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Provides histological services, equipment, and technical expertise for processing and analyses of digestive, pancreatic, and liver tissues as well as three dimensional tissue culture models.�Part of the Center for Molecular Studies in Digestive and Liver Diseases

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• SciCrunch
• 4 years ago - submitted by Edyta Vieth

Core provides services to assess cardiovascular function in mouse models and to provide validated surgical models of heart and vascular disease in mice to assess genetic or therapeutic interventions. Works with investigators to design and implement study along with any associated grant applications, animal protocol submissions and manuscript preparation. While central focus of facility is cardiovascular research, techniques employed are often useful to investigators in other fields. Helps to assess your needs and provide necessary technical training and scientific assistance in animal protocol preparation. Core runs on a fee for service model.�Accordingly, investigators will be responsible for costs incurred for their projects and prior animal protocol approval by Penn IACUC., THIS RESOURCE IS NO LONGER IN SERVICE. Documented on September 16,2025.

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• SciCrunch
• 4 years ago - submitted by Edyta Vieth

Fosters the use of qualitative and mixed methods research methodologies with focus on integrating key stakeholder perspectives and goals into research designs. Collaborates with investigators to address timely, pressing questions across diverse disciplines and works with investigators to provide conceptual as well as technical support for broad research programs, including clinical, community based, and implementation science research questions.

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• SciCrunch
• 4 years ago - submitted by Edyta Vieth

Provides equipment for aerobic and anaerobic culture of microbial species in both batch and continuous systems, as well as targeted metabolomic services of amino, bile, and short chain fatty acids. Offers training and usage for culture equipment; consultation regarding experimental design, and; anaerobic culture services. Examples of culture studies include isolation of microbial taxa from mammalian samples; interrogation of the physiology of microbial strains under different conditions (e.g., anaerobic/microaerobic/aerobic, differing nutrient limitations) using isolated strains or strains obtained from culture collections (another service offered by the core); co-culturing of defined microbial consortia to investigate microbe-microbe interactions, and; preparation of microbial products (live bacteria, heat-killed bacteria, bacterial supernatants) from single or defined-mixed microbial cultures for use in mammalian cell culture and/or animal model systems.

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• SciCrunch
• 4 years ago - submitted by Edyta Vieth

Core within Division of Gastroenterology provides services which�represents intersection between host and their microbes in both�preclinical and clinical human subject research.Offers human biospecimen repository with associated clinical metadata, instrumentation/access to critical analytic services to characterize expression (i.e. genomics, transcriptomics, metabolomics, microbial culture, etc.) in both microbes and�their mammalian hosts, as well as expertise to extend pre-clinical in vitro and animal model research into human clinical domain. �

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• SciCrunch
• 4 years ago - submitted by Edyta Vieth

BioBank supports researchers by providing centralized access to large number of annotated blood and tissue samples.

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• SciCrunch
• 4 years ago - submitted by Edyta Vieth

Provides unique equipment and expertise to facilitate modern biophysical characterization and structural analysis of proteins and other biomolecules., THIS RESOURCE IS NO LONGER IN SERVICE. Documented on September 16,2025.

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• SciCrunch
• 4 years ago - submitted by Edyta Vieth

Core works with existing resources to provide targeted study design and biostatistics support to ITMAT/CTSA investigators.Services include protocol review, study design, proposal development, and performance of simple to potentially substantial complex analyses. SDAB integrates support available with HUP and CHOP Center for Human Phenomic Science (CHPSs), expertise and resources of faculty in Center for Clinical Epidemiology and Biostatistics / Department of Biostatistics and Epidemiology (CCEB/DBE), Biostatistics Analysis Center (BAC), and Biostatistics and Data Management Core (BDMC) at CHOP.

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• SciCrunch
• 4 years ago - submitted by Edyta Vieth

Offers services to assist with design and implementation of microbiome studies.Assist with longitudinal studies as well as pilot studies.� Pilot studies can be rapidly implemented with human intervention core staff, project managers and research coordinators.

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• SciCrunch
• 4 years ago - submitted by Edyta Vieth

Provides support including experimental design, islet isolation, and performance of and/or training in range of assays for physiological, metabolic, and morphometric assessment of pancreatic islets as wells as many other tissues and cell types. Offers islet isolation and culture, free intracellular calcium ion measurements, quantitative oxygen consumption of pancreatic islets, electrode based closed cell respirometry, and access to Agilent�s� Seahorse Extracellular Flux Analyzer XFe96.

