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Core enables the use of primary human organoids as tissue models for discovery, translation and regenerative medicine by providing:access to high-quality, well-characterized neonatal through adult human organoid lines from multiple organs for investigators studying human development and disease; access to detailed protocols; access to specialized, quality controlled and batch-tested reagents; expertise, guidance and training; help obtaining data;help establishing organoid lines;letters of support for grant submissions.
Fully automated digital PCR system integrating four functions: chip loading, droplet generation, PCR amplification, and signal reading, enabling ultra-multiplex quantitative detection. The device adopts innovative "solid oil-water separation" droplet generation technology, ensuring stable droplets with a high effective ratio. It supports multi-color fluorescence channels and independent temperature control for dual modules, equipped with AI intelligent denoising and recognition functions.
This integrated digital PCR device combines four functions—chip loading, droplet generation, PCR amplification, and signal reading—into one, achieving full process automation and significantly reducing human error. It is compact in size, making it easy to transport and maintain. It is compatible with multiple PCR mixes, has high droplet stability (≥95%), and uses a glass substrate chip to ensure high-quality signal output. It supports single-sample testing, avoiding waste of consumables, and is suitable for flexible and efficient experimental requirements. Translated with DeepL.com (free version)
Software tool to assess gene relevance while enhancing dimensionality-reduction performance. Used to quantify gene relevance and improve dimensionality reduction.
Employer-sourced medical and drugs claims database of the under-65 working population and their dependents, as well as 65+ with Medicare supplemental insurance paid by employers.
Web portal that ranks journals and countries based on their scientific influence, using data from the Scopus database. Provides bibliometric indicators like the SCImago Journal Rank (SJR) indicator, which measures citation impact, and the h-index, which reflects both the productivity and citation impact of a journal or researcher. Portal allows users to analyze journals by subject area, category, and country, offering a valuable tool for assessing research impact and comparing scientific performance.
Software application for identifying transcriptomic and epigenomic changes.
BioDigital Qing is a digital PCR system with automated droplet preparation and reagent formulation, enabling all essential steps of digital PCR—including compartmentalization, thermal cycling, and data acquisition—to be completed on a single instrument. Utilizing nucleic acid quantification technology, it allows for absolute quantification without the need for a standard curve. A large volume of reaction mixture is partitioned or digitized into thousands of small, independent reactions, such that each microchamber contains either one or zero target copies. The original concentration is then calculated using statistical methods based on the number of positive and negative microchambers.
Core performs next generation sequencing for RNA and DNA samples, as well as provides support for downstream analysis.
Cell DIVE Multiplex Imaging Solution is Leica Microsystems’ open, highly customizable platform that combines precision-engineered hardware, iterative staining/dye‑inactivation protocols, and intuitive software to visualize 60+ biomarkers from a single tissue section—delivering crystal-clear, whole‑tissue imaging at the single‑cell level.
X-Light V3 in combination with DeepSIM X-Light super-resolution system. Super-resolution microscopy system used to visualize cellular structures and dynamics at nanoscale resolution, typically around 100 nm in XY and 300 nm in Z. It's designed for both live and fixed cell imaging, including complex 3D models like tissues and organoids, and can be seamlessly integrated with existing confocal microscopes like the X-Light V3.
High-resolution mass spectrometer designed for comprehensive multiomics research. It combines a high-performance Orbitrap mass analyzer with a tribrid architecture (quadrupole, linear ion trap, and Orbitrap) for enhanced ion separation, fragmentation, and detection capabilities. This instrument is particularly well-suited for analyzing proteins, lipids, and metabolites in a single experiment, enabling researchers to gain deeper insights into biological systems
Software R package to identify, annotate and visualize isoform switches with functional consequences from both short- and long-read RNA-seq data. Analysis of alternative splicing and isoform switches with predicted functional consequences (e.g. gain/loss of protein domains etc.) from quantification of all types of RNASeq by tools such as Kallisto, Salmon, StringTie, Cufflinks/Cuffdiff etc.
Software tool, which combine graph deep learning and protein language model, for accurate enzyme function and catalytic site prediction.
Core offers consultation and training to investigators on range of microscopy techniques, including super-resolution, confocal, multi-photon, and advanced fluorescence imaging and image analysis.
Software supporting framework for "Foundation Model of Electronic Medical Records for Adaptive Risk Estimation".
Software tool as simulation program of hypothalamus-pituitary-adrenal axis (HPA axis, aka corticotropic feedback control) for education and research, based on nonlinear MiMe-NoCoDI model and implemented with CyberUnits Bricks library.
System designed for the recording and analysis of animal vocalizations. It supports full-spectrum audio capture from up to four arenas simultaneously using USB microphones, enabling precise, synchronized data collection. The software architecture incorporates advanced analysis capabilities that streamline the identification, quantification, and interpretation of vocal behaviors. UltraVox XT can also process imported audio files, expanding its applicability beyond live recordings. These features make it a versatile tool for animal behavior researchers, with flexibility to meet both current and evolving experimental needs.
Cytometry and Cell Imaging Core provides researchers with access to equipment in three main pipelines:Cell and tissue imaging resources, including microscopes and a slide scanner;Flow cytometry, including analytical flow cytometry and cell sorting.;Mass cytometry (CyTOF).Core provides instrument training, help with experimental design and technical support. Core specializes in antibody-based techniques.Provides expertise in cell sorting, imaging and high-parameter analysis of cells and tissues.
Core provides tissue-based and clinical laboratory assays, biospecimens, consultative pathology services, multiparametric imaging, mass spectrometry, molecular pathology, mouse models and advanced cellular therapeutics for basic, translational, and clinical research.