We support boolean queries, use +,-,<,>,~,* to alter the weighting of terms
Object-oriented software for model-robust covariance matrix estimators. Starting out from the basic robust Eicker-Huber-White sandwich covariance methods include: heteroscedasticity-consistent (HC) covariances for cross-section data; heteroscedasticity- and autocorrelation-consistent (HAC) covariances for time series data (such as Andrews' kernel HAC, Newey-West, and WEAVE estimators); clustered covariances (one-way and multi-way); panel and panel-corrected covariances; outer-product-of-gradients covariances; and (clustered) bootstrap covariances. All methods are applicable to (generalized) linear model objects fitted by lm() and glm() but can also be adapted to other classes through S3 methods.
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Portuguese national research infrastructure which provides expert consultation for the safe and effective use of vector technologies, and offers custom design and production services for multiple viral types to the national research community and other stakeholders.
Core for radioactive sample analysis and storage. Provides next generation in-vivo metabolism and biological assessment of new radiopharmaceuticals in clinical and preclinical studies. Houses analytical instruments dedicated for use with radioactive biospecimens.
Offers advanced instrumentation and expert support to advance understanding of brain function and brain disease by providing researchers with access to cutting-edge technologies. Provides access to advanced instrumentation for optical microscopy, genomics, metabolic imaging and other technologies, as well as image analysis software. Provides expert support and training, data quality and interpretation.
Web server for interactive and collaborative online docking to assist small compound molecular docking. In silico assessment of protein receptor interactions with small ligands.
Semi-manually curated database for biologically relevant ligand-protein binding interactions. Structure data are collected primarily from Protein Data Bank (PDB), with biological insights mined from literature and other specific databases. Database used for serving needs of ligand-protein docking, virtual ligand screening and protein function annotation.BioLiP2 offers significantly greater coverage of nucleic acid-protein interactions, and interactions involving large complexes, integrates structural alignment algorithms with structure prediction techniques, which enables composite protein structure and sequence-based searching.
Web application for protein-ligand binding site prediction. Starting from given structure of target proteins, COACH will generate complementray ligand binding site predictions using two comparative methods, TM-SITE and S-SITE, which recognize ligand-binding templates from the BioLiP protein function database by binding-specific substructure and sequence profile comparisons.
Web application for ligand binding site prediction. Used for prediction of ligand binding sites from protein structure.
Hub for clinical, genetic and functional datasets of preclinical cancer models.Provides details of cell model relationships, patient and clinical information, as well as access to associated genetic and functional datasets. Passports database contains curated details and standardized annotation for cell models, including cancer organoid cultures. Users can navigate database via tissue, cancer-type, genetic feature and data availability to select model. REST-API provides programmatic data access and exploration.
Software tool to read level DNA methylation analysis of bisulfite converted sequencing data.
Core provides high memory parallel processing environments and software in support of the university research, academic, and cybersecurity missions. HPC clusters use multiple computers to process data in parallel, greatly reducing the time to solution for most computational science tasks. They also provide storage to manage very large data sets.
Federally funded facility committed to advancing scientific research by delivering high-quality proteomic data. Provides proteomics analysis, technology, services, and rigorous quality standards.
Software tool to control Illumina HiSeq 2500 System. Open source Python code base and flow cell design that converts Illumina HiSeq 2500 instrument, comprising epifluorescence microscope with integrated fluidics, into open platform for programmable applications without need for specialized engineering or software development expertise.Enables non-specialists to develop and implement fluidics coupled imaging methods in benchtop system.
INECOL focuses on research on natural resources, conservation, and biodiversity, aiming to solve ecological problems and generate scientific knowledge.
Core supports research in various scientific disciplines through advanced microscopy techniques (fluorescence, electron, and optical) and micro-CT. Provides technical services, consultation and training in advanced microscopy.
Core provides iPSC cell culture laboratory with access to curated and validated iPSC lines for neurodegeneration research. Provides robotic and fully automated high-content imaging system to perform high-throughput screening on living brain cells (iPSC derived through reprogramming) to understand the mechanisms behind neurodegeneration at the molecular level.
Facility offers services, combining expert guidance and technologies including Sanger Sequencing, Next-Generation Sequencing, Single-Cell Sequencing, qPCR, Quantity and Quality of DNA and RNA measurement.
Facility for characterization and expression level quantitation of proteins (isolated or in an extract) and small molecules/metabolites by mass spectrometry (MS) and/or chromatography. Services include protein identification, labeled and label-free comparative proteomics by Orbitrap mass spectometry, protein/small molecule quantification using targeted mass spectometry (PRM and SRM/MRM mass spectometry), high throughput protein immune-protein assays (384-well Luminex/ELISA assay), etc.
Core dedicated to providing cutting-edge magnetic resonance imaging services for human participants. Provides Human 3 Tesla MRI system from Siemens for human research with proper IRB approval and approved MRI protocols.