brain activation maps produced by MRI and PET studies.

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• SciCrunch
• 13 years ago - by Anonymous

Watch NOW : http://online-tvchannel.org/nfl-allaccess/

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• SciCrunch
• 8 years ago - submitted by Khan online

Provides technology and service capabilities in super resolution microscopy, image analysis, immunohistochemistry, and histopathology services. Provides consultations and technical support on histopathology services and experimental design.

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• RRID
• 2 years ago - by Anonymous