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• SciCrunch
• 4 years ago - submitted by Edyta Vieth

CyTOF�enables multi-parametric high-dimensional single�cell analysis�of more than 40 markers per cell, with�minimal background and compensation�issues.�Core�offers variety of�CyTOF-related services including�reagent distribution, consultation,�antibody conjugation, and data acquisition.�

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• SciCrunch
• 4 years ago - submitted by Edyta Vieth

Core assists faculty, staff, and students with conducting research projects using electronic health record data.Facilitates access to clinical data and performs data analysis using artificial intelligence, ontologies, natural language processing, machine learning, and visual analytics. Provides innovative research services by applying data science to clinical data in order to learn actionable healthcare knowledge and develop impactful solutions for improving patient care. Services include facilitating access to Penn Medicine clinical data resources, performing data analysis using diverse computational methods, and providing tools for exploratory data analysis/visualize with priority access to the IBI Idea Factory for immersive display of data and research results. �

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• SciCrunch
• 4 years ago - submitted by Edyta Vieth

Core aims to facilitate and build capacity for community based research and community engagement, while enhancing translation of research and technological developments to key public health and community stakeholders. Offers consultation on community engagement, training in participatory research methods, and assistance with development, implementation, and evaluation of community translation activities. Core is part of the Penn Institute for Translational Medicine and Therapeutics (ITMAT).

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• SciCrunch
• 4 years ago - submitted by Edyta Vieth

Human tissue procurement service within Department of Pathology at HUP, that assists investigators with collection, processing and preservation of research samples. Our staff will personalize sample acquisition and processing to meet project requirements. Samples (malignant, normal, diseased, etc.) and biofluids can be preserved in a range of methods (fresh, frozen, fixed, etc.).

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• SciCrunch
• 4 years ago - submitted by Edyta Vieth

Linux based High Performance Computing resource available to faculty conducting research related to medical imaging and informatics. There are over 150 compute nodes with more than 5000 Intel Xeon CPUs and 58TB of RAM, over 100 GPUs, and 600TB of storage in the cluster. Facility management structure is designed to encourage data sharing and use of common software on this powerful resource, particularly in development of new software and application of imaging to new domains.

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• SciCrunch
• 4 years ago - submitted by Edyta Vieth

Core offers immunoassay, metabolite, and HPLC services to basic, translational, and clinical investigators performing diabetes and related metabolic disease research.RIA /Biomarkers Core is located on the 12th floor of Smilow Center for Translational Research.Approximately 100 different diabetes, obesity and metabolism-related biomarkers from multiple species including human can be assayed using radioimmunoassay (RIA), enzyme-linked immunosorbent assay (ELISA, both absorbance and fluorometric), multiplex ELISA on the Luminex platform, and enzymatic and HPLC methods for an expanding variety of diabetes and metabolism related metabolites, hormones, catecholamines and cytokines derived from blood, urine, and tissue samples.

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• SciCrunch
• 4 years ago - submitted by Edyta Vieth

Provides comprehensive services essential to the conduct of clinical research projects, including Phase I-IV, multi-center, randomized, clinical trials, registry, and cohort studies. Offers expert staff who maintain a strong focus on data integrity and quality and offers support in optimizing process tracking and management to enhance operational efficiency. Core specializes in the following: Study design and development; Site management and training; Data collection, processing, and quality control; Regulatory requirements and reporting; Database development, storage, and security; System integration (e.g., EPIC data); 21CFR Part 11 Compliance; Proposal development and administration; REDCap development; Honest Broker services.

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• SciCrunch
• 4 years ago - submitted by Edyta Vieth

Facility provides comprehensive viral and molecular support in area of basic, translational and clinical HIV research, consultation, training, and mentoring.Is available to develop customized viral and molecular support services as needed. Offers deep sequencing support and single genome amplification services.

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• SciCrunch
• 4 years ago - submitted by Edyta Vieth

CHPS is comprised of several Clinical Research Cores designed to facilitate research process. Provides resources, environment, operations, and training to support and promote high quality clinical and translational research by qualified investigators.

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• SciCrunch
• 4 years ago - submitted by Edyta Vieth

Supports next generation infrastructure for clinical data storage and management, next generation analytics, next generation infrastructure for support of clinical research including new clinical trials management system and software, next generation infrastructure for centralizing and integrating external sources of data such as genomics data. Enables future clinical and translational research through biomedical informatics education and training targeted at graduate students, postdoctoral students, residents, fellows, as well as faculty across the biomedical research spectrum.

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• SciCrunch
• 4 years ago - submitted by Edyta Vieth