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Web interactive digital tool for tracking the health of vital reef ecosystems all around the world. Reef Life Survey program uses scientists and citizen scuba divers to survey fishes on coral and rock reefs throughout the world. Marine life monitoring programm.
Windows-based software (PC use only) that provides a tool for the determination of coral cover using transect photographs. A specified number of spatially random points are distributed on a transect image and the features underlying the points are user-identified. Coverage statistics are then calculated and the results sent to Excel spreadsheets automatically. CPCe can be used for image calibration and area analysis of benthic features. Excel sheets are automatically generated to summarize the area calculations for each image.
Software set of tools useful in the analysis of benthic terrain. Includes tools for geomorphology and classification.
Software open-source platform for integrated analysis of spatial transcriptomics and metabolomics data. It integrates spatial pattern recognition, differential comparison, network construction, and functional annotation into a unified workflow. Enables to explore gene-metabolite co-regulation mechanisms through an intuitive web interface, revealing spatial heterogeneity in tissue development and disease progression.
SBSR core consists of the Protein Purification unit and the Structure Determination unit. Protein Purification unit produces homogeneous, high-quality proteins well suited for downstream biophysical studies and structure determination. Structure Determination unit employs X-ray crystallography, Cryo-EM, and advanced AI-assisted analytical tools for structure determination and imaging.
Fully automated high-content imaging platform that uses cyclic immunofluorescence to enable high-plex spatial profiling of hundreds of protein markers and dozens of RNAs on the same tissue section, accelerating spatial biology and multiomics research workflows.
Core provides access to advanced imaging and analytical instrumentation, expert technical support, hands-on training, and collaborative project support. Services include high-resolution imaging through Scanning Electron Microscopy (SEM) and Transmission Electron Microscopy (TEM) to examine surface features, internal structures, microstructures, nanoparticles, biological specimens, and engineered materials at micro- to nanoscale resolution; X-Ray Diffraction (XRD) for phase determination and crystallographic analysis; Atomic Force Microscopy (AFM) for nanoscale surface characterization. Provides solid analyzer and rheometer for evaluating material properties and behavior. Specialized sample preparation services include polishing, ultramicrotomy, sputter coating, and other preparation techniques needed for microscopy and materials analysis. Individualized, non-credit instruction is available for instrument operation and sample prep techniques. Offers expert support with sample preparation, data acquisition, sample analysis, troubleshooting, and preparation of results for reports, proposals, presentations, and publications.
Micro X-ray Computed Tomography Shared Research Facility (XCT-SRF) provides access to an X-ray microscope and micro-CT instrument, and expertise in experiment planning, sample preparation, and data analysis and visualisation. The facility is capable of 3D imaging and analysing a wide range of material samples, with a focus on supporting research in healthcare, manufacturing, and energy applications.
Instrument to increase the rate of tissue clearing. Provides optimal imaging and staining quality. Delipidates for best antibody diffusion and minimal light scatter, and ensures maximum preservation of fluorescent protein signals with optimized buffers that maintain pH. Nanoporous membranes prevent common issues including tissue damage, contamination, browning, black precipitates, and deformation.
Software bioinformatic framework for reconstructing 4D spatial transcriptomics atlas and spatiotemporal analyses+.
Software tool for cell type specific enhancer-gene predictions using ABC model.
Software tool for assigning statistical confidence estimates to chromosomal contact maps produced by genome-wide genome architecture assays such as Hi-C.
Software supervised learning framework for chromatin loop detection in genome-wide contact maps.
Standardized, open-source framework of classes and properties designed to annotate and interlink data regarding metabolites, species taxonomy, ecological traits, and environmental interactions. It powers the METRIN-KG knowledge graph, mapping the chemical diversity of Earth's species to support biodiversity conservation. Knowledge representation schema designed to capture, contextualize, and structure chemical diversity data across all known species. It reuses and harmonizes several existing ontologies, while introducing over 100 new concepts and relations to enable interoperability and data reuse.
Software pipeline for generating knowledge graph integrating emi, trydb, globi datasets. Code for constructing a knowledge graph that integrates enriched metabolite data from Experimental Natural Products Knowledge Graph (ENPKG), LOTUS (available through Wikidata), plant trait data from TRY, and biotic interaction data from Global Biotic Interactions (GloBI). It performs taxonomic alignment against Wikidata records and generates Resource Description Framework (RDF) triples representing taxonomic relationships, traits, and species interactions. The resulting knowledge graph is queryable via a SPARQL (SPARQL Protocol and RDF Query Language) endpoint.
Knowledge base platform that provides scientists worldwide with tools for searching, exploring, and visualizing Neuroscience knowledge represented by knowledge graphs (KGs). Provides tools that enable scientists to contribute new information (or knowledge) to the platform and is expected to be a go-to destination for all neuroscience-related research needs. Allows making predictions and new inferences in addition to querying and viewing information.
Mouse Biology Shared Resource (MBSR) provides knockout, transgenic, and humanized murine cancer models and related services for advancing translational cancer research. Additionally, the MBSR offers services to enhance the use of existing mouse models or to facilitate the development of new mouse models for cancer research, including genetic alteration (e.g., CRISPR/Cas9-mediated gene targeting, transgenesis), surgical manipulation (e.g., patient-derived xenografts (PDX), cell-derived allografts (CDA) and xenografts (CDX)), and environmental challenges (e.g., diet, chemotherapeutic agents). can produce a wide range of allele-speci?c mouse models and offers innovative technologies to phenotype mouse models that mimic human conditions.
Molecular Pharmacology and Chemical Biology Shared Resource (MPCBSR) provides services for the assessment of new therapeutics, including clinical trial specimens and determination of clinical PK/PD and potential drug-drug interactions (DDI), pharmacological studies on novel therapeutics in preclinical models, including DM/PK/PD, on-target mechanisms, biomarkers, and combination effects, and chemical synthesis of new compounds and drug delivery nanomaterials for improved therapy.
Software R package from the Allen Institute designed to build, standardize, and analyze single-cell RNA-seq-based cell type taxonomies. It utilizes a structured Allen Institute schema (AIT) to organize cell annotations and metadata, enabling hierarchical, data-driven cell type classification
General, open-standard schema for cell annotations and related metadata. Provides programmatically accessible standard designed to record additional metadata about individual cell type annotations, including marker genes used as evidence and details of automated annotation transfer. Standard is represented as JSON schema as this allows all metadata to be gathered in a single, compact validatable file - which includes a link to a cell by gene matrix file of annotated data. However, the schema is designed so that it can be decomposed into individual tables suitable for use in dataframes/TSVs and flattened onto obs in AnnData format.