Curator Dashboard

Software tool to predict CD4+ T cell epitopes, model MHC-II antigen presentation, and assess immune responses. It helps scientists with vaccine design, cancer neoantigen discovery, and tracking viral mutations.

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• 3 weeks ago - by Anonymous

Software tool for predicting MHC class II antigen immunogenicity through transfer learning. Used to predict whether epitope-MHC class II complex can elicit T cell response.

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• 3 weeks ago - by Anonymous

Software tool that predicts how protein pieces bind to Major Histocompatibility Complex (MHC) molecules. It uses deep learning to process peptide sequences, handle variable lengths, and evaluate both common and rare alleles. Used to predicts peptide-MHC binding. Can predict binding for common or rare alleles of MHC class I or II with a single neural network architecture.

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• 3 weeks ago - by Anonymous

Web multimodal recurrent neural network tool designed to predict HLA-II (Human Leukocyte Antigen class II) peptide ligand presentation. It uses cell HLA alleles, peptide sequences, and source genes to evaluate antigen presentation. Used for predicting the likelihood of antigen presentation from a gene of interest in the context of specific HLA class II alleles.

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• 3 weeks ago - by Anonymous

Webserver for predicting immunogenic neoantigens. Used to identify immunogenic neoepitopes by capturing the structural properties of peptide-MHC pairs with T cell reactivity.

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• 3 weeks ago - by Anonymous

Environmentally controlled facility that provides the equipment, advice, and technical support required to enable research involving laboratory rodents. Provides husbandry, care, and animal welfare while supporting preclinical in vivo models. Provides technical, husbandry, and legislative support.

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• 3 weeks ago - submitted by Nadia Cross

Core provides bioanalytical and pharmacokinetic support for the research groups and associated clinical trials within the institute, creating a bridge between the laboratory and clinic. Offers services performing bioanalysis using mass spectrometry, quantify therapeutic drugs as well as small molecule cancer related metabolites (targeted metabolomics), analysis of samples from matrices including plasma, blood, tissues, tumours, and cells.

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• 3 weeks ago - submitted by Nadia Cross

Variant interpretation platform for clinical genetics laboratories. Automates ACMG/AMP 2015 classification using Bayesian point-based framework (Tavtigian et al. 2018) with BayesDel ClinGen SVI-calibrated thresholds (Pejaver et al. 2022). Integrates 8 reference databases (gnomAD v4.1, ClinVar, dbNSFP 4.9c, SpliceAI, gnomAD Constraint, HPO, ClinGen, Ensembl VEP). Analyzes nuclear and mtDNA variants, structural and copy-number variants (SV/CNV), with trio/family and cohort analysis. Supports HPO-based phenotype matching with semantic similarity scoring, biomedical literature mining across 2M+ PubMed publications, and structured clinical report generation. Delivers full clinical interpretation of whole genome sequencing (WGS) in under 15 minutes. EU-hosted on dedicated infrastructure in Helsinki, Finland (GDPR-compliant).

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• 3 weeks ago - submitted by Vladimir Mitev

Software tool for synteny block discovery, evolutionary breakpoint identification, and ancestral genome reconstruction. Used in comparative genomics and evolutionary biology, enabling deeper insights into genomic architecture and evolutionary relationships.

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• 3 weeks ago - submitted by Ajay Bhatia

Core supports researchers in the use of modern light microscopy systems. Provides advanced optical imaging equipment, technical expertise, and hands-on training for biomedical and clinical research projects. Microscope platforms include confocal and multiphoton microscopy for imaging fluorescently labeled structures to enable the investigation and characterization of cells, tissues, organisms, and biomaterials with high spatial and temporal resolution.

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• 3 weeks ago - submitted by Michael Vogt

Software R package to audit research outputs for compliance with open science best practices. Evaluates adherence to standards such as pre-registration and data availability. Used for automated checks of research outputs for best practices.

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• 3 weeks ago - by Anonymous

Web browser-based platform designed to work with biological sequences without needing to install specialized software or create an account. Bioinformatics toolkit for DNA, RNA and protein sequence analysis: reverse complement, translation, ORF finding, primer/oligo Tm and design, restriction sites and cloning, protein properties, codon optimisation, CRISPR guide design, and sequence alignment. Also exposes a Model Context Protocol (MCP) server and JSON REST API for programmatic and AI-agent access. No account or API key required.

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• 3 weeks ago - by Anonymous

Core provides support for data analysis, statistics, and software development. Offers advice on experimental design, statistical modelling, and hypothesis testing and runs training courses to assist research scientists in performing their own analyses.

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• 3 weeks ago - by Anonymous

Proteomics Facility is the centralized service unit of the Medical Faculty of RWTH Aachen University for the analysis of proteome samples. Offers sample preparation and mass spectrometric analysis, as well as bioinformatic processing of raw data (identification and quantification) of peptides and proteins, along with functional bioinformatic analysis of the resulting datasets.

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• 3 weeks ago - by Anonymous

Core provides Next Generation Sequencing (NGS) expertise and services including nucleic acid sample extraction, quantification, RT-qPCR and Quality Control (QC), experimental design, advanced data analysis.

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• 3 weeks ago - submitted by Julia Franzen

Core facility provides genome editing services in vitro and in vivo for translational cancer research. Services span functional genomics (CRISPR screens across cells, organoids and patient-derived xenograft models, integrated with single-cell RNA sequencing), transgenics (embryo manipulation, pronuclear injection, electroporation, cryopreservation, and import/export of genetically modified models), and multimodal pre-clinical trials run through a dedicated Small Animal Hospital using genetically engineered, xenograft and orthotopic models. Offers experimental design consultation to match editing technologies to each research question.

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• 3 weeks ago - submitted by Nadia Cross

Ocular service platform and research company launched by Topcon Healthcare. Provides researchers with ethically sourced, de-identified real-world datasets and clinical trial data for artificial intelligence (AI) and digital health innovation. Primary service is providing AI-ready datasets (such as retinal images, visual function metrics, and EMRs). Access to these databases is generally not a direct "consumer free" service; rather, researchers and sponsors must navigate a structured application and review process overseen by an independent Data Access and Governance (DAG) committee. While IDHea aggregates clinical screening data from routine optometry visits, the patient-facing eye imaging itself is usually part of standard care.

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• 3 weeks ago - by Anonymous

Core is multi-user and service laboratory that offers comprehensive genetic and genomic services. Provides expert consultation, grant application support, training, and both standard and customized sequencing library preparation. Collaborates on genomics, transcriptomics and epigenomics projects.

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• 3 weeks ago - by Anonymous

Core offers research instrumentation for hands-on use to researchers. Provides molecular biology, analytical, and imaging instruments to serve RI’s biomedical scientists totaling 3800 sq. ft. in the URI College of Pharmacy building.

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• 3 weeks ago - submitted by Chris Hemme

System enables precise recording and stimulation of electrogenic cells across multiple wells, combining single-cell sensitivity with scalable experimental capacity. MaxTwo captures electrical activity from individual cells and complex networks with high precision, allowing scientists to detect even the smallest action potentials. This accelerates data collection and deepens insight into cellular function. Used in neuroscience and drug discovery. It features thousands of microscopic sensors embedded in culture plates that record the electrical activity (action potentials) of living cells, such as neurons and heart cells, at single-cell and subcellular resolutions.

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• 3 weeks ago - by Anonymous