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Core provides Illumina next-generation sequencing and single-cell RNA sequencing to support gene expression and genomic research. Core services include Illumina Sequencing: High-throughput, fast-turnaround genomic sequencing runs; Single-Cell Transcriptomics: Single-cell RNA sequencing (scRNA-seq) chemistries to map gene expression at individual cell resolution; Gene Expression Analysis: Support for studies examining transcriptional changes, host resistance mechanisms, and inflammatory responses.
Standalone, Windows-based software program designed to identify and annotate low-complexity purine and pyrimidine regions as well as user-defined nucleotide sequences within prokaryotic and eukaryotic genomes. It features a graphical user interface and performs rapid "one-go" genome analyses without requiring high-performance computing clusters. Software for detection and annotation of sequence tracks of chosen nucleic acid bases with defined length in genome. Used to identify low-complexity regions containing DNA sequences of selected nucleotide(s) and to annotate the data with the support of NCBI/Genome database.
Software Python framework for analysis of single-molecule FRET data.
Software tool for detection of sample swaps and cross-individual contamination in whole-genome and whole-exome tumor–normal sequencing experiments. Used for human tumor-normal studies to perform concordance verification (= samples coming from the same individual), as well as cross-individual contamination level estimation in whole-genome and whole-exome sequencing experiments.
Software Python package and service for the genome-writing era, the modality that installs new information into genome (inserting genes, flipping or excising kilobases, placing programmable landing pads). Used for verification and grounding layer for AI-driven genome writing: checks proposed genomic edits against validated tools and calibrated models rather than relying on language model outputs alone.
Software application for genome-writing design AI: screens an AI-generated editing plan across five hazard axes and returns allow, flag-for-review, or refuse with cited evidence and a signed design passport. Used to prevent engineered organisms or artificial intelligence DNA designs from causing harm or escaping control.
A verification and grounding layer for AI-driven genome writing: checks proposed genomic edits against validated tools and calibrated models rather than relying on language model outputs alone.
The cellenONE® is an open platform for single-cell isolation and nanoliter-scale dispensing. It leverages the sciDROP PICO technology combined with advanced vision processing to enable real-time, highly precise single-cell isolation and dispensing. Gentle acoustic droplet generation ensures excellent cell viability, making it suitable for cell line development and single-cell sequencing applications. insuffcient information letter
Core provides centralized services, consultation, training and technical support to advance transgenic animal genotyping and cardiovascular, metabolic and behavioral phenotyping research.
Health care organization in Maine, serving communities across Maine and New Hampshire. Includes MaineHealth Institute for Research to support research at MaineHealth ranging from basic laboratory-based research through translational research, which works to apply basic discoveries to medical problems, to clinical research, which studies the direct application of new drugs, devices and treatment protocols to patients, to health services research which seeks to use research methods to help improve and evaluate health care delivery programs and new technologies.
Core offers a variety of preclinical imaging services. Small animal imaging core facility with high-resolution ultrasound (FujiFilm, Vevo F2, Visual Sonics) and micro CT (SkyScan 1276 (Bruker), micro CT with in vivo and ex vivo capabilities, Caliper IVIS Lumina LT (Revvity). Offers complete services for non-destructive, longitudinal optical imaging with bioluminescence and fluorescence capabilities of mice.
Core facility provides microscopy services including confocals, epifluorescence, 2-photon, lightsheet, superresolution, slide scanning and image analysis.
Core offers integrated biobanking, histology, digital pathology and other advanced tissue analysis services to support basic, translational and clinical research.
Software Python library to manage metabolic networks. Python library for hAndling metaData of METabolism.
Software tool for informed prediction and analysis of bacterial metabolic pathways and genome-scale network. Used to predict metabolic pathways and automatically reconstruct microbial metabolic models.
Software Phyton tool for genome-scale metabolic model reconstruction. Used for reconstruction of species and community level metabolic models.
Ultrasonic shearing instrument used to fragment chromatin, shear DNA and RNA, and lyse cells.
Core provides services, shared research equipment and technical support for flow cytometric analysis and high-speed cell sorting. Used to study cells using multi-laser instruments, separate specific cell populations, and design experiments.
Core offers nanofabrication services and tools for lithography, deposition, etch, and characterization. Used for researching, building, and measuring materials on a microscopic scale. Provides cleanroom space and advanced tools for academic and industry projects.
Core is fully equipped histological laboratory providing embedding station, automatic coverslipper, immunohistological platforms for standardized and automated immunohistochemistry, slide scanners, laser microdissection and light-sheet fluorescence microscope.