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Software R package for spatially resolved transcriptomics analysis and visualization.
Software R package to calculate spatial distance between spots from spatial transcriptome data. Calculates nearest neighbor distances between specified cell types and provides comprehensive visualization tools to explore spatial patterns. Used for analyzing spatial relationships between cell types in spatial transcriptomics data, studying cell-cell interactions, immune microenvironment characterization, and spatial organization of tissues.
Software R package that automatically classifies the cells in the scRNA data by segregating non-malignant cells of tumor microenviroment from the malignant cells. It also infers the copy number profile of malignant cells, identifies subclonal structures and analyses the specific and shared alterations of each subpopulation.
Software tool for signature analysis and visualization for single-cell RNA-seq data by selecting for gene signatures which describe coordinated variation between cells.
Software R package for learning cell types and cell type-specific differential expression in spatial transcriptomics data. Used for cell type identification (including cell type mixtures) and cell type-specific differential expression for spatial transcriptomics.
Software R package to convert Seurat objects to 10x Genomics Loupe files. Works with Seurat objects to create a .cloupe file. The .cloupe file can then be imported into Loupe Browser v7.0 for data visualization and further exploration.
Open benchmark for scientific critique honesty and epistemic calibration on recent life-science and biomedical literature. It tests whether models keep claims inside what the evidence allows (overclaim / planted-flaw / falsifier selection) and whether stated confidence is calibrated, with judge-free MCQ axes plus open-ended critique scoring.
Browser-based tool to open almost any sequence file — FASTA, FASTQ, GenBank, EMBL, Swiss-Prot, AB1/ABIF, SCF, Clustal, Stockholm, PHYLIP, NEXUS, MSF, PIR and more — see every sequence inside, pick the ones you want, and save them as FASTA. The format is detected from the file content, not from the extension, so unlabelled or misnamed files still open. Runs entirely in the browser — files are never uploaded.
Browser-based viewer for GenBank and GenPept files. Renders an interactive linear and circular feature map, the annotated source text, and the nucleotide/protein sequence side by side. Translates CDS features using the record's own genetic code and translation qualifiers, flags where the stored /translation disagrees with a plain translation, and adds optional computed layers: ORF prediction and restriction-site mapping. Handles multi-record files. Runs entirely in the browser — files are never uploaded.
Browser-based viewer for Sanger sequencing chromatograms in AB1/ABIF and SCF format. Opens .ab1/.abi/.fsa files, shows raw and analysed traces, basecalls, quality values and the ABIF directory, and puts two reads side by side for comparison. Aligns a read against a reference sequence to highlight mismatches. Exports the read as FASTA, FASTQ or ABIF and the chromatogram as a high-resolution image. Runs entirely in the browser — files are never uploaded.
The Zeiss Axio Incubation Microscope is an inverted fluorescence incubation microscope equipped with CO2 and temperature control designed for live cell imaging, advanced biological research and automated fluorescence imaging. This microscope can perform varied transmitted light and multi-channel fluorescence light imaging including z-stack, tiling, time series and multi-area time series measurement and is fully equipped with color and monochrome imaging modes. The system’s Apotome is able to maintain focus over long periods of time during time series imaging. Objectives include long working distance/multi-immersion/oil immersion ranging from 5x to 100x. Compatible sample carriers include slides, petri dishes and multi-well plates.
Centralised service facility for flow cytometry. Supports users in purification and analysis of (cell) samples using flow cytometry, FACS-based experiments from selection of experimental approach, provision of proven protocols and reagents, to performance of cell sorting as a service, equipment training and assistance with sample FACS-based analysis. Offers evaluation of FACS data and provides digital licences for common analysis software.
Provides manufacturing micro- and nanofluidic devices for biomedical research, equipment and resources for applications with micro- and nanofabrication needs. Facility conisists of ISO class 7 cleanroom space, housing tools and materials for techniques including photolithography, nano-imprint lithography, plasma (dry) etching (ICP-RIE), wet etching, thin film deposition, scanning electron microscopy (VP-SEM), atomic force microscopy, contact angle goniometry, ellipsometry, profilometry, wafer dicing, wire bonding, laser ablation and engraving, 3D printing, hot embossing, and COMSOL software for device modeling. In addition, the facility has numerous microscopes for general inspection, ovens and furnaces, ultrapure water, and dedicated process fume hoods.
Software R Package to calculates partial and semi-partial (part) correlations along with p-value. Fast Calculation to Semi-partial Correlation Coefficients.
Web-based application, based on DNA microarrays results, to improve gene prognostic analysis performance by using the same bioinformatics process. Statistical mining tool of published annotated breast cancer transcriptomic data (DNA microarrays [n = 11 552] and RNA-seq [n = 5 023]). It offers the possibility to explore gene-expression of genes of interest in breast cancer.
Software R package and web server for T cell state assessment and its applications in immune environment prediction.
Core specializes in multi-omics and next-generation sequencing data analysis from genetics, genomics, proteomics, metabolomics, and microbiome studies, with expertise in single-cell technologies as well as AI/ML applications in bioinformatics. Provides expertise, supports grant writing and manuscripts and comprehensive data analysis services.
Core is a shared research resource of the COBRE on Opioids and Overdose at Brown University Health. Provides expertise in biostatistics, epidemiology, study design, data management, data visualization, and quantitative research methods. Services include statistical consultation, power and sample size estimation, analytic support, data infrastructure guidance, data collection strategies, and training for investigators conducting substance use, overdose, and related public health research.
The BUH-COBRE Translational & Transformative Research Core is a shared research resource of the COBRE on Opioids and Overdose at Brown University Health. The Core supports the translation of research findings into clinical practice, community implementation, and public health impact. Services include qualitative research consultation, implementation and dissemination support, development of recruitment and educational materials, video production services, access to specialized research resources, and drug-checking research support.
Core is a shared research resource of the COBRE on Opioids and Overdose at Brown University Health. The Core supports community-engaged research by connecting investigators with community partners, people with lived and living experience, healthcare organizations, and other stakeholders. Services include community consultation, Community Advisory Board support, participant recruitment and retention strategies, dissemination planning, stakeholder engagement, and guidance on equitable and ethical research practices.