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Core is equipped with instrumentation supporting areas of NMR, EPR and related techniques.

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• 2 years ago - submitted by John Warren

Core to bring together community of knowledge and best practise from three Faculty of Science and Engineering Departments: Chemistry, EES and Materials. Provided equipment is housed across numerous parts of campus with bulk being operated from Engineering Building A and Chemistry. Offers technical expertise in techniques such as residual stress analysis, texture analysis, phase identification in crystalline and semi crystalline powders and solid materials, single crystal and small angle scattering. Machines are available for examination of both small specimens and large components, and for wide range of materials.

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• 2 years ago - submitted by John Warren

Core to build partnerships with government, National Facilities, industrial and academic stakeholders at Harwell and beyond, to jointly address challenges set by UK’s Industrial Strategy through research and to discover and develop innovative techniques and technologies to enhance facility science, data analytics and workplace safety.

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• 2 years ago - submitted by John Warren

Flexible system that supports various slide sizes, different objectives, SILA optical sectioning device, oil dispenser, cameras, loaders, and LED/laser light sources with multiple filter sets. VS200 supports brightfield, darkfield, polarization, phase contrast, and fluorescence, with possibility to scan sample using multiple techniques at the same time. VS200 software supports offline analysis, deep learning, 3D deconvolution, and batch conversion to standard file formats. It also supports the NIS-SQL database for data management and the DICOM format for easy integration into lab information management system.

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• 2 years ago - by Anonymous

Company for development, manufacture, sale and provision of solutions for biological microscopes, industrial microscopes, industrial endoscopes, non-destructive inspection equipment, X-ray analyzers, etc.

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• 2 years ago - by Anonymous

Immunophenotyping core provides services for isolation of cellular populations from tissues, automated quantification of cell numbers, quantification of GFP, DAPI, RFP, Cy5 or Cy7 positive populations, automated quantification of cytokine concentration in supernatants and biological samples, and flow cytometric and microscopic assay development and execution.Provides training and education opportunities.

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• SciCrunch
• 2 years ago - submitted by Edyta Vieth

Facility works with investigators to obtain and analyze high-quality nutrition and body composition data from study participants. Staff and facilities are located in the Schubert Research Clinic at Cincinnati Childrens Hospital. Core provides diet assessment services.

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• 2 years ago - submitted by Edyta Vieth

Core supports data analysis, network modeling, and data science research. Provides training and education opportunities.

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• 2 years ago - submitted by Edyta Vieth

Facility includes Analytic Redox Biology and Molecular Signaling Sub-Cores. Provided services include measurements of reactive oxygen species, reactive nitrogen species, reactive sulfide species, protein, peptides, metabolites, and lipids in cell culture and tissue samples. High-performance liquid chromatography systems, coupled with UV-vis and fluorescence detectors to quantify cellular and mitochondrial superoxide production, hydrogen sulfide pools (free sulfide, sulfide bound to transitional metals, and sulfane sulfur), and thiols (glutathione, GSH/GSSG, cysteine, cystine, homocysteine, persulfides, and glutathionylation).Instruments include Sievers NO Analyzer (NOA 280i, GE), Agilent 8890 GC and 8335 sulfur chemiluminescence detector ,Thermo Scientific Orbitrap Exploris 480 and SCIEX Triple Quad 7500 mass spectrometer. Molecular Signaling Sub-Core offers services for molecular cloning and site-directed mutagenesis, design and production of vectors for CRISPR/Cas9 modification of vascular cells, services for endothelial, smooth muscle, and cardiac myocyte cell isolation, for generation of vascular cell lines, and for lentivirus production for transient or stable modification of cardiovascular cells, access to equipment and expertise for studying cellular effects of hypoxia/reoxygenation injury (Coy Hypoxic Chamber, CLARIOstar Spectrofluorometer), for automated capillary Western blot analysis (ProteinSimple Jess Simple Western), and for high-resolution fluo-respirometry to study mitochondrial function (Oroboros O2k modular system).

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• SciCrunch
• 2 years ago - submitted by Edyta Vieth

Core provides imaging support to investigators who use small animal models in their research. Offers bioluminescence and fluorescence imaging, X-ray imaging, computed tomography, and positron emission tomography. Core provides imaging support services for investigators, including assistance in experimental design, conducting animal studies including anesthetization and imaging acquisition, and processing and interpreting imaging data.

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• SciCrunch
• 2 years ago - submitted by Edyta Vieth

Core provides services for mouse genotyping and tissue histology, access to tools for analyzing cardiovascular function, data analysis, expertise and training. Services include genotyping using PCR or RT PCR, histology services with tissue processing, paraffin-embedding and sectioning, along with several cardiovascular relevant histological stains such as Picrosirius Red and Masson Trichrome.

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• SciCrunch
• 2 years ago - submitted by Edyta Vieth

Core provides access to research services, educational and training opportunities, and technologies including cellular metabolism, flow cytometry, fluorescence, confocal, super resolution confocal microscopy, next generation sequencing, and real-time PCR. Provides assistance with all aspects of these technologies, including experimental design, protocol optimization, instrument operation, and data analysis.

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• SciCrunch
• 2 years ago - submitted by Edyta Vieth

Web service for online data drawing and analysis, personalized data analysis, scientific research mapping, online page/database development and hosting. Used for high throughput sequencing data analysis including eccDNA-seq, MeRIP-seq, circRNA-seq, miRNA-seq, mRNA-seq, LncRNA-seq, piRNA-seq, ChIP-seq, etc.

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• 2 years ago - by Anonymous

Software code package associated to the paper: Lemke et al. Information flow between motor cortex and striatum reverses during skill learning. 2023. Quantifies information theoretic quantities used in the associated study.

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• 2 years ago - submitted by Marco Celotto

Software application as MATLAB scripts to compute measures of Feature-specific Information Transfer (FIT) and conditional FIT (cFIT). FIT quantifies direction and magnitude of information flow about specific feature S (such as feature of sensory stimulus) between simultaneously recorded brain regions X and Y. cFIT quantifies amount of directed feature information transmitted between regions X and Y that cannot be potentially routed through region Z.

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• 2 years ago - submitted by Marco Celotto

Software finite element analysis package. Used to solve field problems.

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• 2 years ago - by Anonymous

The Metabolomics, Lipidomics, and Proteomics Platform facilitates metabolism-related and molecular research, serving researchers from academia and industry in Luxembourg and beyond. We specialize in the comprehensive analysis of small molecules and proteins within complex biological matrices. Our advanced analytical infrastructure and broad method portfolio accelerate scientific discoveries across biology, biomedicine, and systems biology.

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• SciCrunch
• 2 years ago - submitted by Edyta Vieth

Software tool that quantifies tumor content in cfDNA from 0.1× coverage whole-genome sequencing data without prior knowledge of tumor mutations. Used to simultaneously segment genome, predict large scale copy number alterations, and estimate tumor fraction of ultra low pass whole genome sequencing sample.

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• 2 years ago - by Anonymous

Software tool for annotating fusion transcripts, incorporated into Trinity Cancer Transcriptome Analysis Toolkit utilities, and leveraging databases including CTAT Human Fusion Lib.

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• 2 years ago - by Anonymous

Software application to estimate presence of MRD in plasma cfDNA WGS through evaluation of matched tumour-derived mutations (SNVs or CNVs).

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• 2 years ago - by Anonymous