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Community project portal by team consisting of members of eLife Early Career Advisory Group, Protocols.io, Addgene and Code Ocean, developing resources and teaching workshops to enable researchers to do reproducible research. Collaboration between volunteers in research, industry, and startups in area of reproducibility to make researchers aware of tools that they can use to improve reproducibility of their work.
Core is veterinary diagnostic laboratory and research pathology core. Provides laboratory animal diagnostics, clinical and health surveillance screening necessary for the care and use of animals in research, and expert pathology support for basic and translational research.
Blog that provides an on-line forum where the members of the MacArthur Foundation Research Network on Law and Neuroscience can share their ideas and interact with not only other researchers but also with the interested public more generally. One of the main goals of the blog is to provide a resource with information about cutting edge research at the cross-roads of neuroscience, law, and philosophy.
Provided core services include Sanger DNA Sequencing, Next Generation DNA Sequencing (Four Illumina MiSeqs, four Illumina NextSeq 500s and one Illumina NovaSeq 6000),Next Generation Automated Library Sample Prep (Perkin Elmer Sciclone Genomic, ChIP, RNAseq and other methods), Single Cell DNA and RNA-Seq (10X Genomics Chromium), Bioanalyzer Analysis DNA and RNA (Two Agilent 2100 BioAnalyzers and two Agilent 2200 TapeStations), Qiagen Qiacube Automated DNA / RNA Prep (single to multiple samples), Oligonucleotide Ordering (IDT Portal), Reagents and Supplies Ordering (multiple vendors / products). Facility web based Laboratory Information Management System (LIMS) provides users with access to order services and supplies as well as retrieve data and review and pay invoices all online.
Independent, non-profit research organization in Great Falls, Montana near the Rocky Mountain Front.
Raw data from various QTL (quantitative trait loci) studies using rodent inbred line crosses. Data are available in the .csv format used by R/qtl and pseudomarker programs. In some cases analysis scripts and/or results are posted to accompany the data. These data are provided as a courtesy to the genetic mapping community and may be used for purposes of developing or testing new analysis methods or software and for meta-analysis of quantitative traits. The authors of the datasets retain individual ownership of the data. As a courtesy to the authors, please alert them in advance of any publications that result from reanalysis of these data or obtain permission prior to redistribution of data or results. In all data sets and files, the marker locations have been translated to Cox build 37 coordinates unless otherwise stated. Please consider contributing your data to the QTL Archive.
The mass spectrometry core facility offers instrumentation for characterizing elements and compounds across the entire mass range from quantitative metal analysis to intact protein mass measurement. Instrumentation is also available for proteomics, metabolomics, MALDI imaging and HDX-MS. Specialized mass spectrometers encompass variety of ionization techniques and separation devices to cover wide range of analytical capabilities. The facility accepts samples and will perform requested analysis. Staff can also offer training to conduct experimentation. Instrumentation include Bruker timsTOF fleX, Thermo Orbitrap Fusion, Bruker Microflex and ultrafleXtreme MALDI-TOF, Agilent GC-MS, Waters Xevo TQD with UPLC, Waters Synapt G2Si with full HDX automation, Perkin Elmer NexION ICP-MS
Software tool for visualizing high dimensional data using novel conceptual framework for learning and visualizing manifold to preserve both local and global distances.
A prototype bioinformatics tool for designing hypotheses and evaluating them for consistency with existing knowledge. It consists of a modeling framework with the ability to accommodate diverse biological information sources, an event-based ontology for representing biological processes at different levels of detail, a database to query information in the ontology, and programs to perform hypothesis design and evaluation. There are five key components involved in making HyBrow work. # The Event-based ontology for representing biological knowledge # The Discreet Event Systems based conceptual framework which provides the theory that allows us to make statements in a context free formal language (made up of the ontology) and evaluate the statements for validity using constraints declared on existing data # The rule library that provides the steps to apply those constraints and decide support, contradiction or no comment. # The relational database that stores existing information structured into the ontology. # The user interface.
Web service of Inter-university Consortium for Political and Social Research. Self-publishing repository for social, behavioral, and health sciences research data. Used for deposit of replication data sets for researchers who need to publish their raw data associated with journal article so that other researchers can replicate their findings.
