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Software tools to register histological section images and cell count locations to mouse brain atlas. Semi automated workflow and GUI for automated brain slice histology alignment, registration, and cell quantification. Used to explore Allen Mouse Brain Atlas, register asymmetric slice images to atlas using manual input, and analyze region of interest data by registering locations of fluorescently labeled cells to standardized regions of Atlas.
Software R package for data analysis, graphics, utility operations, functions for computing sample size and power, simulation, importing and annotating datasets, imputing missing values, advanced table making, variable clustering, character string manipulation, conversion of R objects to LaTeX and html code, and recoding variables.
Software R package to create tidy data frames of marginal effects for ggplot from model outputs. Used to compute marginal effects and adjusted predictions from statistical models and returns result as tidy data frames.
Software tool to calculate enrichment scores. Generates human and machine readable labels that quantify features enriched in sample. Used to identify multiple populations of cells and to compare each population to all of other remaining cells from original sample.
Software R package for modeling beta distributed dependent variables, e.g., rates and proportions. In addition to maximum likelihood regression (for both mean and precision of beta distributed response), bias corrected and bias reduced estimation as well as finite mixture models and recursive partitioning for beta regressions are provided.
Software tool as adapter that abstracts SingleCellExperiment container in form of tibble and allows data manipulation, plotting and nesting.
Offers high speed cell sorting and bench top flow cytometric analysis services as well as training and support to research community.Instruments include BD FACSAria Fusion Cell Sorter,4-Laser | 16-Colour (2B/3R/5YG/6V) within Class II Type A2 BioSafety Cabinet and BD LSRFortessa X-20 Cell Analyzer 4-laser | 16-Colour (2B/3R/5YG/6V).
Software program for interactive processing of LC-MS-based metabolomics data. Open source cross platform metabolomics data analyser. Used to reduce complexity of metabolomics analysis by developing highly intitute interface for exploring and validating metabolomics data. Program features multi-file chromatographic aligner, peak-feature detector, isotope and adduct calculator, formula predictor, pathway visualizer, and isotopic flux animator. Data from both triple quadropole and full spectrum instruments is supported.
Reference database of human transcriptional regulatory interactions. Manually curated database of human and mouse transcriptional regulatory networks.
Software Python library for mixed effects meta regression including meta analysis.
Understanding the mechanism of cell death and survival is the key content of toxicological analysis and drug development and application. Since the cell death pathway is complex and dynamic, multi-parameter analysis is very important for the accurate detection of this process.
Clinical Imaging Core Service Center includes RADCORE, Tumor Response Assessment (TRAC) and Research imaging guided biopsies cores. Supports cancer clinical trials. RADCORE staff include clinical research professionals with range of expertise in imaging based clinical research protocols and offers services in consultation, management of research protocols and Radiology IND/IDE support office. Tumor Response Assessment Core (TRAC) team of Radiologist is skilled in evaluating tumor response imaging assessments for patients enrolled in cancer clinical trials being conducted at UPHS. Research imaging guided biopsies Interventional Radiology and technical staff provides consultation to define biopsy protocol and pathology tissue collection.
Provides project based bioinformatics support for ITMAT translational researchers. Provides computational infrastructure and programming support needed to conduct high-throughput proteomics experiments. We also support other genomics high-throughput technologies to a lesser extent. The projects range from building Web applications for data analysis pipelines, scripting, clinical and basic science research support, and database and algorithm development. Recent efforts have focused on explorations of new models of computation, specifically cloud computing and GPUs, for use in genomic scale research.
Core provides consultations and fee for service support in big data analyses using methods of data science in biomedical and health research related to digestive disease and liver research.
Flow cytometry analysis software for fast analysis, easy collaborative access to data, and tailored data visualization.
Software package for liquid chromatography mass spectrometry retention time alignment.
Facility is focused on characterization of multifunctional soft materials. Includes four instrumentation suites based on soft matter centered research areas which will be unified by general theme of characterization of hierarchically structured multicomponent, multifunctional soft materials: Molecular Characterization, Processing and Mechanics, Thin Films and Interfacial Analysis, and Nanostructure Characterization.
Provides infrastructure for imaging based small animal research.Includes noninvasive anatomy, physiology, and biochemistry assessment for disease detection and therapeutic monitoring.