Curator Dashboard

Software R package for assessment of PCR artifacts in RNA-Seq data. Used for duplication rate quality control for RNA-Seq datasets.

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• 9 months ago - submitted by Holger Klein

Software open-source Python library providing graphical user interface for visualization and manual curation of large-scale electrophysiological data. It is optimized for high-density multielectrode arrays containing hundreds to thousands of recording sites.

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• 9 months ago - by Anonymous

Specialized, compact, all-in-one fiber photometry system designed to monitor neural activity or neurotransmitter levels in freely moving animals. By combining multiple built-in LEDs (405-440 nm, 460-490 nm, etc.) and photodetectors, it enables simultaneous, multi-wavelength measurement of calcium indicators (e.g., GCaMP) and red fluorophores alongside isosbestic controls to correct for movement artifacts.

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• 9 months ago - by Anonymous

Specialized, high-performance power supplies and controllers designed for neuroscience research, specifically to drive Connectorized LEDs and fiber-coupled light sources. They offer 1, 2, or 4 independent channels for controlling light intensity, modulation (CW, TTL, analog), and complex, software-defined, or automated pulse sequences required for optogenetics and photometry experiments.

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• 9 months ago - by Anonymous

FPGA-based data acquisition unit designed for real-time monitoring of neural activity in behaving animals. It synchronizes excitation light sources (LED drivers) with detection (photodetectors) to record fluorescence signals, typically using lock-in amplification to filter noise and separate multiple wavelengths (e.g., ).

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• 9 months ago - by Anonymous

Core provides immunopathological services from sample embedding and staining to microscopic evaluation. Full service for histopathology includes tissue embedding, staining of tissue sections and microscopic analysis: preparation of paraffin blocks,cutting of cryo and paraffin sections,histochemistry,immunohistochemistry/-fluorescence/multiplexing, in-situ hybridization,Scoring/quantification,storage.

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• 9 months ago - submitted by Edyta Vieth

Software tool for calling copy number variants (CNVs) from human DNA sequencing data. It can work either with germline data, or paired tumor/normal samples. Its primary input is aligned reads (in .bam format), and its primary output is a report (in a .vcf file) giving the copy number status of the genome.

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• 9 months ago - submitted by Mitchell Cheung

Core provides comprehensive proteomic analyses using LC-MS platforms, supporting post-translational modifications, protein-protein interactions, spatial proteomics, and single-cell workflows with bioinformatics.

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• 9 months ago - submitted by Edyta Vieth

Mayo Clinic's Biomedical Imaging Resource Core in Rochester, Minnesota, focuses on supporting and advancing research in biomedical imaging and visualization sciences. Provides guidance on protocol design, routine image analysis, and custom software and hardware solutions. Also, media and model production resources are available to investigators for the creation of high-quality visualizations and physical models of research data.Core provides services to all Mayo Clinic faculty and staff engaged in research. Also, services may be available on a limited basis to investigators and research collaborators outside Mayo Clinic. Before scheduling, contact the core to design optimal settings for the specified imaging task.

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• 9 months ago - submitted by Edyta Vieth

Core generates transgenic and gene-targeted mice for researchers at Mayo Clinic's campuses in Arizona, Florida and Minnesota to enable researchers to observe how genes, or mutant variations of genes, are expressed. Provides services to all Mayo Clinic faculty and staff engaged in research. Also, services are offered to non-Mayo investigators and research collaborators.

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• 9 months ago - submitted by Edyta Vieth

Web-based platform for flexible and reproducible neuroimaging meta-analysis. Enables to create customized, reproducible neuroimaging meta-analyses with no code/low code solutions. It integrates a regularly updated centralized literature database (NeuroStore) with tools for systematic study curation and annotation following PRISMA guidelines, allowing users to search across tens of thousands of indexed fMRI studies or import external study lists. Analyses can be executed locally or in the cloud using the NiMARE Python library, and results can be interactively reviewed, shared, and archived, facilitating transparent meta-analyses and collaborative knowledge building.

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• 9 months ago - by Anonymous

Core provides comprehensive services for generation of viral particles from existing vectors or newly created vectors.

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• 9 months ago - submitted by Thorsten Trimbuch

Software quality-assurance layer for pathway enrichment interpretation that converts enrichment term lists into context-conditioned, evidence-linked, schema-bounded claims and assigns PASS/ABSTAIN/FAIL via predefined, rule-based audit gates (stability, context validity stress tests, evidence-link integrity, and contradiction checks), producing decision-grade reports with audit logs. The LLM is confined to proposal-only steps; final decisions are mechanical and reproducible.

