We support boolean queries, use +,-,<,>,~,* to alter the weighting of terms
Software Rust library with Python bindings for bounded-memory, near-real-time preprocessing of high-density (Neuropixels-scale) extracellular electrophysiology recordings. It streams bandpass filtering, common median referencing, and whitening one chunk at a time with the Python Global Interpreter Lock released, bounding peak memory by chunk size rather than recording length.
Multi-organism database containing interactions and roles of proteins in inter- and intracellular signaling and transcriptional and post-transcriptional regulation.
Software R package to detect empty droplets, damaged, and intact cells, and accurately distinguish them from one another. Identification of empty droplets and damaged cells in scRNAseq data.
Software R package for fast Wilcoxon rank sum test and auROC analysis.
Software tool as linear mixed-effects model estimation algorithm. Single-cell differential expression analysis using linear mixed-effects models.
Web browser-based platform for multiplexed imaging and spatial transcriptomics. Used for interactive discovery of spatial biology at scale.
Software toolkit for processing multiplexed tissue images. Used for multiplexed tissue image processing and analysis that integrates previously developed computational tools.
Software tool to build the "network twin" of 2D and 3D tissues from segmented microscopy images. Used for network generation from segmented tissue images.
Software tool for assignment of cell type across a range of single-cell technologies such as Imaging Mass Cytometry (IMC). Probabilistic model to assign cells to cell types by integrating prior knowledge of marker proteins.
Core specializes in advanced analysis of proteins to investigate brain functions and neurological disorders. Provides equipment to study protein structure, interactions, and modifications. Services include Mass Spectrometry and Advanced Analysis, Protein Production and Engineering, Amplification of Misfolding Proteins, Highly Sensitive Multiplexed Immunodetection, Sample Preparation and Fractionation.
Software molecular interaction-guided graph learning framework for multi-omics cancer classification. Graph Neural Network-Oriented Multi-Omics Integration Network for Cancer Classification.
Clinical neuroscience research institute in Tulsa, Oklahoma, dedicated to identifying biological markers and developing advanced interventions for mental health conditions, including disorders of mood, anxiety, eating, and substance use.
Core provides centralized recruitment, screening, and standardized self-report, interview-based, and behavioral assessments to support psychiatric and mental health research. Using validated measures aligned with transdiagnostic frameworks, the Core facilitates efficient participant recruitment, high-quality data collection, and reproducible assessment procedures across studies. By providing consistent, reliable phenotyping and behavioral data, the Core accelerates research, supports multidisciplinary investigations of mood and anxiety disorders, and serves as a shared resource for investigators within LIBR and collaborating institutions.
Core offers confocal and conventional fluorescence microscopes and image analysis resources. Provides access to standard and advanced imaging instrumentation. Imaging services include help with live cells, fixed samples, model organisms, small animals, single molecules or at most points in between.
Automated incubator and storage device for robotic integration to manage and incubate microplates for cell cultures, assay screening, and biologics workflows without human intervention. Maintains specific temperatures, high humidity, and stable CO₂ levels to keep cells alive and assays viable. Uses ContraCon thermal decontamination (without harmful gases) to maintain a sterile environment and protect sensitive samples.
Reference database of inferred immune receptor genes. Public repository used by immunologists and computational biologists to publish, review, and maintain adaptive immune receptor (antibody and T-cell receptor) genes. Curated database of Ig and TR receptor germline sequences. Provides sets for use in receptor repertoire annotation and analysis, in formats suitable for widely-used analysis tools. Enables reproducible, evidence-based analysis of immune receptor diversity across populations and species, supporting both fundamental immunology research and precision medicine applications.
Core is dedicated process development and through GMP production facility within the UNL College of Engineering, primary focus on microbial (bacteria, yeast) expression systems. Offers biopharmaceutical process development and biomanufacturing services that transition discoveries to non-clinical studies and Phase I/II and early Phase III clinical trials.
Software tool to infer and map cell-to-cell communication networks using single-cell RNA sequencing (scRNA-seq) or proteomics data. Used for inference of intercellular networks from single-cell transcriptomics.
Software R package for calculation and interactive exploration of cell-cell signaling network topologies contained in single-cell RNA-sequencing data. Used to explore cell-cell connectivity patterns based on ligand and receptor data in heterogeneous single-cell datasets.
Software Python toolkit for multi-cellular communication network construction and network analysis of multispecies single-cell and bulk gene expression and proteomic data.