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A major biomedical research institute located in the northeastern corner of Berlin, Germany, with a mission of translating discoveries from molecular research into applications to improve the prevention, diagnosis, and treatment of major human diseases. The work of the MDC''s 57 research groups centers around three classes of disease which have an enormous impact on society: * Cardiovascular and metabolic diseases * Cancer * Nervous system disorders

• Organization
• SciCrunch
• 15 years ago - submitted by Andrea Stagg

Core Facility provides functional genomics, highthroughput screening (HTS), and high-content screening (HCS) services toward the discovery of novel cancer targets and elucidation of complex, aberrant cellular pathways. Offers assistance and training in range of cloning, customized library design, lentivirus production, assay development, screening, and image analysis considerations to assist researchers in harnessing these powerful target identification tools and drug screening methodologies. Offers CRISPR-mediated transcriptional activation/interference (CRISPRa/CRISPRi) technologies combined with lentivirus delivery systems, customized stable isogenic cell line generation (knockout, HDR-directed knock-in, knockdown, base editing, and prime editing) toward the generation of unique cancer cell line models.

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• RRID
• 11 months ago - submitted by Patrick Badua

THIS RESOURCE IS NO LONGER IN SERVICE, documented on January 29, 2013. Supplemental data for the paper Changes in mitochondrial function resulting from synaptic activity in the rat hippocampal slice, by Vytautas P. Bindokas, Chong C. Lee, William F. Colmers, and Richard J. Miller that appears in the Journal of Neuroscience June 15, 1998. You can view digital movies of changes in fluorescence intensity by clicking on the title of interest.

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• SciCrunch
• 17 years ago - by Anonymous

The largest agricultural research institute in Japan for basic life sciences focusing on understanding the biological phenomena of agriculturally important plants, insects, microbes and animals to create innovative technologies, and eventually contribute to the solution of global issues such as food shortage due to rapid population growth and environmental problems due to climate change. Research activities are pursued in a 5-year cycle to intensify all efforts towards a common goal and to forge the way for new breakthroughs with direct impact to agricultural productivity.

• Organization
• SciCrunch
• 13 years ago - submitted by Andrea Stagg

Represents central facility and does not operate for profit, engaging in academic research collaborations and service provision on collaborative basis. Provides infrastructure for all kinds of sequencing, gene mapping and whole genome association studies in complex diseases as well as the validation of copy number variations.

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• RRID
• 11 months ago - by Anonymous

It is a specialized research center supported by the Protein Structure Initiative (PSI) of the National Institute of General Medical Sciences (NIGMS), one of the National Institutes of Health (NIH). PSI is a federal, university, and industry effort aimed at dramatically reducing the costs and lessening the time it takes to determine a three-dimensional protein structure. The long-range goal of PSI is to solve 10,000 protein structures in 10 years and to make the three-dimensional atomic-level structures of most proteins easily obtainable from knowledge of their corresponding DNA sequences. CESG is located within the Department of Biochemistry at the University of Wisconsin-Madison (Madison, WI) and the Department of Biochemistry at the Medical College of Wisconsin (Milwaukee, WI). CESG develops new methods and technologies to address unique eukaryotic bottlenecks and disseminates its methodologies and experimental results to the scientific community worldwide through: :- Cell-Free Protein Production Workshops :- Plasmids at PSI Materials Repository :- Posters Presented at Scientific Meetings :- Publications in PubMed / PubMed Central :- Sesame (LIMS) Available for Researchers :- Solved Structures in the Protein Data Bank :- Technology Dissemination Reports They have welcomed requests by researchers to solve eukaryotic protein structures, particularly medically relevant proteins, through our Online Structure Request System for Researchers. They have solved many community-nominated targets and deposited information about these targets in public databases and published on our investigations and findings. Sponsors: CESG is supported by NIH / NIGMS Protein Structure Initiative grant numbers U54 GM074901 and P50 GM064598.

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• SciCrunch
• 14 years ago - by Anonymous

StemCore Laboratories is a high-throughput genomics facility within the Ottawa Hospital Research Institute (OHRI). StemCore Laboratories is developing a world-class infrastructure for genomics, bioinformatics, and proteomics, and is capable of facilitating large-scale scientific research and biotechnology projects. Stemcore Laboratories seeks out projects that are challenging, cutting-edge, extend the boundaries of biological knowledge, and will positively impact the state of human health. Funded: Genome Canada, The Ontario Genomics Institute, The Canadian Foundation for Innovation, The Government of Ontario, The Stem Cell Network, Stantive Solutions

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• SciCrunch
• 17 years ago - by Anonymous

Core facility that provides microscopy training, imaging solutions, image processing and analysis services, and consultation. Offers imaging techniques and expertise, including spinning disc confocal microscopy, two-photon confocal microscopy, super resolution microscopy, total internal reflection microscopy, wide field microscopy, fluorescence spectroscopy, photo-manipulation techniques (e.g. FRAP, photoablation, optogenetics, and optical tweezers) and live cell imaging.

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• RRID
• 10 months ago - by Anonymous

AMSER is a portal of educational resources and services built specifically for use by those in Community and Technical Colleges but free for anyone to use. AMSER provides links to resources for faculty, staff, librarians, students and others for use in both educational settings or in their pursuit of life long learning. Sponsors: AMSER is funded by the National Science Foundation (NSF) as part of the National Science Digital Library, and is being created by a team of project partners led by Internet Scout.

