Curator Dashboard

Core provides fully automated high throughput screening (HTS) of Compound Libraries (130,000+ compounds) for both enzyme/protein-based assays and cell-based assays, using Caliper Life Sciences Staccato system;Genomic siRNA screening with siARRAY whole human genome siRNA library from Dharmacon targeting 21,000 genes, using Agilent Bravo system;High-Content Screening using ImageXpress Micro automated fluorescent microscope with live cell, bright field, phase contrast and integrated plate handling with Thermo Catalyst CRS, and image analysis using MetaXpress software;High Throughput Molecular Biology reagents and services, including access to cDNA libraries (Human ORFeome collection, 15,000 genes) and 96 and 384-well bead clean-ups and PCR setup (Biomek FX and Agilent Bravo), and other automation steps in collaboration with SFGF;High-throughput assay development assistance with cell culture, experiment design, robotic programming and Standard Operating Procedure drafting;Screening data analysis assistance with protocols, hit determination and structure activity analyses using MDL chemical database ISIS/HOST, Plate Manager, Assay Explorer and Report Manager. Use of microplate reader detection systems, including Tecan Infinite M1000 and Infinite M1000 PRO and Molecular Devices Analyst GT for fluorescence; fluorescence polarization; time-resolved fluorescence; absorbance and luminescence (with injectors and AlphaScreen); and Flexstation II 384, for kinetic fluorescence reads to measure calcium mobilization and ion channels.Use of liquid-handling robots, including Sciclone ALH3000 (96- and 384-well pipetting), Agilent Bravo (96- and 384-well pipetting), Velocity11 VPrep (96-well pipetting), Bio-Tek plate washers/dispensers, Matrix Wellmate and Titertek/Labsystems Multidrop microplate dispensers, and Velocity11 PlateLoc plate heat sealer;Training for most of these services.

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• SciCrunch
• 7 years ago - submitted by Edyta Vieth

An experiment in web-database access to large multi-dimensional data sets using a standardized experimental platform to determine if the larger scientific community can be given simple, intuitive, and user-friendly web-based access to large microarray data sets. All data in PEPR is also available via NCBI GEO. The structure and goals of PEPR differ from other mRNA expression profiling databases in a number of important ways. * The experimental platform in PEPR is standardized, and is an Affymetrix - only database. All microarrays available in the PEPR web database should ascribe to quality control and standard operating procedures. A recent publication has described the QC/SOP criteria utilized in PEPR profiles ( The Tumor Analysis Best Practices Working Group 2004 ). * PEPR permits gene-based queries of large Affymetrix array data sets without any specialized software. For example, a number of large time series projects are available within PEPR, containing 40-60 microarrays, yet these can be simply queried via a dynamic web interface with no prior knowledge of microarray data analysis. * Projects in PEPR originate from scientists world-wide, but all data has been generated by the Research Center for Genetic Medicine, Children''''s National Medical Center, Washington DC. Future developments of PEPR will allow remote entry of Affymetrix data ascribing to the same QC/SOP protocols. They have previously described an initial implementation of PEPR, and a dynamic web-queried time series graphical interface ( Chen et al. 2004 ). A publication showing the utility of PEPR for pharmacodynamic data has recently been published ( Almon et al. 2003 ).

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• SciCrunch
• 17 years ago - by Anonymous

Public research university in Lincoln, England. The University has origins that trace back to 1861, and obtained university status in 1992 and its present name and structure in 2001.

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• SciCrunch
• 17 years ago - submitted by Andrea Stagg

Core provides centralized service for generating AAV particles for cardiovascular studies. The CCDS Virus Production Core offers the production of either pre-made (ex. AAV8-GFP, AAV8 mPCSK9 D377Y) or custom AAVs.

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• SciCrunch
• 1 year ago - submitted by Edyta Vieth

Software tool which provides interactive visualization capability for the integrated analysis of high-dimensional gene expression data. Visual analytics for the integrated analysis of microarray data.

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• SciCrunch
• 13 years ago - by Anonymous

Private research university in Coral Gables, Florida.

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• SciCrunch
• 16 years ago - submitted by Stephen Larson

Core provides services for the use of Xenograft (PDX) models listed in open global catalogue of PDX models for comprehensive search and attribute filtering support for clinico-pathological and molecular data. Molecular data and visualization of profiled models could be accessed through the institute's portal.

