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Core provides advanced NMR spectroscopy for researching the atomic-level structure, dynamics, and interactions of biological macromolecules. It supports structural biology, biocatalysis, and drug discovery by analyzing proteins, DNA, RNA, and carbohydrates. Includes 800MHz NMR spectrometer with H/F-C-N Cryoprobe.
Attune CytPix Flow Cytometer combines acoustic focusing flow cytometry with a high-speed camera to simultaneously collect fluorescent data and high-resolution brightfield images for each cell. It is used for automated, AI-driven morphological analysis alongside traditional immunophenotyping, allowing users to validate cell populations, identify cell-to-cell interactions, and verify cell health (e.g., apoptosis, contamination) in real-time. Attune CytPix is a benchtop analysis cytometer with 4 lasers (488, 405, 561, and 633nm) and a brightfield camera.
High-end 300kV instrument designed for automated, high-resolution 3D imaging of biological samples, such as proteins and viruses, at molecular or atomic levels. It enables researchers to study samples in their native, hydrated state, primarily for drug discovery and structural biology.
Fully automated instrument used for nondestructive, in-situ, micro-scale elemental characterization. It is generally equipped with five vertical crystal spectrometers (WDS) and an energy dispersive analyzer (EDS), operating via proprietary Windows-based Peak Sight software or updated with third-party software like Probe for EPMA.
Ultra-high-resolution, Schottky field-emission scanning electron microscope (FE-SEM) designed for advanced nano-characterization, combining in-lens technology with a super hybrid lens to achieve 0.8 nm resolution. It is utilized for high-resolution imaging, elemental analysis (EDS/WDS), and crystallographic analysis (EBSD) of materials, magnetic samples, and non-conductive specimens, even at very low voltages (down to 10 V).
Spectrometer includes: Fast Ion Filter, Bent Trap for Pre-Accumulation, High-speed Quadrupole, Faster Stepped Collision Energy, Enhanced Dynamic Range mode, TMT HR mode, low input mode, Enhanced Spectral Processing, support for Hybrid DIA experiments, and expanded BioPharma option including Thermo Scientific™ Astral™ analyzer support for top-down and middle-down measurements. Used to accelerate deep proteomics and single-cell analysis. Combines fast scan rates with high-resolution, accurate-mass (HRAM) measurements to detect more proteins, analyze thousands of cells daily, and improve precision oncology or clinical biomarker discovery. THIS RESOURCE IS NO LONGER IN SERVICE. Documented on July 13,2026.
Molecular Taxonomy of the Breast Cancer International Consortium (METABRIC) is a landmark study and dataset comprising primary breast tumour samples with detailed genomic, transcriptomic, and clinical data. It identified ten distinct "integrative clusters" (IntClust) based on copy number aberrations and gene expression, revealing new, clinically relevant subtypes with varying prognoses.
Facility contains equipment for all basic molecular biology needs. Training and help are provided. Provides molecular biology services ranging from DNA preparations to cloning and mutagenesis projects.
Software MATLAB toolbox for the automatic segmentation of the hippocampus in brain MRI images. It implements a novel patch-based label fusion method that cooperates with a non-rigid registration-based label fusion approach. Used to automatically and accurately segment the hippocampus in MRI scans by combining two techniques.
Software code used in the multi-omics study of clear cell Renal Cell Carcinoma (ccRCC).
Source code for work submitted to journal. Multimodal foundation model for pan-cancer prognosis prediction developed on 14,468 patients across 30 cancer types using a collaborative multi-expert architecture that retains unique signals from each modality while modeling their interactions.
Non-profit research consortium located in Harlem, NY, providing advanced structural biology technologies to academic and commercial researchers. Founded by nine institutions, it specializes in cryo-electron microscopy (Cryo-EM), NMR spectroscopy, and X-ray crystallography to analyze molecular structures for drug discovery.
Software R package provides wrapper functions to compute parametric, nonparametric, and bootstrap confidence intervals (CIs) for comparing two samples, specifically designed for all-pairs or many-to-one comparisons. It enables, but does not enforce, adjustments for multiple testing.
High-resolution, benchtop Quadrupole Time-of-Flight mass spectrometer designed for characterizing small molecules and biotherapeutics. Used for analyzing complex samples, offering quantitative/qualitative data, and seamless integration with ACQUITY Premier LC systems.
Stand-alone software package for translation of individual tumor genomes for precision cancer medicine. PCGR interprets primarily somatic SNVs/InDels and copy number aberrations. The software extends basic gene and variant annotations from the Ensembl's Variant Effect Predictor (VEP) with oncology-relevant, up-to-date annotations, and produces interactive HTML reports intended for clinical interpretation.
Software tool as natural language interface integrated with MDV that allows users to generate high-quality interactive visualisations through natural language commands. ChatMDV employs a retrieval-augmented generation (RAG) pipeline combined with large language models (LLMs) to translate user queries into reproducible Python code and interactive output. Module to add chatbot functionality to query Multi-Dimensional Viewer projects.
Web tool for analyzing, annotating and sharing multi-dimensional data. Visualisation platform used for spatial analysis.
Database offers integrated multi-omic data for patients across 33 cancer types. It encompasses gene expression, DNA methylation, somatic mutations, proteomic profiles, and chromatin accessibility, drawing from TCGA, GTEx, and CPTAC projects. Users can compare gene expression, DNA methylation, and protein levels between tumor and normal tissues, identifying differentially expressed genes and proteins, and examining gene-to-gene correlations. Provides oncogene mutation profiles and allows for survival analysis based on gene expression and methylation, linked to clinical parameters. Facilitates exploration of multi-omic correlations, such as gene expression with DNA methylation, and their variations with mutation status. Extends its analytical capabilities to include six major oncoviruses, offering insights into their impact on gene expression, methylation, and patient survival.
Web application made for plotting genomic data. Used for genomic composite visualization for bioinformaticians and bench scientists to visualize and analyze signal occupancy across genomic regions.
Automated instrument designed to extract, purify, and quantify nucleic acids (DNA/RNA) from diverse biological samples, preparing them for Next-Generation Sequencing (NGS). It accelerates laboratory workflows, allowing 20 minutes of hands-on time to yield NGS ready samples in ~2 hours.