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• SciCrunch
• 17 years ago - by Anonymous

Hospital known officially as the Sir Mortimer B. Davis Jewish General Hospital since 1978, is an acute-care teaching hospital in Montreal, Quebec, Canada. The hospital is affiliated with McGill University

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• SciCrunch
• 13 years ago - submitted by Andrea Stagg

This dataset includes human brain stimulated-echo (STE) diffusion MRI (dMRI) images acquired at the long diffusion time of 1 second from 10 healthy volunteers and an ex vivo brain hemisphere, as described by Aganj et al (MRM 2026). Also included are MPRAGE T1 images for all scans and standard dMRI images for the 10 in vivo scans. All images have been anonymized, and the T1 images have been de-faced.

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• NIF
• 10 months ago - submitted by Iman Aganj

Provides support for the Apache community of open-source software projects. The Apache projects are characterized by a collaborative, consensus based development process, open and pragmatic software license, and a desire to create high quality software that leads the way in its field.

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• SciCrunch
• 14 years ago - by Anonymous

A research institute focused on the application of state of the art genomics and bioinformatics to advance plant, animal and microbial research to promote a sustainable bioeconomy. TGAC is a hub for innovative bioinformatics founded on research, analysis and interpretation of multiple, complex data sets. We host one of the largest computing hardware facilities dedicated to life science research in Europe.

• Organization
• SciCrunch
• 15 years ago - submitted by Andrea Stagg

Software R package to compute and illustrate the multiple facets of Functional Diversity. Provides graphical functions based on the ggplot library to illustrate FD values through customizable and high-resolution plots of species distribution among functional entities or in a multidimensional space. All functions include internal validation processes to check for errors in data formatting which return detailed error messages. Used to compute a global assessment of functional diversity by gathering computation of alpha and beta functional indices.

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• RRID
• 9 months ago - submitted by zhu pengjin

V3D is a handy, fast, and versatile 3D/4D/5D Image Visualization & Analysis System for Bioimages & Surface Objects. It also provides many unique functions, is Open Source, supports a very simple and powerful plugin interface and thus can be extended & enhanced easily. V3D-Neuron is a powerful 3D neuron reconstruction, visualization, and editing software built on top of V3D. Both V3D and V3D-Neuron have recently been published in Nature Biotechnology (April, 2010), and Highlighted in Nature Methods (May, 2010), and Science News (April, 2010), etc. V3D is a cross-platform (Mac, Linux, and Windows) tool for visualizing large-scale (gigabytes, and 64-bit data) 3D image stacks and various surface data. It is also a container of powerful modules for 3D image analysis (cell segmentation, neuron tracing, brain registration, annotation, quantitative measurement and statistics, etc) and data management. This makes V3D suitable for various bioimage informatics applications, and a nice platform to develop new 3D image analysis algorithms for high-throughput processing. In short, V3D streamlines the workflow of visualization-assisted analysis. In the latest V3D development, it can render 5D (spatial-temporal) data directly in 3D volume-rendering mode; it supports convenient and interactive local and global 3D views at different scales. It even has a Matlab file IO toolbox. A user can now write his/her own plugins to take advantage of the V3D platform very easily.

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• SciCrunch
• 17 years ago - by Anonymous

Department of Health and Social Care is a department of Her Majesty's Government, responsible for government policy on health and adult social care matters in England.

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• SciCrunch
• 19 years ago - submitted by Andrea Stagg

Facility for protein production. Provides services for protein expression and purification, assists with projects in designing strategies for high level expression of soluble proteins, provides vectors and strains. Offers clonning the gene of interest into expression vectors, rapid screening for optimal combinations of vectors, strains and expression conditions and producing protein of interest in E. coli, Pichia pastoris, mammalian and insect cells. Produces biomass at 1L to 10L scale using multiple bioreactor system for high cell density fermentation of bacteria and yeast cells and reusable bioreactor for cell culture. Proteins are then purified using standard techniques and chromatography systems. Quality control is routinely assessing protein identity, purity, stability and folding using set of different biochemical and biophysical methods.

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• SciCrunch
• 2 years ago - submitted by Edyta Vieth

THIS RESOURCE IS NO LONGER IN SERVICE, documented on July 16, 2013. The International Observatory on Neuro-Information is the central source of knowledge, research and data on all skills and issues for Neuroscience applied in Information Sciences. It is an initiative of the Documentation Sciences Foundation, from Spain, which aims to gather information, express opinions, prepare documents, make comparative research, support and promote policy-making, evaluate trends, and take other appropriate action relating to the Neuroscience and its application to the Information Sciences (Libraries, Archives, Documentation centers), and how the traditional knowledge of Information Sciences can bring expertise in data visualization and retrieval techniques, records management, quality assurance and usability in Neuroscience. The Observatory may work together, or in agreement with other national or international organizations pursuing similar or compatible aims.

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• SciCrunch
• 17 years ago - by Anonymous

A funding agency for basic research in Finland and operates within the administrative sector of the Ministry of Education. Their mission is to finance high-quality scientific research, act as a science and science policy expert, and strengthen the position of science and research. The Academy works to contribute to the renewal, diversification and increasing internationalisation of Finnish research. Its operation covers the full spectrum of scientific disciplines.

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• SciCrunch
• 17 years ago - by Anonymous

Specialized, collaborative unit providing bioinformatics, biostatistics, and data analysis services to researchers across Kentucky. It enhances biomedical research capacity through expert support in experimental design, grant application assistance, and high-throughput data analysis, primarily serving faculty and students at member institutions.

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• RRID
• 9 months ago - submitted by Eric Rouchka