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Core offers imaging services including design, build, upgrade, and repair optical systems. Provides high-throughput, automated, and custom-built imaging infrastructure and open-source optical tools for neuroscience and biological research. Services include Automated Whole-Brain Imaging, Histology and Spatial Transcriptomics, In-Vivo Microscopy Technical Services.
An open-source software for developing personalized genome browsers that work in web browsers.
Web tool as map based application for browsing, visualizing and analyzing diverse suite of curated global and regional geoscience data sets. These cover geophysics, geology, geochemistry, physical oceanography, climatology, and more. Runs with Java under Windows, Mac OS X, Linux and Unix/Solaris operating systems.
Core provides access to custom production of novel transgenic, gene knockout, and gene knockin rat and mouse models, management of rat model breeding colonies, assisting research staff with procedures involving production and maintenance of transgenic mouse and rat strains. Provides both sperm and embryo cryopreservation/recovery, IVF, ICSI, pronuclear microinjection. Provides consultation involving colony breeding issues.
A pipeline to analyze paired end RNA-Seq data to generate gene expression values (RPKM) and gene-fusion candidates.
Open source, community developed library that provides range of different methods, which include enhanced sampling algorithms, free energy methods, tools to analyze vast amounts of data produced by molecular dynamics simulations. PLUMED 2 is complete rewrite of the code in object oriented programming language C plus plus. This new version introduces greater flexibility and greater modularity, which both extends its core capabilities and makes it far easier to add new methods and CVs. It also has simpler interface with the MD engines and provides single software library containing both tools and core facilities.
Software Python package and command-line toolkit for processing and analyzing three-dimensional brain imaging data, particularly cleared-tissue light-sheet fluorescence microscopy datasets. Supports image preprocessing, atlas registration, cell segmentation and quantification, voxel-wise statistical analysis, cluster characterization, and region-wise analysis of fluorescence intensity and cell density. UNRAVEL also facilitates integration of brain-wide imaging results with Allen Institute resources, including the Allen Brain Cell Atlas and neuronal connectivity datasets, to investigate the cellular and circuit-level organization of observed brain activity patterns.
A community created to advance the use and value of next-generation sequencing through knowledge sharing.
Database of orthologous protein coding genes across vertebrates, arthropods, fungi, basal metazoans, and bacteria.
Preclinical Imaging Shared Resource at the Medical College of Wisconsin Cancer Center provides small animal imaging services including micro-CT, PET/CT, SPECT/CT, and/or optical imaging along with image acquisition, analysis, and consultation for investigators.
Genotype Calling and Copy Number Analysis tool for Affymetrix SNP 5.0 and 6.0 and Illumina arrays.
Core facilitates access, generation, and usage of novel in vitro mouse and human organoid systems to promote innovative basic and translational research and disease modeling. Provides expertise in genome editing technologies for targeted knock outs, point mutations, and reporter generation in organoid systems. Provides many specialized medias and reagents to support most common organoid culture systems.
Core is supported by NH-INBRE and CIBBR. The goal of the DSC is to integrate bioinformatics, statistics, and data science resources across UNH, and the state of New Hampshire through our NH-INBRE partners to build capacity in Data Science by providing access to the expertise, infrastructure, and training necessary for modern research.
Software for strand specific peak-pair calling in ChIP-exo replicates.
Web tool for detecting and characterising biosynthetic gene clusters in bacteria and fungi. AntiSMASH 6 increases number of supported cluster types from 58 to 71, displays modular structure of multi modular BGCs, adds new BGC comparison algorithm, allows for integration of results from other prediction tools, and detects tailoring enzymes in RiPP clusters.
Web-based repository and analysis site for connectivity matrices that have been derived from neuroimaging data including different imaging modalities, subject groups, and studies. Users can analyze connectivity matrices that have been shared publicly and upload their own matrices to share or analyze privately.
Portal to download and visualize rat gene expression and associations between genotypes and molecular phenotypes, uniformly processed across tissues.
Function for differentially methylated regions (DMR) detection that is a part of the charm package in R/Bioconductor.
Software lightweight Python library for computational pipelines. Reproducible pipeline framework.
An open organization engaged in the development of interoperable online metadata standards that support a broad range of purposes and business models. DCMI''s activities include work on architecture and modeling, discussions and collaborative work in DCMI Communities and DCMI Task Groups, annual conferences and workshops, standards liaison, and educational efforts to promote widespread acceptance of metadata standards and practices. The Dublin Core Metadata Initiative provides simple standards to facilitate the finding, sharing and management of information. DCMI does this by: * Developing and maintaining international standards for describing resources * Supporting a worldwide community of users and developers * Promoting widespread use of Dublin Core solutions The major characteristics of DCMI as an organization are (the three Is): * Independent: DCMI is not controlled by specific commercial or other interests and is not biased towards specific domains nor does it mandate specific technical solutions * International: DCMI encourages participation from organizations anywhere in the world, respecting linguistic and cultural differences * Influenceable: DCMI is an open organization aiming at building consensus among the participating organizations; there are no prerequisites for participation The development and maintenance of a core set of metadata terms (the DCMI Metadata Terms) continues to be one of the main activities of DCMI. In addition, DCMI is developing guidelines and procedures to help implementers define and describe their usage of Dublin Core metadata in the form of Application Profiles. This work is done in a work structure that provides discussion and cooperation platforms for specific communities (e.g. education, government information, corporate knowledge management) or specific interests (e.g. technical architecture, accessibility). Anyone wishing to participate may do so by simply joining the appropriate mailing list for the activity of interest. The DC-General mailing list is the general forum for community participation and announcements.