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Project combines immunology and computational biology laboratories in effort to establish complete road map of gene-expression and regulatory networks in all immune cells. Project will generate, with rigorously standardized conditions, complete compendium of genome-wide data sets showing expression of protein-coding genes for all defined cell populations of mouse immune system.
Core works with academic and industrial partners to develop and house advanced microscopy instrumentation and analysis tools.Provides custom microscopes to support users in their advanced imaging needs.
Open source software package for morphometric quantification of networks from 3D image stacks. Combines required tools for complete analytical workflow, from raw image to final measured values.
Facility is equipped with instruments for both high throughput and high content biochemical and cell based assays, including live cell assays.
Portal includes information about genetic studies of drug abuse in outbred rats. Data center created in 2014 to perform genome wide association studies on numerous behavioral traits that have well established relevance to drug abuse using outbred rats.
Software tool as open source controller for machine tools. Can drive milling machines, lathes, 3D printers, laser cutters, plasma cutters, robot arms, hexapods, and more.
Microscopy imaging system. Easily generates publication quality images at high throughput speeds.
Core provides researchers access to multiplex analysis of any sample type using commercially available or in house developed assays.Includes simultaneous measurement of multiple biomarkers in single small sample volume. Offers expertise in sample preparation and handling and knowledge that comes with extensive experience.
Web visualization tool that provides access to interactive exploration of pancreatic islet genomic data. Allows access and exploration of pancreatic islet epigenomic and transcriptomic data produced by different labs worldwide.
Software R package for analyzing UMI-4C chromatin contact data. Used to analyze chromatin contact profiles obtained by UMI-4C.
Core provides in house investigators and external clients with equipment for multiparameter flow cytometric analysis and cell sorting, training and expert assistance with various techniques in flow cytometry,cell sorting as well as consultation in experimental design, data analysis, presentation, and publication.
Software to design gRNAs pools in non-model genomes and CRISPR-Cas systems. Used to design CRISPR-Cas guide RNA pools in non model genomes.
Software R package as recursive partitioning for classification, regression and survival trees. Implementation of most of functionality of 1984 book by Breiman, Friedman, Olshen and Stone.
Software tool as structural variant classifier for exonic deletions and duplications. Supervised learning method to predict pathogenicity of human genome structural variants.Used to distinguish pathogenic SVs from benign SVs that overlap exons.
Core provides services for Experimental Design, Metagenomics, Comparative Expression Analyses, Variant Analyses, and Systems Biology. Overarching umbrella encompassing four distinct shared resource facility arms: DNA Analysis,Microarray,Massively Parallel Sequencing Facilities,Bioinformatics Shared Resource.
Single photon avalanche diodes camera for time correlated single photon counting imaging. Time resolved photon counting camera with in pixel timing electronics what enables time tagging of incoming photons with accuracy of 55ps.
Dual beam FIB/FESEM system, containing both focused Ga plus ion beam and ultra high resolution field emission scanning electron column and their combined use. Dual beam focused ion beam scanning electron microscope for nanofabrication.
Core helps to carry out analysis and research on SARS-COV2 virus. Provides COVID-19/ SARS-COV2/ 2019-nCoV Research Tools and Services.Team has developed related proteins, antibodies, nucleic acid extraction kits and other products to help researchers quickly develop effective anti-COVID-19 drugs and vaccines.Provides preclinical research services, various in vivo and in vivo research models, and in vivo diagnostic immunoassay services.
Software implements germline and somatic variant calling pipelines based on best practices pipelines from Broad Institute using Spark framework. Produces VCF output file which contains single nucleotide polymorphisms (SNPs) and short insertions and deletions (indels) when supported by used tools. Program requires Spark on either local cluster with one or more nodes, Amazon EMR cluster or Docker image to run.
Software tool can be used to calculate kappa, chance adjusted measure of agreement, for any number of cases, categories, or raters.