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Facility supports micro- and nanoscale fabrication, microsensor development, and atomic-scale materials synthesis. Provides comprehensive technical capabilities, including microlithography (mask aligners, photoresist processing, laser lithography), thin film deposition (e-beam evaporation, sputtering, PECVD, atomic layer deposition), and advanced characterization tools (profilometry, spectroscopic ellipsometry). Fabrication processes are supported by both dry etching (DRIE, RIE) and wet chemical processing (RCA clean, KOH etch, solvent benches), as well as thermal processing systems such as diffusion furnaces and rapid thermal annealing.
A collection of tools for MRI T1 brain image segmentation in the Windows environment. It helps construct a complete pipeline with necessary preprocessing and postprocessing procedures besides brainparser, the core program of our fast brain segmentation. The execution of the whole pipeline can be completed in 2 hours with good segmentation results. Execution requires: FSL
An Antibody supplier
Core offers custom peptide services. Facility provides expertise and instrumentation dedicated to chemical synthesis, purification, and characterization of peptides and peptide materials. Provides standard and catalog peptides, and synthesis of specialty custom peptides modified to fit specific research needs.
This central project points to all open-source and open-data initiatives provided by the German Cancer Research Center in the field of diffusion MRI.
MPI Research exists to provide comprehensive discovery, safety evaluation, bioanalytical, and analytical services that meet the requirements of biopharmaceutical, medical device, animal health, and chemical companies as we partner globally to bring safer and more effective products to the world. Our goal is to exceed the expectations of our Sponsors and maintain the highest respect in our industry by providing customized, responsive, and on-time services that add value to our Sponsors'' efforts to discover, develop, and enhance products in regulated international environments. We excel as a high performance, high quality organization because of our scientific knowledge and experience, integrity, trust, teamwork, and dedication to strong and enduring Sponsor relationships. MPI Research has conducted thousands of drug safety, discovery, bioanalytical, and analytical studies. We offer extensive support and resources including, but not limited to * A wide and diverse range of classes of compounds * All routes of administration except inhalation * Studies with numerous species and models * Comprehensive reporting capabilities Flexibility and ample capacity enable us to * Accommodate multiple requirements simultaneously * Adjust schedules readily * Produce results quickly Responding to a broad spectrum of research needs: Working in partnership with pharmaceutical, biotech, medical device, and chemical companies, we conduct customized preclinical research throughout the discovery and development process, from early proof of concept testing to regulatory submissions, including IND, EPA/OPPTS, NDA, PMA, and 510K.
Core provides high-plex immunohistochemistry (PhenoCycler/CODEX) on human and mouse FFPE tissues, image analysis (IHC, mIHC, high-plex), and support for collaborative and fee-for-service projects.
GAMMA suite is an open-source cross-platform data mining software package designed to analyze neuroimaging data. A neuroimaging study often focuses on biomarker detection and classification. We designed and implemented a Bayesian, multivariate, nonparametric suite of algorithms for analyzing neuroimaging data. The GAMMA suite can be used for brain morphometric analysis, lesion-deficit analysis, and functional MR data analysis.
Biotechnology company that develops products for genomics research and molecular diagnostics, such as systems for DNA and protein analysis, DNA and protein fractionation technologies, and other sequencing equipment.
Non-profit research consortium located in Harlem, NY, providing advanced structural biology technologies to academic and commercial researchers. Founded by nine institutions, it specializes in cryo-electron microscopy (Cryo-EM), NMR spectroscopy, and X-ray crystallography to analyze molecular structures for drug discovery.
Project to provide long-term hosting and release for small tools related to medical image analysis. Source repository contains highly experimental code intended for collaborative development. However, any interested parties are welcome to browse/reuse code. Stable/evolved projects will be moved to independent projects.
The OIE is the intergovernmental organization responsible for improving animal health worldwide. The need to fight animal diseases at global level led to the creation of the Office International des Epizooties through the international Agreement signed on January 25th 1924. In May 2003 the Office became the World Organisation for Animal Health but kept its historical acronym OIE. It is recognised as a reference organisation by the World Trade Organization (WTO) and in 2013 had a total of 178 Member Countries. The OIE maintains permanent relations with 45 other international and regional organisations and has Regional and sub-regional Offices on every continent.
Genomics core is a self-supporting core facility specializing in Sanger sequencing, SNP/fragment analysis, and Next Generation DNA Sequencing using Illumina's MiSeq platform. Provides sequencing services.
A data analysis environment for diffuse optical tomography (DOT) functional neuroimaging data. Developed to process data from steady-state time-series measurements, it allows for maximal flexibility in the number and positions of optodes. The central component is an application called NAVI. Features include: # An electronic ledger (records metadata for all data transformations). # Data conditioning (e.g., frequency-filtering, selection of data on the basis of signal-to-noise ratio.) # 2D or 3D image formation and display. # Interpretation: atlas-based mapping; automated anatomical labeling; GLM; data-driven methods (e.g., PCA, ICA); model-based (e.g., dynamic causal modeling) and data-driven (e.g., correlation) connectivity analysis. Another important component is the Brain Model Generator, which includes FEM meshes for all parts of the head accessible to DOT measurements. The user can input the numbers of optodes, and manually specify their locations or input tracking-system data.
Software R package for power analysis of generalized linear mixed models by simulation. Used to calculate power for generalised linear mixed models.
Scientific and educational institution dedicated to exploring the diversity of life on Earth and human culture. It is renowned for its collection of over 40 million artifacts and specimens, including world-class dinosaur fossils, ancient cultural exhibits, and active scientific research labs.
Geometry format under the Neuroimaging Informatics Technology Initiative (NIfTI). Basically, it is the surface-file format complement to the NIfTI volume-file format .nii. Programs which support the Gifti format, intended to allow exchange of each others surface files, include: Freesurfer, Caret, BrainVISA, Brain Voyager, CRkit, VisTrails and AFNI.
Core provides access to instruments including:FEI Tecnai 12 Spirit TEM, FEI Tecnai F20 (200kV) FEG-TEM 200kV FEG-TEM,Gatan US4000 4k x 4k CCD, bottom-mount,CryoTEM and electron tomography,High-resolution TEM;FEI Tecnai F20 (200kV) FEG-TEM,300kV FEG-TEM,Gatan US4000 4k x 4k CCD, bottom-mount,CryoTEM and electron tomography,High-resolution TEM,FEI/Phillips CM100 (100kV) TEM,100kV, tungsten TEM,2k x 2k AMT CCD, bottom-mount.
Core focuses on quantitative bioanalytical assay development, validation and implementation for drugs, metabolites and biomarkers in blood, serum, plasma, urine, ultrafiltrate and microdialysate utilizing mass spectrometry techniques.
To enable widespread application of the Biological parametric mapping (BPM) approach, they introduce robust regression and non-parametric regression in the neuroimaging context of application of the general linear model. Biological parametric mapping (BPM) has extended the widely popular statistical parametric approach to enable application of the general linear model to multiple image modalities (both for regressors and regressands) along with scalar valued observations. This approach offers great promise for direct, voxelwise assessment of structural and functional relationships with multiple imaging modalities. However, as presented, the biological parametric mapping approach is not robust to outliers and may lead to invalid inferences (e.g., artifactual low p-values) due to slight mis-registration or variation in anatomy between subjects.