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Core provides researchers with specialized resources to inform thoughtful and testable intervention strategies. Core services include survey and database development, qualitative research and health economics consultation, participant recruitment, primary data collection, and access to a mobile clinical research van.
Core provides investigators with data acquisition and management, advanced biostatistical modeling, and secure high-performance computing (HPC) infrastructure. Provides researchers with tools they need to successfully conduct rigorous, impactful population health research in rural and frontier communities.
Labeled calcium indicators are molecules that exhibit an increase in fluorescence upon binding Ca2+. They have uses in many calcium signaling investigations, including measuring intracellular Ca2+, following Ca2+ influx and release, and multiphoton excitation imaging of Ca2+ in living tissues. Cells may be loaded with the AM ester forms of these calcium indicators by adding the dissolved indicator directly to dishes containing cultured cells. The fluorescence signal from these cells is generally measured using fluorescence microscopy, fluorescence microplate assays, or flow cytometry.
CellTrace™ Violet Cell Proliferation Kit is used for in vitro and in vivo labeling of cells to trace multiple generations using dye dilution by flow cytometry.
Software tool as C++ implementation of the variant caller VarDict used in cancer research and clinical genomics to analyze next-generation sequencing (NGS) data from DNA or RNA samples to detect genetic mutations.
Federal government hospital located at 830 Chalkstone Avenue in Providence, Rhode Island. Run by the Department of Veterans Affairs, it provides medical care, emergency services, and mental health support to military veterans in Rhode Island and nearby parts of Massachusetts.
Software analysis pipeline for CUT&RUN and CUT&TAG experiments that includes QC, support for spike-ins, IgG controls, peak calling and downstream analysis. Used to process and analyze CUT&RUN, CUT&Tag, and TIP-seq genomic data. It maps protein-DNA interactions and chromatin profiles (similar to ChIP-seq, but with lower background noise) in a reproducible, portable way.
Core provides investigators with access to specialized expertise in primary cell isolation, ex vivo organ function assessment, histology, and advanced tissue imaging. The Core supports cardiovascular, pulmonary, and vascular research through customized experimental services, consultation, and rigorous functional and molecular analyses that accelerate mechanistic discovery and translational research.
Biotechnology company that connects patients and healthy donors directly with medical researchers. It collects human biological samples such as blood, plasma, and immune cells to help pharmaceutical companies develop new drugs, diagnostics, and cell therapies. Human biospecimen provider.
Core translates genomic and molecular discoveries into clinical diagnostic and therapeutic applications, focusing heavily on spatial "omics" and advanced tissue analysis. Services include Spatial Profiling: Houses specialized tools like the NanoString GeoMx® Digital Spatial Profiler to map RNA and proteins inside tissue sections; Multiplex Immunofluorescence: Uses platforms like Akoya Opal™ and Leica Cell DIVE™ to image over 40 custom protein markers on a single tissue sample; Histology and Sample Prep: Provides tissue microarray (TMA) construction, laser capture microdissection, microtomy (sample sectioning), and whole-slide digital scanning; Image Analysis: Uses advanced software (such as HALO) to quantify and evaluate tissue biomarker stains.
Core oversees humane animal care, housing, veterinary oversight, and regulatory compliance for all vertebrate research and teaching facilities across campus, partnering with the Institutional Animal Care and Use Committee (IACUC).
Control and acquisition software package for the Olympus FLUOVIEW FV3000 confocal laser scanning microscope system. File formats; OIR, OIF, OIB and VSI are supported. File exporting function to general file formats (BITMAP, JPEG, PNG, TIFF, WMV, OIF, OIB, FluoView Multi-TIFF) is available.
Software modular Snakemake pipeline for personalised neonatigen discovery and prioritisation using Patient Specific Functional Interaction Networks. Used for identifying and prioritizing personalized tumor neoantigens from DNA and RNA sequencing data. It detects candidate epitopes arising from somatic variants, gene fusions, and alternative-splicing events, and integrates HLA binding, expression, gene essentiality, and patient-specific gene co-expression network features to rank biologically relevant vaccine candidates.
Histology Core specializes in processing, embedding, sectioning, and staining of animal tissues. The core can supply standard hematoxylin-eosin (H&E) staining, and a variety of standard special stains are available. The Histology Core also offers veterinary pathology support through GEMpath Inc.
Core provides Illumina next-generation sequencing and single-cell RNA sequencing to support gene expression and genomic research. Core services include Illumina Sequencing: High-throughput, fast-turnaround genomic sequencing runs; Single-Cell Transcriptomics: Single-cell RNA sequencing (scRNA-seq) chemistries to map gene expression at individual cell resolution; Gene Expression Analysis: Support for studies examining transcriptional changes, host resistance mechanisms, and inflammatory responses.
Standalone, Windows-based software program designed to identify and annotate low-complexity purine and pyrimidine regions as well as user-defined nucleotide sequences within prokaryotic and eukaryotic genomes. It features a graphical user interface and performs rapid "one-go" genome analyses without requiring high-performance computing clusters. Software for detection and annotation of sequence tracks of chosen nucleic acid bases with defined length in genome. Used to identify low-complexity regions containing DNA sequences of selected nucleotide(s) and to annotate the data with the support of NCBI/Genome database.
Software Python framework for analysis of single-molecule FRET data.
Software tool for detection of sample swaps and cross-individual contamination in whole-genome and whole-exome tumor–normal sequencing experiments. Used for human tumor-normal studies to perform concordance verification (= samples coming from the same individual), as well as cross-individual contamination level estimation in whole-genome and whole-exome sequencing experiments.
Software Python package and service for the genome-writing era, the modality that installs new information into genome (inserting genes, flipping or excising kilobases, placing programmable landing pads). Used for verification and grounding layer for AI-driven genome writing: checks proposed genomic edits against validated tools and calibrated models rather than relying on language model outputs alone.