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Software tool for haplotype aware CNV analysis from single-cell RNA-seq, ATAC-seq, and multiome. Haplotype aware analysis of somatic copy number variations from single-cell transcriptomes. It integrates signals from gene expression, allelic ratio, and population-derived haplotype information to accurately infer allele-specific CNVs in single cells and reconstruct their lineage relationship.
Core offers services in the field of bulk, single cell, spatial omics, FACs sorting and sequencing.
Specialized, compact confocal laser scanning microscope designed for high-resolution 3D fluorescence imaging. Key features include 2048 x 2048 pixel resolution, a point-scan mechanism, and compatibility with Zeiss Zen software for 3D reconstruction and image processing.
High-resolution 3D X-ray microscope (micro-CT) designed for non-destructive, submicron imaging of internal structures in materials science, electronics, and life sciences. It allows researchers to visualize 3D details at 500 nm resolution without cutting samples, using "Resolution at a Distance" (RaaD™) technology to image large or complex items.
Core provides instrumentation, training, and high-level scientific and technical expertise relating to conventional and spectral cytometry, cell sorting, small particle analysis, ELISA/ELISpot, PBMC processing and cryopreservation, and multiplex assays.
Facility focused on next-generation sequencing services. Offers advanced capabilities in next-generation sequencing, single-cell sequencing, and genomics and epigenomics services.
Cancer genomics project management and data sharing support facility.
Core offers high-throughput sequencing, genotyping, single-cell multi-omics, and spatial biology services as well as training and consultation. Next Generation Sequencing (NGS) technologies including Illumina and Element Biosciences short-read sequencing, PacBio and Nanopore long-read sequencing services provide sequencing and library preparation for these platforms. Genotyping is performed on the Fluidigm EP1 System for low to medium assay numbers, genotyping-by-sequencing assays, and with a range of genotyping-by-sequencing technologies (e.g. multiplexed amplicon, single-primer extension, reduced representation, and skim-seq protocols). Gene expression analysis is carried out by RNA-seq on short-read sequencers as well as full-length transcript sequencing on long-read systems. Single-cell transcriptome (high-throughput single-cell gene expression profiling) and multi-ome studies are enabled by our 10X Genomics Chromium X system and Parse Biosciences assays. Spatial transcriptome profiling is supported on the Xenium and Visium HD platforms with the help of our CytAssist instrument for fresh-frozen, fixed-frozen, and FFPE tissue sections. We offer annual Illumina and PacBio sequencing library preparation workshops, free consultations on project considerations and experimental design, and custom sequencing library prep solutions.
Facility provides access to human stem cells, 3D organoids, and other human-relevant disease models to support more predictive drug discovery, improved safety and toxicity assessment, and deeper mechanistic insight. Leveraging organoid and microphysiological platforms, the core enables next-generation therapeutics and clinical trial-in-a-dish approaches that advance biomedical innovation and precision medicine.
Software user-friendly Shiny interface for measuring marker panel efficiency according to previous datasets and visualizing CNV profiles.
Software R packages with Shiny Interface. Modular R Shiny application that serves as a unified hub that lets users install and launch specialized breeding analysis tools - all from a single interface, with no command-line setup required.
Benchtop microfluidic cell sorter designed to gently analyze, sort, and plate live cells (stem cells, antibody-producing cells, immune cells) using low pressure and sterile, disposable fluidics. It enables high-viability sorting while preventing cross-contamination.
Automated 3D cell culture bioreactor designed to grow large, functional organoids and spheroids by simulating microgravity via a clinostat. It provides a low-shear environment, enhancing nutrient/oxygen diffusion and cellular communication to produce more physiologically relevant tissue models compared to traditional methods.
Specialized gene transfection system designed to introduce molecules (DNA, RNA, siRNA, CRISPR/Cas9) into difficult-to-transfect cells, tissues, and embryos. It uses a unique 4-step, multi-pulse technology to maximize transfection efficiency while maintaining high cell viability.
Full-service core facility specializing in high throughput assay development and screening of chemical and genomic probes.
Software tools to measure the penetration depth of a fluorescently stained molecule into the skin.
Core offers instrumentation for electrical/magnetic/optical characterization of thin film and semi-conductor materials and devices. Temperature range depending on technique is -1.8K to 400K.
Core provides high-plex immunohistochemistry (PhenoCycler/CODEX) on human and mouse FFPE tissues, image analysis (IHC, mIHC, high-plex), and support for collaborative and fee-for-service projects.
HPTLC plates deliver fast and quantitative analysis of complex samples for manual or automated use. Our HPTLC silica plates work three times faster than conventional TLC plates – and they are more sensitive. The particle sizes range in HPTLC is between 4-8 µm, which creates a smoother surface and a higher separation power than TLC plates.
Core supports and enhance research and education by providing access to characterization and process instrumentation. Expert staff provides the assistance and guidance necessary so that students, faculty, and industry get the most effective and appropriate use of facility resources. NRF facilities encompass 100+ instruments, tools and techniques as well as a 7,000 sq. ft. Class 100-1000 Cleanroom facility. Facilities also include instrumentation that allows characterization of radioactive samples.