We support boolean queries, use +,-,<,>,~,* to alter the weighting of terms
Facility provides access to Chromium iX platform from 10X Genomics. This allows user to barcode single cells or nuclei and process them for single cell RNA-seq, single nucleus ATAC-seq or single nucleus Multiome ATC + Gene Expression protocols.
Software 16S rRNA analysis workflow with QIIME2 and Snakemake.
Open source, interoperable software tool to remove duplicate citations in biomedical systematic reviews.
Core offers specialised microinjection services for generating transgenic strains of fruit fly Drosophila melanogaster.
Software R package to perform statistical analysis of differential protein expression for quantitative proteomics data.
Software tool to determine whether two priori sets of genes show statistically significant differences between two biological states. Statistical approach to quantify relative enrichment of two gene sets.
Web infrastructure for visualizing and remixing microbial ‘omics data. Software visualization platform to view next-generation sequencing data, such as RNA-seq counts.
Aims to stop biological time and extend ability to bank and transport cells, aquatic embryos, tissue, skin, whole organs, microphysiological systems and whole organisms. Builds advanced biopreservation technologies to eliminate or mitigate ice formation, cryoprotective agent toxicity, and slow and/or non-uniform rewarming.
Software tool for spatial domain identification from spatially resolved transcriptomics with multi-modal feature representation.
Workflow for preprocessing cfDNA samples. Unified, standardized, and ready-to-use workflow for processing whole genome sequencing cfDNA samples from liquid biopsies. Includes steps for pre-processing raw cfDNA samples, quality control and reporting. Additionally, several optional utility functions like GC bias correction and estimation of copy number state are included. Provides specialized methods for extracting coverage derived signals and visualizations comparing cases and controls.
Core supports research in chemistry, biochemistry, molecular biology, engineering and related fields. The MRRC operates six solution-state NMR spectrometers (400 to 800 MHz), a solid-state 300 MHz NMR instrument, and an X-band EPR spectrometer. Most instruments are equipped with sample changers for increased sample throughput.
Macromolecular X-ray Crystallography Facility provides all resources for Crystal Screening and Optimization, Data Collection and Structure Determination of macromolecules.
Provides access and training for confocal and super-resolution light microscopy systems with support for experimental design and data visualization.
Core provides analysis of large and small molecules using several ionization methods, low or high resolution, hyphenated techniques, proteomics, and metabolomics.
Electron microscopy core with both service and individual use options.
Cloud-based high performance computing for specialised analyses on environmental omics.
Software R package to analyse large volumes of data. Extracts structure of data without the need to build any model to represent it. Provides functions for data exploration via PCA, and allows the user to generate publication ready figures.
Software environment for subtomogram averaging of cryo-EM data. Development tool for subtomogram averaging of cryo-EM data in high-performance computing environments.
Core uses mass spectrometry to characterize proteins as well as other biologically-derived molecules. Specializes in characterization of protein post-translational modifications, including glycosylation, phosphorylation, acetylation and persulfidation.Provides identification of protein-interactions including determination of protein-protein crosslinks and quantitative comparisons of complex samples.
Core provides basic husbandry, training, supplies, and specialized service support for medical research at IU School of Medicine.