Core offers advanced services to detect, quantify, and characterize pathogens, as well as assess host immune responses. Supports both standardized and custom assay developments. MVSC is composed of three integrated units: Virology Unit which provides viral stocks for variety of viruses at BSL2 and BSL3, as well as assay services including virus expansion and characterization, viral titer by plaque and TCID50 assays, live virus neutralization and inhibition assays at both BSL-2 and –3. Viruses currently in use by the core include SIV, HIV, Zika, Dengue, SARS-CoV-2, Mayaro, Eastern Equine Encephalitis Virus, Poliovirus, Enterovirus D68, and others. Luminex and Serology Unit Services include antibody detection in serum or plasma by Luminex-based assays and/or ELISA for SPF-agents such as SIV, SRV, STLV, B virus, SFV, CMV, RRV, SVV, SV40, and LCV, and non-SPF infectious agents like measles, Burkholderia pseudomallei, Trypanosoma cruzi, Mycobacterium tuberculosis, and SARS-CoV-2. This unit also offers services for cytokine quantification in body fluids including serum and CSF, as well as tissue culture supernatant. Sequencing Unit provides services related to quantitative PCR and RT PCR detection of viruses such as SIV, Zika, and SARS-CoV-2, as well as next generation sequencing services including whole genome (pathogen or host), epigenetics, targeted amplicons, and 16S and ITS metagenomics. Sequencing unit also performs single cell RNA-seq (10x and Parse) assays as well as NGS based genotyping of NHP, including for major histocompatibility complex (MHC) allelic genotyping.
Study designed to assess the effects of oral supplementation of high doses of macular xanthophylls (lutein and zeaxanthin) and/or omega -3 LCPUFAs (DHA and EPA) for the treatment of AMD and cataract.
System that consists of Application Programming Interface which controls access to information stored in database, and web interface that provides way of interacting with data stored in GenTaR database. Users can track production and phenotyping of different types of mutant allele. Allows consortia to follow progress made in characterising set of genes that they are interested in. To create new project or plan, or to view consortium gene list in GenTaR credentials to log into GenTaR are required. Project search box enables to look for projects working on specific gene by entering gene symbol or gene MGI accession identifier. Search results without logging in will only include public data. Otherwise application search results also include data for Protected and Restricted projects.
Software Bayesian statistical modeling R package for hierarchical statistical modeling (aka graphical modeling). It enables writing general models along with methods such as Markov chain Monte Carlo (MCMC), particle filtering (aka sequential Monte Carlo), Laplace approximation and other general methods.
A web-based tool that provides composite interpretations for microarray data comparing two sample groups as well as lists of genes from diverse sources of biological information. It provides multiple gene set analysis methods for microarray inputs as well as enrichment analyses for lists of genes. It screens redundant composite annotations when generating and prioritizing them. It also incorporates union and subtracted sets as well as intersection sets. Users can upload their gene sets (e.g. predicted miRNA targets) to generate and analyze new composite sets.
Offers services in customized end point assays using human WB/PBMCs for clinical trials, ELISPOT, multiplex cytokine analysis, cell energy analysis, blood processing and cryopreservation,up to 20 color flow cytometry phenotyping and up to 11color FACS cell subset sorting. Provides consultation, data analysis, and Flow Cytometry training course.
Software R package defines S4 classes for single-cell genomic data and associated information, such as dimensionality reduction embeddings, nearest-neighbor graphs, and spatially-resolved coordinates. Provides data access methods and R-native hooks to ensure the Seurat object is familiar to other R users.
The Open Annotation Collaboration project aims to facilitate the emergence of a Web and Resource-centric interoperable annotation environment that allows leveraging annotations across the boundaries of annotation clients, annotation servers, and content collections. To this end, interoperability specifications will be devised. Additionally, this project will demonstrate through implementations an interoperable annotation environment enabled by the interoperability specifications in settings characterized by a variety of annotation client/server environments, content collections, and scholarly use cases and will seed widespread adoption by deploying robust, production-quality applications conformant with the interoperable annotation environment in ubiquitous and specialized services, tools, and content used by scholars -- e.g.: Zotero, AXE, LORE, Co-Annotea, Pliny; JSTOR, AustLit, MONK. Alpha3 Data Model: The Open Annotation Data Model specifies an approach for associating annotations with resources, using a methodology conformant with the Architecture of the World Wide Web and the Linked Data initiative. It draws on the Annotea model, as well as more recent extensions of that model.
Core provides services, including repair of lab equipment and biosafety cabinets, metal and acrylic fabrication, woodworking, welding, machining, and calibration of pipets.
Software R package to calculate similarity metrics to facilitate copy number variant comparison among samples and/or methods.