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• 9 months ago - by Anonymous

High-sensitivity, compact benchtop tandem quadrupole mass spectrometers designed for trace-level quantification in complex samples. Primarily used for PFAS testing, pharmaceutical bioanalysis, clinical diagnostics, and environmental contaminant analysis, offering enhanced performance for negative ion-mode compounds. Used for quantifying drug residues, metabolites in biological samples, and impurities, with specific IVD models available for clinical settings. Equipped with StepWave XR technology to handle high-throughput, complex matrix samples with minimal maintenance.

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• 9 months ago - by Anonymous

Core offers large-animal experimental hybrid operating room equipped for cardiological and cardiothoracic interventions, including advanced angiography and multimodal intraprocedural imaging, to support patient-oriented preclinical research and education. Facility enables design, conduct, and veterinary-supervised aftercare of acute and chronic large-animal studies and hands-on training courses on implants, ventricular assist devices, artificial hearts, and percutaneous procedures for structural heart valve disease at phantom models and large-animal models. Core functions and services Performance of animal experimental studies and training courses in an experimental hybrid OR environment. Consultation on study design, model selection, and preparation of animal experiment applications for regulatory approval. Provision of anesthesia and surgical assistance, including perioperative and intensive care support. Specialist veterinary support for acute and chronic studies, ensuring animal welfare and scientific quality. Housing and husbandry for large laboratory animals such as sheep, pigs, and minipigs as part of the experimental program. Equipment and technology Hybrid operating room with Philips Allura Clarity FD20 angiography system tailored to cardiology and cardiac surgery interventions. Comprehensive software tools including Echo-, Heart-, and Vesselnavigator for image-guided procedures. EPIQ7 and CX50 ultrasound systems supporting TTE, TEE, ICE, and IVUS imaging modalities for structural and interventional procedures. Carto-3, OPTIS Integrated System, and XperCT platforms for 3D mapping and intravascular or intracardiac imaging. Heart–lung machine and ECMO systems for cardiopulmonary support during complex experimental interventions. Organizational context and availability Located at Campus Virchow-Klinikum as part of the Forschungseinrichtungen für Experimentelle Medizin and operated in cooperation with the Deutsches Herzzentrum Berlin. Provides core facility research infrastructure of the Charité faculty for translational cardiovascular research and advanced training in a large-animal setting. Certified according to ISO 9001:2015, indicating a documented quality management system for its services.

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• 9 months ago - by Anonymous

Facility for high resolution imaging of biological samples at cryogenic temperatures. Amongst other applications such as single particle data collection, our high-end instrumentation is suited to perform in situ structural biology by combining cryoCLEM, lamella FIB-milling, and cryo-electron tomography.

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• 9 months ago - by Anonymous

Core provides services supporting generation, modification, cryopreservation, and rederivation of genetically modified rodent models for biomedical research, generates genetically modified mouse models via both targeted and random mutagenesis using tools such as CRISPR/Cas9 in zygotes or embryonic stem (ES) cells, provides cryopreservation and rederivation of existing animal models to preserve hygienic integrity. Services for rodent transgenic model development include: Pronuclear Injection and amp; Viral Transgenesis with introduction of genetic constructs into zygotes using microinjection or lentiviral systems; ES Cell-Based Techniques: use of embryonic stem cell manipulation for genetic targeting; Embryo Transfer: transferring manipulated embryos into recipient females; In Vitro Fertilization (IVF): assisted reproductive technology to generate embryos for manipulation or cryopreservation; Cryopreservation: freezing of embryos and sperm for archiving or rederivation of lines as required. Facility’s expertise includes quality control of cryopreserved material to ensure viability upon thawing.

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• 9 months ago - by Anonymous

Software open AI-Powered Platform for 2D Temporal Plant Phenotyping.

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• 9 months ago - submitted by Rafael Nicolás Gaggion Zulpo

Core offers access to Nuclear Magnetic Resonance (NMR) spectroscopy studies. Facility houses three solution-state FT-NMR instruments operating at proton frequencies of 400, 500 and 600 MHz, a TD-NMR 20 MHz relaxometer and an EPR spectrometer. UC-NMR Core Facility provides researchers and institutions with expertise, services and tools to carry out research requiring solution Nuclear Magnetic Resonance spectroscopy.

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• 9 months ago - by Anonymous

Core provides histological services in order to facilitate productivity and success of investigators based in the Rangos Research Center and researchers in other units of the University of Pittsburgh and UPMC, as well as clients in other academic institutions in the Pittsburgh area.

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• 9 months ago - submitted by Riley Gedrys