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• SciCrunch
• 1 year ago - submitted by Edyta Vieth

The mission of the Association for Neuroscience Departments and Programs is to advance education and research training in academic neuroscience. We serve member programs and their trainees by maintaining a searchable directory of neuroscience training programs in North America and around the globe. An important goal for the ANDP is disseminate information about neuroscience education and training, and this is achieved through Fall and Spring meetings as well as electronic resource development. We perform a biannual survey of neuroscience education and training that provides key information on current trends in trainees, faculty and programs. Outstanding neuroscience educators are recognized with an annual ANDP award. Active ANDP members create an advocacy group for neuroscience that informs policy makers about neuroscience research and workforce needs. We work to be the stewards of the discipline..

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• SciCrunch
• 17 years ago - by Anonymous

Collegiate research university in Oxford, England. Teaching as early as 1096, making it the oldest university in English speaking world and world second oldest university in continuous operation.

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• SciCrunch
• 17 years ago - submitted by Andrea Stagg

Animal models of human disease are an invaluable research resource in the medical research community.Core provides services in the creation of animal models to the local research community and clients across Canada

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• SciCrunch
• 1 year ago - submitted by Edyta Vieth

A computer-readable format for representing models of biochemical reaction networks in software. It''s applicable to models of metabolism, cell-signaling, and many others. This website is the portal for the global SBML development effort; you can find information about all aspects of SBML.

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• SciCrunch
• 14 years ago - by Anonymous

Public research university in Tampa, Florida. It is part of the State University System of Florida.

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• SciCrunch
• 16 years ago - submitted by Andrea Stagg

Facility for conducting preclinical and clinical brain imaging research in the field of mental health. Provides platform to analyze brain imaging data from functional and structural neuroimaging techniques.

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• SciCrunch
• 1 year ago - submitted by Edyta Vieth

An evidence taxonomy for pharmacologic studies that, when combined with a set of inclusion criteria, enable drug experts to specify what their confidence in a drug mechanism assertion would be if it were supported by a specific set of evidence.

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• SciCrunch
• 13 years ago - by Anonymous

A public research university in Texas that offers degree programs in engineering, business, political science and the natural sciences at the undergraduate and graduate levels. The university also houses research that focuses on space science, bioengineering, cybersecurity, nanotechnology, and behavioral and brain sciences.

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• SciCrunch
• 17 years ago - submitted by Stephen Larson

Facility features 7 state of the art high field NMR instruments ranging from 400 to 600 MHz. The facility provides a diverse selection of probes including room temperature, LN2 cooled probes, 10mm Polymer probes, Diffusion and Solid-State NMR probes. The entire suite of 1D, 2D, Diffusion and Solid-State NMR capabilities are available for a broad range of nuclei.

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• SciCrunch
• 1 year ago - submitted by Edyta Vieth

THIS RESOURCE IS NO LONGER IN SERVICE, documented on July 16, 2013. A database of biochemical compound information. All files are available for download, and all entries are cataloged by accession number. Klotho is part of a larger attempt to model biological processes, beginning with biochemistry.

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• SciCrunch
• 17 years ago - by Anonymous

Institution in Wisconsin consisting of 13 four-year universities and 13 freshman-sophomore UW Colleges campuses.

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• SciCrunch
• 15 years ago - submitted by Andrea Stagg

A software package designed to determine the methylation parameter at each cytosine or cytosine-guanine position in the human genome. FadE uses color reads produced by the SOLiD sequencer or nucleotide reads produced by the Illumina or 454 sequencing platforms.

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• SciCrunch
• 13 years ago - by Anonymous

Health Research Funding is designed to bring researchers with peer-reviewed, worthwhile, unfunded projects together with patient advocacy organizations and other funding sources. Working together, we hope to foster the funding of new research that will provide hope to millions of people in this country with chronic diseases and disabilities. * We invite researchers with promising projects that have been scored but not funded by the NIH to submit their abstracts. By registering, you will be able to search for information about organizations that fund research and their requests for abstracts. * Researchers with proposals that have been peer-reviewed but not funded by a NHC member patient advocacy organization may also register. The National Health Council (NHC) developed this site with input from the National Institutes of Health (NIH), the nation''s medical research agency.

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• SciCrunch
• 17 years ago - by Anonymous