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Software tool to build the "network twin" of 2D and 3D tissues from segmented microscopy images. Used for network generation from segmented tissue images.
Software tool for assignment of cell type across a range of single-cell technologies such as Imaging Mass Cytometry (IMC). Probabilistic model to assign cells to cell types by integrating prior knowledge of marker proteins.
Core specializes in advanced analysis of proteins to investigate brain functions and neurological disorders. Provides equipment to study protein structure, interactions, and modifications. Services include Mass Spectrometry and Advanced Analysis, Protein Production and Engineering, Amplification of Misfolding Proteins, Highly Sensitive Multiplexed Immunodetection, Sample Preparation and Fractionation.
Software molecular interaction-guided graph learning framework for multi-omics cancer classification. Graph Neural Network-Oriented Multi-Omics Integration Network for Cancer Classification.
Clinical neuroscience research institute in Tulsa, Oklahoma, dedicated to identifying biological markers and developing advanced interventions for mental health conditions, including disorders of mood, anxiety, eating, and substance use.
Core provides centralized recruitment, screening, and standardized self-report, interview-based, and behavioral assessments to support psychiatric and mental health research. Using validated measures aligned with transdiagnostic frameworks, the Core facilitates efficient participant recruitment, high-quality data collection, and reproducible assessment procedures across studies. By providing consistent, reliable phenotyping and behavioral data, the Core accelerates research, supports multidisciplinary investigations of mood and anxiety disorders, and serves as a shared resource for investigators within LIBR and collaborating institutions.
Core offers confocal and conventional fluorescence microscopes and image analysis resources. Provides access to standard and advanced imaging instrumentation. Imaging services include help with live cells, fixed samples, model organisms, small animals, single molecules or at most points in between.
Automated incubator and storage device for robotic integration to manage and incubate microplates for cell cultures, assay screening, and biologics workflows without human intervention. Maintains specific temperatures, high humidity, and stable CO₂ levels to keep cells alive and assays viable. Uses ContraCon thermal decontamination (without harmful gases) to maintain a sterile environment and protect sensitive samples.
Reference database of inferred immune receptor genes. Public repository used by immunologists and computational biologists to publish, review, and maintain adaptive immune receptor (antibody and T-cell receptor) genes. Curated database of Ig and TR receptor germline sequences. Provides sets for use in receptor repertoire annotation and analysis, in formats suitable for widely-used analysis tools. Enables reproducible, evidence-based analysis of immune receptor diversity across populations and species, supporting both fundamental immunology research and precision medicine applications.
Core is dedicated process development and through GMP production facility within the UNL College of Engineering, primary focus on microbial (bacteria, yeast) expression systems. Offers biopharmaceutical process development and biomanufacturing services that transition discoveries to non-clinical studies and Phase I/II and early Phase III clinical trials.
Software tool to infer and map cell-to-cell communication networks using single-cell RNA sequencing (scRNA-seq) or proteomics data. Used for inference of intercellular networks from single-cell transcriptomics.
Software R package for calculation and interactive exploration of cell-cell signaling network topologies contained in single-cell RNA-sequencing data. Used to explore cell-cell connectivity patterns based on ligand and receptor data in heterogeneous single-cell datasets.
Software Python toolkit for multi-cellular communication network construction and network analysis of multispecies single-cell and bulk gene expression and proteomic data.
Fully automated IHC/ISH slide staining system with 30 independent slide drawers, single-piece workflow, and capacity for 90 slides/8-hour shift. Automated IHC/ISH slide stainer that handles baking, deparaffinization, and staining. It optimizes laboratory efficiency through continuous access and independent temperature control across its 30 individual slide drawers, supporting a vast library of over 250 ready-to-use assays.
Leica BOND-III Fully Automated IHC and ISH Staining System
Fully automated slide stainer used in clinical pathology and research laboratories. Automatically processes tissue samples. Uses antibodies to detect and visualize specific proteins or antigens within a tissue sample. Uses labeled DNA or RNA probes to detect and map specific genetic sequences or chromosomal abnormalities within the tissue.
Nanofabrication and characterization facility that provides open access to advanced cleanroom infrastructure, instrumentation, and technical expertise. Offers infrastructure for fabrication and characterization of nanoscale materials, systems and devices. Provides user training, process development assistance, and access to specialized expertise for research and prototyping.
Motorized rotary microtome designed to cut extremely thin, uniform slices of paraffin-embedded tissue samples so they can be mounted on glass slides for microscopic examination and disease diagnosis. Offers three sectioning modes (automated, semi-automated, and manual) and features an automatic electronic brake and an anti-static waste tray for enhanced laboratory efficiency.
Software R package that estimates the distance between cell populations in high-dimensional gene-expression space. Used for identification of perturbed cell types in single-cell RNA-seq data.