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Full service sequencing facility to assist with genetic and genomic research. Part of Integrated Genomics Cores. Offers comprehensive library services, NextGen sequencing and alternative technologies including long reads. Offers library preparations and multiple sequencing platforms including MiSeq, HiSeq, NovaSeq, NextSeq, BioNano, Oxford Nanopore. Services also include using techniques and data analyses via sister core BARC.
Provides biospecimen sample processing, extraction and biorepository services. Offers expertise to advance preclinical and clinical studies.
Provides support for mass spectrometry based proteomics and metabolomics research. With advanced instrumentation and highly trained staff, core offers consultation and services in sample preparation, sample separation, data collection and data analysis.
Supports development and maintenance of preclinical mouse models, including patient derived xenografts, cell line xenografts and genetically engineered mouse models.
Provides in vivo imaging technology and infrastructure to support basic and preclinical research. Offers diverse array of imaging modalities, including ultrasound and optical imaging, MRI, micro-CT and multiphoton microscopy.
Supports investigators seeking evaluations of immunologic responses in basic and early stage clinical research settings. Provides resources and expertise to evaluate cellular immunologic processes and responses through reagents, molecular and cellular assays, assay development support and research consulting services.
Helps investigators integrate, interpret and explore large and diverse datasets. Provides services that support analysis of large scale datasets for biomedical researchers, drawing on expertise in computational biology, software engineering and cloud architecture. Offers project based scientific analysis by bioinformaticians, automation of analytical pipelines using workflow management platforms, publication of complex datasets with web accelerated graphics, training and documentation to enable scientist driven computation.
Includes services from sterile cell sorting for therapeutic applications to whole cell mass spectrometry, diagnostics and early stage clinical trials. Provides expertise from experimental design to data analysis and troubleshooting, therapeutic cell sorting. Supports isolation of cells for Phase 1 clinical trials of cellular immunotherapies.
Provides expertise in anatomic pathology technologies. Offers routine and special staining, immunohistochemistry, in situ hybridization and digital pathology in support of internal and external investigators who rely on histological analysis.
Offers techniques to resolve structures from cellular ultrastructure to molecular interactions. Offers expertise in EM sample preparation and imaging, cryogenic electron microscopy, technologies and services, training through complexities of electron microscopy workflow, from sample preparation to image processing. All users must be trained by core staff.
Core teams of technicians, veterinarians, pathologists and operations specialists offer services in diagnostic and research pathology and support development and maintenance of preclinical mouse models, including mice bearing humanized immune system. Provides access to high quality technical services and immune deficient mice. Can perform individual technical services or complete entire in vivo experiments. Facilities are fully accredited by Association for Assessment and Accreditation of Laboratory Animal Care International and comply with all U.S. Department of Agriculture, Public Health Service, Washington state and local area regulations.
Provides advanced light microscopy services for biomedical and translational research including workflow, training for independent work, assistance and technical support in microscopy techniques, quantitative image analysis. Offers training and support for imaging and analyzing gels and blots.
Designs campaign strategies for generation and identification of novel monoclonal antibody compositions. Our projects encompass range of applications in oncology, viral therapeutics and diagnostics.
Through Shared Resources, investigators in Fred Hutch/University of Washington Cancer Consortium and external academic and industry organizations can access services tailored to their specific research goals, including novel assay development or early access to new technologies.
Provides set of services that encompass experimental design, data generation and data interpretation. Expert genomics and bioinformatics teams are available to consult and collaborate at every step of process and work closely together to develop optimized experimental strategies to ensure that appropriate technology and data analysis tools are used to address each unique scientific question.
Provides access to variety of microscope modalities including laser scanning and spinning disk confocal, multiphoton, wide field deconvolution, CFP/YFP FRET, TIRF, single molecule imaging, and more. Offers customized microscopy training, advise and help with sample preparation, image quantification, and offer basic microscope maintenance. Can streamline your data handling and image visualization as well as automate your image analysis workflow through customized Fiji macros.
Web server for potential drug target identification using pharmacophore mapping approach.Designed to identify potential target candidates for given probe small molecules including drugs, natural products, or other newly discovered compounds with binding targets unidentified using pharmacophore mapping approach. Used for potential drug target identification with comprehensive target pharmacophore database.
Software R tool as simple R implementation of PhenoGraph algorithm, which is clustering method designed for high dimensional single cell data analysis.
Portal provides genomic and transcriptomic data for researchers interested in Hydractinia genomics and molecular biology. Includes browsers for the H. symbiolongicarpus and H. echinata genome assemblies and interactive interface for interrogating H. symbiolongicarpus single cell gene expression atlas. Provides gene pages with functional annotation data for every gene model for both species, including protein domain composition and orthology predictions.
Software miniscope analysis pipeline that requires low memory and computational demand so it can be run without specialized hardware. Offers interactive visualization that allows users to see how parameters in each step of pipeline affect output.