We support boolean queries, use +,-,<,>,~,* to alter the weighting of terms
A commercial adeno-associated virus (AAV) vector driving the expression of Cre recombinase under the control of the CaMKIIa promoter, enabling targeted recombination in glutamatergic neurons. Provided by BrainVTA.
A commercial adeno-associated virus (AAV) vector containing a double-floxed inverted orientation (DIO) cassette for Cre-dependent expression of the excitatory DREADD hM3D(Gq) and mCherry reporter under the EF1a promoter. Provided by BrainVTA.
Web-based tool for analysis of sets through Venn diagrams. Allows set unions in Venn diagrams to be explored thoroughly, by consequence extending the ability to analyze combinations of sets with additional observations, yielded by novel interactions between joined sets.
Stand-alone open-source software with graphical user interface for analysis of time-lapse microscopy images. Combines bio-image analysis and mathematical modeling for study of DNA repair dynamics.
Core promotes conduct of high-quality qualitative research with focus on integrating key stakeholder perspectives into research designs. It helps investigators with study design, funding proposals, data collection, and analysis to understand contextual, sociocultural, and experiential factors in health.
Tissue bank and full service histology core. Provides support for tissue banks staining imaging and spatial applications.
The Roy J. Carver Center for Genomics (CCG) is a research and service center within the Department of Biology on the campus of the University of Iowa (UI). The CCG maintains a centralized laboratory with equipment and instruments available for investigators to use in their molecular research.
Core offers light microscopy and imaging services. Provides access to and training on various confocal microscopes.
Software nuclei instance segmentation and classification framework based on hybrid task cascade.
National Cancer Institute (NCI)-sponsored randomized, controlled study (1993–2001) of ~155,000 adults aged 55-74 to evaluated whether organized, regular screenings could reduce cancer deaths compared to usual care. Portal provides randomized, controlled trial data used to determine whether certain screening exams reduce mortality from prostate, lung, colorectal and ovarian cancer.
Open-source foundation model for histology. Vision transformer model trained on haematoxylin and eosin stained tissue whole slide histology images. AI foundation model for pathology, developed by French startup Bioptimus. Launched as one of the largest open-source models for digital pathology, it is trained on histopathology slides for tasks like tissue classification, mutation prediction, and cancer subtyping.
Software tool for processing Epi-Proteomics mass spectrometry data. Discriminates isobaric histone peptides using distinguishing fragment ions in their tandem mass spectra and extracts the chromatographic area under the curve using previous knowledge about peptide retention time. Nanoflow liquid chromatography coupled with high resolution tandem mass spectrometry-based quantification tool for histone peptides, which can also be adapted to analyze nonhistone protein samples. EpiProfile 2.0 is extended version of v1.0 for enhanced quantification of histone peptides based on LC-MS/MS analysis.
Software tool to reverse-engineer transcriptional regulatory networks from co-expressed gene sets by identifying master transcription factors (TFs) and their direct target genes. It operates by scanning for enriched TF binding motifs in promoter regions, utilizing over 10,000 position weight matrices (PWMs) for human, mouse, and Drosophila. Used to enable gene regulatory network mapping directly based on motif enrichment in co-expressed gene set.
Core supports fundamental, translational, and clinical research by providing advanced services and expertise in cytometry, photonic microscopy, mass imaging, in vivo imaging, and bioinformatics. The cytometry and mass imaging unit offers flow, spectral and mass cytometry, cell sorting, multiplex panel development, and high‑dimensional data analysis. Photonic microscopy unit provides comprehensive support from sample preparation to image processing, with access to widefield, confocal, multiphoton and super‑resolution systems, and benefits from national recognition through IBISA and France BioImaging labels. The platform also hosts clinical transfer imaging activities (SP2I), developing optical tools for surgery and pathology in close collaboration with clinicians, with numerous funded projects and industrial partnerships. Request for citation from this core facility is to use the full name (synonym in this record) and address of the core: "Université Paris-Saclay, Gustave Roussy, INSERM, Analyse moléculaire, modélisation et imagerie de la maladie cancéreuse, F-94805 Villejuif, France, Plateforme d'Imagerie et Cytometrie PFIC (RRID:SCR_028222)"
Gustave Roussy is Europe’s leading comprehensive cancer center, located in Villejuif near Paris, France. It is a premier institution dedicated entirely to cancer treatment, research, and teaching, often ranked among the top oncology hospitals worldwide. Founded in 1925, it specializes in personalized medicine, rare cancers, and complex tumors.
Tokyo Chemical Industry Co., Ltd. (TCI) is a leading global manufacturer of specialty organic chemicals, founded in 1946. They produce over 30,000 research chemicals, including laboratory chemicals, reagents, and functional materials. TCI also acts as a supplier, offering custom synthesis and bulk production from milligrams to tons.
Image acquisition system to capture of chemiluminescence and fluorescence images. Using cooled CCD technology in combination with motorised optical lens, Fusion FX7 offers very high sensitivity and extended dynamic range. Data produced are directly compatible with image analysis software developed by VILBER and 1D image can be transformed into 3D results with Bio-1D and the Bio-Gene software.
Neuroanatomy-anchored Information Management Platform for collaborative BICAN data generation developed by UTHealth Houston. Serves as metadata tracking engine to support generation, management, and sharing of brain research data. Integrates data production pipelines across brain banks, laboratories, sequencing centers, and data archives. Platform enables integrative and collaborative, consortium-scale FAIR data generation within the BICAN project. Platform is designed to manage complex dataset, including tissue samples and sequencing data, through Specimen Portal and Sequence Library Portal. Portals provide multiple types of data interfaces through dashboards, APIs, faceted queries, and batch data ingestion and exporting.
Web tool to search life science articles with AI you can verify and control. Life science search engine designed to hit the sweet spot between classical search and AI-assisted research.
Core offers tools to precisely modify the genome of cells and organisms using CRISPR-Cas9-based editing, CRISPR interference (CRISPRi), and CRISPR activation (CRISPRa) systems. Our platforms enable high-throughput genetic screening, gene knockouts, transcriptional modulation, and sequence editing with high efficiency and scalability.