We support boolean queries, use +,-,<,>,~,* to alter the weighting of terms
Open source software tool as library for implementation of gradient boosting with various machine learning algorithms.Optimized distributed gradient boosting library designed to be highly efficient, flexible and portable.Supports regression, classification, ranking and user defined objectives.
Software application as structural pharmacology workbench that reports negative result for cognition-related CNS targets. It runs real structure prediction, computes real chemical and physicochemical properties, validates every record against a contract, and attaches a provenance record to every value.
The Barth Syndrome Foundation, together with our affiliates, is a community of families, physicians, scientists, donors and volunteers around the world. As our mission statement says, we are dedicated to saving lives through education, advances in treatment, and finding a cure for Barth syndrome - a sometimes fatal, oftentimes debilitating genetic disease. Our work includes: * Raising awareness among physicians, scientists, and the general public; * Supporting relevant research through an international grant research program; * Providing a caring and educational community for affected families; and * Hosting a unique information resource. Working together we are making a difference in the lives of children and their families. One day there will be a cure; we hope you will help us make that day come sooner. We are the only world-wide volunteer organization dedicated to saving lives through education, advances in treatment and pursuit of a cure for Barth syndrome (BTHS). We started in 2000, after the first international conference held in Baltimore, MD (USA) where families from around the world met to discuss BTHS. As a result, we made a unanimous decision to work together to find a cure for this multi-system disorder. Our Foundation strives to accelerate progress through collaboration between families and scientists. We encourage family participation in research. Also, we provide several ways to keep up-to-date about advances in science and medicine. Our principal education event is our biennial international scientific, medical and family conference, which brings together the largest number of individuals interested in Barth syndrome. Our Family Services team is continually developing new informational resources in response to the needs of families, individuals, and professionals working with those affected by Barth syndrome.
Software suite of tools to qualitatively and quantitatively evaluate outcomes of genome editing experiments in which target loci are subject to deep sequencing and provides integrated, user friendly interface. Used for analysis of CRISPR-Cas9 genome editing outcomes from sequencing data. CRISPResso2 provides accurate and rapid genome editing sequence analysis.Used for analysis of deep sequencing data for rapid and intuitive interpretation of genome editing experiments.
Core provides flow cytometry services.
A cell culture collection to service the research community and provide an International Depository Authority recognized patent depository for Europe. The collections currently hold over 40,000 cell lines representing 45 different species, 50 tissue types, 300 HLA types, 450 monoclonal antibodies and at least 800 genetic disorders. ECACC has developed a comprehensive range of cell culture services and diversified into new product areas such as high quality genomic DNA extracted from cell lines. ECACC is one of the four collections which constitute the Health Protection Agency Culture Collections (HPA Culture Collections). Its products include: General Cell Collection, Hybridoma Collection, Primary Cells, Neuron Culture Kits, HepaRG Cells, GPCR Cell Lines, HLA-Typed Collection, Human Random Control Collection, Human Genetic Collection, and DNA Products. Its services include: Assay Ready Cells, Cell Culture Management Services, Contract Cell Culture, Cell Line Identity Verification, Genetic Support Services, Mycoplasma Testing and Eradication, Patent Deposits, Safe Deposits, Sterility Testing, and Training.
Software tool as framework querying ontology terms within SciCrunch and SciCrunch SciGraph endpoints.
The Mitochondrial Function and In Vivo Imaging (MF-II) Core provides specialized expertise, advanced instrumentation, and comprehensive services for assessing mitochondrial function, metabolism, cardiopulmonary physiology, and in vivo structure and function. The Core supports cardiovascular, pulmonary, and vascular research through high-resolution metabolic and mitochondrial analyses, noninvasive imaging, hemodynamic assessment, and established preclinical disease models. The MF-II Core works collaboratively with investigators to provide experimental design consultation, technical expertise, data acquisition, and analysis to generate high-quality, reproducible data.
AlloSource is a non-profit organization founded in 1994 on a promise to honor and respect the gift of donation by responsibly developing, processing and distributing life-saving and life-enhancing allografts for our communities. Today, each of our 300 employees continues to fulfill this promise through multi-shift, 360-day processing to the highest quality and service standards. We strive to be the tissue network patients and the world''s most respected transplant teams ask for by name. This is accomplished by understanding the needs of our doctors and by providing the best tissue for our recipients. We offer more than 200 standard and customized precision allograft products, and act as a trusted and knowledgeable partner to the medical community, all with the intention of maximizing medical impact. In 1995, Allosource evolved from a local tissue bank in Denver, Colorado into a national organization serving communities around the country. Today, AlloSource is one of the largest, most respected tissue banks in the United States. Through our growth we''ve remained committed to the wishes of donor families, the needs of our surgeon customers, and the hopes of our patient recipients. Our promise of doing more with life reflects our unwavering focus on integrity, quality, safety, and respect today, and into the future.
Software Python package to tackle curse of imbalanced datasets in machine learning.Offers number of re-sampling techniques commonly used in datasets showing strong between class imbalance.
Core provides metabolomics services and advanced instrumentation for those researchers in plant, animal and medical sciences.
A provider of bio-implants and organs for transplantation and tissue banking services.
Core supports genome engineering using CRISPR technology. Provide services to generate knockouts, insertions, deletions, and point mutations in various organisms. Services for genome engineering include guideRNA design, homology-directed repair template design, production of modified mammalian cell lines, preparation of reagents for delivery to embryos, and mutation detection by targeted deep sequencing. Pooled screening is also coordinated and supported by our team.We acquire, prepare, and validate pooled libraries as an Institute resource. In coordination of our pooled screen workflow, we work with other teams to track the progress of these projects. Once resulting cell populations from the screen are delivered, our team does genomic DNA purification, target amplification, and preparation for NGS. We now offer a TAIL-PCR service to identify the location of random integration events. We have successfully identified locations in killifish, fly, zebrafish, and sea anemone.Team is responsible for maintaining and distributing clone and vector collections for the Institute.
Core is a bioMT and Dartmouth community resource that supports research programs via production of high quality recombinant proteins. Core assists with the decision-making process, providing expert advice and necessary training on construct design, host selection, optimization of expression conditions and development of purification schemes, makes equipment available to the community and trains researchers to produce recombinant proteins.
A web tool for simple microRNA prediction in genome sequences.
Project to align physical sample identifiers. Used to design, develop, and promote service infrastructure to uniquely, consistently, and conveniently identify material samples, record metadata about them, and persistently link them to other samples and derived digital content, including images, data, and publications.
Core provides service for one-stop spatial biology solutions from sample handling to high-end spatial data generation. Serves as a specialized bridge between laboratory research and clinical application (immuno-patho translation). Offers services in general histology, spatial transcriptomics and spatial proteomics. It primarily focuses on experiment designing, optimisation, spatial proteomic staining and imaging, allowing assay customisation, development and validation.
A microarray data warehouse integrated with a software platform for microarray data analysis. It can be used as a LIMS for DNA chip experiments, also. Unlike other microarray data repositories, it entirely dispenses with free-text format, instead holding all the information in a format ready for statistical analysis.
Software to design gRNAs pools in non-model genomes and CRISPR-Cas systems. Used to design CRISPR-Cas guide RNA pools in non model genomes.
Peptide Search Engine Integrated into the MaxQuant Environment. Andromeda can function independently or as an integrated search engine of MaxQuant computational proteomics platform. The combination enables analysis of large data sets in a simple analysis workflow on a desktop computer. For searching individual spectra Andromeda is also accessible via a web server. Used to identify cofragmented peptides, significantly improving the total number of identified peptides.